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71.发明专利
公开(公告)号：CZ301464B6
公开(公告)日：2010-03-10
申请号：CZ20023721
申请日：2001-05-10
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , VAN DER HEIJDEN JOHANNES A M , KRUSE CORNELIS G , LONG STEPHEN K , VAN SCHARRENBURG GUSTAAF J M
IPC: C07D413/04 , C07D413/10 , A61K31/423 , A61K31/428 , A61K31/4427 , A61K31/4439 , A61K31/445 , A61K31/4523 , A61K31/496 , A61P25/00 , A61P25/16 , A61P25/22 , A61P25/24 , A61P25/30 , A61P43/00 , C07D263/54 , C07D263/58 , C07D277/62 , C07D277/68 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/12 , C07D413/14 , C07D417/04 , C07D417/14
Abstract: Slouceniny obecného vzorce I, jejich soli a profarmaka, zpusob prípravy techto sloucenin reakcí slouceniny obecného vzorce Ia se slouceninou Q-Hal, a farmaceutické kompozice obsahující tyto slouceniny. Tyto slouceniny vykazují zajímavé farmakologické vlastnosti díky kombinaci (cástecného) agonismu vuci clenum podrodiny dopaminových D.sub.2.n. receptoru a afinite k relevantním serotoninovým nebo/a noradrenergním receptorum. Proto lze tyto slouceniny použít k lécení príslušných onemocnení, zejména poruch centrální nervové soustavy, úzkosti, deprese, Parkinsonovy choroby a závislostí.
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公开(公告)号：ZA200705897B
公开(公告)日：2009-09-30
申请号：ZA200705897
申请日：2007-07-18
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , PRAS-RAVES MARIA L , VAN SCHARRENBURG GUSTAAF J M , KEIZER HISKIAS G , VAN VLIET BERNARD J
IPC: A61K20090101 , A61P20090101 , C07D20090101
Abstract: The present invention relates to 5-imino-5H-[1,2,4]-dithiazol-3-yl-amine and [1,2,4]-dithiazolidine-3,5-diylidene-diamine derivatives as inducers of gluthathione-S-transferase (GST) and NADPH quinone oxidoreductase (NQO), to methods for the preparation of these compounds and to novel intermediates useful for the synthesis of said [1,2,4]-dithiazoli(di)ne derivatives. The invention also relates to the use of a compound disclosed herein for the treatment of adverse conditions associated with cytotoxicity in general and apoptosis in particular. The invention relates to compounds of the general formula (I): wherein wherein the symbols have the meanings given in the specification.
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公开(公告)号：SI1919883T1
公开(公告)日：2009-04-30
申请号：SI200630214
申请日：2006-08-21
Applicant: SOLVAY PHARM BV
Inventor： KOOPMAN THEODORUS S M , KOSTER HENDRIK J , VAN AMSTERDAM PETER H , FEENSTRA ROELOF W , VERHAGE MARINUS , MCCREARY ANDREW C , HESSELINK MAYKE B , VAN SCHARRENBURG GUSTAAF J M
IPC: C07D263/00 , A61K31/00 , A61P25/00 , C07D295/00
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公开(公告)号：SI1824479T1
公开(公告)日：2009-04-30
申请号：SI200530566
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD J , HESSELINK MAYKE B , KRUSE CORNELIS G , VAN SCHARRENBURG G J M
IPC: A61K31/00 , A61P25/00 , C07D263/00
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公开(公告)号：PL1824479T3
公开(公告)日：2009-04-30
申请号：PL05816322
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD J , HESSELINK MAYKE B , KRUSE CORNELIS G , VAN SCHARRENBURG G J M
IPC: A61K31/423 , A61P25/00 , C07D263/58
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Patent Agency Ranking
公开(公告)号：HK1120261A1
公开(公告)日：2009-03-27
申请号：HK08112134
申请日：2008-11-06
Applicant: SOLVAY PHARM BV
Inventor： KOOPMAN THEODORUS S M , KOSTER HENDRIK J , AMSTERDAM PETER H VAN , FEENSTRA ROELOF W , VERHAGE MARINUS , MCCREARY ANDREW C , HESSELINK MAYKE B , SCHARRENBURG GUSTAAF J M VAN
IPC: A61K20060101 , A61P20060101 , C07D20060101
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公开(公告)号：PT1824479E
公开(公告)日：2009-01-30
申请号：PT05816322
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VLIET BERNARD J VAN , HESSELINK MAYKE B , KRUSE CORNELIS G , SCHARRENBURG GUSTAAF J M VAN
IPC: A61K31/423 , A61P25/00 , C07D263/58
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公开(公告)号：HRP20080538T3
公开(公告)日：2008-12-31
申请号：HRP20080538
申请日：2008-10-22
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VLIET BERNARD J VAN , HESSELINK MAYKE B , KRUSE CORNELIS G , SCHARRENBURG GUSTAAF J M VAN
IPC: A61K31/423 , A61P25/00 , C07D263/58 , C07D413/12
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：AT413173T
公开(公告)日：2008-11-15
申请号：AT05816322
申请日：2005-12-06
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , STOIT AXEL , TERPSTRA JAN-WILLEM , PRAS-RAVES MARIA L , MCCREARY ANDREW C , VAN VLIET BERNARD , HESSELINK MAYKE , KRUSE CORNELIS , VAN SCHARRENBURG G J M
IPC: A61K31/423 , A61P25/00 , C07D263/58
Abstract: The invention relates to a group of novel phenylpiperazine derivatives with a dual mode of action: serotonin reuptake inhibition and partial agonism on dopamine -D2 receptors. The invention also relates to the use of a compound disclosed herein for the manufacture of a medicament giving a beneficial effect. The compounds have the general formula (1) wherein the symbols have the meanings given in the specification.
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公开(公告)号：ZA200704219B
公开(公告)日：2008-05-28
申请号：ZA200704219
申请日：2007-05-23
Applicant: SOLVAY PHARM BV
Inventor： FEENSTRA ROELOF W , JAN-WILLEM TERPSTRA , MCCREARY ANDREW C , HESSELINK MAYKE B , VAN SCHARRENBURG GUSTAAF J M , AXEL STOIT , PRAS-RAVES MARIA L , VAN VLIET BERNARD J , KRUSE CORNELIS G
IPC: A61K20090101 , A61P20090101 , C07D20090101
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