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公开(公告)号:JP2003135903A
公开(公告)日:2003-05-13
申请号:JP2002215214
申请日:2002-07-24
Applicant: BASF AG
Inventor: RAULS MATTHIAS , GELDER RICHARD VAN , WAGNER KATRIN , BERNARD HARALD
IPC: B01D9/02 , B01D9/00 , C07C403/00 , C07C403/08 , C07C403/14 , C07C403/20
Abstract: PROBLEM TO BE SOLVED: To provide a method for manufacturing crystals of small grain sizes and simultaneously a narrow grain size distribution. SOLUTION: The method for crystallizing the crystals below 100 μm in average grain size comprises performing crystallization by simultaneously using ultrasonic waves to be directly introduced by using a sonotrode into a solution or suspension of a compound to be crystallized and a specific proportional agitation driving power.
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公开(公告)号:WO9722621A3
公开(公告)日:1998-02-26
申请号:PCT/EP9605518
申请日:1996-12-11
Applicant: BASF AG , AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
CPC classification number: A61K38/08
Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)¿s?-K in which R?1, R2¿, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:CA2237721C
公开(公告)日:2008-01-29
申请号:CA2237721
申请日:1996-12-11
Applicant: BASF AG
Inventor: RITTER KURT , ZIERKE THOMAS , BARLOZZARI TERESA , KLING ANDREAS , BUSCHMANN ERNST , BERNARD HARALD , HAUPT ANDREAS , HEGE HANS-GUENTHER , WEYMANN JURGEN , JANSSEN BERND , ULLRICH MARTINA , LIETZ HELMUT , AMBERG WILHELM
IPC: A61K38/00 , C07K7/06 , A61K31/00 , A61K38/07 , A61K38/08 , A61P35/00 , A61P35/02 , C07K1/00 , C07K5/10
Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)s-K in which R1, R2, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:BG64563B1
公开(公告)日:2005-07-29
申请号:BG10247998
申请日:1998-05-22
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: The invention relates to new peptides with the formula R1R2N-CHX-CO-A-B-D-E-(G)s-K, where R1, R2, A, B, D, E, G, K, X and s have the meanings listed in the description. The invention also relates to methods for the preparation of the above peptides having antineoplastic properties.
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公开(公告)号:AU731458B2
公开(公告)日:2001-03-29
申请号:AU1192597
申请日:1996-12-11
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:DE19850301A1
公开(公告)日:2000-05-04
申请号:DE19850301
申请日:1998-10-30
Applicant: BASF AG
Inventor: BERNARD HARALD , RIECHERS HARTMUT
IPC: C07C51/43 , C07B57/00 , C07C51/487 , C07C59/11 , C07C59/48 , C07C59/64 , C07C51/347
Abstract: The invention relates to racemate splitting of 2-hydroxypropionic acids by reacting racemic acid with an optically active base and subsequently separating a diastereomeric salt from the acid and the base. The invention is characterized in that 1-(4-chlorophenyl)ethylamine is used as optically active base.
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公开(公告)号:AT188485T
公开(公告)日:2000-01-15
申请号:AT95917963
申请日:1995-04-26
Applicant: BASF AG
Inventor: AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: PCT No. PCT/EP95/01577 Sec. 371 Date Nov. 4, 1996 Sec. 102(e) Date Nov. 4, 1996 PCT Filed Apr. 26, 1995 PCT Pub. No. WO95/30691 PCT Pub. Date Nov. 16, 1995The compound Me2Val-Val-MeVal-Pro-Pro-NHBzlxHCl is described. It is prepared from Z-Val-Val-MeVal-Pro-OR1 where Z and R1 have the meanings stated in the description. The compound shows antineoplastic activity.
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公开(公告)号:SK76798A3
公开(公告)日:1999-02-11
申请号:SK76798
申请日:1996-12-11
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:DE59504450D1
公开(公告)日:1999-01-14
申请号:DE59504450
申请日:1995-04-26
Applicant: BASF AG
Inventor: AMBERG WILHELM , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , JANITSCHKE LOTHAR , JANSSEN BERND , KARL ULRICH , KLING ANDREAS , MUELLER STEFAN , DE POTZOLLI BERND , RITTER KURT , THYES MARCO , ZIERKE THOMAS
Abstract: Compounds of the formulawhere R1, R2, R3 and R4 have the meaning stated in the description, and a process for preparing them are described. The compounds are suitable as starting material for synthesizing substances which are active against tumors.
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公开(公告)号:PL327175A1
公开(公告)日:1998-11-23
申请号:PL32717596
申请日:1996-12-11
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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