公开(公告)号：US20080259328A1

公开(公告)日：2008-10-23

申请号：US12047844

申请日：2008-03-13

Applicant: Ryoichi HIRANO ,  Riki Ogawa

Inventor： Ryoichi HIRANO ,  Riki Ogawa

IPC: G01N21/00

CPC classification number: G01N21/95607 ,  G01N2021/95676 ,  G01N2201/0631

Abstract: A reticle defect inspection apparatus that suppresses deterioration of optical components resulting from luminescent spots generated by an integrator and can sustain a defect inspection with high precision for a long time is provided. The reticle defect inspection apparatus is a reticle defect inspection apparatus for inspecting for defects on a reticle using a pattern image obtained by irradiating the reticle on which a pattern is formed with light. And the apparatus includes an illuminating optical system for irradiating the reticle with an inspection light and a detecting optical system for detecting a pattern image of the reticle irradiated with the inspection light, wherein the illuminating optical system comprises an integrator for equalizing illumination distribution of the inspection light and a moving mechanism for enabling the integrator to slightly move in a direction perpendicular to an optical axis of the integrator.

Abstract translation: 提供了一种掩模版缺陷检查装置，其抑制由积分器产生的发光点导致的光学部件的劣化，并且能够长期高精度地进行缺陷检查。 掩模版缺陷检查装置是使用通过用光照射其上形成图案的掩模版获得的图案图像来检查掩模版上的缺陷的掩模版缺陷检查装置。 该装置包括用于用检查光照射标线的照明光学系统和用于检测用检查光照射的掩模版的图案图像的检测光学系统，其中照明光学系统包括用于均衡检查的照明分布的积分器 光和移动机构，用于使积分器能够在垂直于积分器的光轴的方向上稍微移动。

公开(公告)号：US20070263914A1

公开(公告)日：2007-11-15

申请号：US11684484

申请日：2007-03-09

Applicant: Clark Tibbetts

Inventor： Clark Tibbetts

IPC: G06K9/00

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

Abstract: An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CCD having an imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire micro array.

Abstract translation: 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 该装置还包括具有电荷耦合器件（CCD）的成像单元，该CCD具有被针孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像 。

公开(公告)号：US07242472B2

公开(公告)日：2007-07-10

申请号：US10866747

申请日：2004-06-15

Applicant: Yan Rung Lin ,  Teh Ho Tao ,  Zu Sho Chow ,  Ding Kun Liu

Inventor： Yan Rung Lin ,  Teh Ho Tao ,  Zu Sho Chow ,  Ding Kun Liu

IPC: G01J3/30

CPC classification number: G01N21/6428 ,  G01N21/6456 ,  G01N2021/6419 ,  G01N2021/6441 ,  G01N2201/0631

Abstract: The present invention discloses a biochip detection system for detecting a biochip labeled with multiple fluorophores. The biochip detection system comprises a broadband light source for generating a light beam, a stand for supporting the biochip, a light integrator positioned between the broadband light source and the biochip, a lens set for adjusting the cross-sectional area of the light beam, a first filter module positioned on the optical path of the light beam, a detector, e.g., CCD camera, photodiode array, for detecting a fluorescence beam emitted from the biochip, and a second filter module positioned on the optical path of the fluorescence beam. The light integrator can be a light tunnel, a lens array or a holographic diffuser for uniforming the intensity distribution of the light beam and changing the cross-sectional shape of the light beam into a rectangle.

Abstract translation: 本发明公开了一种用于检测用多种荧光团标记的生物芯片的生物芯片检测系统。 生物芯片检测系统包括用于产生光束的宽带光源，用于支撑生物芯片的支架，位于宽带光源和生物芯片之间的光积分器，用于调节光束横截面积的透镜组， 定位在光束的光路上的第一滤光器模块，用于检测从生物芯片发射的荧光束的CCD相机，光电二极管阵列的检测器和位于荧光束的光路上的第二滤光器模块。 光积分器可以是光通道，透镜阵列或全息漫射器，用于使光束的强度分布均匀并将光束的横截面形状改变成矩形。

公开(公告)号：US4600302A

公开(公告)日：1986-07-15

申请号：US593470

申请日：1984-03-26

Applicant: Burton H. Sage, Jr.

Inventor： Burton H. Sage, Jr.

IPC: G01N33/49 ,  G01N15/14 ,  G01N33/48 ,  G01N21/64

CPC classification number: G01N15/1434 ,  G01N15/147 ,  G01N2015/1497 ,  G01N2201/0631

Abstract: A flow cytometry apparatus for determining one or more characteristics of particles or the like flowing in a liquid stream includes a nozzle for generating a liquid flow stream for moving particles therethrough substantially one at a time. An arc lamp provides a beam of incoherent light to illuminate the particles moving in the flow stream. A prism in the light beam modifies non-uniform incoherent light, as provided by said arc lamp, to a more uniform beam of illumination which is directed to the flowing particles. A detector is included for detecting light with respect to each moving particle and for associating the detected light with one or more characteristics of the particles.

Abstract translation: 用于确定在液体流中流动的颗粒等的一个或多个特性的流式细胞仪装置包括用于产生用于每次一个地移动颗粒的液体流的喷嘴。 弧光灯提供非相干光束以照射在流动流中移动的颗粒。 光束中的棱镜将由所述弧光灯提供的非均匀非相干光改变为更均匀的照射光束，其被引导到流动的颗粒。 包括检测器，用于检测相对于每个移动颗粒的光，并将检测到的光与颗粒的一个或多个特性相关联。

公开(公告)号：KR101089045B1

公开(公告)日：2011-12-02

申请号：KR1020070064558

申请日：2007-06-28

Applicant: (주)바이오니아

Inventor： 박한이 ,  최일규 ,  박한오

IPC: C12Q1/68

CPC classification number: G01N21/6445 ,  G01J3/0224 ,  G01J3/4406 ,  G01N21/6452 ,  G01N2021/6478 ,  G01N2021/6484 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: 본 발명은 다수의 미량 시료를 중합효소연쇄반응과 같은 핵산 증폭반응을 수행하면서 반응 중에 생성되는 반응산물의 생성을 실시간으로 모니터링 하기 위한 핵산증폭반응산물의 실시간 모니터링 장치에 관한 것이다.
구체적으로 본 발명은, 여기광과 형광의 간섭을 효율적으로 분리하기 위해 편광자(Polarizer), 편광빔분할기(Polarizing Beam Splitter), 편광변환기(Polarization Converting System) 등을 포함하는 생화학 반응의 실시간 모니터링장치에 대한 것이다.
PCR, Q-PCR, 편광자, 편광빔분할기, 여기광

公开(公告)号：KR100647317B1

公开(公告)日：2006-11-23

申请号：KR1020050010186

申请日：2005-02-03

Applicant: 삼성전자주식회사

Inventor： 옥경식 ,  김수현 ,  김진태 ,  오광욱

IPC: G01N21/64

CPC classification number: G01J3/10 ,  G01J3/02 ,  G01J3/0218 ,  G01J3/0256 ,  G01J3/4406 ,  G01J2003/1213 ,  G01N21/05 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2021/0346 ,  G01N2021/3174 ,  G01N2021/6419 ,  G01N2021/6421 ,  G01N2021/6471 ,  G01N2021/6484 ,  G01N2201/0221 ,  G01N2201/0407 ,  G01N2201/0461 ,  G01N2201/0612 ,  G01N2201/0627 ,  G01N2201/0631 ,  G01N2201/0806 ,  G01N2201/0833

Abstract: A multi-channel fluorescence measuring optical system and a multi-channel fluorescence sample analyzer using the optical system are provided. The multi-channel fluorescence measuring optical system, which irradiates light onto a plurality of sample channels and detecting fluorescence radiated from samples (m), includes: a light source (10); an integrator (20) for giving the light irradiated from the light source a uniform intensity distribution; a sample holder (30) having a plurality of sample channels on which the samples (m) are mounted, wherein the samples (m) are exited by the light emitted from the integrator (20); a beam splitter (25) between the integrator (20) and the sample holder (30) for dividing the incident light in a predetermined ratio; and a light detecting unit (40) for detecting fluorescence from the samples (m) through the beam splitter (25). Preferably, the light intensities of fluorescence images are detected using optical fiber bundles and photodiodes, the manufacturing cost can be greatly reduced, and the optical system can be miniaturized.

公开(公告)号：KR1020150050523A

公开(公告)日：2015-05-08

申请号：KR1020147031005

申请日：2013-04-04

Applicant: 그로브 인스트루먼츠 인코퍼레이티드

Inventor： 하준마한누 ,  쿤스테반

IPC: A61B5/1455 ,  A61B5/026 ,  G01N21/31 ,  G01N21/35 ,  G01N21/49 ,  G01N33/49

CPC classification number: A61B5/14532 ,  A61B5/0051 ,  A61B5/1455 ,  A61B5/6816 ,  A61B5/6826 ,  A61B2560/0431 ,  A61B2562/0233 ,  A61B2562/146 ,  F04C2270/041 ,  G01N21/1717 ,  G01N21/314 ,  G01N21/359 ,  G01N21/474 ,  G01N21/49 ,  G01N33/49 ,  G01N2021/3148 ,  G01N2021/4709 ,  G01N2021/475 ,  G01N2201/0221 ,  G01N2201/0631 ,  G01N2201/0636

Abstract: 파이버리스트랜스플렉턴스프로브(20)를이용하여샘플매트릭스(22) 중의타겟분석물의농도를비침습적으로측정하는방법및 장치가개시된다. 이러한방법및 장치는상이한파장의적어도 2개의성분으로이루어지는전자기복사선의빔을샘플매트릭스(22)로지향시키고, 후방산란된복사선을샘플매트릭스(22)에서 2개의파장의차등흡수율을나타내는신호를출력하는검출기(18)로안내하는것을포함한다. 트랜스플렉턴스프로브(20)는내부반사면(52)을갖는테이퍼진관형하우징(50), 외부반사면(45)을갖는광학로드(40), 및프로브와샘플매트릭스(22)의표면사이에서인터페이스의역할을하는검출윈도우(46)를포함한다. 설명된방법및 장치는혈액을포함하는조직(22)에서혈당의농도를측정하는데에특히유용하다.

公开(公告)号：KR1020090004925A

公开(公告)日：2009-01-12

申请号：KR1020087024612

申请日：2007-03-09

Applicant: 테사레 엘엘씨

Inventor： 티베트클락

IPC: G01N21/00 ,  G01N33/48 ,  G01N33/548

CPC classification number: G01J3/02 ,  G01J3/0229 ,  G01J3/10 ,  G01J3/2846 ,  G01N21/6428 ,  G01N21/6452 ,  G01N21/6456 ,  G01N2201/0626 ,  G01N2201/0631

Abstract: An apparatus and method are provided for creating an image of a microarray. The apparatus includes at least one light source configured to direct light toward the microarray. The apparatus includes an excitation filter configured to filter the light into a first frequency band towards dichromatic mirror. The dichromatic mirror reflects light onto the microarray causing the microarray to emit electromagnetic energy. The apparatus includes emission filter configured to filter the electromagnetic energy within a second frequency band. The apparatus further includes an imaging unit having a charged coupled device (CCD), the CC having an Imaging surface masked by a pinhole blind such that when the pinhole blind receives electromagnetic energy from the emission filter, an image is created of the entire microarray.

Abstract translation: 提供了一种用于创建微阵列图像的装置和方法。 该装置包括被配置为将光引向微阵列的至少一个光源。 该装置包括被配置为将光过滤到朝向二色镜的第一频带的激励滤波器。 二色镜将光反射到微阵列上，导致微阵列发射电磁能。 该装置包括被配置为过滤第二频带内的电磁能的发射滤波器。 所述装置还包括具有电荷耦合器件（CCD）的成像单元，所述CC具有由针孔盲孔掩蔽的成像表面，使得当针孔盲孔从发射滤光片接收电磁能时，产生整个微阵列的图像。

公开(公告)号：US20240125594A1

公开(公告)日：2024-04-18

申请号：US17769543

申请日：2020-10-16

Applicant: VIRELUX Inspection Systems Sàrl

Inventor： Tom Reichert ,  Gérard Baseotto

IPC: G01B11/25 ,  G01B5/00 ,  G01B11/16 ,  G01B11/24

CPC classification number: G01B11/2545 ,  G01B5/0025 ,  G01B11/167 ,  G01B11/2441 ,  G01N2021/8864 ,  G01N2201/0631

Abstract: A method and system for scanning an outer surface of a three-dimensional object, the outer surface being reflective, the method comprising the following steps: (a) projecting a light pattern on the object with a relative movement between the light pattern and the object; (b) recording with cameras images of the light pattern reflected by the outer surface during the relative movement; (c) processing the recorded reflection images by identifying the outline of the light pattern and determining from the outline characteristics of the outer surface; wherein the light pattern comprises at least one homogenously illuminated strip extending transversally to a direction of the relative movement with at least one border with a non-straight profile so as to form a non-constant width of the strip; and in step (c) the speed of the relative movement is taken into account for determining a three-dimensional definition of the outer surface.

公开(公告)号：US20240035983A1

公开(公告)日：2024-02-01

申请号：US18221043

申请日：2023-07-12

Applicant: WiTrins s.r.o.

Inventor： Pavel Linhart

IPC: G01N21/88 ,  G01N21/95

CPC classification number: G01N21/8806 ,  G01N21/9501 ,  G01N21/8851 ,  G01N2021/8845 ,  G01N2201/06153 ,  G01N2201/0631 ,  G01N2021/8874

Abstract: An inspection system and a method for analyzing defects in a product, in particular a printed circuit board product, a semiconductor wafer or the like, the inspection system includes a projection device , an optical detection device , and a processing device, the projection device having an illuminating unit and a spectrometer member configured to split white light into its spectral components and project a multichromatic light beam thus formed from monochromatic light beams onto a product at an angle of incidence β, the optical detection device having a detection unit comprising a camera and an objective , the camera being configured to detect the multichromatic light beam reflected on the product in a detection plane of the detection unit, the detection plane being perpendicular, preferably orthogonal, to a product surface of the product, the illuminating unit having at least two light-emitting diodes disposed in a row and an exit aperture extending along the row.