Multisource device for photometric analysis and associated chromogens
    61.
    发明授权
    Multisource device for photometric analysis and associated chromogens 失效
    用于光学分析和相关色素的多媒体设备

    公开(公告)号:US5073029A

    公开(公告)日:1991-12-17

    申请号:US481450

    申请日:1990-02-16

    Abstract: An optoelectronic device is provided which permits rapid sequential measurement of the optical density of multiple samples. The device employs a plurality of light-emitting diodes (LEDs) as light sources and a plurality of photodiodes as light detectors. In a preferred embodiment, arrays of LEDs paired with photodiodes are adapted to measure the optical density of samples contained in multiwell plastic plates (microplates) conventionally used for immunoassays.

    Abstract translation: 提供了一种允许快速连续测量多个样品的光密度的光电子器件。 该装置使用多个发光二极管(LED)作为光源和多个光电二极管作为光检测器。 在优选实施例中,与光电二极管配对的LED阵列适于测量通常用于免疫测定的多孔塑料板(微孔板)中包含的样品的光密度。

    Photometric apparatus for multiwell plates having a positionable lens
assembly
    62.
    发明授权
    Photometric apparatus for multiwell plates having a positionable lens assembly 失效
    具有可定位透镜组件的多孔板的光度测定装置

    公开(公告)号:US4892409A

    公开(公告)日:1990-01-09

    申请号:US218874

    申请日:1988-07-14

    Applicant: Harry F. Smith

    Inventor: Harry F. Smith

    Abstract: The invention relates to photometric apparatus and method for determining a characteristic of individual ones of a plurality of samples contained within a plurality of sample chambers. The photometric apparatus includes an enclosure; a substantially uniform source of radiation coupled to the enclosure such that a plurality of sample chambers, disposed within the enclosure, are simultaneously illuminated by the uniform source; and apparatus for detecting an amount of radiation which is transmitted through individual ones of the sample chambers, the detecting apparatus having an output signal having a magnitude which is a function of the amount of radiation which is transmitted through an individual one of the sample chambers. The substantially uniform source of radiation may include at least one source of radiation having an output comprising wavelengths within a first range of wavelengths and an optically integrating sphere having a radiation input port coupled to the output of the source of radiation and a radiation output port coupled to the enclosure. The photometric apparatus may further include radiation directing devices interposed between the radiation output port and the plurality of sample chambers for simultaneously directing radiation emanating from the output port into each of the sample chambers. The directed radiation may be either focussed or collimated.

    Abstract translation: 本发明涉及用于确定包含在多个样品室内的多个样品中的各个样品的特性的光度测定装置和方法。 测光装置包括外壳; 耦合到外壳的基本上均匀的辐射源,使得设置在外壳内的多个样品室同时被均匀光源照射; 以及用于检测通过单个样本室传输的辐射量的装置,该检测装置具有输出信号,该输出信号的幅度是通过单独一个样本室传输的辐射量的函数。 基本上均匀的辐射源可以包括至少一个辐射源,其具有包括在第一波长范围内的波长的输出和具有耦合到辐射源的输出的辐射输入端口的光学积分球,以及辐射输出端口 到外壳。 测光装置还可以包括插入在辐射输出端口和多个样品室之间的辐射导向装置,用于同时将从输出端口发出的辐射引导到每个样品室中。 定向辐射可以是聚焦的或准直的。

    Rapid and automatic fluorescence immunoassay analyzer for multiple
micro-samples
    63.
    发明授权
    Rapid and automatic fluorescence immunoassay analyzer for multiple micro-samples 失效
    用于多个微量样品的快速和自动荧光免疫分析仪

    公开(公告)号:US4626684A

    公开(公告)日:1986-12-02

    申请号:US513307

    申请日:1983-07-13

    Applicant: Isaac J. Landa

    Inventor: Isaac J. Landa

    Abstract: An apparatus uses a rapid and efficient method for conducting fluorescence measurements, such as immuno assay, of a plurality of samples of a substance using pulsed or continuous light energy, front-end fluorescent optics, a mechanism which allows for lateral and tranverse scanning of rows and columns of wells, and spectra emission analysis of the spectra from the excited samples.

    Abstract translation: 一种装置使用快速和有效的方法进行使用脉冲或连续光能的物质的多个样品的荧光测量,例如免疫测定,前端荧光光学器件,允许横向扫描和横向扫描行的机构 和列的列,以及来自激发样品的光谱的光谱发射分析。

    USE OF RAMAN SPECTROSCOPY TO MONITOR CULTURE MEDIUM

    公开(公告)号:US20230175967A1

    公开(公告)日:2023-06-08

    申请号:US17885167

    申请日:2022-08-10

    Applicant: Biogen MA Inc.

    CPC classification number: G01N21/65 G01J3/44 G01N2201/0446 G01N2201/06113

    Abstract: In one aspect, the disclosure provides a method of defining a Raman signature of a culture component, the method comprising: obtaining a Raman spectrum of a culture component in a non-interfering or minimally-interfering solution, identifying peaks in the Raman spectrum that are associated with the culture component, obtaining a Raman spectrum of a culture medium comprising the culture component, and, removing peaks of the culture component in the Raman spectrum of the culture medium that are distorted compared to the peaks identified in the Raman spectrum of the culture component in a non-interfering or minimally-interfering solution.

    ARRAY LEVEL FOURIER PTYCHOGRAPHIC IMAGING
    67.
    发明申请

    公开(公告)号:US20170299854A1

    公开(公告)日:2017-10-19

    申请号:US15636494

    申请日:2017-06-28

    Abstract: In one aspect an imaging system includes: an illumination system including an array of light sources; an optical system including one or more lens arrays, each of the lens arrays including an array of lenses, each of the lenses in each of the one or more lens arrays in alignment with a corresponding set of light sources of the array of light sources; an imaging system including an array of image sensors, each of the image sensors in alignment with a corresponding lens or set of lenses of the one or more lens arrays, each of the image sensors configured to acquire image data based on the light received from the corresponding lens or set of lenses; a plate receiver system capable of receiving a multi-well plate including an array of wells, the plate receiver system configured to align each of the wells with a corresponding one of the image sensors; and a controller configured to control the illumination of the light sources and the acquisition of image data by the image sensors, the controller further configured to perform: an image acquisition process including a plurality of scans, each scan associated with a unique pattern of illumination, each of the image sensors configured to generate an image for a respective one of the wells during each scan; and an image reconstruction process during which the controller performs a fourier ptychographic operation to generate a reconstructed image for each of the wells based on the image data captured for the respective well during each of the scans.

    System and method for determining the concentration of tetrahydrocannabinol
    69.
    发明授权
    System and method for determining the concentration of tetrahydrocannabinol 有权
    用于测定四氢大麻酚浓度的系统和方法

    公开(公告)号:US09291552B2

    公开(公告)日:2016-03-22

    申请号:US14631995

    申请日:2015-02-26

    Abstract: The present describes a system and method for determining the concentration of tetrahydrocannabinol (THC) including a tray comprising a first analyte including an infusion of a solvent and cannabis, a light emitting element configured to illuminate the first analyte, a light receiving element configured to receive a first light transmitted through the first analyte, and a control circuit configured to calculate a concentration of tetrahydrocannabinol in the first analyte based at least in part on the first light.

    Abstract translation: 本发明描述了一种用于测定四氢大麻酚(THC)的浓度的系统和方法,所述系统和方法包括包含第一分析物的托盘,所述第一分析物包括溶剂和大麻的输注,被配置为照射所述第一分析物的发光元件,被配置为接收 透射通过第一分析物的第一光;以及控制电路,被配置为至少部分地基于第一光计算第一分析物中的四氢大麻酚的浓度。

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