公开(公告)号：US20150310170A1

公开(公告)日：2015-10-29

申请号：US14432178

申请日：2013-03-15

Applicant: APERIO TECHNOLOGIES, INC.

Inventor： Dirk SOENKSEN ,  Mark WRENN ,  Zoya VOLYNSKAYA

IPC: G06F19/00

Abstract: Medical image based collaboration system and methods are provided. A collaboration server 40 creates a medical image based case in response to a request from a requesting system 10 and populates the case with the minimum required information comprising at least a digital medical image and a case number. The collaboration server 40 provides the medical image based case to a consulting system 30 and receives analysis information in response. The collaboration server 40 stores the analysis information in association with the medical image based case and provides the analysis information to the consulting system 30 to complete the medical image based collaboration.

Abstract translation: 提供了基于医学图像的协作系统和方法。 协作服务器40响应于来自请求系统10的请求创建基于医学图像的情况，并且使用包括至少数字医学图像和病例号的最小必需信息来填充病例。 协作服务器40将医学图像的情况提供给咨询系统30，并且响应地接收分析信息。 协作服务器40与基于医学图像的情况相关联地存储分析信息，并将分析信息提供给咨询系统30，以完成基于医学图像的协作。

公开(公告)号：US08755579B2

公开(公告)日：2014-06-17

申请号：US13771831

申请日：2013-02-20

Applicant: Aperio Technologies, Inc.

Inventor： Dirk G. Soenksen

IPC: G06K9/00

CPC classification number: G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

Abstract: Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

Abstract translation: 使用与作为计算机控制的显微镜幻灯片扫描器的一部分的定位台同步的线性阵列检测器，全自动快速扫描和数字化整个显微镜样品或显微镜样本的大部分的装置和方法。 本发明提供了一种用于组合从样本的连续扫描获得的图像条带到单个邻接数字图像中的方法。 本发明还提供了一种用于以不同放大率静态显示该大数字图像的子区域的方法，以及整个样本的缩小的放大宏图像。 本发明还提供了一种用于在或不与操作者交互的情况下动态显示邻接数字图像的部分的方法。 在本发明的一个优选实施例中，扫描器的所有元件都是具有到互联网或本地内部网的主要连接的单个外壳的一部分。 在该实施例中，优选的样品类型是显微镜载玻片，并且照明和成像光学元件与针对衍射极限数字成像优化的透射模式光学元件一致。

公开(公告)号：US20040252875A1

公开(公告)日：2004-12-16

申请号：US10371586

申请日：2003-02-21

Applicant: Aperio Technologies, Inc.

Inventor： Greg J. Crandall ,  Ole Eichhorn ,  Allen H. Olson ,  Dirk G. Soenksen

IPC: G06K009/00 ,  G06K009/36

CPC classification number: G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

Abstract: A data management system and method for processing, storing, and viewing the extremely large imagery data that is rapidly produced by a linear-array-based microscope slide scanner is provided. The system receives, processes, and stores imagery data produced by the linear-array-based microscope slide scanner at approximately 3 GB per minute. The data are received as a series of overlapping image stripes and combined into a seamless and contiguous baseline image. The baseline image is logically mapped into a plurality of regions that are individually addressed to facilitate viewing and manipulation of the baseline image. The data management system enables imagery data compression while scanning and capturing new image stripes. This advantageously eliminates the overhead associated with storing uncompressed image stripes. The image compression also creates intermediate level images, thereby organizing the baseline image into a variable level pyramid structure referred to as a virtual slide. The data management system efficiently converts image stripes into a high quality virtual slide that allows rapid panning and zooming by image viewing software in accordance with the individually addressed regions. The virtual slide also allows efficient processing by an algorithm framework. The data management system is costs effective and scaleable, employs standard image file formats and supports the use of virtual slides in desirable applications such as telemedicine, telepathology, microscopy education, and the analysis of high value specimens such as tissue arrays.

Abstract translation: 提供了一种用于处理，存储和查看由基于线性阵列的显微镜幻灯片扫描仪快速产生的极大图像数据的数据管理系统和方法。 系统以每分钟3 GB的速度接收，处理和存储由基于线性阵列的显微镜幻灯片扫描仪生成的图像数据。 数据被接收为一系列重叠的图像条纹并组合成无缝和连续的基线图像。 基线图像被逻辑地映射到单独寻址的多个区域中，以便于观察和操纵基线图像。 数据管理系统在扫描和捕获新的图像条纹时可以进行图像数据压缩。 这有利地消除了与存储未压缩图像条纹相关联的开销。 图像压缩还创建中间级图像，从而将基线图像组织成称为虚拟幻灯片的可变级金字塔结构。 数据管理系统有效地将图像条纹转换成高质量的虚拟幻灯片，其允许通过图像查看软件根据单独寻址的区域进行快速平移和缩放。 虚拟幻灯片还允许通过算法框架进行有效的处理。 数据管理系统具有成本效益和可扩展性，采用标准图像文件格式，并支持虚拟幻灯片在远程医疗，远程病理学，显微镜教育等理想应用中的应用，以及组织阵列等高价值标本的分析。

公开(公告)号：US09213177B2

公开(公告)日：2015-12-15

申请号：US13909935

申请日：2013-06-04

Applicant: Aperio Technologies, Inc.

Inventor： Allen Olson ,  Greg Crandall ,  Dirk G. Soenksen

IPC: H04N7/18 ,  G02B21/36 ,  G02B21/00 ,  G02B21/24 ,  H04N5/232

CPC classification number: G02B21/365 ,  G02B21/002 ,  G02B21/244

Abstract: Methods and apparatus are provided for computing focus information during scanning digital microscope slide data with a line scan camera. The systems and methods include a dynamically interleaved procedure that works by moving the specimen relative to the objective lens while the height of the objective lens is adjusted relative to the stage. Imagery data is acquired at a plurality of objective lens heights the image data from the objective lens height having maximum contrast is stored and combined into a composite digital image of at least a portion of the specimen.

Abstract translation: 提供了用线扫描相机扫描数字显微镜幻灯片数据时计算焦点信息的方法和装置。 该系统和方法包括动态交错过程，其通过相对于物镜移动样本而相对于该阶段调节物镜的高度而起作用。 在多个物镜高度处获取图像数据，从具有最大对比度的物镜高度的图像数据被存储并组合成至少一部分样本的复合数字图像。

公开(公告)号：US08780401B2

公开(公告)日：2014-07-15

申请号：US13921105

申请日：2013-06-18

Applicant: Aperio Technologies, Inc.

Inventor： Ole Eichorn ,  Allen Olson

IPC: G06K15/00 ,  G06F3/12

CPC classification number: G06K9/46 ,  G06T1/00

Abstract: Systems and methods for processing the content of a digital image of a microscope sample. In an embodiment, identifications of algorithm(s) and digital slide image(s) may be received over a network. Parameter data may also be received for the identified algorithm(s). The identified digital slide image(s) may then be retrieved and the identified algorithm(s) may be executed to analyze the retrieved digital slide image(s). The execution of the algorithm(s) may be constrained based on the received parameter data.

Abstract translation: 用于处理显微镜样品的数字图像的内容的系统和方法。 在一个实施例中，可以通过网络接收算法和数字幻灯片图像的标识。 也可以为所识别的算法接收参数数据。 然后可以检索所识别的数字幻灯片图像，并且可以执行所识别的算法来分析所检索的数字幻灯片图像。 可以基于接收到的参数数据来约束算法的执行。

公开(公告)号：US20130279807A1

公开(公告)日：2013-10-24

申请号：US13921105

申请日：2013-06-18

Applicant: Aperio Technologies, Inc.

Inventor： Ole Eichhorn ,  Allen Olson

IPC: G06K9/46

CPC classification number: G06K9/46 ,  G06T1/00

Abstract: A system and method for processing and analyzing virtual microscopy digital images (“digital slides”) is provided. The system comprises an algorithm server that accesses a plurality of image processing and analysis routines. The algorithm server additionally accesses a plurality of digital slides. The algorithm server executes a selected routine on an identified digital slide and provides the resulting data. The digital slide is accessed locally or remotely across a network. Similarly, the image processing and analysis routines are accessed locally or remotely across a network, or both. Advantageously, certain common sub-routines may be stored locally for inclusion in other local or remotely accessed routines. Use of image processing and analysis routines may be restricted through a monitor process that authenticates requests to process or view digital slides. Variations in restrictions to images provide rich diversity in access levels that allow sharing of digital slides and demonstrations of image processing algorithms.

Abstract translation: 提供了一种用于处理和分析虚拟显微数字图像（“数字幻灯片”）的系统和方法。 该系统包括访问多个图像处理和分析例程的算法服务器。 算法服务器还访问多个数字幻灯片。 算法服务器在识别的数字幻灯片上执行所选择的例程，并提供所得到的数据。 数字幻灯片可以通过网络在本地或远程访问。 类似地，图像处理和分析例程通过网络本地或远程访问，或两者兼而有之。 有利地，某些公共子例程可以被本地存储以包含在其他本地或远程访问的例程中。 图像处理和分析程序的使用可能会通过对进程或查看数字幻灯片的请求进行验证的监视进程来限制。 对图像限制的变化提供了访问级别丰富的多样性，允许共享数字幻灯片和图像处理算法的演示。

公开(公告)号：US20130162802A1

公开(公告)日：2013-06-27

申请号：US13771831

申请日：2013-02-20

Applicant: Aperio Technologies, Inc.

Inventor： Dirk G. Soenksen

IPC: H04N7/18

CPC classification number: G02B21/367 ,  G02B21/002 ,  G02B21/0036 ,  G02B21/008 ,  G02B21/14 ,  G02B21/245 ,  G02B21/26 ,  G02B21/32 ,  G02B21/34 ,  G02B21/365 ,  G06F19/00 ,  H04N1/053 ,  H04N1/1903 ,  H04N1/193 ,  H04N1/19573 ,  H04N5/2256 ,  H04N5/23206 ,  H04N7/18 ,  H04N7/183 ,  H04N2201/04727 ,  H04N2201/04755

Abstract: Apparatus for and method of fully automatic rapid scanning and digitizing of an entire microscope sample, or a substantially large portion of a microscope sample, using a linear array detector synchronized with a positioning stage that is part of a computer controlled microscope slide scanner. The invention provides a method for composing the image strips obtained from successive scans of the sample into a single contiguous digital image. The invention also provides a method for statically displaying sub-regions of this large digital image at different magnifications, together with a reduced magnification macro-image of the entire sample. The invention further provides a method for dynamically displaying, with or without operator interaction, portions of the contiguous digital image. In one preferred embodiment of the invention, all elements of the scanner are part of a single-enclosure that has a primary connection to the Internet or to a local intranet. In this embodiment, the preferred sample type is a microscope slide and the illumination and imaging optics are consistent with transmission mode optics optimized for diffraction-limited digital imaging.

公开(公告)号：US20040167806A1

公开(公告)日：2004-08-26

申请号：US10787773

申请日：2004-02-26

Applicant: Aperio Technologies, Inc.

Inventor： Ole Eichhorn ,  Anne Brumme

IPC: G06F017/60 ,  G06K009/00 ,  B41F001/00 ,  G06K001/00 ,  B41J001/00 ,  B41B001/00 ,  G06F015/00

CPC classification number: H04L65/403 ,  G02B21/26 ,  G02B21/32 ,  G06F3/1454 ,  G06F17/241 ,  G06F17/30905 ,  G06F19/00 ,  G06F19/321 ,  G06Q50/24

Abstract: Virtual slide image data and corresponding information are stored in a data storage area on a virtual slide image server. A client viewer requests image data at a particular resolution. The image server obtains corresponding image data from the data storage area at a resolution nearest to the requested resolution. The image data is then sent to the client viewer. The client viewer receives the image data and scales the image data to the requested resolution prior to displaying the image data.

Abstract translation: 虚拟幻灯片图像数据和相应的信息存储在虚拟幻灯片服务器上的数据存储区域中。 客户端查看器以特定分辨率请求图像数据。 图像服务器以最接近请求的分辨率的分辨率从数据存储区域获取相应的图像数据。 然后将图像数据发送到客户端查看器。 在显示图像数据之前，客户端查看器接收图像数据并将图像数据缩放到所请求的分辨率。

公开(公告)号：WO2014065868A1

公开(公告)日：2014-05-01

申请号：PCT/US2013/032293

申请日：2013-03-15

Applicant: APERIO TECHNOLOGIES, INC.

Inventor： EICHHORN, Ole

IPC: G06F17/30 ,  G06F17/40 ,  G06Q50/22

CPC classification number: G06F17/30268 ,  G06F17/30274 ,  G06F19/00 ,  G06F19/321 ,  G06Q10/10 ,  G06Q30/06 ,  G06Q50/22

Abstract: Systems and methods for managing an image repository for pathology. In an embodiment, a search request is received. One or more digital slide images are identified from an image repository based on the search request. A user is provided access to the identified digital slide images. In addition, each of a plurality of collections of digital slide images are associated with a search rating, and a value for each of the plurality of collections is computed based on the associated search rating and a size of the collection.

Abstract translation: 用于管理病理图像库的系统和方法。 在一个实施例中，接收到搜索请求。 基于搜索请求从图像存储库识别一个或多个数字幻灯片图像。 为用户提供对所识别的数字幻灯片图像的访问。 此外，数字幻灯片图像的多个集合中的每一个都与搜索等级相关联，并且基于相关联的搜索评级和集合的大小来计算多个集合中的每一个的值。

公开(公告)号：WO2013165576A1

公开(公告)日：2013-11-07

申请号：PCT/US2013/031045

申请日：2013-03-13

Applicant: APERIO TECHNOLOGIES, INC.

Inventor： ZOU, Yunlu ,  CRANDALL, Greg J. ,  OLSON, Allen

IPC: G02B21/00 ,  G01B9/04

CPC classification number: G02B21/006 ,  G02B21/245 ,  G02B21/361 ,  G02B21/365

Abstract: Systems and methods for capturing a digital image of a slide using an imaging line sensor and a focusing line sensor. In an embodiment, a beam-splitter is optically coupled to an objective lens and configured to receive one or more images of a portion of a sample through the objective lens. The beam-splitter simultaneously provides a first portion of the one or more images to the focusing sensor and a second portion of the one or more images to the imaging sensor. A processor controls the stage and/or objective lens such that each portion of the one or more images is received by the focusing sensor prior to it being received by the imaging sensor. In this manner, a focus of the objective lens can be controlled using data received from the focusing sensor prior to capturing an image of a portion of the sample using the imaging sensor.

Abstract translation: 使用成像线传​​感器和聚焦线传感器捕获幻灯片的数字图像的系统和方法。 在一个实施例中，分束器光学耦合到物镜并且被配置为通过物镜接收样品的一部分的一个或多个图像。 分束器同时将一个或多个图像的第一部分提供给聚焦传感器，并将一个或多个图像的第二部分提供给成像传感器。 处理器控制舞台和/或物镜，使得一个或多个图像的每个部分在被成像传感器接收之前由聚焦传感器接收。 以这种方式，可以在使用成像传感器捕获样本的一部分的图像之前，使用从聚焦传感器接收的数据来控制物镜的焦点。