公开(公告)号：AU555418B2

公开(公告)日：1986-09-25

申请号：AU1721883

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  WACKER OSKAR ,  BASCHANG GERHARD ,  TARCSAY LAJOS

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  A61K37/02

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：NO150885C

公开(公告)日：1985-01-09

申请号：NO803030

申请日：1980-10-10

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  STANEK JAROSLAV ,  TARCSAY LAJOS ,  HARTMANN ALBERT

IPC: A61K31/70 ,  A61P37/04 ,  C07H15/04 ,  C07J17/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H15/12

公开(公告)号：NO150885B

公开(公告)日：1984-09-24

申请号：NO803030

申请日：1980-10-10

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  STANEK JAROSLAV ,  TARCSAY LAJOS ,  HARTMANN ALBERT

IPC: A61K31/70 ,  A61P37/04 ,  C07H15/04 ,  C07J17/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H15/12 ,  C07C103/52

公开(公告)号：ZA8305357B

公开(公告)日：1984-03-28

申请号：ZA8305357

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  WACKER OSKAR ,  BASCHANG GERHARD ,  TARCSAY LAJOS

IPC: A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H ,  A61K

CPC classification number: C07K9/005

公开(公告)号：NO832691L

公开(公告)日：1984-01-24

申请号：NO832691

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  TARCSAY LAJOS ,  WACKER OSKAR ,  BASCHANG GERHARD

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：FI832639A

公开(公告)日：1984-01-24

申请号：FI832639

申请日：1983-07-20

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  WACKER OSKAR ,  BASCHANG GERHARD ,  TARCSAY LAJOS

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07C

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：HU182011B

公开(公告)日：1983-12-28

申请号：HUCI001917

申请日：1979-02-23

Applicant: CIBA GEIGY AG

Inventor： BASHANG GERHARD ,  DIETRICH FELIX M ,  GISLER ROLAND ,  HARTMANN ALBERT ,  STANEK JAROSLAV ,  TARCSAY LAJOS

IPC: G01N33/531 ,  A61K38/14 ,  A61K39/00 ,  A61K39/385 ,  A61K39/39 ,  C07H9/04 ,  C07H15/04 ,  C07H23/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/76 ,  C07K16/00 ,  C07K19/00 ,  C07C103/52 ,  C07G7/00

公开(公告)号：DK337883D0

公开(公告)日：1983-07-22

申请号：DK337883

申请日：1983-07-22

Applicant: CIBA GEIGY AG

Inventor： HARTMANN ALBERT ,  WACKER OSKAR ,  BASCHANG GERHARD ,  TARCSAY LAJOS

IPC: A61K31/70 ,  A61K38/00 ,  A61K38/14 ,  A61K38/17 ,  A61P31/12 ,  A61P35/00 ,  C07H15/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07H15

Abstract: The compounds of the formula I (I) in which each of R1, R4 and R6, independently of the others, represents hydrogen or lower alkanoyl, R2 represents C1-4-alkyl, hydroxymethyl or phenyl, R3 represents hydrogen or methyl, R5 represents hydrogen or C1-3-alkyl, R7 represents C1-3-alkyl that is unsubstituted or substituted by hydroxy, mercapto or methylthio, R8 represents hydrogen or lower alkyl, X represents oxygen or the group NH, Y represents C1-4-alkylidene, and each of R9 and R10, independently of the other, represents C11-17-alkyl or C11-17-alkenyl, and their salts, have an immunostimulating activeity.

公开(公告)号：AU7975182A

公开(公告)日：1982-07-29

申请号：AU7975182

申请日：1982-01-22

Applicant: CIBA GEIGY AG

Inventor： BASCHANG GERHARD ,  HARTMANN ALBERT ,  WACKER OSKAR ,  TARCSAY LAJOS

IPC: A61K39/39 ,  A61P31/04 ,  A61P37/00 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  A61K31/70 ,  C07H15/04 ,  C07H15/12 ,  C07H23/00

Abstract: There are described hexopyranose compounds of the formula I and salts thereof having immunomodulatory action, which can be used, for example, in the form of pharmaceutical preparations, and also together with antibiotics, and processes for their manufacture. (I) The variables are as described in the disclosure. The invention relates to the above-mentioned compounds as immunomodulators, especially as immunostimulants, their use as pharmacologically active substances, especially their use as immunomodulators, particularly as immunostimulants, and their use for the manufacture of pharmaceutical preparations, and to pharmaceutical preparations containing these compounds.

公开(公告)号：DD153843A5

公开(公告)日：1982-02-03

申请号：DD22287980

申请日：1980-07-25

Applicant: CIBA GEIGY AG

Inventor： TARCSAY LAJOS ,  BASCHANG GERHARD ,  HARTMANN ALBERT ,  STANEK JAROSLAV

IPC: C07H13/00 ,  A61K38/00 ,  A61K38/14 ,  A61K39/39 ,  A61P37/04 ,  C07K1/06 ,  C07K1/113 ,  C07K9/00 ,  C07K14/52 ,  C07K14/53 ,  C07K14/535 ,  C07F9/09

Abstract: The invention relates to pharmaceutical preparations that contain an antibiotic and a muramylpeptide of the formula I or a salt thereof, to processes for their manufacture and to a method for increasing the antibiotic effectiveness of antibiotics. (I) In the formula I, X represents carbonyl or carbonyloxy, R1 represents optionally substituted alkyl or aryl, R2, R3, R4 and R6 represent hydrogen or lower alkyl, R5 represents hydrogen, optionally substituted lower alkyl, cycloalkyl, aryl or nitrogen-containing heterocyclyl, or R4 and R5 together represent also C3-C4 alkylene, R7 represents hydrogen or free, esterified or amidated carboxyl, one of the radicals A1 and A2 represents a radical of the formula II and the other of the radicals A1 and A2 represents optionally substituted or functionally modified hydroxy or amino. (II) In the formula II, T represents NH or O, Y represents an optionally substituted alkylene group that can also be interrupted by oxycarbonyl or iminocarbonyl, W represents hydrogen and Z represents an optionally esterified or etherified 1,2-dihydroxyethyl or 2-hydroxyethyl group, or W and Z represent an optionally esterified or etherified hydroxymethyl group.