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    CURING AGENT OF AUTOIMMUNE DISEASE
    1.
    发明专利
    CURING AGENT OF AUTOIMMUNE DISEASE 失效

    公开(公告)号：JPH02300132A

    公开(公告)日：1990-12-12

    申请号：JP11964589

    申请日：1989-05-12

    Applicant: KAO CORP

    Inventor： OTSUJI KAZUYA ,  INAOKA KAZU ,  HONDA YASUKI ,  OKAMOTO KIKUHIKO ,  TANAKA MORIHISA ,  MATSUMOTO TSUKASA ,  IIJIMA KOJI ,  CHIYOU SOUTETSU

    IPC: C08B37/00 ,  A61K31/715 ,  A61P37/00 ,  C12N5/04 ,  C12P19/04

    Abstract: PURPOSE:To obtain the subject curing agent useful for glomerular nephritis, articular rheumatism, systemic erythematosus and intractable disease of blood vessel, etc., exhibiting excellent removing effect for immune complex with a slight side effect containing specific acidic heteropolysaccharide as active ingredient. CONSTITUTION:The aimed agent contains arabinose, mannose, galactose, glucuronic acid and xylose outwardly secreted by callus derived from plant such as a part of flower of Polianthes Tuberosa L. belonging to genus Polianthes L. as constituting sugars. Said acidic heteropolysaccharides having bonding forms and constituting ratios expressed by the formula and 1X10 -2X10 molecular weight are contained in said agent as active ingredients. Said active ingredients are obtained by culturing under completely artificial control with slight variations of yield of the polysaccharides, total sugar content, uronic acid content, protein content, water content and constituting ratio of neutral sugar. Said active ingredient also has high uniformity and solubility in water, thus is administrated as injection agent with dissolving in physiological saline solution, etc., or as oral administration such as tablet in mixing with carrier.

    ANTIALLERGIC AGENT
    2.
    发明专利
    ANTIALLERGIC AGENT 失效

    公开(公告)号：JPS63119427A

    公开(公告)日：1988-05-24

    申请号：JP26360186

    申请日：1986-11-05

    Applicant: KAO CORP

    Inventor： KOBAYASHI TORU ,  SATO TOMOKAZU ,  INAOKA KAZU ,  TAKANO SATOSHI ,  ITO SUSUMU ,  OKAMOTO KIKUHIKO

    IPC: A61K31/715 ,  A61P37/08 ,  A61P43/00

    Abstract: PURPOSE:To obtain an antiallergic agent having excellent antiallergic action, antagonizing action on blood platelet activation factor, antihistamine action and high safety, containing a mannan as an active ingredient. CONSTITUTION:The aimed substance is obtained by using a mannan (e.g. yeast mannan), a polysaccharide comprising mannose as a main constituent component, as an active component and by pharmaceutical manufacturing by a conventional procedure. Mannans can be collected from various microorganisms and plants by a well-known method and mannans sold on the market can be used. For example, yeast mannan exists in cell wall of yeast fungus, cultivated under a culture condition and extracted. A dose is 10-500mg per adult daily and administered dividedly once - several times.

    SUBSTANCE FRACTIONATED FROM PEACH LEAF AND BATH LIQUID CONTAINING THE SAME SUBSTANCE
    3.
    发明专利
    SUBSTANCE FRACTIONATED FROM PEACH LEAF AND BATH LIQUID CONTAINING THE SAME SUBSTANCE 失效

    公开(公告)号：JPH03197419A

    公开(公告)日：1991-08-28

    申请号：JP33722689

    申请日：1989-12-26

    Applicant: KAO CORP

    Inventor： MORI SHINOBU ,  YOROZU HIDENORI ,  SATO HIROTAKA ,  INAOKA KAZU ,  NISHIZAWA YOSHINORI

    IPC: A61K8/00 ,  A61K8/97 ,  A61K36/736 ,  A61Q19/10

    Abstract: PURPOSE:To obtain the subject substances fractionated from a peach leaf, having a high solubility to water, a high stability, a high antiinflammatory effect and a high safety to the skin by treating an extract from a peach leaf with active carbon. CONSTITUTION:A peach leaf is extracted at 50-90 deg.C using water and/or a lower alcohol (A mixture obtained by blending ethanol with 20-50wt.% water is preferable) as the extraction solvent in an amount of 6-12 pts. wt. based on 1 pts.wt. raw material and the resultant extract is filtered and/or concentrated according to the conventional method. Active carbon is then added thereto in an amount of 0.01-5wt.%, preferably 0.1-2wt.% based on the peach leaf as the raw material followed by stirring. The active carbon is then removed by a suitable method such as filtration, thus obtaining the objective substances fractionated from the peach leaf. A bath liquid obtained by blending the resultant fractionated substances is free from generating turbidity of hot water and shows an excellent bathing effect.

    HYPOTENSIVE AGENT
    4.
    发明专利
    HYPOTENSIVE AGENT 失效

    公开(公告)号：JPS63101327A

    公开(公告)日：1988-05-06

    申请号：JP24495986

    申请日：1986-10-15

    Applicant: KAO CORP

    Inventor： KOBAYASHI TORU ,  SATO TOMOKAZU ,  INAOKA KAZU ,  TAKANO SATOSHI ,  ITO SUSUMU

    IPC: A61K31/715 ,  A61P9/12

    Abstract: PURPOSE:To provide a hypotensive agent containing mannan as an active component. CONSTITUTION:An hypotensive agent having high safety can be produced by using a mannan (e.g. mannan originated from microorganism: mannan obtained from the cell of yeast of Saccharomyces genus, mold such as Penicillium, bacteria such as Bacillus polymyxa, etc.; mannan originated from vegetables: ivory palm mannan, red algae mannan, etc.; glucomannan: mannan containing galactonse in addition to mannose and obtained from the tuberous root of devil's tongue, bulb of lily, narcissus, etc.; galactomannan: mannan containing galactose in addition to mannose such as locust beam gum; etc.), preferably yeast mannan, as an active component. It can be used in the form of a drug for intravenous injection or oral drug such as tablet, capsule, granule, fine particle, etc. It is administered preferably at a dose of 10-500mg daily preferably in 1 - several divided doses.

    NOVEL TOLUQUINONE COMPOUND
    8.
    发明专利
    NOVEL TOLUQUINONE COMPOUND 失效

    公开(公告)号：JPH0449259A

    公开(公告)日：1992-02-18

    申请号：JP15574590

    申请日：1990-06-14

    Applicant: KAO CORP

    Inventor： INAOKA KAZU ,  NISHIZAWA YOSHINORI ,  TONE HIROSHI ,  KAMIYA TETSURO

    IPC: A61K31/12 ,  A61K31/047 ,  A61K31/122 ,  A61P9/12 ,  C07C39/19 ,  C07C50/26

    Abstract: NEW MATERIAL:A toluquinone compound of formula I or II. USE:A medicine such as cerebral circulation improving agent, antiinflammatory agent, face paint or antifungal agent. Giving vasohypotonic, antiinflammatory, melanization-inhibitory and antifungal activities. PREPARATION:Seaweed belonging to Fucales such as Sargassum macrocarpum is extracted with a solvent such as ethanol or methanol followed by purification with chromatography, thus obtaining the objective compound of the formula I or II, in high yield. Alternatively, using a known compound of formula III as raw material, the objective compound can be obtained through an established organic synthesis.

    ANTICANCER AGENT
    10.
    发明专利
    ANTICANCER AGENT 失效

    公开(公告)号：JPH02215721A

    公开(公告)日：1990-08-28

    申请号：JP3602189

    申请日：1989-02-17

    Applicant: KAO CORP

    Inventor： OTSUJI KAZUYA ,  YOSHIZUKA NAONOBU ,  SUZUKI HIROYUKI ,  HONDA YASUKI ,  INAOKA KAZU ,  SUGIMURA YORIO

    IPC: A61K36/18 ,  A61K31/715 ,  A61P35/00 ,  C08B37/00

    Abstract: PURPOSE:To obtain an anticancer agent containing specific acidic heteropolysaccharides induced from a plant of the genus Polianthes L. as an active ingredient and extremely reduced in side effects. CONSTITUTION:The aimed anticancer agent containing arabinose, mannose, galactose, glucuronic acid and xylose as ingredients, having binding manner and constituent ratio expressed by the formula and containing acidic heteropolysaccharides having 1X10 -2X10 molecular weight as an active ingredient. The above-mentioned polysaccharides are obtained by culturing a part of organ or tissue of a plant (e.g. Polianthes tuberosa L.) belonging to the genus Polianthes used as an explant in a culture medium containing a plant hormone to induce callus and subjecting the callus to culture; preferably shake culture in a culture medium (preferably liquid medium) containing a plant hormone at 20-30 deg.C for 15-30 day and collecting from the cultured product.

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