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公开(公告)号：KR1020120098142A
公开(公告)日：2012-09-05
申请号：KR1020110017894
申请日：2011-02-28
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
CPC classification number: G01K11/00 , A61B5/01 , A61B5/441 , A61Q17/04 , G01K13/002
Abstract: PURPOSE: A method for generating a heat protection factor is provided to generate a heat protection factor, thereby objectively evaluating an effect of a cosmetic product including heat protection materials. CONSTITUTION: A first area spread with heat protection materials and a second area which is no the heat protection materials are heated respectively(S1). Saturation temperature of the first area is measured(S3). The saturation temperature of the second area is measured. An energy corresponding to heat heated in the first area is divided into the saturation temperature of the first area for calculating a first energy(S5). The energy corresponding to heat heated in the second area is divided into the saturation temperature of the second area for calculating a second energy. A heat protection factor of the heat protection materials is calculated by dividing the first energy into the second energy(S6). [Reference numerals] (AA) Start; (BB) End; (S1) Applying heat in a first area where a heat protection material is spread and a second area where no heat protection material is spread; (S2) Periodically measuring the temperature of the first area and the second area; (S3) Determining whether the temperature of the first area and the second area reaches a saturation temperature; (S4) Calculating the minimum heating amount of the first area and the second area; (S5) Calculating first and second energy by using the minimum heating amount of the first area and the second area and the saturation temperature; (S6) Calculating a heat protection factor of a heat protection material by using the first and second energy
Abstract translation: 目的：提供一种产生热保护因子的方法以产生热保护因子，从而客观地评估包括耐热材料的化妆品的效果。 构成：分散加热保护材料的第一个区域和不是热保护材料的第二个区域（S1）。 测量第一区域的饱和温度（S3）。 测量第二区域的饱和温度。 对应于在第一区域中加热的热量的能量被划分为用于计算第一能量的第一区域的饱和温度（S5）。 对应于在第二区域中加热的热量的能量被分成用于计算第二能量的第二区域的饱和温度。 通过将第一能量除以第二能量来计算热保护材料的热保护系数（S6）。 （附图标记）（AA）开始; （BB）结束; （S1）在散热保护材料的第一区域和没有热保护材料扩散的第二区域施加热量; （S2）周期性地测量第一区域和第二区域的温度; （S3）确定第一区域和第二区域的温度是否达到饱和温度; （S4）计算第一区域和第二区域的最小加热量; （S5）通过使用第一区域和第二区域的最小加热量和饱和温度来计算第一和第二能量; （S6）通过使用第一和第二能量来计算热保护材料的热保护系数
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公开(公告)号：KR1020100120585A
公开(公告)日：2010-11-16
申请号：KR1020090039462
申请日：2009-05-06
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
IPC: A61K31/202 , A61P17/16 , A61K8/36 , A61Q19/08
Abstract: PURPOSE: A composition of external use skin formulation for anti-aging and moisturizing is provided to suppress MMP(matrix metalloprotease) increase. CONSTITUTION: A composition of external use skin formulation contains 0.001-10 weight% of 11,14,17-Eicosatrienoic acid(ETA) as an active ingredient. ETA is contained in oil phase. The composition is used for preventing aging through reduction of collagenase expression. The composition is also used for skin moisturizing by suppressing skin barrier damage.
Abstract translation: 目的：提供抗老化和保湿的外用皮肤制剂组合物，以抑制MMP（基质金属蛋白酶）增加。 构成：外用皮肤制剂的组合物含有作为活性成分的11,14,17-二十碳三烯酸（ETA）的0.001-10重量％。 ETA含在油相中。 该组合物用于通过降低胶原酶表达来预防老化。 该组合物还可用于通过抑制皮肤屏障损伤来进行皮肤保湿。
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公开(公告)号：KR100921947B1
公开(公告)日：2009-10-15
申请号：KR1020030082144
申请日：2003-11-19
Applicant: (주)아모레퍼시픽
CPC classification number: A61Q19/02 , A61K8/4986 , A61K8/97 , A61K2800/70
Abstract: 본 발명은 멜라닌 합성경로를 조절하여 멜라닌 과다 생성 억제; 멜라닌 색소의 조절; 및 멜라닌 배출 촉진;의 3단계로 미백작용을 하는 피부 미백 화장료 조성물에 관한 것이다. 더욱 상세하게는, 본 발명의 피부 미백 화장료 조성물은 멜라닌 과다 생성 억제 미백기능과 동시에 멜라닌 색소 조절 미백기능을 하는 EPS 복합체 및 멜라닌 배출촉진제로서 각질제거제를 함유하여 우수한 미백효과를 나타낸다.
멜라닌 * 각질제거 * 미백 * EPS 복합체-
74.发明公开카텝신 Ｇ 저해제를 함유하는 피부노화 방지용 피부외용제조성물 및 항노화용 물질을 스크리닝하는 방법 有权用于外用于含皮肤抑制剂G抑制剂以防止皮肤老化的筛选组合物和用于开发抗病材料的筛选方法
公开(公告)号：KR1020080040612A
公开(公告)日：2008-05-08
申请号：KR1020070111803
申请日：2007-11-02
Applicant: (주)아모레퍼시픽
IPC: A61K31/166 , A61K8/44 , A61K8/34 , A61Q19/08
CPC classification number: A61K8/42 , A61K2800/522 , A61Q19/08
Abstract: A skin external composition comprising a cathepsin G inhibitor is provided to prevent an adhesion protein from being degraded by intrinsic aging and photo-aging, reduce the production of metalloproteinase and inhibit the activity of metalloproteinase, thereby being more potent anti-aging substance than existing anti-aging substances. A method for screening anti-aging materials is provided to develop the anti-aging materials which effectively inhibit the quantitative and qualitative increase of metalloproteinase, resulting from the degradation of an adhesion protein by cathepsin G in skin cells without direct UV irradiation. A skin external composition for preventing skin aging comprises 0.01-10 wt% a cathepsin G inhibitor as an effective ingredient, wherein the cathepsin G inhibitor is at least one selected from the group consisting of compounds represented by formulae(1) to (4). The composition is formulated into skin lotion, astringent lotion, milk lotion, nourishing cream, essence, massage cream, eye cream, pack, body lotion, body cream, body oil or body essence. A method for screening an anti-aging material comprises the steps of: (a) adding an anti-aging candidate material to a substrate in the presence of cathepsin G enzyme; and (b) measuring the inhibition of activity of the cathepsin G enzyme. Further, the measure of the inhibition of activity of the cathepsin G enzyme is performed by measuring a concentration of a produced metalloprotease.
Abstract translation: 提供包含组织蛋白酶G抑制剂的皮肤外用组合物，以防止粘附蛋白由于内在老化和光老化而降解，减少金属蛋白酶的产生并抑制金属蛋白酶的活性，从而比现有的抗老化物质更有效的抗衰老物质 化学物质。 提供了一种筛选抗衰老材料的方法，以开发有效抑制金属蛋白酶定量和定性增加的抗衰老材料，这是由皮肤细胞中组织蛋白酶G在组织蛋白酶G中的降解引起的，而不需要直接的紫外线照射。 用于防止皮肤老化的皮肤外用组合物包含0.01-10重量％的组织蛋白酶G抑制剂作为有效成分，其中组织蛋白酶G抑制剂是选自由式（1）至（4）表示的化合物中的至少一种。 该组合物配制成皮肤洗剂，收敛剂，乳液，滋养霜，精华液，按摩霜，眼霜，包装，身体乳液，身体霜，身体油或身体精华。 用于筛选抗衰老材料的方法包括以下步骤：（a）在组织蛋白酶G酶存在下将抗老化候选材料加入到底物中; 和（b）测量组织蛋白酶G酶的活性的抑制。 此外，组织蛋白酶G酶的活性的抑制的测量是通过测量产生的金属蛋白酶的浓度进行的。
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公开(公告)号：KR100774437B1
公开(公告)日：2007-11-08
申请号：KR1020060113662
申请日：2006-11-17
Applicant: (주)아모레퍼시픽
IPC: A61K31/343 , A61K8/49 , A61Q19/02
CPC classification number: A61K8/4973 , A61K31/343 , A61Q19/02
Abstract: A skin external composition for skin-whitening containing manassantin B is provided to inhibit mobility of melanin by inhibiting binding of melanophilin as a carrier of melanosome in a melanocyte with myosin 5a, thereby forming melanosome aggregation and whitening the skin. A skin external composition for skin-whitening contains 0.001-10% of manassantin B which is extracted from Saururus chinensis Baill by extracting Saururus chinensis Baill with water or organic solvent selected from ethanol, methanol, butanol, ether, ethylacetate, chloroform and methylene chloride, filtering the extract, concentrating the filtered solution under reduced pressure, extracting the concentrate with methylene chloride and concentrating the extract under reduced pressure, and is formulated as solution, suspension, emulsion, paste, gel, cream, lotion, powder, soap, surfactant-containing cleansing, oil, powder foundation, emulsion foundation, wax foundation or spray.
Abstract translation: 提供含有马桑丁汀B的皮肤外用组合物，用于通过抑制作为黑素细胞的黑素体的载体的黑色素细胞与肌球蛋白5a的结合来抑制黑色素的迁移，从而形成黑素体聚集并使皮肤变白。 用于皮肤美白的皮肤外用组合物含有0.001-10％的苦参碱B，其通过用水或选自乙醇，甲醇，丁醇，乙醚，乙酸乙酯，氯仿和二氯甲烷的有机溶剂萃取中华白菜， 过滤浓缩滤液，减压浓缩萃取液，减压浓缩，配制成溶液，悬浮液，乳液，糊剂，凝胶，乳液，乳液，粉末，皂，表面活性剂， 含有清洁，油，粉底，乳液粉底，蜡基或喷雾剂。
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Patent Agency Ranking
公开(公告)号：KR100636737B1
公开(公告)日：2006-10-20
申请号：KR1020050032607
申请日：2005-04-20
Applicant: (주)아모레퍼시픽
IPC: C07C225/20
Abstract: Provided are a gallic acid adamantamine amide compound which inhibits the generation of melanin, a method for preparing the compound, and a cosmetic composition containing the compound. The gallic acid adamantamine amide compound is represented by the formula 1. The method comprises the steps of dissolving gallic acid in a solvent, adding a catalyst and a base to the solution drop by drop, and reacting it with acetic anhydride to prepare the acetylated compound represented by the formula II (See the reaction scheme 1); dissolving the acetylated compound in a solvent and adding a base, ethyl chloroformate and adamantamine to prepare the amide compound represented by the formula III; and reacting the obtained amide compound with a base to hydrolyze it, thereby preparing the gallic acid adamantamine amide compound represented by the formula 1. Preferably the catalyst is dimethyl aminopyridine; and the base is triethylamine.
Abstract translation: 本发明提供抑制黑色素生成的没食子酸金刚胺酰胺化合物，其制备方法以及含有该化合物的化妆品组合物。 没食子酸金刚烷胺酰胺化合物由式1表示。该方法包括以下步骤：将没食子酸溶解在溶剂中，逐滴向溶液中加入催化剂和碱，并使其与乙酸酐反应以制备乙酰化的化合物 由式II表示（参见反应方案1）; 将乙酰化的化合物溶解在溶剂中，加入碱，氯甲酸乙酯和金刚烷胺制备式III所示的酰胺化合物; 并使所得酰胺化合物与碱反应以将其水解，从而制备式1代表的没食子酸金刚烷胺酰胺化合物。优选该催化剂是二甲基氨基吡啶; 碱是三乙胺。
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公开(公告)号：KR102045879B1
公开(公告)日：2019-11-18
申请号：KR1020180042940
申请日：2018-04-12
Applicant: (주)아모레퍼시픽 , 경희대학교 산학협력단
IPC: G01N33/50 , G01N33/68 , A23L33/13 , A61K31/7105 , A61K31/713 , A61K48/00 , A61P27/02
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公开(公告)号：KR101859500B1
公开(公告)日：2018-05-21
申请号：KR1020100121220
申请日：2010-12-01
Applicant: (주)아모레퍼시픽
Abstract: 본발명은콜라겐 4, 라미닌, 니도젠및 프로테오글라이칸을포함하는 3차원매트릭스용조성물및 상기조성물을이용하여제조한 3차원매트릭스를개시한다. 또한본 발명은상기 3차원매트릭스를이용하여세포를배양하는방법을개시한다.
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