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公开(公告)号：KR1019900002051B1
公开(公告)日：1990-03-31
申请号：KR1019870006973
申请日：1987-07-01
Applicant: 한국과학기술연구원
IPC: C07D209/04
Abstract: The method for preparing N-(2-halopropionyl)-proline derivatives of formula (I), used as an inhibitor against angiotensin and antihypertensive agent, is presented. Thus, 4.1g of proline benzylester is dissolved in 20ml of chloroform and the above mixture is cooled in water-ice bath. Then, 1.7g 2-bromopropionyl chloride is dropped slowly in 15ml of chloroform containing proline ester. The above mixture is stirred at 25≦̸C C for 2 hrs and the obtained chloroform layer is washed with water three times, evaporated and purified. In (I), R1 is H, C1-10 lower alkyl or aryl; R2 and R3 are each H, C1-4 alkyl, aryl, amino or cyano; X is Cl, Br or I.
Abstract translation: 提出了制备用于抑制血管紧张素和抗高血压药的式（I）的N-（2-卤代丙酰基） - 脯氨酸衍生物的方法。 因此，将4.1g脯氨酸苄基酯溶于20ml氯仿中，将上述混合物在水 - 冰浴中冷却。 然后，将1.7g 2-溴丙酰氯缓慢滴入含有脯氨酸酯的15ml氯仿中。 将上述混合物在25℃，C℃下搅拌2小时，所得氯仿层用水洗涤三次，蒸发并纯化。 在（I）中，R 1为H，C 1-10低级烷基或芳基; R2和R3各自为H，C1-4烷基，芳基，氨基或氰基; X是Cl，Br或I.
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公开(公告)号：KR1020130010514A
公开(公告)日：2013-01-29
申请号：KR1020110059157
申请日：2011-06-17
Applicant: 한국과학기술연구원
IPC: C07D401/04 , A61K31/4439 , A61P35/00
Abstract: PURPOSE: A method for preparing a novel aryl- and heteroaryl-substituted pyrazole derivative and a pharmaceutical composition containing the derivative are provided to be used as a melanoma proliferation inhibitor. CONSTITUTION: An aryl- and heteroaryl-substituted pyrazole derivative is denoted by chemical formula I. A method for proliferating the derivative or a pharmaceutically acceptable salt thereof comprises a step of reacting 3-phenyl-4-pyridinyl pyrazole derivative of chemical formula III with phenyl chloroformate to prepare a compound of chemical formula IV. A pharmaceutical composition for preventing or treating melanoma contains the derivative or pharmaceutically acceptable salt and a pharmaceutically acceptable carrier.
Abstract translation: 目的：提供一种制备新型芳基 - 和杂芳基取代的吡唑衍生物的方法和含有该衍生物的药物组合物，用作黑素瘤增殖抑制剂。 构成：芳基和杂芳基取代的吡唑衍生物由化学式I表示。增殖衍生物或其药学上可接受的盐的方法包括使化学式III的3-苯基-4-吡啶基吡唑衍生物与苯基 氯甲酸酯以制备化学式IV的化合物。 用于预防或治疗黑素瘤的药物组合物含有衍生物或药学上可接受的盐和药学上可接受的载体。
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公开(公告)号：KR101074521B1
公开(公告)日：2011-10-17
申请号：KR1020080118863
申请日：2008-11-27
Applicant: 한국과학기술연구원
Abstract: 본발명은혈당강하효능을갖는천연칼슘화합물에관한것으로, 보다상세하게는생체내 흡수도가높고이온화도가높아서피투여자에대하여칼슘흡수율이월등히높고필수원소등의유익한원소도제공하는패각이온화칼슘이우수한혈당강하효과가있으므로상기패각이온화칼슘을혈당조절용조성물, 또는당뇨병예방및 치료용조성물의유효성분으로유용하게사용될수 있다.
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公开(公告)号：KR1020100130871A
公开(公告)日：2010-12-14
申请号：KR1020090049608
申请日：2009-06-04
Applicant: 한국과학기술연구원
CPC classification number: A61K36/704 , A23L33/105 , A23V2200/328 , A61K9/08 , A61K9/10 , A61K9/14 , A61K9/20 , A61K9/48 , A61K2236/33 , Y10S514/866
Abstract: PURPOSE: A composition containing Rhizoma Polygoni Cuspidati extract for reducing blood glucose is provided to use in food or pharmaceutical composition for preventing and treating diabetes. CONSTITUTION: A composition for reducing blood glucose contains crude extract of Rhizoma Polygoni Cuspidati isolated using ethanol or spirit or extract isolated using ethylacetate or butanol from the crude extract. The composition is a food or pharmaceutical composition. The food is manufactured in the form of tablet, granule, powder, capsule and liquid. The pharmaceutical composition is manufactured in the form of tablet, pill, powder, granule, capsule, suspension, emulsion, syrup, aerosol or injection. A composition for preventing or treating diabetes contains the extract of Rhizoma Polygoni Cuspidati as an active ingredient.
Abstract translation: 目的：提供含有用于降低血糖的枸杞提取物的组合物，用于预防和治疗糖尿病的食品或药物组合物中。 构成：用于降低血糖的组合物含有使用乙醇或精油分离的粗提物粗提物或使用乙酸乙酯或丁醇从粗提取物中分离的提取物。 组合物是食品或药物组合物。 食品以片剂，颗粒，粉末，胶囊和液体的形式制成。 药物组合物以片剂，丸剂，粉剂，颗粒剂，胶囊剂，悬浮剂，乳剂，糖浆剂，气雾剂或注射剂的形式制备。 用于预防或治疗糖尿病的组合物含有枸杞提取物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020100059089A
公开(公告)日：2010-06-04
申请号：KR1020080117736
申请日：2008-11-25
Inventor： 조정혁
IPC: C02F1/467 , C02F9/00 , C02F103/08
CPC classification number: A01K61/13 , A01K63/04 , Y02A40/814 , C02F1/467 , C02F9/00 , C02F2103/08 , C02F2201/002
Abstract: PURPOSE: A seawater sterilization method and seawater sterilization equipment are provided to use the seawater in cultivation of virus free seedling or cultivation of marine products, because pathogenic bacteria or virus contained in the seawater is effectively removed. CONSTITUTION: A seawater pasteurization method comprises a step for sterilizing by the electric potential difference and electrolysis, and a step for processing the sterilized seawater through the chlorine dioxide processor. The seawater sterilization transaction equipment comprises the following; a pre-processor(1) filtering impurities included in the seawater containing pathogenic bacteria or virus; an inverse filtering device(7) which re-filters and washes the filtered preprocessing seawater; an electric potential difference sterilizer(3) sterilizing the seawater by an oxidizer or hypochlorous acid which is created from the electrolysis of the seawater, the seawater is sterilized by the electric potential difference which is created by electrode after the filtered seawater is passed through the electric potential difference sterilizer in which electrode is included; and a chlorine dioxide processor(10) in which the seawater is sterilized by the chlorine dioxide.
Abstract translation: 目的：提供海水灭菌方法和海水灭菌设备，使用海水培养无病毒幼苗或培养海产品，因为海水中包含的病原菌或病毒被有效去除。 构成：海水灭菌方法包括通过电位差和电解进行灭菌的步骤，以及通过二氧化氯处理器处理灭菌海水的步骤。 海水灭菌交易设备包括以下内容： 预处理器（1）过滤包含在含有病原菌或病毒的海水中的杂质; 反过滤装置（7），其对过滤的预处理海水进行过滤和洗涤; 电位差灭菌器（3）通过由海水电解产生的氧化剂或次氯酸对海水进行灭菌，海水由经过过滤的海水经过电极后由电极产生的电位差消毒， 包含电极的电位差灭菌器; 和二氧化氯处理器（10），其中海水由二氧化氯灭菌。
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公开(公告)号：KR100959281B1
公开(公告)日：2010-05-26
申请号：KR1020080118862
申请日：2008-11-27
Applicant: 한국과학기술연구원
CPC classification number: A23L7/196 , A23L33/10 , A23V2002/00 , A23V2200/328 , A23V2250/1578
Abstract: PURPOSE: A manufacturing method of rice with hypoglycemic effect is provided to adjust a physiological function for preventing diabetes by powdering and sintering sea shells, and to cultivate rice with ionized calcium powder. CONSTITUTION: A manufacturing method of rice with hypoglycemic effect includes the following steps: fertilizing rice with ionized calcium three times after forming ears from the rice; crushing shell to a size of 1.5 ~ 10cm; sintering the shell after loading the crushed shells to a sintering tank by gradually elevating temperature to 1200°C; gradually cooling the temperature of the sintering tank to 200 ~ 400°C while maintaining the shells in the sintering tank; cooling the sintering tank to 100 ~ 150°C; and manufacturing the ionized calcium in the air.
Abstract translation: 目的：提供具有降血糖作用的水稻的制造方法，通过粉化和烧结海壳来调节防止糖尿病的生理功能，并用离子钙粉培养大米。 构成：具有降血糖作用的水稻的制造方法包括以下步骤：从水稻中形成耳朵后，用离子钙三次施米; 破碎壳尺寸为1.5〜10cm; 通过逐渐升温至1200℃将粉碎的壳体装载到烧结罐中来烧结壳体; 将烧结罐的温度逐渐降低至200〜400℃，同时保持烧结槽中的壳体; 将烧结罐冷却至100〜150℃; 并在空气中制造电离钙。
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公开(公告)号：KR100947278B1
公开(公告)日：2010-03-11
申请号：KR1020070086301
申请日：2007-08-27
Applicant: 한국과학기술연구원
IPC: A61K36/62 , A61K36/8994 , A61K36/54 , A61P3/04
Abstract: 본 발명은 하엽을 주성분으로 하고, 의이인 및 함초를 부성분으로 하는 10 여종 천연물의 알코올 추출 조성물에 관한 것으로 비만 및 기타 비만 관련 질환 치료 활성과 억제 활성을 가지는 경구용 제제와 그 제조 방법 및 상기 조성물을 포함한 비만 치료제에 관한 것이다.
본 발명에 따르면, 하엽, 생강, 계지의 알코올 추출물과, 의이인, 함초 등의 알코올 추출물과 식이 섬유 등으로 구성되어, 비만 및 비만 관련 질환 치료에 사용되는 경구용 제제에 주재료로 사용됨을 특징으로 하는 비만 및 비만 관련 질환 치료 치료 활성을 가지는 조성물과; 상기 조성물의 성분들을 제조하는 방법 및 비만 및 비만 관련 질환 치료 활성을 가지는 조성물을 이용한 비만 치료제가 제공된다.
비만, 하엽, 의이인, 함초, 알코올 추출-
公开(公告)号：KR1020090013414A
公开(公告)日：2009-02-05
申请号：KR1020070077498
申请日：2007-08-01
CPC classification number: C01B11/022
Abstract: A solid composition for the production of a chlorine dioxide solution with excellent long-term stability is provided to obtain a high yield of chlorine dioxide, prevent materials such as chlorite(ClO2-) or hydrochloric acid(ClO3-) harmful to the human body from being produced when the solid composition is dissolved into water, and prevent individual raw materials from reacting with each other in a solid composition state even when the solid composition is stored for a long time. A composition for the production of a chlorine dioxide solution comprises: material formed in a solid phase to provide chlorine in an aqueous solution phase; a solid type organic acid or inorganic acid with a pKa value of 4 or less; sodium chlorite; and sodium bicarbonate. The material formed in a solid phase to provide chlorine in an aqueous solution phase is calcium hypochlorite, sodium dichloro isocyanuric acid, or sodium bromo chloro isocyanuric acid chloramine T. A tablet for the production of a chlorine dioxide solution comprises an upper layer(A) consisting of an organic acid of calcium hypochlorite, sodium dichloro isocyanuric acid, or sodium bromo chloro isocyanuric acid chloramine T, a lower layer(B) of sodium chlorite and sodium bicarbonate, and an intermediate layer(C) formed between the upper and lower layers as a separation layer separating the upper and lower layers, the intermediate layer consisting of a water-soluble polymer, salt, potassium chloride, potassium sulfate, or mixtures thereof.
Abstract translation: 提供用于生产具有优异的长期稳定性的二氧化氯溶液的固体组合物以获得高产率的二氧化氯，防止对人体有害的诸如亚氯酸盐（ClO 2 - ）或盐酸（ClO 3 - ）的物质 当固体组合物溶解在水中时，即使固体组合物长时间储存，也可以防止各种原料在固体组成状态下彼此反应。 用于生产二氧化氯溶液的组合物包括：以固相形成的材料，以在水溶液相中提供氯; pKa值为4以下的固体型有机酸或无机酸; 亚氯酸钠 和碳酸氢钠。 形成在固相中以在水溶液相中提供氯的材料是次氯酸钙，二氯异氰脲酸钠或溴氯异氰脲酸氯胺T.用于生产二氧化氯溶液的片剂包括上层（A） 由次氯酸钙的有机酸，二氯异氰脲酸钠或溴氯异氰尿酸氯胺T，亚氯酸钠和碳酸氢钠的下层（B）和形成在上层和下层之间的中间层（C）组成 作为分离上层和下层的分离层，中间层由水溶性聚合物，盐，氯化钾，硫酸钾或其混合物组成。
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80.发明公开순환재배시스템을 이용한 기능성 함유 두채류의 재배방법, 그로부터 재배된 두채류 및 이를 이용한 건조분말의제조방법 및 그 용도 无效使用圆形培养系统生产的豆粕芽孢杆菌的方法，其生产的豆粕，其制备干燥产品及其用途的方法
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