公开(公告)号：DK0827749T3

公开(公告)日：2001-05-28

申请号：DK97203411

申请日：1993-12-10

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  FAICT DIRK ,  BURKE RON

IPC: A61K9/08 ,  A61K31/70 ,  A61K33/00 ,  A61K38/00 ,  A61K38/01 ,  A61K38/02 ,  A61K47/26 ,  A61K47/42 ,  A61M1/14 ,  A61M1/28 ,  A61P7/08 ,  A61M1/18

Abstract: The solution contains as osmotic agents both dectrose and polypeptides. The polypeptides are synthetic and are 4 to 10 amino acids long.

公开(公告)号：AU701724B2

公开(公告)日：1999-02-04

申请号：AU2655195

申请日：1995-05-25

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  HENDERSON LEE W

IPC: A61K9/08 ,  A61K31/19 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P7/08 ,  A61P13/12 ,  A61M1/16

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

公开(公告)号：SG48704A1

公开(公告)日：1998-05-18

申请号：SG1995002051

申请日：1993-12-10

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  JONES MICHAEL R

IPC: A61K31/195 ,  A61K31/198 ,  A61K31/40 ,  A61K31/405 ,  A61K31/415 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61K9/08

Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.

公开(公告)号：BR9506021A

公开(公告)日：1997-10-14

申请号：BR9506021

申请日：1995-05-25

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  HENDERSON LEE W

IPC: A61K9/08 ,  A61K31/19 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P7/08 ,  A61P13/12 ,  A61M1/16

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

公开(公告)号：NZ259242A

公开(公告)日：1997-03-24

申请号：NZ25924293

申请日：1993-12-10

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  JONES MICHAEL R

IPC: A61K31/195 ,  A61K31/198 ,  A61K31/40 ,  A61K31/405 ,  A61K31/415 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P13/00 ,  A61P13/02 ,  A61P15/00 ,  A61K31/70 ,  A61K33/06 ,  A61K9/08

Abstract: The present invention provides a dialysis solution that contains amino acids for treating and/or preventing malnutrition in a peritoneal dialysis patient. The amino acid composition is optimized to minimize metabolic acidosis while normalizing amino acid plasma profiles.

公开(公告)号：TR199500780A2

公开(公告)日：1996-06-21

申请号：TR9500780

申请日：1995-06-29

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  HENDERSON LEE W

IPC: A61K9/08 ,  A61K31/19 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P7/08 ,  A61P13/12 ,  B01D61/26 ,  A61K

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g. pH of 70 to 74 and contains bicarbonate at a concentration that is found in normal blood. Additionally, the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

公开(公告)号：CA2169451A1

公开(公告)日：1996-01-18

申请号：CA2169451

申请日：1995-05-25

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  HENDERSON LEE W

IPC: A61K9/08 ,  A61K31/19 ,  A61K31/194 ,  A61K31/70 ,  A61K31/7004 ,  A61K33/00 ,  A61K33/10 ,  A61K33/14 ,  A61M1/28 ,  A61P7/08 ,  A61P13/12

Abstract: A peritoneal dialysis solution that is biochemically balanced to correct metabolic acidosis associated with chronic renal failure in a more physiological manner. The peritoneal dialysis solution has a physiological pH, e.g., pH of 7.0 to 7.4, and contains bicarbonate at a that is found in normal blood. Additionally the solution contains carbon dioxide at a partial pressure that is similar to partial pressure of carbon dioxide found in normal blood. The peritoneal dialysis solution also contains a weak acid with a pKa of less than 5.0.

公开(公告)号：CA2156733A1

公开(公告)日：1995-07-27

申请号：CA2156733

申请日：1995-01-23

Applicant: BAXTER INT

Inventor： MARTIS LEO ,  BURKE RON ,  SHOCKLEY TY ,  HENDERSON LEE W ,  FALLER BERNADETTE

IPC: A61M1/14 ,  A61K31/715 ,  A61K33/14 ,  A61M1/28

Abstract: A peritoneal dialysis solution comprising as osmotic agents approximately 2.0 to about 6.0 % (w/v) maltodextrins and approximately 0.25 to about 2.0 % (w/v) amino acids. The peritoneal dialysis solution will also include other components such as sodium, chloride, lactate, bicarbonate, calcium, and magnesium.

公开(公告)号：AU627140B3

公开(公告)日：1992-06-26

申请号：AU8389091

申请日：1991-09-13

Applicant: BAXTER INT

Inventor： MARTIS LEO

IPC: A61K33/14 ,  A61K33/06

公开(公告)号：CA2352561C

公开(公告)日：2009-02-10

申请号：CA2352561

申请日：2000-07-27

Applicant: BAXTER INT

Inventor： BALTEAU PATRICK ,  MARTIS LEO ,  HARTMAN JEAN-PIERRE ,  FAICT DIRK ,  PELUSO FRANCESCO ,  DUPONCHELLE ANNICK

IPC: A61J3/00 ,  A61K33/10 ,  A61J1/05 ,  A61J1/10 ,  A61J1/20 ,  A61K31/19 ,  A61K33/06 ,  A61K33/14 ,  A61M1/14 ,  A61M1/16 ,  A61M1/28 ,  A61M1/34 ,  A61P13/12

Abstract: The present invention provides devices and methods for stabilizing bicarbona te- based solutions for peritoneal dialysis or hemofiltration. The bicarbonate-based solutions of the present invention are formulated and stored in at least two parts - an alkaline bicarbonate concentrate and an acidic concentrate. The alkaline bicarbonate concentrate is adjusted to have a pH of about 8.6 to 10.0. The acidic concentrate is adjusted to have a stable, acidic pH ranging from about 1.0 to 3.0. Upon mixing, although some variation in the pH of the mixed bicarbonate solution exists, the inventors have discovered that with the appropriate selection of the parameters of the concentrates, the pH of the mixed solution is alway s within an acceptable physiological range.