公开(公告)号：JPS62181242A

公开(公告)日：1987-08-08

申请号：JP25867686

申请日：1986-10-31

Applicant: BASF AG

Inventor： RENTZEA COSTIN ,  HIMMELE WALTER ,  BUSCHMANN ERNST ,  AMMERMANN EBERHARD ,  POMMER ERNST-HEINRICH

IPC: A01N33/04 ,  A01N33/06 ,  A01N33/08 ,  A01N33/10 ,  A01N37/34 ,  A01N43/08 ,  A01N49/00 ,  C07C67/00 ,  C07C209/00 ,  C07C211/17 ,  C07C211/27 ,  C07C211/29 ,  C07C211/35 ,  C07C211/40 ,  C07C211/44 ,  C07C211/48 ,  C07C211/52 ,  C07C213/00 ,  C07C217/62 ,  C07C253/00 ,  C07C255/58 ,  C07D307/14 ,  C07D307/52

公开(公告)号：WO9722621A3

公开(公告)日：1998-02-26

申请号：PCT/EP9605518

申请日：1996-12-11

Applicant: BASF AG ,  AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

CPC classification number: A61K38/08

Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)¿s?-K in which R?1, R2¿, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：CA2237721C

公开(公告)日：2008-01-29

申请号：CA2237721

申请日：1996-12-11

Applicant: BASF AG

Inventor： RITTER KURT ,  ZIERKE THOMAS ,  BARLOZZARI TERESA ,  KLING ANDREAS ,  BUSCHMANN ERNST ,  BERNARD HARALD ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  WEYMANN JURGEN ,  JANSSEN BERND ,  ULLRICH MARTINA ,  LIETZ HELMUT ,  AMBERG WILHELM

IPC: A61K38/00 ,  C07K7/06 ,  A61K31/00 ,  A61K38/07 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K5/10

Abstract: Novel peptides of the following formula (I): R1R2N-CHX-CO-A-B-D-E-(G)s-K in which R1, R2, A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：BG64563B1

公开(公告)日：2005-07-29

申请号：BG10247998

申请日：1998-05-22

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JUERGEN ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: The invention relates to new peptides with the formula R1R2N-CHX-CO-A-B-D-E-(G)s-K, where R1, R2, A, B, D, E, G, K, X and s have the meanings listed in the description. The invention also relates to methods for the preparation of the above peptides having antineoplastic properties.

公开(公告)号：CA2347757C

公开(公告)日：2005-05-17

申请号：CA2347757

申请日：1999-10-13

Applicant: BASF AG

Inventor： VIERGUTZ WOLFGANG ,  BUSCHMANN ERNST ,  STEINER GERD ,  PFEIFFER THOMAS ,  KREI GEORG ARNOLD ,  HENNINGSEN MICHAEL ,  BISCHOF NORBERT ,  MUNSCHAUER RAINER

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: The invention relates to a method for producing (+)-exo-6-phenyl-3--azabicyc lo- [3.2.0]heptanes of formula (I) in which R represents hydrogen, chlorine, bromine, fluorine or methoxy. The inventive compounds ar e characterized in that a bisallyl ammonium salt of formula (II), in which R has the above-mentioned meanings and X- represents an anion , is photo-cyclized in an inert solvent while adding a sensitizer in a glass apparatus, and the selected (+)-exo-isomer (I) is precipitated as ditoluoyl tartrate using (-)-ditoluoyl tartaric acid from the obtained mixture, and this ditoluoyl tartrate is optionally recrystalliz ed out of an alcohol/water mixture.

公开(公告)号：CA2118814C

公开(公告)日：2002-03-26

申请号：CA2118814

申请日：1992-09-01

Applicant: BASF AG

Inventor： SCHAEFER BERND ,  BUSCHMANN ERNST ,  REISSENWEBER GERNOT

IPC: C07C253/10 ,  C07C253/30 ,  C07F9/535 ,  C07C67/30 ,  C07C69/65 ,  C07C201/12 ,  C07C205/00 ,  C07C255/35

Abstract: A process is disclosed for producing .alpha.-chlor-methylen- triorganylphosphorane carboxylic acid derivatives having the for- mula (I), in which R stands for C organic substituents; A stands for CN or C O- B; B stands for C or O organic residues that re- main inert in chlorinating conditions, by chlorinating phosphoranes having t he formula (II) with chlorine. Chlorination is carried out in the presence of a mineral base as hydrogen chloride acceptor, whereas chlorine and the base are synchronously but separ- ately introduced into the reaction mixture according to their consumption. T he products (I) obtained by this process represent im- portant intermediates for plant protective substances.

公开(公告)号：ES2164259T3

公开(公告)日：2002-02-16

申请号：ES96925746

申请日：1996-07-12

Applicant: BASF AG

Inventor： BUSCHMANN ERNST ,  ZIERKE THOMAS

IPC: C07C231/02 ,  C07C237/02 ,  C07K1/06 ,  C07K1/08 ,  C07K7/06

Abstract: PCT No. PCT/EP96/03075 Sec. 371 Date Jan. 20, 1998 Sec. 102(e) Date Jan. 20, 1998 PCT Filed Jul. 12, 1996 PCT Pub. No. WO97/05096 PCT Pub. Date Feb. 13, 1997A process for preparing alpha -(N,N-dialkylamino) carboxamides of the formula I where the substituents have the stated meanings, comprises reacting the corresponding free acids with primary or secondary amines in the presence of anhydrides of an alkanephosphonic acid.

公开(公告)号：NO20011822L

公开(公告)日：2001-04-20

申请号：NO20011822

申请日：2001-04-10

Applicant: BASF AG

Inventor： BISCHOF NORBERT ,  BUSCHMANN ERNST ,  HENNINGSEN MICHAEL ,  KREI GEORG ARNOLD ,  MUNSCHAUER RAINER ,  PFEIFFER THOMAS ,  STEINER GERD ,  VIERGUTZ WOLFGANG

IPC: A61K31/40 ,  C07D209/52 ,  C07B37/10 ,  C07D20060101

Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.

公开(公告)号：AU731458B2

公开(公告)日：2001-03-29

申请号：AU1192597

申请日：1996-12-11

Applicant: BASF AG

Inventor： AMBERG WILHELM ,  BARLOZZARI TERESA ,  BERNARD HARALD ,  BUSCHMANN ERNST ,  HAUPT ANDREAS ,  HEGE HANS-GUENTHER ,  JANSSEN BERND ,  KLING ANDREAS ,  LIETZ HELMUT ,  RITTER KURT ,  ULLRICH MARTINA ,  WEYMANN JURGEN ,  ZIERKE THOMAS

IPC: A61K38/00 ,  A61K31/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K1/00 ,  C07K7/06

Abstract: Novel peptides of the formula R R N-CHX-CO-A-B-D-E-(G)s-K in which R , R , A, B, D, E, G, K, X, and s have the meanings stated in the description, and the preparation thereof are described. The novel peptides have an antineoplastic effect.

公开(公告)号：AU1036500A

公开(公告)日：2000-05-08

申请号：AU1036500

申请日：1999-10-13

Applicant: BASF AG

Inventor： BISCHOF NORBERT ,  BUSCHMANN ERNST ,  HENNINGSEN MICHAEL ,  KREI GEORG ARNOLD ,  MUNSCHAUER RAINER ,  PFEIFFER THOMAS ,  STEINER GERD ,  VIERGUTZ WOLFGANG

IPC: C07D209/52 ,  A61K31/40 ,  C07B37/10 ,  C07D20060101

Abstract: A process for preparing (+)-exo-6-phenyl-3-azabicyclo[3.2.0]heptanes of the formula Iwhere R is hydrogen, chlorine, bromine, fluorine or methoxy, which comprises photocyclizing a bisallylammonium salt of the formula IIwhere R has the meanings given above and X- is an anion, in an inert solvent in a glass apparatus with addition of sensitizer and precipitating using (-)-ditoluoyltartaric acid the desired (+)-exo-isomer I as ditoluoyltartrate from the resulting mixture, with or without recrystallization of this tartrate from an alcohol/water mixture.