公开(公告)号：EP2856254A4

公开(公告)日：2016-08-17

申请号：EP13798044

申请日：2013-05-23

Applicant: SIEMENS HEALTHCARE DIAGNOSTICS

Inventor： JASPERSE JEFFREY R

IPC: G03B9/14 ,  G01N21/64 ,  G03B7/08 ,  G03B7/095 ,  G03B9/42

CPC classification number: G02B26/04 ,  G01N21/64 ,  G01N21/645 ,  G01N33/50 ,  G01N2201/0221 ,  G01N2201/0648 ,  G01N2201/068 ,  G03B9/14 ,  G03B11/043 ,  H01J43/00

Abstract: A shutter assembly includes a first shutter blade having a first toothed arm extending therefrom and a first light transmitting aperture therein, and a second shutter blade positioned adjacent and parallel to the first shutter blade. The second shutter blade has a second toothed arm extending therefrom and a second light transmitting aperture therein. The first and second shutter blades are supported to allow parallel linear motion. A motor gear is disposed between, and meshed with, the first and second toothed arms such that rotation of the gear causes the first and second shutter blades to move linearly in opposite directions between an open position in which the first and second light transmitting apertures are in an overlapping relationship with respect to one another, and a closed position in which the first and second light transmitting apertures are in a non-overlapping relationship with respect to one another.

公开(公告)号：EP1163497B1

公开(公告)日：2004-05-12

申请号：EP00915795.9

申请日：2000-02-18

Applicant: Packard Instrument Company, Inc.

Inventor： DUEBENDORFER, Juerg ,  JONES, Donald ,  NEUMANN, Kenneth ,  WANG, Chang

IPC: G01J3/30 ,  G01J1/58 ,  G01N21/25 ,  G01N21/64 ,  G01N35/02

CPC classification number: G01N21/6452 ,  G01N2201/0648

Abstract: An apparatus for measuring light in samples using a high intensity light source (12), is presented. The system utilizes bifurcated fiber bundle (26) to transmit light at the excitation and emission wavelength bands. It also uses a band-pass filter (36) for eliminating extraneous light, including that which corresponds to the excitation wavelength range, while permitting the emitted light to pass to a detector (41) for quantitation. The system employs a shutter (39) to shield the detector (41) while the laser light source is activated, and a controller to intermittently activate the laser light and close the shutter. The apparatus preferably includes lenses (16, 17, 37) for better illumination and read out conditions. The apparatus is employed in Luminescence Oxygen Channeling Immunoassays. The method has high sensitivity, accuracy and precision, and the apparatus is highly compact. Accordingly, the analyzer can perform assays in nanoliter to microliter sample volumes in standard microplates having at least 96, 384 or 1536 wells.

公开(公告)号：EP1163497A4

公开(公告)日：2002-04-24

申请号：EP00915795

申请日：2000-02-18

Applicant: PACKARD INSTRUMENT CO INC

Inventor： DUEBENDORFER JUERG ,  JONES DONALD ,  NEUMANN KENNETH ,  WANG CHANG

IPC: G01N21/64 ,  G01J3/30 ,  G01J1/58 ,  G01N21/25 ,  G01N35/02

CPC classification number: G01N21/6452 ,  G01N2201/0648

Abstract: An apparatus for measuring light in samples using a high intensity light source (12), is presented. The system utilizes bifurcated fiber bundle (26) to transmit light at the excitation and emission wavelength bands. It also uses a band-pass filter (36) for eliminating extraneous light, including that which corresponds to the excitation wavelength range, while permitting the emitted light to pass to a detector (41) for quantitation. The system employs a shutter (39) to shield the detector (41) while the laser light source is activated, and a controller to intermittently activate the laser light and close the shutter. The apparatus preferably includes lenses (16, 17, 37) for better illumination and read out conditions. The apparatus is employed in Luminescence Oxygen Channeling Immunoassays. The method has high sensitivity, accuracy and precision, and the apparatus is highly compact. Accordingly, the analyzer can perform assays in nanoliter to microliter sample volumes in standard microplates having at least 96, 384 or 1536 wells.

公开(公告)号：EP0355738A3

公开(公告)日：1991-02-27

申请号：EP89115264.7

申请日：1989-08-18

Applicant: HITACHI, LTD.

Inventor： Hashimoto, Hiroshi ,  Umetsu, Hiroshi ,  Imai, Kyoko ,  Kawase, Masumi (née Suzuki)

IPC: G01N21/64 ,  G01N35/00

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N2201/0648 ,  G01N2201/124

Abstract: A fluorophotometer for use in automatic equip­ment of chemical analysis is disclosed which includes a shutter (45) provided in an optical system (17 to 22, 25) on the exciting light side for blocking the optical path of exciting light, a shutter driving device (44) for driving the shutter so that the shutter is kept at a state that the optical path of exciting light is blocked and then kept a state that the optical path of exciting light is made open, each time a train of reaction vessels is intermittently moved, and a processor (43) for storing a first output signal which is delivered from a photodetector (30) for the detection of fluorescence in a period when the optical path of exciting light is blocked, and for correcting a second output signal which is delivered from the photodetector in a period when the optical path of exciting light is made open, by the first output signal. Further, a method of measuring the intensity of fluorescence in the automatic equipment of chemical analysis is disclosed.

公开(公告)号：EP0355738A2

公开(公告)日：1990-02-28

申请号：EP89115264.7

申请日：1989-08-18

Applicant: HITACHI, LTD.

Inventor： Hashimoto, Hiroshi ,  Umetsu, Hiroshi ,  Imai, Kyoko ,  Kawase, Masumi (née Suzuki)

IPC: G01N21/64 ,  G01N35/00

CPC classification number: G01N21/64 ,  G01N21/6428 ,  G01N2201/0648 ,  G01N2201/124

Abstract: A fluorophotometer for use in automatic equip­ment of chemical analysis is disclosed which includes a shutter (45) provided in an optical system (17 to 22, 25) on the exciting light side for blocking the optical path of exciting light, a shutter driving device (44) for driving the shutter so that the shutter is kept at a state that the optical path of exciting light is blocked and then kept a state that the optical path of exciting light is made open, each time a train of reaction vessels is intermittently moved, and a processor (43) for storing a first output signal which is delivered from a photodetector (30) for the detection of fluorescence in a period when the optical path of exciting light is blocked, and for correcting a second output signal which is delivered from the photodetector in a period when the optical path of exciting light is made open, by the first output signal. Further, a method of measuring the intensity of fluorescence in the automatic equipment of chemical analysis is disclosed.

Abstract translation: 一种用于在化学分析的自动设备使用荧光光度计是圆盘游离缺失，其包括快门（45），用于阻挡激发光的光路设置在光学系统（17〜22，25）上的激发光侧，快门驱动装置（ 44）用于驱动快门所以做了快门保持在状态没有激发光的光路被阻断，然后保持的状态下没有激发光的光路是由开放的，每个反应容器的列车被间歇地移动时间 和用于存储的第一输出信号的所有这是从用于检测在一段的荧光的光检测器（30）输送时激发光的光路被阻断，以及用于校正的第二输出信号的所有的处理器（43），其被传递 从在期间光检测器当激发光的光路是由开放的，由所述第一输出信号。 此外，测量荧光的强度在化学分析的自动化设备的方法游离缺失盘。

公开(公告)号：EP0018390A1

公开(公告)日：1980-11-12

申请号：EP79900645

申请日：1979-12-17

Applicant: BECKMAN INSTRUMENTS INC

Inventor： HAUNOLD OTTO ,  GREENE MALBONE WATSON

IPC: G01N21/76 ,  G01N21/64 ,  G01J3/02 ,  G01N21/25 ,  G03B9/00

CPC classification number: G01N21/0332 ,  G01N21/763 ,  G01N2201/0648

Abstract: Un assemblage de support d'echantillons et d'obturateurs (20) pour photometre comprend un corps de chambre d'echantillon nage fixe (40) monte a proximite d'un dispositif photosensible (18). Un passage lumineux est prevu de la chambre d'echantillonnage (53) au dispositif photosensible (18) et un obturateur est prevu pour fermer et ouvrir de maniere selective le trajet de la lumiere entre le dispositif photosensible (18) et la chambre d'echantillonnage (53) sans deplacer celle-ci. Des moyens d'echange de chaleur comprenant une pompe de chaleur (63) et un reservoir de chaleur (68) sont prevus pour maintenir la temperature desiree dans la chambre (53). Le corps de la chambre d'echantillonnage (40) est relie thermiquement a la pompe de chaleur (63) et est de preference isole thermiquement des moyens ou il est monte. Dans une realisation, la pompe de chaleur (63) et le reservoir de chaleur (68) sont relies de maniere souple.

公开(公告)号：EP2957894A1

公开(公告)日：2015-12-23

申请号：EP14172657.0

申请日：2014-06-17

Applicant: Siemens Healthcare Diagnostics Products GmbH

Inventor： Meller, Paul ,  Beier, Axel ,  Nerreter, Stefan

IPC: G01N21/51 ,  G01J3/44 ,  G01N21/65 ,  G01N33/49 ,  G01N33/487 ,  G01N33/493 ,  G01N21/47

CPC classification number: G01N21/51 ,  G01J3/0208 ,  G01J3/42 ,  G01J3/44 ,  G01J3/4412 ,  G01N2021/4707 ,  G01N2201/0648

Abstract: Die Erfindung betrifft ein Streulichtanalysesystem (1) mit mindestens einem Mittel (8) zur Erzeugung eines Strahlenbündels entlang einer optischen Achse (30), mindestens einer Aufnahmeposition (4) für eine Messzelle (2), mindestens einem Mittel (25, 26, 27, 28, 29) zur Fokussierung eines Strahlenbündels, mindestens einer Blende (14) mit einer definierten Öffnung (17) und mindestens einem Fotodetektor (6), wobei das Mittel (8) zur Erzeugung eines Strahlenbündels ein in mindestens einer Richtung senkrecht zur optischen Achse (30) konvergentes Strahlenbündel erzeugt und wobei das Mittel (8) zur Erzeugung eines Strahlenbündels, die Aufnahmeposition (4) für eine Messzelle (2), das Mittel (25, 26, 27, 28, 29) zur Fokussierung eines Strahlenbündels, die Blende (14) und der Fotodetektor (6) derart angeordnet sind, dass das konvergente Strahlenbündel in einer in der Aufnahmeposition (4) angeordneten Messzelle (2) einen ersten Fokus (35) ausbildet und nach dem Durchtritt durch eine in der Aufnahmeposition (4) angeordnete Messzelle (2) wenigstens teilweise auf das Mittel (25, 26, 27, 28, 29) zur Fokussierung eines Strahlenbündels trifft und wobei das Strahlenbündel nach Wechselwirkung mit dem Mittel (25, 26, 27, 28, 29) zur Fokussierung des Strahlenbündels einen zweiten Fokus (37) ausbildet und wobei die Öffnung (17) der Blende (14) im Bereich des zweiten Fokus (37) positioniert ist, und das Strahlenbündel dann wenigstens teilweise auf den Fotodetektor (6) trifft.

Abstract translation: 本发明涉及一种光散射分析系统（1）具有至少一个装置（8），用于沿光轴产生辐射光束（30），至少一个接收位置（4），用于测量单元（2），至少一个装置（25，26，27， 28，29），用于聚焦辐射束，至少一个膜片（14）（具有限定的开口17），和至少一个光电检测器（6），其中，所述装置（8），用于向所述光学轴线产生辐射束，垂直（在至少一个方向上 30）产生一个会聚光束，并且其中所述装置（8），用于生成辐射束时，记录位置（4），用于聚焦辐射束，孔径测量单元（2），所述装置（25，26，27，28，29）（ 14）和光检测器（6）被布置成使得布置在所述会聚光束束（测量（2），具有第一焦点（35）形成，并且，细胞穿过一个在后的接收位置4） 布置在接收位置（4）的测量单元（2）至少部分地基于所述装置（25，26，27，28，29）适用于聚焦的辐射束，辐射光束用的装置（25，26，27，28相互作用后，29 ），用于至少部分地聚焦辐射束形成第二焦点（37），并且其中在所述第二焦点（37）的区域中的孔（14）的开口（17）被定位，并且光束然后在光检测器（6）适用。

公开(公告)号：EP1969350A2

公开(公告)日：2008-09-17

申请号：EP06848985.5

申请日：2006-12-13

Applicant: Hach Company

Inventor： MITCHELL, Thomas, Owen

IPC: G01N21/64

CPC classification number: G01N21/643 ,  G01N21/8507 ,  G01N2201/0648

Abstract: A method and apparatus for visually detecting when a luminescent dissolved oxygen sensor is operating is disclosed. In one example embodiment of the invention, a shutter (216) is placed into the light tight container. When the shutter (216) is open, a user can see into the light tight container and verify probe operation. When the shutter (216) is closed, external light is prevented from entering the light tight container and affecting measurement accuracy. In another example embodiment of the invention, one end of a light pipe (526) is placed on the outside of the light tight container, and the other end is positioned to view the light source (504) of the probe. In another example embodiment of the invention a second light source (628), visible on the outside of the light tight container, is used to verify operation of the probe. In another example embodiment of the invention, a predetermined area is left open in the optically opaque hydrostatically transparent (814) on the face of the sensor window, allowing a user to see light from the sensor when the sensor is operating properly.

公开(公告)号：EP1366351A2

公开(公告)日：2003-12-03

申请号：EP02700526.3

申请日：2002-02-27

Applicant: Imaging Research, Inc.

Inventor： ZARATE, Carlos ,  DONDERS, Paul ,  YEKTA, Ahmed ,  MASOUMI, Zahra ,  RAMM, Peter

IPC: G01N21/64

CPC classification number: G01N21/6408 ,  G01N2201/0648

Abstract: The present invention relates to an apparatus and method for imaging time resolved fluorescence in biochemical and medical samples. In a primary aspect, the device includes a lens of large aperture, a flash lamp in the illumination path, a fast-acting solid state shutter or a gated detector in the emission path, a device for delivering homogenous monochromatic illumination to a plurality of wells distributed within a microwell plate, a digital camera of high quantum efficiency, and a computer. under computer control, the lamp is pulsed at short intervals. The fast-acting emission shutter or gated detector operates to limit exposure of the camera to a period some microseconds after the extinction of each lamp pulse, during which only delayed fluorescence is transmitted to the camera. The invention achieves simultaneous time resolved imaging of a plurality of samples, with high sensitivity and high throughput.

公开(公告)号：EP0286119B1

公开(公告)日：1993-12-08

申请号：EP88105634.5

申请日：1988-04-08

Applicant: Kabushiki Kaisha Meidensha

Inventor： Fukuoka, Masayoshi ,  Matsuyuki, Akira

IPC: G01N21/76

CPC classification number: G01N21/76 ,  G01N2021/0375 ,  G01N2201/0231 ,  G01N2201/0253 ,  G01N2201/0648