公开(公告)号：NO975710L

公开(公告)日：1998-02-02

申请号：NO975710

申请日：1997-12-05

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：NO975711A

公开(公告)日：1998-01-30

申请号：NO975711

申请日：1997-12-05

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06

CPC classification number: C07K7/06 ,  A61K38/00 ,  C07K5/101

公开(公告)号：NO975711D0

公开(公告)日：1997-12-05

申请号：NO975711

申请日：1997-12-05

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/04 ,  C07K5/103 ,  C07K7/06 ,  C07K

Abstract: Novel compounds of the formulaR1R2N-CHX-CO-A-B-D-(E)s-(F)t-(G)U-KIin which R1, R2, A, B, D, E, F, G, K, X, s, t, and u have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：AU677696B2

公开(公告)日：1997-05-01

申请号：AU7498494

申请日：1994-08-08

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BRANA MIGUEL FERNANDEZ ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  BERLANGA JOSE MARIA CASTELLANO ,  MOSET MARINA MORAN ,  VEGA MARIA JESUS PEREZ DE

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：BR9407257A

公开(公告)日：1996-09-24

申请号：BR9407257

申请日：1994-08-08

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  FERNANDEZ BRANA MIGUEL ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  CASTELLANO BERLANGA JOSE MARIA ,  MORAN MOSET MARINA ,  PEREZ DE VEGA MARIA JESUS

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：AU669710B2

公开(公告)日：1996-06-20

申请号：AU4066293

申请日：1993-05-10

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  EMLING FRANZ ,  ROMERDAHL CYNTHIA

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  A61P35/02 ,  C07K5/062 ,  C07K5/08 ,  C07K5/083 ,  C07K5/087 ,  C07K5/10 ,  C07K5/103 ,  C07K5/107 ,  C07K7/06 ,  A61K37/02

Abstract: Novel derivates of dolastatin of formula (I) in which R , R , A, B, D, E, F, G, K, X, t, u, v, and w have the meanings stated in the description, and the preparation thereof are described. The novel substances have an antineoplastic effect.

公开(公告)号：HU9600360D0

公开(公告)日：1996-04-29

申请号：HU9600360

申请日：1994-08-08

Applicant: BASF AG

Inventor： BOUSQUET PETER ,  CASTELLANO BERLANGA JOSE MARIA ,  FERNANDEZ BRANA MIGUEL ,  KEILHAUER GERHARD ,  MORAN MOSET MARINA ,  PEREZ DE VEGA MARIA JESUS ,  QIAN XIAO-DONG ,  ROMERDAHL CYNTHIA

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：NO960632D0

公开(公告)日：1996-02-16

申请号：NO960632

申请日：1996-02-16

Applicant: BASF AG

Inventor： KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BRANA MIGUEL FERNANDEZ ,  QIAN XIAO-DONG ,  BOUSQUET PETER ,  BERLANGA JOSE MARIA CASTELLANO ,  MOSET MARINA MORAN ,  VEGA MARIA JESUS PEREZ DE

IPC: A61K31/47 ,  A61K31/473 ,  A61P35/00 ,  C07D221/14 ,  A61K31/435

Abstract: Disclosed herein are compounds pharmaceutical compositions containing same of the formula 1. A compound of the Formula wherein X, X', X'' and X''', A, B, D, R, and R' are as identified in the specification and their preparation. Pharmaceutical compositions containing same can be used in the treatment of cancer.

公开(公告)号：CZ157595A3

公开(公告)日：1996-01-17

申请号：CZ157595

申请日：1993-12-04

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  A61K38/07

公开(公告)号：ZA9309389B

公开(公告)日：1995-06-15

申请号：ZA9309389

申请日：1993-12-15

Applicant: BASF AG

Inventor： HAUPT ANDREAS ,  JANSSEN BERND ,  RITTER KURT ,  KLINGE DAGMAR ,  KEILHAUER GERHARD ,  ROMERDAHL CYNTHIA ,  BARLOZZARI TERESA ,  QIAN XIAO-DONG

IPC: A61K38/00 ,  A61K38/08 ,  A61P35/00 ,  C07K1/00 ,  C07K5/02 ,  C07K5/027 ,  C07K7/02 ,  C07K7/06 ,  C07K ,  A61K

CPC classification number: C07K7/02 ,  A61K38/00 ,  C07K5/0205