公开(公告)号：PL322771A1

公开(公告)日：1998-02-16

申请号：PL32277196

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: A metered dose inhaler characterised in that part or all of its internal surfaces are coated with a polymer blend of one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients, wherein a) the fluorocarbon polymer is selected from the group consisting of PTFE, PFA, FEP and mixtures thereof, b) the non-fluorocarbon polymer is selected from the group consisting of polyamideimides, polyimides, polyethersulfones, polyphenylene sulfides and amine-formaldehyde thermosetting resins, (c) the inhaler comprises a can made of metal whose interior surfaces are coated with the polymer blend.

公开(公告)号：PL322770A1

公开(公告)日：1998-02-16

申请号：PL32277096

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：MX9707863A

公开(公告)日：1997-11-29

申请号：MX9707863

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14 ,  A61K09/72

Abstract: Un inhalador de dosis medida que tiene parte o el total de sus superficies interna revestidas con uno o más polímeros de fluorocarburo, opcionalmente en combinacion con uno o más polímeros sin fluorocarburo, para distribuir una formulacion del fármaco para inhalacion que comprende albuterol o una sal del mismo fisiologicamente aceptable, y un propulsor de fluorocarburo, opcionalmente en combinacion con uno o más de otros agentes farmacologicamente activos y uno o más excipientes.

公开(公告)号：MX9707862A

公开(公告)日：1997-11-29

申请号：MX9707862

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL THOMAS

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14 ,  B05D05/08

Abstract: Un inhalador de dosis regulada que tiene parte o todas de estas superficies internas recubiertas con uno o más polímeros de fluorocarbono, opcionalmente en combinacion con uno o más polímeros sin fluorocarbono, para preparar una formulacion del fármaco para inhalacion que comprende de propionato de fluticasona, o un solvato aceptable fisiologicamente del mismo, en combinacion con uno o más de otros agentes activos farmacologicamente o uno o más excipientes.

公开(公告)号：NO974737D0

公开(公告)日：1997-10-13

申请号：NO974737

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14 ,  A61K

Abstract: Metered dose inhaler having all or part of its internal surfaces coated with one or more fluorocarbon polymers, opt. in combination with one or more non-fluorocarbon polymers, is used for dispensing an inhalation drug formulation comprising albuterol (also known as salbutamol) or one of its salts, and a fluorocarbon propellant, opt. in combination with one or more other pharmacologically active agents or one or more excipients. Also claimed is a metered dose inhaler system comprising a metered dose inhaler fitted into a suitable channelling device for oral or nasal inhalation of the drug formulation.

公开(公告)号：PL319342A1

公开(公告)日：1997-08-04

申请号：PL31934295

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：NO971422D0

公开(公告)日：1997-03-25

申请号：NO971422

申请日：1997-03-25

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：CA2217954A1

公开(公告)日：1996-10-17

申请号：CA2217954

申请日：1996-04-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  RIEBE MICHAEL T ,  LI-BOVET LI ,  HERMAN CRAIG S

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14 ,  A61K9/12

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：IS1991B

公开(公告)日：2005-02-15

申请号：IS4438

申请日：1997-03-10

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

公开(公告)号：NO316588B1

公开(公告)日：2004-03-01

申请号：NO974737

申请日：1997-10-13

Applicant: GLAXO WELLCOME INC

Inventor： BRITTO IGNATIUS LOY ,  ASHURST IAN C ,  HERMAN CRAIG STEVEN ,  LI-BOVET LI ,  RIEBE MICHAEL THOMAS

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14