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    SYSTEMS AND METHODS FOR PERFORMING PERITONEAL DIALYSIS
    1.
    发明申请
    SYSTEMS AND METHODS FOR PERFORMING PERITONEAL DIALYSIS 审中-公开
    用于执行腹膜透析的系统和方法

    公开(公告)号：WO2004009158A2

    公开(公告)日：2004-01-29

    申请号：PCT/US0322267

    申请日：2003-07-16

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： CHILDERS ROBERT W ,  BROWN DAVID S ,  WARIAR RAMESH ,  KAROOR SUJATHA ,  DIN SHAHID ,  MARTIS LEO ,  BUCHMANN CODY ,  SOLTYS PAUL

    IPC: A61M1/14 ,  A61M1/16 ,  A61M1/28

    CPC classification number: A61M1/1696 ,  A61M1/1656 ,  A61M1/1658 ,  A61M1/166 ,  A61M1/28 ,  A61M1/284 ,  A61M1/285 ,  A61M1/287 ,  A61M1/288 ,  A61M2202/0413 ,  A61M2205/12 ,  A61M2205/3306 ,  A61M2205/3327

    Abstract: In a peritoneal dialysis embodiment of the present invention, spent dialysate from the patient's peritoneal cavity passes, along a patient loop, through a dialyzer having a membrane that separates waste components from the spent dialysate, wherein the patient loop returns fresh dialysate to the patient's peritoneal cavity. The waste components are carried away in a second regeneration loop to a regeneration unit or sorbent cartridge, which absorbs the waste components. The regeneration unit removes undesirable components in the dialysate that were removed from the patient loop by the dialyzer, for example, excess water (ultrafiltrate or UF), toxins and metabolic wastes. Desirable components can be added to the dialysate by the system, such as glucose and electrolytes. The additives assist in maintaining the proper osmotic gradients in the patient to perform dialysis and provide the necessary compounds to the patient.

    Abstract translation: 在本发明的腹膜透析实施方案中，来自患者腹膜腔的用过的透析液沿着患者环路通过具有膜的透析器，该膜将废组分与用过的透析液分开，其中患者环路将新鲜透析液返回至患者的腹膜 腔。 废物组分在第二再生回路中被带走到吸收废物组分的再生单元或吸附剂盒。 再生单元除去透析器中由透析器移除的透析液中不需要的成分，例如过量的水（超滤液或UF），毒素和代谢废物。 理想的组分可以通过该系统添加到透析液中，例如葡萄糖和电解质。 添加剂有助于维持患者适当的渗透梯度以进行透析并向患者提供必需的化合物。

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    2.
    发明申请
    "BIOSENSOR FOR DIALYSIS THERAPY" 审中-公开
    “用于DIALYSIS治疗的生物传感器”

    公开(公告)号：WO03097121A2

    公开(公告)日：2003-11-27

    申请号：PCT/US0312816

    申请日：2003-04-23

    Applicant: BAXTER INT

    Inventor： PAN LI ,  WARIAR RAMESH ,  MARTIS LEO ,  HOLMES CLIFF ,  CHILDERS ROBERT ,  DIN SHAHID

    IPC: A61M1/16 ,  B01D61/32 ,  A61M

    CPC classification number: B01D61/32 ,  A61M1/1609 ,  A61M1/28

    Abstract: A biosensor capable of monitoring a number of different constituents of a dialysate solution used during dialysis therapy is provided. The biosensor of the present invention includes an integrated array of reactive elements and sensing elements that can be hydraulically coupled to the dialysate solution. In this regard, the biosensor can be utilized to provide on-line monitoring of total solutes removed from a patient during dialysis therapy, infection levels, and/or other desirable parameters such that an overall assessment of dialysis therapy can be readily evaluated.

    Abstract translation: 提供能够监测在透析治疗期间使用的透析液的多种不同成分的生物传感器。 本发明的生物传感器包括能够液压耦合到透析液的反应元件和感测元件的集成阵列。 在这方面，生物传感器可用于提供在透析治疗，感染水平和/或其它期望参数期间从患者移除的总溶质的在线监测，使得可以容易地评估透析治疗的总体评估。

    5.
    发明专利
    未知

    公开(公告)号：AT505223T

    公开(公告)日：2011-04-15

    申请号：AT03765630

    申请日：2003-07-16

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： CHILDERS ROBERT W ,  BROWN DAVID S ,  WARIAR RAMESH ,  KAROOR SUJATHA ,  DIN SHAHID ,  MARTIS LEO ,  BUCHMANN CODY ,  SOLTYS PAUL

    IPC: A61M1/14 ,  A61M1/16 ,  A61M1/28

    Abstract: A system for dialysis is disclosed. An example peritoneal dialysis system includes a peritoneal dialysis machine including a pumping mechanism, and a sensor configured to measure a property of peritoneal dialysis fluid. The peritoneal dialysis system also includes a disposable cassette operable with the peritoneal dialysis machine. The disposable cassette includes a fluid source inlet for accepting fluid from a fluid source and a fluid flow path in fluid communication with the fluid source inlet. The fluid flow path includes a pump chamber operable with the pumping mechanism to pump fluid through the fluid flow path. The disposable cassette also includes a concentrate inlet for fluidly communicating concentrate to the fluid flow path, and a sensor chamber located along the fluid flow path and operable with the sensor. The sensor is configured to provide feedback to the peritoneal dialysis machine for mixing the concentrate for forming peritoneal dialysis fluid.

    8.
    发明专利
    未知

    公开(公告)号：BR0317450A

    公开(公告)日：2005-11-16

    申请号：BR0317450

    申请日：2003-12-18

    Applicant: BAXTER INT ,  BAXTER HEALTHCARE SA

    Inventor： MARTIS LEO ,  CHOO CAROLYN ,  ZIESKE PAUL

    IPC: A61K31/718 ,  A61K31/724 ,  A61M1/28

    Abstract: Icodextrin-based solutions and methods of making same that can be used during medical therapy, such as dialysis therapy are provided. The icodextrin-based solution at least includes a first solution containing icodextrin at a pH ranging from about 1.5 to about 5.0 and a buffer solution at a pH ranging from about 7.0 to about 12.0 that are so constructed and arranged allowing the icodextrin-based solution to be mixed prior to infusion into a patient. The icodextrin-based solutions of the present invention can be made at physiologic pH and with minimal glucose degradation products.

    9.
    发明专利
    未知

    公开(公告)号：DE69531426D1

    公开(公告)日：2003-09-11

    申请号：DE69531426

    申请日：1995-01-23

    Applicant: BAXTER INT

    Inventor： MARTIS LEO ,  BURKE RON ,  SHOCKLEY TY ,  HENDERSON LEE W ,  FALLER BERNARDETTE

    IPC: A61K31/715 ,  A61K33/14 ,  A61M1/28 ,  A61M1/14

    Abstract: The method relates to providing an osmotic agent for a peritoneal dialysis solution containing sodium chloride and optionally lactate, bicarbonate, calcium and magnesium ions. The osmotic agent added comprises a first composition with a weight average molecular weight of ≥ 10,000 daltons and 0.25 to 2.0 (% w/v) of a second composition with a weight average molecular weight of ≤ 300 daltons.

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