RESISTANCE CIRCUIT STABILIZATION AND PULSE DURATION CONTROL SYSTEMS FOR ELECTROPORATION INSTRUMENTS

    公开(公告)号:EP1461625A4

    公开(公告)日:2006-05-31

    申请号:EP02790046

    申请日:2002-12-06

    CPC classification number: C12M35/02 A61N1/0412 A61N1/08 A61N1/325 A61N1/327

    Abstract: Systems, methods and apparatus for stabilizing resistance measurements in electroporation systems so as to achieve high-accuracy measurements, and for controlling the pulse duration, or time constant, of electroporation pulses. Circuitry is provided to accurately determine the resistance Rs of a sample 25 in the electroporation system, for example a sample 25 provided in an electroporation cuvette. Additionally, a resistance control system is provided to automatically measure the resistance of a sample 25, determine a capacitance and determine a parallel add-on resistance R2 that substantially provides a desired pulse duration (time constant) for an electroporation pulse.

    Abstract translation: 用于稳定电穿孔系统中的电阻测量以实现高精度测量并且用于控制电穿孔脉冲的脉冲持续时间或时间常数的系统,方法和设备。 提供电路以精确确定电穿孔系统中样品25的电阻Rs,例如电穿孔试管中提供的样品25。 另外,提供电阻控制系统以自动测量样品25的电阻,确定电容并确定基本上为电穿孔脉冲提供期望脉冲持续时间(时间常数)的并联附加电阻R2。

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