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    76.
    发明专利
    未知

    公开(公告)号：DK125642C

    公开(公告)日：1977-09-26

    申请号：DK416869

    申请日：1969-08-01

    Applicant: HOECHST AG

    Inventor： WEYER R ,  AUMUELLER W ,  WEBER H ,  MUTH K ,  SCHMIDT F H

    IPC: C07C311/58 ,  C07C303/36 ,  C07C303/38 ,  C07C311/59 ,  C07D233/96 ,  C07D333/20 ,  C07C143/833

    Abstract: 1,233,354. Benzenesulphonyl-ureas. FARBWERKE HOECHST A.G. 14 Feb., 1969 [2 Aug., 1968], No. 8218/69. Heading C2C. Novel compounds I (including salts thereof) wherein X signifies the groups II or III in which R signifies C 1-4 alkyl, Z signifies halogen, C 1-4 alkyl or C 1-4 alkoxy and Z 1 signifies halogen or C 1-4 alkyl are obtained according to standard methods. N - [4 - (# - Aminoethyl) - benzenesulphonyl]. N 1 - (# 2 - cyclohexenyl) - urea is prepared by saponifying the #-acetamidoethyl-compound. 1 - [4 - (# - - ethyl) - benzenesulphonyl] - 3 - (#2. cyclohexenyl)-parabanic acid is prepared by the interaction of 1-(#2-cyclohexenyl)-parabanic acid and 4 - (# - - ethyl) - benzenesulphochloride. #2 - Cyclohexenyl isocyanate is prepared by heating N - (#2 - cyclohexenyl) - N 1 ,N 1 - diphenyl-urea. The cyclohexenylamine salt of N-[4 - (# - - ethyl) - benzenesulphonyl] - N 1 - aceryl - urea is obtained by mixing the individual compounds and heating. N - (#2 - Cyclohexenyl) - carbamic acid phenyl ester is prepared by the interaction of phenyl chloroformate and #2-cyclohexenylamine. N - Acetyl - N 1 - (#2 - cyclohexenyl) - urea is prepared by the interaction of acetic anhydride and #2-cyclohexenyl-urea. N,N - Diphenyl - N 1 - (#2 - cyclohexenyl)- urea is prepared from diphenyl carbamoyl chloride and #2-cyclohexenylamine. N,N 1 - Di - (#2 - cyclohexenyl) - urea is prepared from #2 - cyclohdxenyl isocyanate and #2-cyclohexenylamine. N - [4 - (# - - ethyl) - benzenesulphonyl] - phenylurethane, -N 1 N 1 - diphenyl - urea, - iminodithio - carbonic acid potassium salt and dimethyl ester, -N 1 - (#2 - cyclohexenyl) - isothiourea methyl ether, -N 1 -(#2-cyclohexenyl)- thiourea and - N 1 - (#2 - cyclohexenyl) - isourea methyl ether and 4-(#- - ethyl) - benzene sulphonamide are also prepared as intermediates. Pharmaceutical preparations exhibiting blood sugar lowering properties and hypoglycemic activity contain I as active ingredient; administration is orally.

    77.
    发明专利
    未知

    公开(公告)号：DK5777A

    公开(公告)日：1977-07-09

    申请号：DK5777

    申请日：1977-01-07

    Applicant: HOECHST AG

    Inventor： HITZEL V ,  WEYER R ,  BOSIES E

    IPC: A61K31/165 ,  C07C67/00 ,  C07C231/00 ,  C07C231/02 ,  C07C231/10 ,  C07C231/12 ,  C07C233/65 ,  C07D213/82 ,  C07D215/48 ,  C07D307/79 ,  C07D311/58 ,  C07D333/38 ,  C07C

    Abstract: The invention relates to acylamino(alkyl)benzene derivatives of the general formula in which W represents a group which can be converted into a carboxyl group, or an aldehyde group or an oxymethyl group or their derivatives or also a low molecular weight alkyl group, preferably a methyl group, X represents an aromatic or hetero-aromatic ring system, Y represents a single chemical bond or a hydrocarbon bridge, and Z represents hydrogen or one or even several other substituents, TO THEIR PREPARATION AND TO PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. The compounds have blood sugar lowering activity and may be used in the therapy of diabetes mellitus.

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