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公开(公告)号：KR101341889B1
公开(公告)日：2013-12-16
申请号：KR1020120058086
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: C07C227/44 , C07C227/26 , C07C229/08
Abstract: 본발명은천연물유래의폴리아미드-12 단량체인 12-아미노도데카논산의제조방법에관한것이다. 보다구체적으로는천연물인피마자유로부터얻을수 있는운데실렌산또는그 에스터로부터폴리아미드계열가소성탄성체(TPE)의원료가되는 12-아미노도데카논산또는그의에스터유도체를제조하는방법에관한것이다. 또한본 발명에따른제조방법에따라제조되는 12-아미노도데카논산은폴리아미드-12의단량체로사용되며, 본발명에따른제조방법은천연유래의피마자유로부터제조될수 있는운데실렌산또는그 에스터로부터제조할수 있는바, 12-아미노도데카논산의새로운친환경적이면서도효율적인제조방법으로이용될수 있다.
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72.发明授权히알루론산―도파민 컨쥬게이트로 표면이 개질된 하이드록시아파타이트 나노입자를 포함하는 실크피브로인 나노섬유 및 이를 이용한 지지체 有权包含用羟丙酸/多巴胺结合物修饰的羟基磷酸酯的纳米纤维素和使用其的SCAFFOLD
公开(公告)号：KR101313898B1
公开(公告)日：2013-09-30
申请号：KR1020120044954
申请日：2012-04-27
Applicant: 대한민국(농촌진흥청장) , 서울대학교산학협력단
CPC classification number: D01F4/02 , A61F2/2846 , A61L24/00 , A61L27/3604 , D01D5/0015 , D01D10/06 , D01F1/10
Abstract: PURPOSE: The complex nanofiber of hydroxyapatite and silk fibroin, a two dimensional structure and a three dimensional structure supporter using the same is provided to easily facilitate the uniformity and guarantee of reappearance, is able to electrospinning for a long time, and useful for cell formation, bond tissue regeneration and supporter as its mechanical property is satisfied. CONSTITUTION: The complex nanofiber uniformly disperses the hydroxyapatite nano particle which surface is reformed with the hyaluronic acid-dopamine conjugate inside the silk fibroin nanofiber. Conjugate of the hyaluronic acid-dopamine is the formation of amide bond by combining the carboxyl group of hyaluronic acid and amine group of dopamine. The hydroxyapatite which surface is reformed with the hyaluronic acid-dopamine conjugate is the combination of two hydroxyl radicals of dopamine to the surface of the hydroxyapatite. The diameter of the complex nanofiber is 100-1000 nm.
Abstract translation: 目的：提供复合纳米纤维的羟基磷灰石和丝素蛋白，二维结构和三维结构支持体，使其易于均匀，保证再现，能长时间静电纺丝，可用于细胞形成 ，粘合组织再生和支持体作为其机械性能得到满足。 构成：复合纳米纤维将丝氨蛋白纳米纤维内透明质酸 - 多巴胺缀合物表面的羟基磷灰石纳米粒子均匀分散。 透明质酸 - 多巴胺的结合物是通过将透明质酸的羧基和多巴胺的胺基组合而形成酰胺键。 表面用透明质酸 - 多巴胺缀合物重整的羟基磷灰石是多巴胺的两个羟基自由基与羟基磷灰石表面的组合。 复合纳米纤维的直径为100-1000nm。
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公开(公告)号：KR1020120128449A
公开(公告)日：2012-11-27
申请号：KR1020110046401
申请日：2011-05-17
Applicant: 서울대학교산학협력단
IPC: C07C227/04 , C07C229/08 , C07C51/097 , C07C55/02
Abstract: PURPOSE: A manufacturing method of 10-aminodecanoic acid or ester derivatives is provided to easily manufacture effectively and environmentally manufacture decanedioic acid through two reactions form a medium compound. CONSTITUTION: A manufacturing method of 10-aminodecanoic acid or ester derivatives comprises: a step of manufacturing a compound indicated in chemical formula 2 through a pre-ozonolysis of an oleic acid indicated in chemical formula 1 or ester thereof; a step of manufacturing a compound indicated in chemical formula 3 through a Henry reaction by putting base into a mixture of compound indicated in chemical formula 2 and nitromethane; a step of manufacturing a compound thorough a removal reaction accepting a leaving group into a hydroxy group of a compound indicated in chemical formula 3 and removing the same; and a step of manufacturing a compound indicated in chemical formula 7 through a reduction reaction of a compound in chemical formula 4 under the presence of a transition metal catalyst. [Reference numerals] (AA) Catalyst, H_2
Abstract translation: 目的：提供10-氨基十一烷酸或酯衍生物的制造方法，通过两种反应形成中等化合物，有效地制造和环境化生产癸二酸。 构成：10-氨基十一烷酸或酯衍生物的制造方法包括：通过化学式1表示的油酸的前臭氧分解或其酯制造化学式2所示的化合物的工序; 将化学式2表示的化合物与硝基甲烷的混合物中的碱进行亨利反应，制造化学式3所示化合物的工序; 将通过化学式3表示的化合物的羟基取代离去基团的除去反应的化合物的制造步骤，并除去该化合物; 以及通过化学式4中的化合物在过渡金属催化剂的存在下的还原反应制造化学式7所示化合物的步骤。 （AA）催化剂，H_2
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公开(公告)号：KR102255066B1
公开(公告)日：2021-05-24
申请号：KR1020200019414
申请日：2020-02-18
Applicant: 중앙대학교 산학협력단 , 서울대학교산학협력단
Abstract: 본발명은 3’-메톡시플라본을유효성분으로포함하는줄기세포의성상세포로의분화유도용조성물등에관한것으로, 본발명의조성물을사용하면기존의줄기세포분화촉진제를사용하지않고성상세포로분화를유도할수 있을뿐만아니라, 분화된성상세포를이용하여신경퇴행성질환을효과적으로치료할수 있을것으로기대된다.
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公开(公告)号：KR101341888B1
公开(公告)日：2013-12-16
申请号：KR1020120058082
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: C07C227/44 , C07C227/26 , C07C229/08
Abstract: 본발명은천연물유래의폴리아미드-11 단량체인 11-아미노운데카논산의제조방법에관한것이다. 보다구체적으로는천연물인올리브유로부터얻을수 있는올레산또는그 에스터로부터폴리아미드계열가소성탄성체(TPE)의원료가되는 11-아미노운데카논산또는그의에스터유도체를제조하는방법에관한것이다. 본발명에따른제조방법에따라제조되는 11-아미노운데카논산은폴리아미드-12의단량체로사용되며, 천연유래의올리브유로부터제조될수 있는올레산또는그 에스터로부터제조할수 있는바, 11-아미노운데카논산의새로운친환경적이면서도효율적인제조방법으로이용될수 있다.
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Patent Agency Ranking
公开(公告)号：KR1020120128466A
公开(公告)日：2012-11-27
申请号：KR1020110046438
申请日：2011-05-17
Applicant: 서울대학교산학협력단
IPC: C07C227/04 , C07C229/08 , C07C51/097 , C07C55/02
Abstract: PURPOSE: A manufacturing method 11-aminoundecanoic acid or ester derivatives thereof is provided to effectively manufacture 11-aminoundecanoic acid and undecanedioic acid which are monomers of polyamide-11 from undesileic acid or ester thereof which can be easily obtain from undesileic acid or ester thereof. CONSTITUTION: A manufacturing method 11-aminoundecanoic acid or ester derivatives thereof comprises: a step of manufacturing a compound indicated in chemical formula 2 through a reductive pre-ozonolysis of undesileic acid indicated in chemical formula 1 or ester thereof; a step of manufacturing a compound indicated in chemical formula 3 by putting base into a mixture of a compound indicated in chemical formula 2 and nitromethane; a step of manufacturing a compound indicated in chemical formula 4 through a removal reaction of a compound indicated in chemical formula 3; a step of manufacturing a chemical formula 7 through reduction of a compound indicated in chemical formula 4 under the presence of a transition metal catalyst. [Reference numerals] (AA) Catalyst, H_2
Abstract translation: 目的：提供制备方法11-氨基十一烷酸或其酯衍生物，以有效地制备作为不溶性酸或其酯的聚酰胺-11单体的11-氨基十一烷酸和十一烷二酸，其可以容易地从不适当的酸或其酯获得。 构成：制备方法11-氨基十一烷酸或其酯衍生物包括：通过化学式1所示的不寻常的酸的还原性预臭氧分解或其酯制备化学式2所示化合物的步骤; 将化学式3所示的化合物与硝基甲烷的化合物混合，制成化学式3表示的化合物的工序; 通过化学式3表示的化合物的去除反应制造化学式4所示化合物的步骤; 通过在过渡金属催化剂的存在下还原化学式4所示的化合物来制造化学式7的步骤。 （AA）催化剂，H_2
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公开(公告)号：KR101894231B1
公开(公告)日：2018-09-05
申请号：KR1020170079224
申请日：2017-06-22
Applicant: 주식회사 에스엠디솔루션 , 서울대학교산학협력단
IPC: A61C17/02 , A61C17/028 , A61C17/022
CPC classification number: A61C17/0211 , A61C17/0208 , A61C17/022 , A61C17/028
Abstract: 본발명은구강세정용마우스피스및 이를포함하는구강세정장치에관한것이다. 보다구체적으로, 외부에펄스발생기로부터발생된펄스가적용된세정액을사용자가착용한구강세정용마우스피스로부터사용자치아에분사할수 있는구강세정용마우스피스및 이를포함하는구강세정장치에관한것이다. 본발명에따른구강세정용마우스피스및 이를포함하는구강세정장치는, 스스로양치질에의한구강관리가어려운사람들을위한구강위생관리에효과적이며, 특히양치질을한 것과같은효과를발휘할수 있고, 펄스발생기로부터발생한펄스를세정액에적용하여, 구강내 부위별로적절한펄스가적용된세정액을분사할수 있으므로, 보다효율적인구강관리를가능하도록할 수있다. 또한, 상기구강세정용마우스피스및 이를포함하는구강세정장치는, 펄스형의고압수형태의세정액분사시, 특정패턴을가지고특정펄스가적용된세정액이복수의개구부를통하여사용자치아에분사되도록사용자스스로가조절할수 있음으로써, 보다사용자편의성이증대될수 있다.
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公开(公告)号：KR101818367B1
公开(公告)日：2018-01-15
申请号：KR1020160109810
申请日：2016-08-29
Applicant: 서울대학교산학협력단
Inventor： 김현정
CPC classification number: A61B5/08 , A61B5/4857 , A61B5/742 , A61B5/746
Abstract: 본발명은진정법수행중의호흡감시시스템에관한것이다. 본발명에따른진정법시행중의호흡감시시스템은, 환자에게많은센서등을부착하는불편이없고, 호흡의이상징후에대한즉각적인판단이가능하며, 진정법수행시 발생될수 있는기도폐쇄및/또는호흡저하등의호흡이상징후를보다신속하고간편하게임상의에게시각적또는청각적으로전달할수 있어, 호흡이상징후에대한합병증을포함한환자의위중한위험을방지할수 있다. 또한, 본발명에따른진정법시행중의호흡감시시스템은, 저렴한비용으로제작가능하고, 진정법이수행되는모든의료분야등에호흡감시시스템으로활용될수 있다.
Abstract translation: 本发明涉及一种在平静过程中的呼吸监测系统。 根据本发明执行的soothe.These系统的呼吸监测，没有安装多个传感器，例如一个病人的不便，可以立即对呼吸和气道阻塞的异常确定的，和/或可以执行soothe.These时生成呼吸， 可以更快更容易地以视觉或听觉方式传送给临床医生，从而防止患者呼吸后出现严重风险，包括并发症。 此外，根据本发明的执法系统平静的呼吸监测中，可以使用作为呼吸监测系统等所有可以以低成本来制造，真正法律执行医疗领域。
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公开(公告)号：KR101413827B1
公开(公告)日：2014-07-01
申请号：KR1020120041958
申请日：2012-04-23
Applicant: 서울대학교산학협력단
Abstract: 본 발명은 내부에 공간을 가진 인산칼슘 지지체의 강도를 증가시키는 방법에 관한 것이다. 내부에 공간을 가진 인산칼슘 지지체는 기계적 강도가 낮아서 힘을 받는 곳에서는 파절의 우려 때문에 사용하기 어렵다. 이에 본 발명은 이와 같은 인산칼슘 지지체의 기계적 강도를 생체친화적인 방법으로 개선하기 위해 생체친화적인 중합체 박막과 인산칼슘 박막을 여려 겹으로 얇게 코팅하는 방법을 사용한다. 생체친화적인 중합체 박막과 인산칼슘 박막을 여려 겹으로 얇게 코팅한 인산칼슘 지지체는 지지체의 고유한 형태를 유지한 상태에서 기계적 강도가 증진된다.
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公开(公告)号：KR1020130134517A
公开(公告)日：2013-12-10
申请号：KR1020120058082
申请日：2012-05-31
Applicant: 서울대학교산학협력단
IPC: C07C227/44 , C07C227/26 , C07C229/08
Abstract: The present invention relates to a method for synthesizing 11-aminoundecanoic acid being a polyamide-11 monomer derived from a natural material and, in particular, to a method for synthesizing 11-aminoundecanoic acid or an ester derivative thereof being a material for polyamide-based thermoplastic elastomer (TPE) from oleic acid or an ester derivative thereof obtainable from olive oil being a natural material. The present invention provides the novel eco-friendly and efficient method for synthesizing 11-aminoundecanoic acid because the 11-aminoundecanoic acid synthesized according to the present invention can be used as a monomer for polyamide-11, and can be synthesized from oleic acid or an ester derivative thereof obtainable from naturally derived olive oil.
Abstract translation: 本发明涉及一种合成作为由天然材料衍生的聚酰胺-11单体的11-氨基十一烷酸的方法，特别涉及一种用于合成作为聚酰胺类材料的11-氨基十一烷酸或其酯衍生物的合成方法 来自油酸的热塑性弹性体（TPE）或其可从橄榄油中获得的酯衍生物作为天然材料。 本发明提供了一种合成11-氨基十一烷酸的新型环保型高效方法，因为根据本发明合成的11-氨基十一烷酸可用作聚酰胺-11的单体，可由油酸或 其衍生物可由天然衍生的橄榄油获得。
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