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    NUEVOS COMPUESTOS TERAPEPTIDOS CON EFECTO ANTINEOPLASICO Y SU OBTENCION
    78.
    发明专利
    NUEVOS COMPUESTOS TERAPEPTIDOS CON EFECTO ANTINEOPLASICO Y SU OBTENCION 未知

    公开(公告)号：CO4750840A1

    公开(公告)日：1999-03-31

    申请号：CO96065733

    申请日：1996-12-13

    Applicant: BASF AG

    Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHE ,  JANSSEN BERND ,  KLING ANDREAS

    IPC: A61K38/00 ,  A61K31/00 ,  A61K38/03 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

    Abstract: Nuevos peptidos de la fórmula I:R1 R2 N-CHX-CO-A-B-D-E-(G)s -K Idonde R1 significa hidrógeno, metilo, o etilo; R2 significa metilo, o etilo; R1 -N-R2 forman juntos un anillo de pirrolidina; A significa un radical valilo, isoleucilo, alo-isoleucilo, 2-terc.-butilglicilo, 2-etilglicilo, norleucilo o norvalilo; B significa un radical N-metil-valilo, N-metil-norvalilo, N-metil-leucilo, N-metil-isoleucilo, N-metil-2-terc.-butilglicilo, N-metil-2-etilglicilo, o N-metilnorleucilo; D significa un radical prolilo, homoprolilo, hidroxiprolilo, o tiazolidin-4-carbonilo; E significa un radical prolilo, homoprolilo, hidroxiprolilo, tiazolidine-4-carbonilo, trans-4-fluoro-L-prolilo, cis-4-fluoro-L-prolilo, trans-4-cloro-L-prolilo o cis-4-cloro-L-prolilo; X es etilo, propilo, butilo, isopropilo, sec. butilo, terc.-butilo ciclopropilo, o ciclopentilo; G significa un radical L-2-terc-butilglicilo, D-2-terc. butilglicilo, D-valilo, D-isoleucilo, D-leucilo, D-norvalilo, 1-aminopentil-1-carbonilo, o 2,2-dimetilglicilo; s es 0 o 1:K significa-NH-C1-8 -alquilo, -NH-C3-8 - alquenilo, -NH-C3-8 -alquinilo, -NH-C6-8 - cicloalquilo, -NH-C1-4 -alqueno C3-8 -cicloalquilo,...

    Novel tetrapeptides as antitumor agents
    79.
    发明专利
    Novel tetrapeptides as antitumor agents 未知

    公开(公告)号：ZA976724B

    公开(公告)日：1999-01-29

    申请号：ZA976724

    申请日：1997-07-29

    Applicant: BASF AG

    Inventor： BARLOZZARI TERESA ,  HAUPT ANDREAS ,  GRIESINGER BERND JANSSEN CHRIS ,  BELIK DANIEL ,  BORETZKY MICHAEL

    IPC: A61K38/00 ,  A61P35/00 ,  C07K4/00 ,  C07K5/02 ,  C07K ,  A61K

    Abstract: The present invention provides anti-tumor peptides of Formula I,A-B-NR3-CHD-CH(OCH3)-CH2CO-E-K(I),and the acid salts thereof. A is an amino acid residue selected from the group consisting of N-methyl-D-prolyl, N-methyl-D-homoprolyl and N,N-dimethyl-2-ethylphenylglycyl, or an amino acid residue of the formula R1R2N-CHX-CO, wherein R1 is a-methyl group or an ethyl group, R2 is a hydrogen atom, a methyl group or an ethyl group, and X is an alkyl group. B is an amino acid residue selected from the group consisting of valyl, isoleucyl, leucyl, and 2-t-butylglycyl. R3 is a hydrogen atom or a methyl group. D is a normal or branched C2-C5-alkyl group. E is an amino acid residue selected from the group consisting of prolyl, homoprolyl, 5-methylprolyl, and phenylalanyl, or E is a residue derived from an amino acid comprising a pyrrolidine group. K is an alkoxy group or an amino group. An additional embodiment of the present invention is a method for treating a malignancy in a mammal, such as a human, comprising administering to the mammal an effective amount of a compound or compounds of Formula I in a pharmaceutically acceptable composition.

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