公开(公告)号：WO1995005803A1

公开(公告)日：1995-03-02

申请号：PCT/US1993007859

申请日：1993-08-20

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  ALI, Yusuf ,  REED, Kenneth, W.

IPC: A61K09/00

CPC classification number: A61K9/0048

Abstract: Universal ophthalmic pharmaceutical vehicles which become viscous on contacting the eye are disclosed. Ophthalmic compositions of the universal vehicle and a pharmaceutically active drug are also disclosed.

Abstract translation: 公开了在接触眼睛时变得粘稠的通用眼用药物载体。 还公开了通用载体的眼用组合物和药物活性药物。

公开(公告)号：WO1994025510A1

公开(公告)日：1994-11-10

申请号：PCT/US1993004080

申请日：1993-04-30

Applicant: ALCON LABORATORIES, INC. ,  LEBOEUF, Albert, R. ,  GREEN, George ,  PIPER, Barbara, A.

Inventor： ALCON LABORATORIES, INC.

IPC: C08J03/28

CPC classification number: C08J7/123 ,  C08J2333/04

Abstract: The tackiness associated with certain soft acrylic polymers can be reduced by plasma treatment of the polymer surface. This is particularly useful with regard to intraocular lenses (IOLs), especially foldable IOLs, which are made from such soft acrylic polymers.

Abstract translation: 通过聚合物表面的等离子体处理可以降低与某些软的丙烯酸类聚合物相关的粘性。 这对于由这种软的丙烯酸类聚合物制成的眼内透镜（IOL），特别是可折叠的IOL尤其有用。

公开(公告)号：WO1994006411A1

公开(公告)日：1994-03-31

申请号：PCT/US1993001434

申请日：1993-02-18

Applicant: ALCON LABORATORIES, INC. ,  DEAN, Thomas, Robert ,  MAY, Jesse, Albert

Inventor： ALCON LABORATORIES, INC.

IPC: A61K09/00

CPC classification number: A61K31/18 ,  A61K31/00 ,  A61K31/38 ,  A61K31/54

Abstract: Compositions and methods for controlling intraocular pressure with carbonic anhydrase inhibitors are disclosed.

Abstract translation: 公开了用碳酸酐酶抑制剂控制眼内压的组合物和方法。

公开(公告)号：WO1993021903A1

公开(公告)日：1993-11-11

申请号：PCT/US1993004226

申请日：1993-05-04

Applicant: ALCON LABORATORIES, INC. ,  CHOWHAN, Masood

Inventor： ALCON LABORATORIES, INC.

IPC: A61K09/00

CPC classification number: A61K9/0048 ,  Y02A50/473 ,  Y10S514/839 ,  Y10S514/84 ,  Y10S514/912 ,  Y10S514/915

Abstract: Water-soluble borate-polyol complexes are useful as buffers and/or antimicrobials in aqueous ophthalmic compositions, including those containing polyvinyl alcohol. These compositions have greater antimicrobial activity than comparable compositions containing typical borate buffers and unexpectedly increase the antimicrobial efficacy of other antimicrobial agents when used in combination. In addition, use of the borate-polyol complexes avoids the incompatibility problem typically associated with the combination of borate buffer and polyvinyl alcohol; therefore, the compositions disclosed herein may also contain polyvinyl alcohol.

Abstract translation: 水溶性硼酸盐 - 多元醇配合物可用作水性眼用组合物中的缓冲剂和/或抗微生物剂，包括含有聚乙烯醇的那些。 这些组合物具有比含有典型硼酸盐缓冲液的相当组合物更大的抗微生物活性，并且当组合使用时意外地增加其它抗微生物剂的抗微生物效力。 此外，使用硼酸盐 - 多元醇复合物避免了通常与硼酸盐缓冲液和聚乙烯醇的组合相关的不相容性问题; 因此，本文公开的组合物还可以含有聚乙烯醇。

公开(公告)号：WO1993003970A1

公开(公告)日：1993-03-04

申请号：PCT/US1991005731

申请日：1991-08-14

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  VLASICH, Richard, J.

IPC: B65D37/00

CPC classification number: B05B11/00 ,  A61F9/0008 ,  B65D35/00

Abstract: A unit dose dispenser (10) for dispensing a composition (15) includes a compressible, air filled container (12) in communication with an open end (14a) of a tube (14) filled with the composition (15). The opposite end (19) of the tube (14) through which the composition (15) is dispensed is sealed with a removable closure cap (17) to maintain sterility of the composition (15) prior to use. By removing the cap (17) and applying external pressure (F) to compress the container (12), air is forced to enter the tube (14) and eject, by displacement, composition (15) from the tube (14). To completely eject the predetermined dosage (15) that completely fills the tube (14), the volume of air or other gaseous propellant within the compressible container (12) is greater than the volume of the unit dose (15).

Abstract translation: 用于分配组合物（15）的单位剂量分配器（10）包括与填充有组合物（15）的管（14）的开口端（14a）连通的可压缩充气容器（12）。 组合物（15）分配的管（14）的相对端（19）用可移除的封闭帽（17）密封，以在使用前保持组合物（15）的无菌性。 通过移除盖（17）并施加外部压力（F）以压缩容器（12），空气被迫进入管（14）并且通过从管（14）移位组合物（15）而排出。 为了完全喷射完全填充管（14）的预定剂量（15），可压缩容器（12）内的空气或其它气体推进剂的体积大于单位剂量（15）的体积。

公开(公告)号：WO1992001625A1

公开(公告)日：1992-02-06

申请号：PCT/US1991004891

申请日：1991-07-11

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CLEMENTS, Donald, A. ,  KILLINGER, Fred, M.

IPC: B67D05/58

CPC classification number: B65D81/24 ,  A61J1/145 ,  A61J1/1468 ,  B05B11/00444 ,  B05B11/047 ,  B65D47/2075 ,  B65D51/1616

Abstract: A multiple use container for dispensing fluids, particularly preservative free preparations in variable doses, includes a squeezable container for holding the fluid. A dispenser assembly associated with an exit opening from the container includes a hollow dispensing tip which encloses a fluid valve. The fluid valve utilizes a piston head which sealingly seats in a valve seat. A resilient biasing means holds the piston head in a normally sealed or closed position. A second opening in communication with the interior of the bottle is covered by a hydrophobic filter having a pore size that prevents microbial contaminants from entering the container but prohibits fluid from leaving the container. The bottle is squeezed to force fluid to overcome the biasing pressure of the fluid valve to dispense fluid from the bottle. Upon release of that pressure, the fluid valve closes and air passes through the filter to replace the dispensed fluid. The air entering the container is sterilized by the filter.

公开(公告)号：WO1989010126A1

公开(公告)日：1989-11-02

申请号：PCT/US1989001994

申请日：1989-04-26

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  DE SANTIS, Louis, M.

IPC: A61K31/47

CPC classification number: A61K31/535 ,  A61K31/415 ,  A61K31/42 ,  A61K31/655 ,  A61K45/06 ,  Y10S514/913 ,  A61K31/165 ,  A61K31/135 ,  A61K31/13 ,  A61K2300/00

Abstract: Ophthalmic pharmaceutical compositions useful in controlling elevated intraocular pressure associated with glaucoma and other ophthalmic conditions are described. A method of controlling elevated intraocular pressure with those compositions is also described. The compositions contain a combination of an alpha-2 agonist (e.g., para-amino clonidine) and a beta blocker (e.g., betaxolol).

Abstract translation: 描述了可用于控制与青光眼和其它眼科疾病相关的升高的眼内压的眼用药物组合物。 还描述了利用那些组合物来控制眼内压升高的方法。 组合物含有α-2激动剂（例如对 - 氨基可乐定）和β阻滞剂（例如，倍他洛尔）的组合。

公开(公告)号：WO1988005073A1

公开(公告)日：1988-07-14

申请号：PCT/US1987003396

申请日：1987-12-23

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  BHATIA, Rajkumar, P. ,  HARRIS, Robert, G.

IPC: C11D07/42

CPC classification number: C11D3/38627 ,  C11D3/0078

Abstract: Contact lens cleaning compositions containing a combination of an enzyme and a particulate abrasive material, and a method of cleaning contact lenses with such compositions. The compositions are capable of cleaning soiled contact lenses very rapidly and completely due to a favorable interaction between the enzyme and abrasive components thereof.

Abstract translation: 含有酶和颗粒磨料的组合的隐形眼镜清洁组合物以及用这种组合物清洁隐形眼镜的方法。 由于酶和其研磨组分之间有利的相互作用，组合物能够非常快速和完全地清洁污染的隐形眼镜。

公开(公告)号：WO1998026777A1

公开(公告)日：1998-06-25

申请号：PCT/US1997022686

申请日：1997-12-16

Applicant: ALCON LABORATORIES, INC. ,  YANNI, John, M. ,  GRAFF, Gustav

Inventor： ALCON LABORATORIES, INC.

IPC: A61K31/35

CPC classification number: C07C235/34 ,  A61K31/343 ,  A61K31/353 ,  A61K31/355 ,  A61K47/545 ,  C07D307/80 ,  C07D311/72 ,  Y10S514/912

Abstract: Compounds and methods for treating ocular tissues are disclosed. The methods utilize viscoelastic compositions containing certain compounds having an anti-inflammatory and anti-oxidant moiety covalently linked by an amide or ester bond. The compounds are useful in preventing and treating inflammatory and proliferative disorders through several mechanisms.

Abstract translation: 公开了治疗眼组织的化合物和方法。 该方法利用含有某些具有通过酰胺或酯键共价连接的抗炎和抗氧化部分的化合物的粘弹性组合物。 该化合物可用于通过几种机制预防和治疗炎症和增殖性疾病。

公开(公告)号：WO1998025557A1

公开(公告)日：1998-06-18

申请号：PCT/US1997019904

申请日：1997-10-29

Applicant: ALCON LABORATORIES, INC.

Inventor： ALCON LABORATORIES, INC. ,  CAPETAN, Thomas, G. ,  COHEN, Donald, M.

IPC: A61F09/007

CPC classification number: A61F9/00736 ,  A61B2018/048

Abstract: A surgical handpiece having at least two lumens mounted to a body. One lumen is used for aspiration, the second lumen is used to inject heated surgical fluid for liquefying a cataractous lens. A portion of the second lumen is surrounded by an insulated heating element that heats the surgical fluid as it passes through the second lumen. The handpiece may also contains a device for delivering the surgical fluid through the second lumen in metered pulses of a defined volume.

Abstract translation: 具有安装到身体的至少两个流明的外科手术器具。 一个腔用于抽吸，第二个腔用于注射加热的手术液体液化白内障透镜。 第二腔的一部分被绝缘加热元件围绕，所述绝热加热元件在穿过第二腔时加热手术流体。 手持件还可以包含用于以限定体积的计量脉冲输送外科流体通过第二管腔的装置。