中科微点-全球专利检索

  1. Login
  2. Sign Up

Search Results

1064 records (took 0.044 seconds)

    DISPOSABLE DIRECT CAPTURE DEVICE
    73.
    发明申请
    DISPOSABLE DIRECT CAPTURE DEVICE 审中-公开
    可替代的直接捕获设备

    公开(公告)号：WO2014120344A2

    公开(公告)日：2014-08-07

    申请号：PCT/US2013/074857

    申请日：2013-12-13

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： CACACE, Benjamin

    CPC classification number: G01N1/34 ,  B01J39/26 ,  B01J41/20 ,  B01J47/014 ,  B01J47/022 ,  B01J47/127 ,  B01L3/505 ,  B01L2200/12 ,  B01L2300/0681 ,  B01L2300/123 ,  C07K1/14 ,  C07K1/36 ,  G01N1/405

    Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.

    Abstract translation: 本发明涉及一种液体样品制备装置，例如一次性可折叠的柔性聚合物袋，其包含用于从液体样品直接捕获生物分子的官能化成形聚合物纤维床的吸附帘。 功能化的聚合物纤维床包括原纤化的，脊状的或翼状的纤维结构，其显着增加纤维的表面积，导致当液体样品接触吸附窗帘时，含有生物分子的液体样品的增强的分离，保留和/或纯化 的功能化成形纤维。 液体样品包括未澄清的液体进料或含有一种或多种感兴趣的生物分子的其它液体，包括但不限于疫苗，重组蛋白，细胞，干细胞，单克隆抗体（mAb），蛋白质，抗体，肽，寡肽，核酸， 寡核苷酸，RNA，DNA，寡糖和多糖。

    CONTAINER HAVING MAGNETIC IMPELLER ASSEMBLY WITH HOOD
    74.
    发明申请
    CONTAINER HAVING MAGNETIC IMPELLER ASSEMBLY WITH HOOD 审中-公开
    带有蜗轮蜗杆组件的集装箱

    公开(公告)号：WO2014085034A1

    公开(公告)日：2014-06-05

    申请号：PCT/US2013/068373

    申请日：2013-11-05

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： MORRISSEY, Martin ,  PEREIRA, Brian

    IPC: B01F13/08

    CPC classification number: B01F7/00241 ,  B01F7/162 ,  B01F7/1635 ,  B01F13/0827 ,  B01F13/0872 ,  B01F15/0085

    Abstract: A disposable container, such as a deformable bag, for a fluid, having one or more inlets and one or more outlets and an impeller assembly within the container to cause mixing, dispersing, homogenizing and/or circulation of one or more ingredients contained or added to the container. The impeller assembly has a protective hood surrounding at least a portion of the moveable blades or vanes of the impeller assembly and being above at least a portion of the blades or vanes. The hood surrounds the blades or vanes and arcs over the height of the blades or vanes. The hood is shaped in a dome shape or semi-spherical shape that is around and above the impeller blades and acts as a protector for the container surface against the impeller assembly both during shipping and storage as well as when in use, particularly at lower liquid levels.

    Abstract translation: 用于流体的一次性容器，例如可变形袋，具有一个或多个入口和一个或多个出口以及容器内的叶轮组件，用于引起包含或添加的一种或多种成分的混合，分散，均化和/或循环 到容器 叶轮组件具有围绕叶轮组件的可移动叶片或叶片的至少一部分并且在叶片或叶片的至少一部分上方的保护罩。 发动机罩围绕叶片或叶片并在叶片或叶片的高度上弧形。 发动机罩形成为圆顶形或半球形，其在叶轮叶片周围和上方，并且在运输和储存期间以及在使用时特别是在较低液体下作为用于容器表面抵靠叶轮组件的保护器 水平。

    USE OF CENTRIFUGATION-AIDED INFECTION TO INCREASE VIRUS TITER
    75.
    发明申请
    USE OF CENTRIFUGATION-AIDED INFECTION TO INCREASE VIRUS TITER 审中-公开
    使用离心引发感染增加病毒TITER

    公开(公告)号：WO2013138465A1

    公开(公告)日：2013-09-19

    申请号：PCT/US2013/030880

    申请日：2013-03-13

    Applicant: EMD MILLIPORE CORPORATION

    Inventor： ASHER, Damon, R. ,  LEAHY, Anne, H.

    IPC: C12N7/01 ,  C12N7/02 ,  C12M1/10

    CPC classification number: C12N7/00 ,  C12N2740/13051

    Abstract: The invention relates to a process for increasing the observed titer of a virus stock for the purpose of increasing the calculated log reduction (LRV) in virus clearance studies. A tissue culture or assay plate is seeded with an indicator cell line and titrated with a virus stock followed, by a centrifugation step for about 5 minutes to about 24 hours at a g-force ranging from about 50x g to about 2400x g, and at a temperature from about 4°C to about 39°C. The resulting calculated virus titer after undergoing the centrifugation step is 10-fold higher than the virus titer would be if determined in the absence of the centrifuging step.

    Abstract translation: 本发明涉及一种用于增加病毒储存物观察滴度以增加病毒清除研究中计算的对数降低（LRV）的方法。 用指示细胞系接种组织培养物或测定板，并用病毒原液滴定，然后通过离心步骤以约50xg至约2400xg的g-力离心步骤约5分钟至约24小时，并且在 约4℃至约39℃的温度。 进行离心步骤之后得到的计算病毒滴度比无离心步骤中确定的病毒滴度高10倍。

    METHOD AND APPARATUS FOR FILTERING A LIQUID SAMPLE
    76.
    发明申请
    METHOD AND APPARATUS FOR FILTERING A LIQUID SAMPLE 审中-公开
    用于过滤液体样品的方法和设备

    公开(公告)号：WO2013106081A2

    公开(公告)日：2013-07-18

    申请号：PCT/US2012/041568

    申请日：2012-06-08

    Applicant: EMD MILLIPORE CORPORATION ,  OLIVIER, Stephane ,  METZ, Didier

    Inventor： OLIVIER, Stephane ,  METZ, Didier

    IPC: G01N1/28 ,  B01D29/01 ,  G01N35/10

    CPC classification number: B01D27/04 ,  G01N1/4077 ,  G01N2001/4088

    Abstract: The invention relates to the filtering of liquid samples, preferably in a laboratory environment, for example for collecting micro organisms from the liquid sample for subsequent testing. The invention provides a method for filtering a liquid sample which comprises providing a blank of a deformable sheet material and a filtration medium, deforming the blank to form a funnel extending above and about the filtration medium, introducing the liquid sample to be filtered into the so formed funnel, and filtering the liquid sample from the funnel through the filtration medium, for example to a downstream receptacle. The method is accordingly based on the concept that the funnel is not or at least not completely preformed but provided in a form of a blank of a deformable material sheet which is deformed so as to form the funnel at the point and time of use during filtration.

    Abstract translation: 本发明涉及优选在实验室环境中过滤液体样品，例如用于从液体样品中收集微生物以用于随后的测试。 本发明提供了一种用于过滤液体样品的方法，其包括提供可变形片材和过滤介质的坯件，使坯件变形以形成在过滤介质上方和周围延伸的漏斗，将要过滤的液体样品引入到 形成漏斗，并且将来自漏斗的液体样品通过过滤介质过滤到例如下游容器。 该方法因此基于以下概念：漏斗不是或至少不是完全预成型的，而是以可变形材料片的坯件的形式提供，所述可变形材料片在过滤期间的使用点和使用时期变形以形成漏斗

    SYSTEM AND METHOD FOR PURIFICATION AND DISTRIBUTION OF WATER WITH SEPARATION BARRIER TAKING AWAY THE BIOLOGICAL CONTAMINATION
    77.
    发明申请
    SYSTEM AND METHOD FOR PURIFICATION AND DISTRIBUTION OF WATER WITH SEPARATION BARRIER TAKING AWAY THE BIOLOGICAL CONTAMINATION 审中-公开
    用隔离障碍物进行生物污染的水的净化和分配的系统和方法

    公开(公告)号：WO2012176134A1

    公开(公告)日：2012-12-27

    申请号：PCT/IB2012/053114

    申请日：2012-06-20

    Applicant: EMD MILLIPORE CORPORATION ,  GAIGNET, Yves ,  MEYER, Didier ,  BOLE, Julien

    Inventor： GAIGNET, Yves ,  MEYER, Didier ,  BOLE, Julien

    IPC: C02F9/00 ,  C02F1/32 ,  C02F1/44

    CPC classification number: C02F1/32 ,  C02F1/44 ,  C02F9/005

    Abstract: The invention concerns a treated water purification system (18) comprising a closed water flow loop (107) said loop comprising at least one treated water supply point (A), at least one point of use (U) of purified water, a pump means (101 ), a sterilization means (106) and a filtration means (103), characterized in that the zone (106) comprises the supply point (A) and a water extraction point (P), situated upstream of the supply point (A), and in that the extraction point (P) and the supply point (A) are both situated in a sector (106B) of the sterilization zone (106) that is isolated from the two connection points (R M , R V ) of the loop (107) to the zone (106) by two other sectors (106A, 106C) of the zone (106). Method for use of such a system.

    Abstract translation: 本发明涉及一种经处理的水净化系统（18），其包括封闭的水流回路（107），所述回路包括至少一个经处理的供水点（A​​），至少一个净化水点（U），泵装置 （101），灭菌装置（106）和过滤装置（103），其特征在于，所述区域（106）包括位于供应点（A）上游的供水点（A​​）和水提取点（P） ），并且提取点（P）和供应点（A）都位于与环路的两个连接点（RM，RV）隔离的灭菌区（106）的扇区（106B）中， （106）的两个其它扇区（106A，106C）到所述区域（106）。 使用这种系统的方法。

    NANOFIBER CONTAINING COMPOSITE STRUCTURES
    78.
    发明申请
    NANOFIBER CONTAINING COMPOSITE STRUCTURES 审中-公开
    含有纳米纤维的复合结构

    公开(公告)号：WO2012135679A2

    公开(公告)日：2012-10-04

    申请号：PCT/US2012/031549

    申请日：2012-03-30

    Applicant: EMD MILLIPORE CORPORATION ,  KAS, Onur Y. ,  KOZLOV, Mikhal ,  TKACIK, Gabriel ,  NHIEM, David ,  LEON, Sherry Ashby

    Inventor： KAS, Onur Y. ,  KOZLOV, Mikhal ,  TKACIK, Gabriel ,  NHIEM, David ,  LEON, Sherry Ashby

    IPC: B01D69/12 ,  B01D69/00 ,  B01D71/06 ,  D01D5/00 ,  B01D69/10

    CPC classification number: B01D69/12 ,  B01D71/56 ,  B01D2323/39 ,  B01D2325/02 ,  D01D5/0084

    Abstract: A composite liquid filtration platform including a composite filtration medium featuring an electrospun polymeric nanofiber layer collected on a porous membrane. When in use, the porous membrane acts as a prefilter used upstream from the polymeric nanofiber layer to remove particles from a liquid stream flowing through the composite filtration structure. The nanofiber layer, positioned downstream from the porous membrane, is used as the retentive layer for critical filtration to provide biosafety assurance, and is responsible for capturing microorganisms like bacteria, mycoplasma or viruses. The composite liquid filtration platform provided herein exhibits permeability advantages over conventional porous membranes or nanofiber mats spun on coarse non-wovens.

    Abstract translation: 一种复合液体过滤平台，其包括复合过滤介质，其特征在于在多孔膜上收集的电纺聚合物纳米纤维层。 当使用时，多孔膜用作在聚合物纳米纤维层上游使用的预过滤器，以从流过复合过滤结构的液体流中除去颗粒。 位于多孔膜下游的纳米纤维层用作临界过滤的保留层，以提供生物安全保证，并负责捕获细菌，支原体或病毒等微生物。 本文提供的复合液体过滤平台相对于在粗糙无纺布上纺出的常规多孔膜或纳米纤维垫表现出渗透性优点。

Patent Agency Ranking