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公开(公告)号:JPS62181242A
公开(公告)日:1987-08-08
申请号:JP25867686
申请日:1986-10-31
Applicant: BASF AG
Inventor: RENTZEA COSTIN , HIMMELE WALTER , BUSCHMANN ERNST , AMMERMANN EBERHARD , POMMER ERNST-HEINRICH
IPC: A01N33/04 , A01N33/06 , A01N33/08 , A01N33/10 , A01N37/34 , A01N43/08 , A01N49/00 , C07C67/00 , C07C209/00 , C07C211/17 , C07C211/27 , C07C211/29 , C07C211/35 , C07C211/40 , C07C211/44 , C07C211/48 , C07C211/52 , C07C213/00 , C07C217/62 , C07C253/00 , C07C255/58 , C07D307/14 , C07D307/52
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公开(公告)号:WO9722621A3
公开(公告)日:1998-02-26
申请号:PCT/EP9605518
申请日:1996-12-11
Applicant: BASF AG , AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
CPC classification number: A61K38/08
Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)¿s?-K in which R?1, R2¿, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:CA2237721C
公开(公告)日:2008-01-29
申请号:CA2237721
申请日:1996-12-11
Applicant: BASF AG
Inventor: RITTER KURT , ZIERKE THOMAS , BARLOZZARI TERESA , KLING ANDREAS , BUSCHMANN ERNST , BERNARD HARALD , HAUPT ANDREAS , HEGE HANS-GUENTHER , WEYMANN JURGEN , JANSSEN BERND , ULLRICH MARTINA , LIETZ HELMUT , AMBERG WILHELM
IPC: A61K38/00 , C07K7/06 , A61K31/00 , A61K38/07 , A61K38/08 , A61P35/00 , A61P35/02 , C07K1/00 , C07K5/10
Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)s-K in which R1, R2, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:BG64563B1
公开(公告)日:2005-07-29
申请号:BG10247998
申请日:1998-05-22
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JUERGEN , ZIERKE THOMAS
Abstract: The invention relates to new peptides with the formula R1R2N-CHX-CO-A-B-D-E-(G)s-K, where R1, R2, A, B, D, E, G, K, X and s have the meanings listed in the description. The invention also relates to methods for the preparation of the above peptides having antineoplastic properties.
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公开(公告)号:CA2347757C
公开(公告)日:2005-05-17
申请号:CA2347757
申请日:1999-10-13
Applicant: BASF AG
Inventor: VIERGUTZ WOLFGANG , BUSCHMANN ERNST , STEINER GERD , PFEIFFER THOMAS , KREI GEORG ARNOLD , HENNINGSEN MICHAEL , BISCHOF NORBERT , MUNSCHAUER RAINER
IPC: C07D209/52 , A61K31/40 , C07B37/10 , C07D20060101
Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3--azabicyc lo- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds ar e characterized in that a bisallyl ammonium salt of formula (II), in which R has the above-mentioned meanings and X- represents an anion , is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+)-exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystalliz ed out of an alcohol/water mixture.
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公开(公告)号:CA2118814C
公开(公告)日:2002-03-26
申请号:CA2118814
申请日:1992-09-01
Applicant: BASF AG
Inventor: SCHAEFER BERND , BUSCHMANN ERNST , REISSENWEBER GERNOT
IPC: C07C253/10 , C07C253/30 , C07F9/535 , C07C67/30 , C07C69/65 , C07C201/12 , C07C205/00 , C07C255/35
Abstract: A process is disclosed for producing .alpha.-chlor-methylen- triorganylphosphorane carboxylic acid derivatives having the for- mula (I), in which R stands for C organic substituents; A stands for CN or C O- B; B stands for C or O organic residues that re- main inert in chlorinating conditions, by chlorinating phosphoranes having t he formula (II) with chlorine. Chlorination is carried out in the presence of a mineral base as hydrogen chloride acceptor, whereas chlorine and the base are synchronously but separ- ately introduced into the reaction mixture according to their consumption. T he products (I) obtained by this process represent im- portant intermediates for plant protective substances.
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公开(公告)号:ES2164259T3
公开(公告)日:2002-02-16
申请号:ES96925746
申请日:1996-07-12
Applicant: BASF AG
Inventor: BUSCHMANN ERNST , ZIERKE THOMAS
IPC: C07C231/02 , C07C237/02 , C07K1/06 , C07K1/08 , C07K7/06
Abstract: PCT No. PCT/EP96/03075 Sec. 371 Date Jan. 20, 1998 Sec. 102(e) Date Jan. 20, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05096 PCT Pub. Date Feb. 13, 1997A process for preparing alpha -(N,N-dialkylamino) carboxamides of the formula I where the substituents have the stated meanings, comprises reacting the corresponding free acids with primary or secondary amines in the presence of anhydrides of an alkanephosphonic acid.
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公开(公告)号:NO20011822L
公开(公告)日:2001-04-20
申请号:NO20011822
申请日:2001-04-10
Applicant: BASF AG
Inventor: BISCHOF NORBERT , BUSCHMANN ERNST , HENNINGSEN MICHAEL , KREI GEORG ARNOLD , MUNSCHAUER RAINER , PFEIFFER THOMAS , STEINER GERD , VIERGUTZ WOLFGANG
IPC: A61K31/40 , C07D209/52 , C07B37/10 , C07D20060101
Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.
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公开(公告)号:AU731458B2
公开(公告)日:2001-03-29
申请号:AU1192597
申请日:1996-12-11
Applicant: BASF AG
Inventor: AMBERG WILHELM , BARLOZZARI TERESA , BERNARD HARALD , BUSCHMANN ERNST , HAUPT ANDREAS , HEGE HANS-GUENTHER , JANSSEN BERND , KLING ANDREAS , LIETZ HELMUT , RITTER KURT , ULLRICH MARTINA , WEYMANN JURGEN , ZIERKE THOMAS
Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.
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公开(公告)号:AU1036500A
公开(公告)日:2000-05-08
申请号:AU1036500
申请日:1999-10-13
Applicant: BASF AG
Inventor: BISCHOF NORBERT , BUSCHMANN ERNST , HENNINGSEN MICHAEL , KREI GEORG ARNOLD , MUNSCHAUER RAINER , PFEIFFER THOMAS , STEINER GERD , VIERGUTZ WOLFGANG
IPC: C07D209/52 , A61K31/40 , C07B37/10 , C07D20060101
Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.
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