公开(公告)号：JPH03197419A

公开(公告)日：1991-08-28

申请号：JP33722689

申请日：1989-12-26

Applicant: KAO CORP

Inventor： MORI SHINOBU ,  YOROZU HIDENORI ,  SATO HIROTAKA ,  INAOKA KAZU ,  NISHIZAWA YOSHINORI

IPC: A61K8/00 ,  A61K8/97 ,  A61K36/736 ,  A61Q19/10

Abstract: PURPOSE:To obtain the subject substances fractionated from a peach leaf, having a high solubility to water, a high stability, a high antiinflammatory effect and a high safety to the skin by treating an extract from a peach leaf with active carbon. CONSTITUTION:A peach leaf is extracted at 50-90 deg.C using water and/or a lower alcohol (A mixture obtained by blending ethanol with 20-50wt.% water is preferable) as the extraction solvent in an amount of 6-12 pts. wt. based on 1 pts.wt. raw material and the resultant extract is filtered and/or concentrated according to the conventional method. Active carbon is then added thereto in an amount of 0.01-5wt.%, preferably 0.1-2wt.% based on the peach leaf as the raw material followed by stirring. The active carbon is then removed by a suitable method such as filtration, thus obtaining the objective substances fractionated from the peach leaf. A bath liquid obtained by blending the resultant fractionated substances is free from generating turbidity of hot water and shows an excellent bathing effect.

公开(公告)号：JPH03135907A

公开(公告)日：1991-06-10

申请号：JP27355489

申请日：1989-10-20

Applicant: KAO CORP

Inventor： KAMIYA TETSURO ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI ,  HATTORI MICHIHIRO

IPC: A61K31/185 ,  A61K8/00 ,  A61K8/49 ,  A61Q5/00 ,  A61Q7/00

Abstract: PURPOSE:To obtain a hair rearing agent containing a phthalid derivative as an active ingredient, having excellent hair rearing effect and effective against almost alopecia regardless of difference of disorder and individual difference. CONSTITUTION:The aimed hair rearing agent containing a phthalid derivative expressed by formula I (R is 3-16C straight-chain or branched alkyl or 3-4C straight-chain or branched alkoxy; R is H, hydroxy or methoxy) as an active ingredient. When used, hair nursing medicines ordinarily used, e.g. antiphlogistic agent, cell activating agent and vitamins are as necessary properly blended in addition to the above-mentioned active ingredient. The hair rearing agent is preferably formulated to coating agent such as ointment, lotion or emulsion. Furthermore, every substance of natural substance extracted from Oenanthe plant or synthetic substance obtained by reacting according to the reaction formula may be used as the compound expressed by formula I.

公开(公告)号：JPH02184683A

公开(公告)日：1990-07-19

申请号：JP275889

申请日：1989-01-11

Applicant: KAO CORP

Inventor： SATO HIROTAKA ,  YOROZU HIDENORI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI

IPC: C07D307/88 ,  A61K8/00 ,  A61K8/49 ,  A61K31/34 ,  A61K31/343 ,  A61K31/365 ,  A61P25/00 ,  A61Q1/00 ,  A61Q5/00 ,  A61Q11/00 ,  A61Q13/00 ,  A61Q19/10

Abstract: PURPOSE:A consciousness level depressor for human and animal, containing a specific phthalide derivative as an active ingredient and having superior consciousness level depressive effect, persistence and high safety. CONSTITUTION:The objective consciousness level depressor containing >=1 kinds of phthalide derivatives expressed by the formula (R1 represents H, OH, methoxy, amino or dimethylamino; R2 and R3 represent H or methoxy; R4 represents H, amino or dimethylamino; R5 represents H, alkyl or alkoxyl) (example; butylphthalide, hepthylphthalide, isoamylphthalide or propoxyphthalide). By incorporating the depressor singly or in combination with a compound perfume into a product, it can be used in fragrances, room aromatics, cream, emulsions, cosmetic powder, body lotion, dentifrice, hair product, aerosol product, etc. The amount thereof to be incorporated is 0.3-50wt.%.

公开(公告)号：JPH02167216A

公开(公告)日：1990-06-27

申请号：JP10306989

申请日：1989-04-21

Applicant: KAO CORP

Inventor： SATO HIROTAKA ,  YOROZU HIDENORI ,  ANDO MASATOMO ,  NISHIZAWA YOSHINORI

IPC: A61K8/00 ,  A61K8/49 ,  A61K8/97 ,  A61Q19/10

Abstract: PURPOSE:To obtain a readily usable inexpensive bathing agent, containing an alkylphthalide, alkoxyphthalide or alkylidenephthalide, excellent in promotion of blood circulation, warming effects and good in odor, color, etc., without causing turbidity of bath water. CONSTITUTION:The objective substance obtained by containing an alkylphthalide and/or alkoxyphthalide and/or alkylidenephthalide expressed by formulas I and II (R1 is 3-14C alkyl or alkoxy; R2 is 3-14C alkylidene), further blending gaseous carbon dioxide or a substance generating the gaseous carbon dioxide, an extract of an umbelliferous plant and normally used bathing agent ingredients therewith and preparing a formulation. The bathing agent has preferably a weak acidic pH in use and is prepared so as to provide preferably pH4-7. The agent can be prepared in the form of powder, granule, crystal, tablet, etc.

公开(公告)号：JPS6284072A

公开(公告)日：1987-04-17

申请号：JP22572785

申请日：1985-10-09

Applicant: KAO CORP

Inventor： NISHIZAWA YOSHINORI ,  TAKAISHI NAOTAKE ,  HOTTA HAJIME

IPC: A61K8/67 ,  C07D307/62

Abstract: NEW MATERIAL:An ascorbic acid derivative expressed by formula I (R and R are 1-17C straight-chain or branched alkyl, cycloalkyl or aryl; R CO is 4-18C fatty acid residue branched at the alpha-position or cycloalkanoic acid residue). EXAMPLE:2,3,6-Tri-0-(2-ethylhexanoyl)-L-ascorbic acid. USE:Useful as one component of nutrient supplements or cosmetics. Since the above-mentioned derivative is stable even in an oxidizing atmosphere without coloring with time and has excellent characteristic of high vitamin C activity, cosmetic containing the derivative are stable without discoloration, change in odor and deterioration in activity even in a hydrous system and capable of exhibiting improved vitamin C activity. PREPARATION:For example, as shown in the reaction formula, ascorbic acid is reacted with a halogenated acyl branched at the alpha-position to afford the aimed 2,3-di-0-(alpha-position branched acyl)-6-0-acylascorbic acid expressed by formula I.

公开(公告)号：JP2008105975A

公开(公告)日：2008-05-08

申请号：JP2006288880

申请日：2006-10-24

Applicant: Kao Corp ,  花王株式会社

Inventor： AMANO SHINYA ,  NAKAGIRI YORIKO ,  NISHIZAWA YOSHINORI

IPC: A61K8/55 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To provide a shrinking agent for keratinocyte which acts on a keratinocyte and can convert pores to be inconspicuous.
SOLUTION: The shrinking agent for keratinocyte, or a pore shrinking agent includes a compound or its salt represented by formula (1), where R
1 , and R
2 denote an 8-24C alkyl group, and a 1-24C alkyl group respectively.
COPYRIGHT: (C)2008,JPO&INPIT

Abstract translation: 要解决的问题：提供作用于角质形成细胞的角质形成细胞的收缩剂，并且能够使毛孔变得不显眼。 解决方案：角质形成细胞的收缩剂或孔收缩剂包括由式（1）表示的化合物或其盐，其中R 1 和R 2 分别表示8-24C烷基和1-24C烷基。 版权所有（C）2008，JPO＆INPIT

公开(公告)号：JP2006104209A

公开(公告)日：2006-04-20

申请号：JP2005341449

申请日：2005-11-28

Applicant: Kao Corp ,  花王株式会社

Inventor： TSUJI NAOKO ,  MORIWAKI SHIGERU ,  IMOKAWA GENJI ,  SUZUKI YASUTO ,  NISHIZAWA YOSHINORI

IPC: A61K45/00 ,  A61K8/44 ,  A61K8/55 ,  A61K8/60 ,  A61K31/197 ,  A61K31/664 ,  A61K31/7056 ,  A61P17/00 ,  A61P43/00 ,  A61Q17/04 ,  A61Q19/00

Abstract: PROBLEM TO BE SOLVED: To obtain an agent or to prepare a cosmetic effective for preventing or suppressing the formation of wrinkles.
SOLUTION: The wrinkle preventing agent contains a metal-dependent elastin decomposition enzyme inhibiting agent as an active component.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：获得有效预防或抑制皱纹形成的化妆品或制备化妆品。 防皱剂含有金属依赖弹性蛋白分解酶抑制剂作为活性成分。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005330218A

公开(公告)日：2005-12-02

申请号：JP2004149474

申请日：2004-05-19

Applicant: Kao Corp ,  花王株式会社

Inventor： NISHIZAWA YOSHINORI ,  ICHINOSE SUSUMU

IPC: C07C51/09 ,  C07C27/02 ,  C07C65/32

Abstract: PROBLEM TO BE SOLVED: To provide a method for producing an o-acylbenzoic acid derivative, by which a raw material is readily obtained and an expensive reagent is not required.
SOLUTION: The method for producing an o-acylbenzoic acid derivative represented by formula (3) (R
1 is a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; L is a lower alkyl group; R
2 is an alkyl group; X is a halogen atom) comprises reacting an excessive amount of a phthalic acid diester represented by formula (1) with a Grignard reagent represented by formula (2) and then hydrolyzing the reaction product.
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 待解决的问题：提供一种生产邻酰基苯甲酸衍生物的方法，通过其可以容易地获得原料并且不需要昂贵的试剂。 解决方案：由式（3）表示的邻酰基苯甲酸衍生物的制备方法（R“SP”是氢原子，卤原子，低级烷基或低级烷氧基; L为低级烷基; R 2为烷基，X为卤素原子）包括使由式（1）表示的过量的邻苯二甲酸二酯与由式（1）表示的格氏试剂反应， （2），然后水解反应产物。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2005306886A

公开(公告)日：2005-11-04

申请号：JP2005207051

申请日：2005-07-15

Applicant: Kao Corp ,  花王株式会社

Inventor： HOSHINO TADAHIDE ,  SAITO HIROAKI ,  SUGAI YOSHIYA ,  SUGIYAMA MITSURU ,  NISHIZAWA YOSHINORI ,  KATAYAMA YASUSHI

IPC: A61K8/00 ,  A61K8/42 ,  A61K8/72 ,  A61Q5/02 ,  A61Q5/06 ,  A61Q17/04 ,  A61Q19/00 ,  A61K7/48 ,  A61K7/00 ,  A61K7/075 ,  A61K7/11 ,  A61K7/42

Abstract: PROBLEM TO BE SOLVED: To obtain an external agent composition, basically improving the water retaining ability and barrier functions of the horny layer, excellent in miscibility and mixing stability and capable of being efficiently prepared at a low cost.
SOLUTION: This external agent composition, a humectant and a skin barrier function reinforcing agent, contain each a diamide derivative represented by formula (1) (wherein, R
1a and R
1b are the same or different and represent each a 1-23C branched chain hydrocarbon; R
2a and R
2b are the same or different and represent each a 1-6C divalent hydrocarbon; R
3 s are the same or different and represent each a 2-6C divalent hydrocarbon; and (n) stands for 1 to 100).
COPYRIGHT: (C)2006,JPO&NCIPI

Abstract translation: 要解决的问题为了获得外用剂组合物，基本上提高了角质层的保水性和阻隔功能，混溶性和混合稳定性优异，能够以低成本有效地制备。

解决方案：该外用剂组合物，湿润剂和皮肤屏障功能增强剂含有各自由式（1）表示的二酰胺衍生物（其中，R 1a 和R / SP>相同或不同，表示每个1-23C支链烃; R＆lt; SP＆gt; 2a＆lt; SP＆gt; 2b＆lt; SP＆gt;相同或不同，表示每个1-6C 二价烃; R 3相同或不同，代表2-6C二价烃;（n）代表1至100）。 版权所有（C）2006，JPO＆NCIPI

公开(公告)号：JP2000256203A

公开(公告)日：2000-09-19

申请号：JP5681299

申请日：1999-03-04

Applicant: KAO CORP

Inventor： KANAZAWA SATOSHI ,  OHASHI YUKIHIRO ,  NISHIZAWA YOSHINORI ,  ICHII YUJI ,  MORI SHINOBU ,  SATO MAYUMI

IPC: A23L2/52 ,  A21D13/08 ,  A23L1/30 ,  A23L2/38 ,  A61K8/00 ,  A61K8/96 ,  A61K8/97 ,  A61K31/00 ,  A61K36/18 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61Q19/00 ,  A61Q19/10 ,  A61K35/78 ,  A61K7/00 ,  A61K7/48 ,  A61K7/50

Abstract: PROBLEM TO BE SOLVED: To obtain a banana pericarp extract which facilitates the decomposition of accumulated fat cells and is useful for inhibiting, preventing, improving or the like obesity by extracting banana pericarps with an acidic aqueous solution. SOLUTION: The objective extract is obtained by extracting a banana, e.g. a banana for eating raw (Musa paradisiacal L. var. sapientum or Musa nana Lour.) or a plantain (a banana for cooking) with an acidic aqueous solution (e.g. a mixture or the like of water and a lower alcohol and/or a polyol) of preferably pH of not more than 6 by means of immersing or immersing under stirring or refluxing followed by filtration. The agent for facilitating lipolysis is obtained by including the above extract. Further, on the above accelerator, the above extract is preferably included in proportions of more than 0.005 wt.% in the dry basis when used as a preparation for external use, 0.01-50 wt.% a day per an adult when used as an oral formation or an ingesta and more than 0.01 ppm in bath water when used as a bathing agent.