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公开(公告)号：KR100438386B1
公开(公告)日：2004-07-02
申请号：KR1020010029027
申请日：2001-05-25
Applicant: 한국과학기술연구원
IPC: A61K9/20
Abstract: PURPOSE: A method for preventing hardening pills by adding a water-soluble high polymer and liquid-keeping agent to Chinese herbal drug powder during the manufacture of the pills is provided which permits easy digestion and enhancement of absorption efficiency of the pills. CONSTITUTION: A water-soluble high polymer and a liquid-keeping agent are added to crude drug powder during manufacture of pills. The water-soluble high polymer is selected from the group consisting of a boiled agar solution, boiled starch, aloe, methyl cellulose and methyl acetate. And the liquid-keeping agent is natural oils containing vegetable oils and animal oils, glycerin or propanediol.
Abstract translation: 目的：提供一种通过在药丸制造过程中向中草药粉中添加水溶性高分子和液体保持剂来防止硬化丸的方法，其允许容易消化并提高药丸的吸收效率。 组成：在药丸制造期间将水溶性高聚物和液体保持剂加入生药粉中。 水溶性高聚物选自煮沸的琼脂溶液，煮沸的淀粉，芦荟，甲基纤维素和乙酸甲酯。 液体保持剂是含有植物油和动物油，甘油或丙二醇的天然油。
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公开(公告)号：KR100411237B1
公开(公告)日：2003-12-12
申请号：KR1020010029824
申请日：2001-05-29
Applicant: 한국과학기술연구원
IPC: G01N33/18
Abstract: PURPOSE: Provided is a kit for examining water quality by measuring the concentration of nitrogen and phosphorus contained in a water soluble sample. CONSTITUTION: The kit for examining water quality contains reagents for measurement of each concentration of ammonia, nitrous acid, nitric acid and phosphoric acid, each comparative color band and a reaction vessel. Water quality is examined by measuring the concentration of ammonia, nitrous acid, nitric acid and phosphoric acid contained in a sample using reagents; analyzing the result to confirm if the sample is contaminated and to estimate what causes its contamination.
Abstract translation: 目的：提供一种通过测量水溶性样品中含有的氮和磷浓度来检测水质的试剂盒。 构成：用于检测水质的试剂盒包含用于测量氨，亚硝酸，硝酸和磷酸的各浓度的试剂，各比色带和反应容器。 通过使用试剂测量样品中所含的氨，亚硝酸，硝酸和磷酸的浓度来检查水质; 分析结果以确认样本是否受到污染，并估算导致污染的原因。
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公开(公告)号：KR1020030067161A
公开(公告)日：2003-08-14
申请号：KR1020020007039
申请日：2002-02-07
Applicant: 한국과학기술연구원
IPC: C07D307/83
Abstract: PURPOSE: Provided are kinase inhibitory compounds with dihydrobenzofuran scaffold, which has therapeutic effect on hepatocirrhosis, rheumatism, cancer, sclerosis of the arteries, and the like. CONSTITUTION: Kinase inhibitory compound is characterized by comprising dihydrobenzofuran scaffold, and a functional group attached to the dihydrobenzofuran scaffold and providing hydrogen bond. The kinase inhibitory compound is characteristically represented by the formula(1).
Abstract translation: 目的：提供具有二氢苯并呋喃支架的激酶抑制化合物，其具有对肝硬化，风湿病，癌症，动脉硬化等的治疗作用。 构成：激酶抑制化合物的特征在于包含二氢苯并呋喃支架和连接于二氢苯并呋喃支架并提供氢键的官能团。 激酶抑制化合物由式（1）表征。
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公开(公告)号：KR1020030035974A
公开(公告)日：2003-05-09
申请号：KR1020020065744
申请日：2002-10-28
Applicant: 한국과학기술연구원
CPC classification number: A61K31/352 , A61K36/33
Abstract: PURPOSE: A composition containing an extract of Opuntia ficus-indica var. Saboten Makino and a compound isolated therefrom which exhibit antioxidative action and nerve cell protecting activity is provided. The composition inhibits neurotoxicity caused by cell death and exhibits nerve cell protecting effect on animal models of brain ischemia and is thus expected to be useful for prevention and treatment of cerebral apoplexy, cerebral concussion, Alzheimer's disease, Parkinson's disease, myocardial infarction and brain infarction. CONSTITUTION: A composition for protecting nerve cells contains an ethyl acetate extract of Opuntia ficus-indica and a compound isolated from therefrom as an active ingredient. The ethyl acetate extract contains campherol, dihydroquercetin or quercetin-3-methyl ether as an active ingredient and is prepared by adding 0.1 to 10L of an alcohol solvent to stems, fruits or processed fruits of Opuntia ficus-indica, followed by leaving them at room temperature for 4 to 5 days, filtering, distilling under reduced pressure and then extracting with 0.5 to 2L of ethyl acetate.
Abstract translation: 目的：一种含有仙人掌提取物的组合物。 提供了Saboten Makino和从其分离的化合物，其显示出抗氧化作用和神经细胞保护活性。 该组合物抑制由细胞死亡引起的神经毒性，并且对脑缺血动物模型显示神经细胞保护作用，因此预期可用于预防和治疗脑中风，脑震荡，阿尔茨海默氏病，帕金森病，心肌梗死和脑梗死。 构成：用于保护神经细胞的组合物含有榕属仙茅的乙酸乙酯萃取物和从其分离的化合物作为活性成分。 乙酸乙酯提取物含有荆芥，二氢槲皮素或槲皮素-3-甲醚作为活性成分，并通过向榕树芸苔的茎，果实或加工水果中加入0.1至10L的醇溶剂，然后将其留在室内 温度4〜5天，过滤，减压蒸馏，然后用0.5〜2L乙酸乙酯萃取。
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公开(公告)号：KR1020010076994A
公开(公告)日：2001-08-17
申请号：KR1020000004484
申请日：2000-01-29
Applicant: 한국과학기술연구원
IPC: C07H21/00
Abstract: PURPOSE: Provided is DNA sequence that codes variable region of an antibody having enzymatic activity degrading glycosidic bond. And its expression method is also provided. CONSTITUTION: A DNA sequence coding variable region of an antibody having enzymatic activity degrading glycosidic bond is as follows: DNA sequence represented by sequence ID. No. 1 coding VH chain of antibody for glycosidase, 4f4r; DNA sequence represented by sequence ID. No. 3 coding VH chain of antibody for glycosidase, 6h4h; DNA sequence represented by sequence ID. No. 5 coding VH chain of antibody for glycosidase, Ab2l; DNA sequence represented by sequence ID. No. 7 coding antibody for glycosidase, 4f4r; DNA sequence represented by sequence ID. No. 9 coding VL chain of antibody for glycosidase, 6h4h; or DNA sequence represented by sequence ID. No. 11 coding VL chain of antibody for glycosidase, Ab2l. Wherein, all sequences are described as in the description. The antibody is prepared by expressing a fusion protein of VH and VL in an eukaryote cell or bacteria.
Abstract translation: 目的：提供编码具有酶活性降解糖苷键的抗体的可变区的DNA序列。 并提供其表达方法。 构成：具有酶活性降解糖苷键的抗体的编码可变区的DNA序列如下：由序列ID表示的DNA序列。 1号编码糖苷酶抗体的VH链，4f4r; 由序列ID表示的DNA序列。 3号编码糖苷酶抗体VH链，6h4h; 由序列ID表示的DNA序列。 编码糖基化抗体的第5号VH链，Ab2l; 由序列ID表示的DNA序列。 糖苷酶7号编码抗体，4f4r; 由序列ID表示的DNA序列。 9号编码糖苷酶抗体VL链，6h4h; 或由序列ID表示的DNA序列。 11号编码糖苷酶抗体的VL链，Ab2l。 其中所有序列如描述中所述。 通过在真核细胞或细菌中表达VH和VL的融合蛋白来制备抗体。
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Patent Agency Ranking
公开(公告)号：KR100181640B1
公开(公告)日：1999-05-01
申请号：KR1019960058918
申请日：1996-11-28
Applicant: 한국과학기술연구원
IPC: A61K36/718 , A61K36/756
Abstract: 황련 또는 황백으로부터 약리 활성 물질을 보다 신속하게 정제해내는 방법이 제공된다. 이 방법에 의하면, 황련 또는 황백의 유기 용매 추출액에 ClO
4
- 카운터 이온을 형성하는 화합물을 첨가함으로써 약리 활성 물질을 침전시키고, 침전물을 분배 계수가 높은 용매로 재추출함으로써 베르베린 및 기타 약리 활성을 나타내는 성분들을 간편하고 신속하게 추출·정제할 수 있다.-
公开(公告)号：KR1019940007000A
公开(公告)日：1994-04-26
申请号：KR1019920016613
申请日：1992-09-09
Applicant: 한국과학기술연구원
IPC: C07C405/00
Abstract: 본 발명은 16-페녹시 프로스타트리에노산 유도체의 제조에 유용한 중간체(Ⅰ)을 제조하고, 이 화합물을 이용한 다음 일반식(Ⅱ)의 16-페녹시 프로스타트리에노 산 유도체를 제조하는 방법에 관한 것이
상기식에서 R은 테트라하이드로피라닐, 테트라하이드로푸라닐, 2-에톡시에틸 또는 3-t-부틸 디메틸실릴, 트리이소프로필실릴, 트리에틸실릴과 같은 에테르형성그룹으로, R
1 ,R
2 는 수소, 또는 아세틸과 같은 에스테르 형성그룹이고, P는 수소, 트리메틸실릴, 또는 트리부틸틴이고, Z는 산소 또는 α-히드록실기이며, 파상선은 에피입체 혼합물이다.-
公开(公告)号：KR100068010B1
公开(公告)日：1993-11-25
申请号：KR1019900010844
申请日：1990-07-18
Applicant: 한국과학기술연구원
IPC: C07C405/00
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公开(公告)号：KR1019900001080B1
公开(公告)日：1990-02-26
申请号：KR1019860008538
申请日：1986-10-11
Applicant: 한국과학기술연구원
IPC: C07D231/10
Abstract: A process for prepg. pyrazolone dervis. of formula (I) comprises: (a) reacting halogen derivs. of formula (II) with primary amine of formula R4-NH2 in org. solvent(i.e. water, MeOH, EtOH) for 10 hr at 10-30 deg. C; (b) reacting with secondary haloketo cpd. in org. solvent i.e. benzene, toluene, dioxane in basic media i.e. NaHCO3, NaOH, triethylamine at 20-120 deg. C; and (c) reacting with hydrazine of formula R5NH-NH2 in org. solvent i.e. diethyleneglycole, THF in basic media i.e. KHCO3, NaOH. In the formulas, R1=isopropyl; R4=Me; R5=H or methanesulfonyl; X=Cl, Br or I. (I) are useful as an antipyretic analgesic.
Abstract translation: 一个prepg的过程 吡唑啉酮衍生物 式（I）的化合物包括：（a）使卤素衍生物反应。 式（Ⅱ）化合物与式R 4 -NH 2的伯胺反应。 溶剂（即水，MeOH，EtOH）在10-30℃下搅拌10小时。 C; （b）与二级haloketo cpd反应。 在组织 溶剂，即苯，甲苯，二氧化硅在碱性介质，即NaHCO 3，NaOH，三乙胺中，在20-120度。 C; 和（c）与组分中式R5NH-NH2的肼反应。 溶剂即二乙二醇，在碱性介质中的THF，即KHCO 3，NaOH。 式中R1 =异丙基; R4 =甲基; R5 = H或甲磺酰基; X = Cl，Br或I.（I）可用作解热镇痛药。
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