公开(公告)号：US09855687B2

公开(公告)日：2018-01-02

申请号：US14865940

申请日：2015-09-25

Applicant: Yung-Chieh Tan

Inventor： Yung-Chieh Tan

IPC: B29C44/38 ,  B29C33/00 ,  B29C39/24 ,  B29C39/26 ,  B29C39/42 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B81C1/00 ,  B82Y30/00 ,  B26F1/26 ,  B26F1/28 ,  B26F3/00 ,  B01D39/00 ,  B29C31/04 ,  B29L31/00 ,  B29L31/14

CPC classification number: B29C44/385 ,  B01D39/00 ,  B26F1/26 ,  B26F1/28 ,  B26F3/004 ,  B29C31/042 ,  B29C33/0033 ,  B29C39/24 ,  B29C39/26 ,  B29C39/42 ,  B29C41/12 ,  B29C41/36 ,  B29C41/38 ,  B29C2793/0045 ,  B29L2031/14 ,  B29L2031/737 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00373 ,  B82Y30/00

Abstract: Methods of and devices for manufacturing a multi-layered microfluidic filter are disclosed. In one embodiment, method of manufacturing a multi-layered filter comprises providing a first molding plate that includes a plurality of apertures and is coupled to a flow stream source, applying from the flow stream source a first flow stream to pass through the plurality of apertures of the first molding plate, forming a first membrane layer comprising a first set of pores using the first molding plate and the first flow stream, controlling the first flow stream to generate a second flow stream from the first set of pores of the first membrane layer, and forming a second membrane layer comprising a second set of pores using the second flow stream and the first membrane layer.

公开(公告)号：US09771267B2

公开(公告)日：2017-09-26

申请号：US14040582

申请日：2013-09-27

Applicant: Tsinghua University ,  HON HAI PRECISION INDUSTRY CO., LTD.

Inventor： Yang Wei ,  Liang Liu ,  Shou-Shan Fan

IPC: C01B31/02 ,  D01F9/12 ,  B81C1/00 ,  B82Y30/00 ,  B82Y40/00

CPC classification number: C01B32/168 ,  B81B2201/055 ,  B81C1/00111 ,  B82Y30/00 ,  B82Y40/00 ,  C01B32/162 ,  C01B2202/02 ,  C01B2202/04 ,  C01B2202/06 ,  C01B2202/08 ,  C01B2202/34 ,  C01B2202/36 ,  Y10T428/2982

Abstract: A method for manufacturing a carbon nanotube needle is provided. A carbon nanotube film comprising of a plurality of commonly aligned carbon nanotubes, a first electrode, and a second electrode are provided. The carbon nanotube film is fixed to the first electrode and the second electrode. An organic solvent is applied to treat the carbon nanotube film to form at least one carbon nanotube string. A voltage is applied to the carbon nanotube string until the carbon nanotube string snaps.

公开(公告)号：US20170071540A1

公开(公告)日：2017-03-16

申请号：US15261648

申请日：2016-09-09

Applicant: University of Utah Research Foundation

Inventor： Sandeep Negi ,  Rajmohan Bhandari ,  Mobashir Hasan Shandi

IPC: A61B5/00 ,  B81C1/00 ,  G03F7/20 ,  A61N1/05 ,  C25D5/34 ,  B81B1/00 ,  A61B5/04

CPC classification number: A61B5/685 ,  A61B5/04001 ,  A61B2562/0209 ,  A61B2562/046 ,  A61B2562/125 ,  A61N1/05 ,  A61N1/0502 ,  B81B1/008 ,  B81B2201/055 ,  B81C1/00111 ,  C25D1/003 ,  C25D1/08 ,  C25D5/34

Abstract: A high aspect ratio shadow mask and a method of making and using the high aspect ratio shadow mask can provide multiple conductive trace pathways along high aspect ratio electrodes. The high aspect ratio shadow mask can include a substantially planar base layer and a plurality of hollow high aspect ratio projections extending from the substantially planar base layer. The high aspect ratio shadow mask can further include a plurality of openings along the hollow projections which define trace deposition patterns.

Abstract translation: 高宽比荫罩和制造和使用高宽比荫罩的方法可以提供沿着高纵横比电极的多个导电迹线路径。 高宽比荫罩可以包括基本上平坦的基底层和从基本平坦的基底层延伸的多个中空高宽比突起。 高纵横比荫罩还可以包括沿着中空突起的多个开口，这些开口限定了微量沉积图案。

公开(公告)号：US09266718B2

公开(公告)日：2016-02-23

申请号：US13507368

申请日：2012-06-22

Applicant: Astrid Cachemaille ,  Francois Cannehan

Inventor： Astrid Cachemaille ,  Francois Cannehan

IPC: B81C1/00 ,  A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  Y10T29/49826 ,  Y10T428/24479

Abstract: An out-of-plane microneedle manufacturing process comprises the simultaneous creation of a network of microneedles and the creation of a polygonal shaped hat above each microneedle under formation. The process comprises the following steps: providing bridges between the hats, maintaining the bridges during the remaining microneedle manufacturing steps, removing the bridges, together with the hats, when the microneedles are formed.

Abstract translation: 平面外的微针制造方法包括同时创建微针网络并在形成之前在每个微针上方形成多边形帽。 该方法包括以下步骤：在所述帽子之间提供桥梁，在剩余的微针制造步骤期间保持桥梁，当形成微针时，与帽子一起去除桥梁。

公开(公告)号：US20150374966A1

公开(公告)日：2015-12-31

申请号：US14767073

申请日：2014-02-11

Applicant: CONSIGLIO NAZIONALE DELLE RICERCHE ,  FONDAZIONE ISTITUTO ITALIANO DI TECNOLOGIA

Inventor： PIETRO FERRARO ,  SARA COPPOLA ,  ANDREA FINIZIO ,  SIMONETTA GRILLI ,  VERONICA VESPINI ,  PAOLO ANTONIO NETTI ,  RAFFAELE VECCHIONE ,  ELIANA ESPOSITO

IPC: A61M37/00 ,  B29C59/02

CPC classification number: A61M37/0015 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C37/0053 ,  B29C59/025 ,  B29L2031/7544 ,  B81B2201/055 ,  B81C1/00111

Abstract: There is described a method for making an array of micro-needles, comprising the steps of: depositing a plurality of drops of a liquid substance comprising a polymer on a surface of a starting substrate; positioning a pyroelectric substrate at a certain distance from the starting substrate in such a way that the drops deposited are positioned between said surface of the starting substrate and a surface of the pyroelectric substrate; varying the temperature of the pyroelectric substrate or a part thereof to induce on said surface of the pyroelectric substrate a charge density such that starting from the drops deposited, under the effect of an electrodynamic force, respective cones are formed having a tip facing towards the pyroelectric substrate; determining a consolidation of the cones, to form said micro-needles, preventing the tip of said cones from contacting said surfaces of the pyroelectric substrate.

Abstract translation: 描述了制造微针阵列的方法，包括以下步骤：在起始衬底的表面上沉积多个包含聚合物的液体物质滴; 将热电基板定位在与起始衬底相距一定距离处，使得沉积的液滴位于起始衬底的所述表面和热电衬底的表面之间; 改变热电衬底或其一部分的温度以在热释电衬底的所述表面上诱导电荷密度，使得在电动力作用下从沉积的液滴开始形成相应的锥体，其顶端面向热电 基质; 确定锥体的固结，以形成所述微针，防止所述锥体的尖端接触热电基底的所述表面。

公开(公告)号：US20150224294A1

公开(公告)日：2015-08-13

申请号：US14508451

申请日：2014-10-07

Applicant: The University of Queensland

Inventor： Mark Anthony Fernance KENDALL ,  Derek William Kenneth JENKINS

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61K9/0021 ,  A61K9/0097 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0053 ,  B81B2201/055 ,  B81C1/00111 ,  H01J37/32009 ,  H01J37/3244 ,  H01J2237/334

Abstract: A method of producing projections on a patch including providing a mask on a substrate and etching the substrate using an etchant and a passivant to thereby control the etching process and form the projections, wherein the passivant does not include oxygen.

Abstract translation: 一种在贴片上制造突起的方法，包括在基片上提供掩模，并使用蚀刻剂和钝化剂蚀刻基底，从而控制蚀刻工艺并形成突起，其中钝化剂不包括氧。

公开(公告)号：US20140296780A1

公开(公告)日：2014-10-02

申请号：US14231267

申请日：2014-03-31

Applicant: Bradley Lyon ,  Adrianus I. Aria ,  Masoud Beizai ,  Morteza Gharib

Inventor： Bradley Lyon ,  Adrianus I. Aria ,  Masoud Beizai ,  Morteza Gharib

IPC: A61M37/00

CPC classification number: A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C1/00031

Abstract: Composite CNT microneedle fabrication and finally-constructed delivery device embodiments are described. The microneedles can provide a self-administered, painless alternative to standard hypodermic injection.

Abstract translation: 描述了复合CNT微针制造和最终构造的输送装置实施例。 微针可以为标准皮下注射提供自我施用，无痛的替代方案。

公开(公告)号：US08137736B2

公开(公告)日：2012-03-20

申请号：US12348589

申请日：2009-01-05

Applicant: Mingwei Zhu ,  Yanfeng Chen ,  Zhenlin Wang ,  Yanqing Lu ,  Haixiong Ge ,  Yuefeng Tang

Inventor： Mingwei Zhu ,  Yanfeng Chen ,  Zhenlin Wang ,  Yanqing Lu ,  Haixiong Ge ,  Yuefeng Tang

IPC: B05D3/12

CPC classification number: B81C1/00476 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B81B2201/055 ,  B81B2203/0338 ,  B81B2203/0361 ,  B81C2201/0108

Abstract: A novel method suitable for commercially mass production of hollow microneedle with high quality for delivery of drugs across or into biological tissue is provided. It typically includes the following processes: (1) coating an elongated template of a first material with a second material to form a cover; (2) removing tips of the template and cover to form an opening in the cover; and (3) removing the template of the first material to obtain hollow microneedles of the second material. This simple, efficient and cost-effective fabrication method can mass produce hollow microneedle arrays involving no complicated and expensive equipments or techniques, which can be used in commercial fabrication of hollow needles for delivering drugs or genes across or into skin or other tissue barriers with advantages of minimal damage, painless, long-term and continuous usages.

Abstract translation: 提供了一种适用于商业上大规模生产用于将药物跨越或进入生物组织的高品质的中空微针的新方法。 它通常包括以下过程：（1）用第二材料涂覆第一材料的细长模板以形成盖子; （2）去除模板和盖子的尖端以在盖子上形成开口; 和（3）去除第一材料的模板以获得第二材料的中空微针。 这种简单，高效和成本有效的制造方法可以大规模生产中空微针阵列，其不涉及复杂而昂贵的设备或技术，其可用于商业制造用于将药物或基因跨越或进入皮肤或其它组织屏障的中空针 最小的伤害，无痛，长期和持续的使用。

公开(公告)号：US07981346B2

公开(公告)日：2011-07-19

申请号：US11661113

申请日：2005-08-30

Applicant: Patrick Griss ,  Göran Stemme

Inventor： Patrick Griss ,  Göran Stemme

IPC: B28B1/14 ,  B28B1/48 ,  A61M35/00

CPC classification number: B29C45/2628 ,  A61K9/0021 ,  A61M37/0015 ,  A61M2037/003 ,  A61M2037/0053 ,  B29C2045/0094 ,  B81B2201/055 ,  B81B2203/0361 ,  B81C99/0085 ,  B81C2201/034

Abstract: Method of hollow micro-projections having side walls and at least one opening in a side wall, by a molding technique. The hollow micro-projections are defined by a first, negative mold defining the exterior shape of the micro-projections and a second, positive mold defining the hollow interior shape of the micro-projections. The method includes injecting a moldable material into the space between the two molds, in a state where they have been brought together. The positive and negative molds each have an essentially cylindrical geometry. In the process of bringing the molds together, the mold halves are laterally off-set with respect to each other, such that the distance between an inner wall of the negative mold and the positive mold in the area, ranges from zero to a finite distance. Micro-projections and arrays of micro-projections are also disclosed.

Abstract translation: 通过成型技术的具有侧壁和侧壁中的至少一个开口的中空微型突起的方法。 中空微突起由限定微突起的外部形状的第一负模具和限定微突起的中空内部形状的第二正模定义。 该方法包括将可模塑材料注入到两个模具之间的空间中，并将它们合并在一起。 正负模具各自具有基本上圆柱形的几何形状。 在将模具合在一起的过程中，半模相对于彼此横向偏移，使得阴模的内壁和该区域中的正模之间的距离从零到有限距离 。 还公开了微突起和微突起的阵列。

公开(公告)号：US20110011827A1

公开(公告)日：2011-01-20

申请号：US12621594

申请日：2009-11-19

Applicant: Dae Sik LEE ,  Hyun Woo SONG ,  Moon Youn JUNG ,  Seon Hee PARK

Inventor： Dae Sik LEE ,  Hyun Woo SONG ,  Moon Youn JUNG ,  Seon Hee PARK

IPC: B44C1/22

CPC classification number: A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0046 ,  A61M2037/0053 ,  B29C33/3842 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111

Abstract: Provided is a method of manufacturing a hollow microneedle structure. The method includes forming an injection mold having a through hole, filling the injection mold with a photoresist formed of a viscous material, and extruding the photoresist from the injection mold through the through hole, solidifying the extruded photoresist to form a needle-type photoresist structure, forming a seed layer on the surface of the photoresist structure, forming a metal plated layer on the seed layer, inclining an end tip of the photoresist structure having the metal plated layer, and removing the photoresist from the metal plated layer to form a hollow. Thus, the hollow microneedle structure can be manufactured to have such diameter, length, hardness, and inclination angle as to minimize pain. The hollow microneedle structure can be combined with an apparatus for detecting a biomaterial or injecting cosmetic substances or medicines, and variously applied.

Abstract translation: 提供一种制造中空微针结构的方法。 该方法包括形成具有通孔的注射模具，用由粘性材料形成的光致抗蚀剂填充注射模具，并且通过通孔从注射模具中挤出光致抗蚀剂，固化挤出的光致抗蚀剂以形成针型光致抗蚀剂结构 在光致抗蚀剂结构的表面上形成种子层，在种子层上形成金属镀层，使具有金属镀层的光致抗蚀剂结构的末端倾斜，从金属镀层除去光致抗蚀剂，形成中空 。 因此，可以制造中空微针结构以具有使疼痛最小化的直径，长度，硬度和倾斜角度。 中空微针结构可以与用于检测生物材料或注射化妆品物质或药物的装置组合，并进行各种应用。