公开(公告)号：CH613976A5

公开(公告)日：1979-10-31

申请号：CH1700274

申请日：1974-12-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36

Abstract: A compound of the formula: wherein R1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR2 (where R2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R1), and Y represents acetoxy group or a group of formula -SR3 (where R3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

公开(公告)号：CS192531B2

公开(公告)日：1979-08-31

申请号：CS457177

申请日：1977-07-08

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: A61K31/545 ,  C07D501/60

公开(公告)号：SU667139A3

公开(公告)日：1979-06-05

申请号：SU2196607

申请日：1975-12-09

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKO MASAESI ,  SIRAISI MITSURI ,  MIYAVAKI TOSIO

IPC: C07D501/06 ,  A61K31/545 ,  A61K31/546 ,  C07D501/34 ,  C07D501/36 ,  C07D501/60

公开(公告)号：CH609701A5

公开(公告)日：1979-03-15

申请号：CH1625777

申请日：1974-12-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO

IPC: C07D277/34 ,  C07D277/36 ,  C07D501/24 ,  C07D501/34 ,  C07D501/36 ,  C07D501/28

Abstract: A compound of the formula: wherein R1 represents hydrogen or an alkyl group, X represents oxygen or sulfur or a group of formula -NR2 (where R2 is hydrogen or an alkyl group and in the case of alkyl, it may form a ring jointed with R1), and Y represents acetoxy group or a group of formula -SR3 (where R3 is a nitrogen-containing heterocyclic group), or a pharmaceutically acceptable salt thereof, is found to have a broad antimicrobial spectrum and, in particular, effective against gram-negative bacteria including Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus morganii, as well as gram positive ones. Thus, these compounds may be used for antimicrobial agents in therapeutical purposes.

公开(公告)号：NO772170L

公开(公告)日：1978-03-09

申请号：NO772170

申请日：1977-06-20

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60 ,  C07D

Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.

公开(公告)号：FI771951A

公开(公告)日：1978-03-09

申请号：FI771951

申请日：1977-06-22

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  TSUSHIMA SUSUMU

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D257/04 ,  C07D277/38 ,  C07D277/40 ,  C07D277/46 ,  C07D499/00 ,  C07D501/00 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60 ,  C07D

Abstract: Disclosed are 2-(syn)-hydroxyimino-acetamide derivatives of the formula: wherein Y is hydrogen, hydroxyl, an acyloxy, carbamoyloxy, a quaternary ammonium or a nitrogen-containing heterocyclic ring-substituted thio group; or pharmaceutically acceptable salts or esters thereof are useful as antibacterial agents. Also disclosed are processes for producing them.

公开(公告)号：DE2714419A1

公开(公告)日：1977-10-13

申请号：DE2714419

申请日：1977-03-31

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  YAMAOKA MASAYOSHI ,  MINAMIDA ISAO ,  SHIRAISHI MITSURU ,  NISHIMURA TATSUO

IPC: A61K20060101 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/00 ,  C07D501/04 ,  C07D501/20 ,  C07D501/22 ,  C07D501/24 ,  C07D501/26 ,  C07D501/28 ,  C07D501/34 ,  C07D501/36 ,  C07D501/38 ,  C07D501/46 ,  C07D501/56 ,  C07D501/60

Abstract: A novel cephalosporin derivative of the formula: [wherein X is hydrogen, hydroxyl, acyloxy, alkoxy, carbamoyloxy, quaternary ammonium or a group of the formula -SR1 (where R1 is a nitrogen-containing heterocyclic group)] or a pharmaceutically acceptable salt or ester thereof is found to have potent antibiotic activity against various bacteria, particularly against gram-negative bacteria such as Escherichia coli, Klebsiella pneumoniae, Proteus vulgaris, Proteus mirabilis, Proteus morganii, Proteus rettgeri and Citrobacter freundii.

公开(公告)号：FR2278698A1

公开(公告)日：1976-02-13

申请号：FR7522224

申请日：1975-07-16

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： NUMATA MITSUO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO

IPC: B29C51/00 ,  B29C51/10 ,  B29C51/42 ,  C07D501/04 ,  C07D501/18 ,  C07D501/60

Abstract: 7-Amino-3-cephem-4-carboxylic acids of formula (I) (where R2 is an N-contg. heterocyclic residue), e.g. 7-amino-3-(1-methyl-5-tetrazolyl thiomethyl)-3-cephem-4-carboxylic acid, and their salts and esters are prepd. by reacting 7-(-ketoacylamino cpds. of formula (II): (where R1 is H, lower alkylthio or an N-contg. heterocyclic thio group) or a salt or ester thereof with a cpd. of the formula H2NR3 (III) (where R3 is a hydroxyl gp. or an amino gp. opt. substd. by alkyl or aryl) or a salt thereof. (I) are intermediates for antibiotic cephalosporins. (I) are obtd. in highly pure form.

公开(公告)号：DE2458695A1

公开(公告)日：1975-07-03

申请号：DE2458695

申请日：1974-12-11

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： TERAO SHINJI ,  SHIRAISHI MITSURU ,  MIYAWAKI TOSHIO ,  MINAMIDA ISAO ,  YAMAOKA MASAYOSHI ,  NUMATA MITSUO

IPC: C07D501/24 ,  A61K31/43 ,  A61K31/545 ,  A61K31/546 ,  A61P31/04 ,  C07D20060101 ,  C07D501/04 ,  C07D501/38 ,  C07D501/50 ,  C07D501/52 ,  C07D501/54 ,  C07D501/60

Abstract: 1463999 Cephalosporin derivatives TAKEDA YAKUHIN KOGYO KK 19 Dec 1974 [20 Dec 1973] 54952/74 Heading C2C Novel compounds I (in which R 1 is acyl and R 2 is alkylene optionally substituted by 1-6C alkoxy) and salts thereof are prepared by reacting a lactol of Formula II or an alkyl or acyl derivative thereof with a compound III or a salt thereof or by acylation of a compound IV Compounds II may be prepared by cyclization of compounds V using a hexavalent chromium compound. The compounds V may be prepared by reaction of the corresponding 3-acetoxymethyl cephem compound with lipase. Pharmaceutical compositions useful as antibiotics comprise a compound I together with a suitable excipient.

公开(公告)号：JP2551393B2

公开(公告)日：1996-11-06

申请号：JP25422294

申请日：1994-09-26

Applicant: TAKEDA CHEMICAL INDUSTRIES LTD

Inventor： MINAMIDA ISAO ,  IWANAGA KOICHI ,  OKAUCHI TETSUO

IPC: C07D213/61 ,  A01N33/18 ,  A01N35/08 ,  A01N43/40 ,  A01N43/42 ,  A01N43/60 ,  A01N43/78 ,  A01N47/24 ,  A01N55/00 ,  C07C211/22 ,  C07C211/29 ,  C07C229/34 ,  C07C243/10 ,  C07C311/50 ,  C07D20060101 ,  C07D213/24 ,  C07D213/38 ,  C07D213/40 ,  C07D213/42 ,  C07D213/64 ,  C07D213/70 ,  C07D213/74 ,  C07D213/77 ,  C07D215/12 ,  C07D215/38 ,  C07D239/26 ,  C07D241/12 ,  C07D277/20 ,  C07D277/22 ,  C07D277/28 ,  C07D277/32 ,  C07D277/38 ,  C07D277/42 ,  C07D295/13 ,  C07D295/30 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D403/14 ,  C07D413/12 ,  C07D413/14 ,  C07D417/12 ,  C07D417/14 ,  C07F7/08