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    Plastic microchip for microparticle analysis and method for manufacturing the same
    72.
    发明申请
    Plastic microchip for microparticle analysis and method for manufacturing the same 审中-公开
    用于微粒分析的塑料微芯片及其制造方法

    公开(公告)号：US20070238164A1

    公开(公告)日：2007-10-11

    申请号：US11732979

    申请日：2007-04-05

    Applicant: Hyun Jin Kim

    Inventor： Hyun Jin Kim

    IPC: C12M1/34 ,  H01L21/00

    CPC classification number: G01N15/1484 ,  B01L3/502707 ,  B01L2200/12 ,  B81B2201/058 ,  B81C1/00119 ,  B81C2201/019 ,  B81C2201/036 ,  G01N15/1459 ,  G01N15/1463 ,  G01N2015/1486

    Abstract: Disclosed herein is a plastic microchip used in counting the number of microparticles and a method for manufacturing the same and, more particularly, to a plastic microchip including a negative microgrid pattern formed on a lower substrate, a solvent channel and solvent inlets for a solvent welding process, and a method for manufacturing the plastic microchip by injection molding the lower substrate on which a negative microgrid pattern is formed and by injecting a solvent through the solvent inlets so as to fix an upper substrate to the lower substrate.According to the present invention, it is possible to form a microgrid pattern of a relatively narrow width deeply and uniformly as a negative microgrid pattern is formed on the lower substrate and thereby to provide a clear microgrid pattern, thus facilitating accurate observation of microparticles. Moreover, it is also possible to provide a uniform height of an injection chamber by welding an upper substrate and a lower substrate to each other by a solvent welding process, thus ensuring a more accurate analysis result.

    Abstract translation: 本文公开了用于计数微粒数量的塑料微芯片及其制造方法，更具体地，涉及一种塑料微芯片，其包括形成在下基板上的负微阵列图案，溶剂通道和用于溶剂焊接的溶剂入口 工艺，以及通过注射模制形成负微型格栅图案的下基板并通过溶剂入口注入溶剂以将上基板固定到下基板来制造塑料微芯片的方法。 根据本发明，由于在下基板上形成负的微格栅图案，所以可以深度均匀地形成相对较窄宽度的微网格图案，从而提供清晰的微网格图案，从而有助于微粒的准确观察。 而且，也可以通过溶剂焊接工艺将上部基板和下部基板相互焊接来提供喷射室的均匀高度，从而确保更准确的分析结果。

    Microfluidic device and manufacture thereof
    74.
    发明授权
    Microfluidic device and manufacture thereof 有权
    微流控装置及其制造

    公开(公告)号：US06769444B2

    公开(公告)日：2004-08-03

    申请号：US10454985

    申请日：2003-06-04

    Applicant: Guillaume Guzman ,  Jean-Pierre Themont

    Inventor： Guillaume Guzman ,  Jean-Pierre Themont

    IPC: F15C106

    CPC classification number: B81C1/00119 ,  B01L3/5027 ,  B33Y70/00 ,  B33Y80/00 ,  B81B2201/058 ,  B81B2203/0353 ,  B81C1/00071 ,  B81C2201/019 ,  B81C2201/036 ,  C03B19/063 ,  C03B23/20 ,  Y10T137/0391 ,  Y10T137/0402 ,  Y10T137/2224 ,  Y10T137/6416

    Abstract: The present invention relates to microfluidic devices and to their method of manufacture. The microfluidic devices are original by their specific structure (of sandwich type) and by the materials from which they are made (mainly glasses, glass ceramics, ceramics), and also by their specific method of manufacture, which is based on a vacuum-forming operation. The microfluidic device includes a first assembly including a microstructure and a first substrate, wherein the microstructure is constructed and arranged on the substrate under vacuum. A second assembly includes a second substrate positioned on the microstructure after the first assembly is presintered and adhered thereto by heat treatment to form a one-piece microstructure defining at least one recess between the first and second substrates.

    Abstract translation: 本发明涉及微流体装置及其制造方法。 微流体装置通过它们的具体结构（夹心型）和它们制备的材料（主要是玻璃，玻璃陶瓷，陶瓷）以及它们的具体制造方法是原始的，其基于真空成形 操作。 微流体装置包括包括微结构和第一基底的第一组件，其中微结构在真空下构造和布置在基底上。 第二组件包括位于微结构体上的第二衬底，该第一衬底经预热烧结并通过热处理粘附在微结构上，以形成限定第一和第二衬底之间的至少一个凹部的一体式微结构。

    Nano-size imprinting stamp using spacer technique
    75.
    发明授权
    Nano-size imprinting stamp using spacer technique 有权
    使用间隔技术的纳米尺寸印记邮票

    公开(公告)号：US06743368B2

    公开(公告)日：2004-06-01

    申请号：US10062952

    申请日：2002-01-31

    Applicant: Heon Lee

    Inventor： Heon Lee

    IPC: B32B300

    CPC classification number: B29C59/022 ,  B29C2059/023 ,  B81C99/009 ,  B81C2201/036 ,  B82Y10/00 ,  B82Y40/00 ,  G03F7/0002 ,  Y10T428/24479 ,  Y10T428/2457 ,  Y10T428/24579 ,  Y10T428/24595

    Abstract: A wide-area nano-size imprinting stamp is disclosed. The wide-area nano-size imprinting stamp includes a substrate having a base surface upon which is formed a plurality of micro-features. Each micro-feature includes a plurality of spacers disposed on opposed side surfaces thereof. The spacers extend laterally outward of the opposed side surfaces and the micro-features and the spacers extend outward of the base surface. The micro-features and the spacers are selectively etched to differing heights to define an imprint stamp having an imprint profile. The imprint stamps can be formed on substantially all of a useable area of the substrate and can have complex shapes that vary among the imprint stamps. The imprint stamps can be used as a template for transferring the imprint profile to a mask layer in which the imprint profile will be replicated.

    Abstract translation: 公开了一种广域纳米尺寸印记。 广域纳米尺寸压印印模包括具有基面的基底，在其上形成多个微特征。 每个微特征包括设置在其相对侧表面上的多个间隔物。 间隔件在相对的侧表面的横向外侧延伸，并且微特征和间隔件从基部表面向外延伸。 微特征和间隔物被选择性地蚀刻到不同的高度以限定具有印记轮廓的压印印模。 压印邮票可以形成在基板的基本上所有的可用区域上，并且可以具有在压印邮票之间变化的复杂形状。 印记戳可用作模板，用于将压印轮廓传送到掩模层，在该掩模层中可以复制压印轮廓。

    Method of patterning the surface of an article using positive microcontact printing
    76.
    发明申请
    Method of patterning the surface of an article using positive microcontact printing 有权
    使用正微接触印刷图案化制品表面的方法

    公开(公告)号：US20040102050A1

    公开(公告)日：2004-05-27

    申请号：US10307069

    申请日：2002-11-27

    Applicant: International Business Machines Corporation

    Inventor： Emmanuel Delamarche ,  Matthias Geissler ,  Heiko Wolf

    IPC: H01L021/461

    CPC classification number: G03F7/0002 ,  B81C1/0046 ,  B81C2201/036 ,  B82Y10/00 ,  B82Y30/00 ,  B82Y40/00 ,  C23F1/02

    Abstract: A method is disclosed of patterning the surface of an object. The method comprises the steps of providing an object comprising a substrate having at least one layer formed thereon; forming a first SAM on the layer according to a desired pattern of a first material capable of binding to the layer; forming a second SAM of a second material on a region of the layer that is not covered by the first SAM, in a configuration that is complementary to the desired pattern; and etching the layer through the first SAM. The first material is selected to prevent the formation of the second SAM on the first SAM and to substantially not block the etching of an underlying region of the layer therethrough.

    Abstract translation: 公开了对物体的表面进行图案化的方法。 该方法包括以下步骤：提供包括其上形成有至少一层的基板的物体; 根据能够结合所述层的第一材料的期望图案，在所述层上形成第一SAM; 在所述层的未被所述第一SAM覆盖的区域上形成与所述图案互补的构造的第二材料的第二SAM; 并通过第一SAM蚀刻该层。 选择第一材料以防止在第一SAM上形成第二SAM，并且基本上不阻挡通过其中的层的下部区域的蚀刻。

    Apparatus and method for manufacturing an intracutaneous microneedle array
    78.
    发明申请
    Apparatus and method for manufacturing an intracutaneous microneedle array 有权
    用于制造皮内微针阵列的装置和方法

    公开(公告)号：US20020020688A1

    公开(公告)日：2002-02-21

    申请号：US09956520

    申请日：2001-09-19

    Applicant: The Procter & Gamble Company

    Inventor： Faiz Feisal Sherman ,  Vadim Vladimirovich Yuzhakov ,  Vladimir Gartstein ,  Grover David Owens

    IPC: C23F001/00 ,  B29C069/00

    CPC classification number: B29C51/082 ,  A61M37/00 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/003 ,  A61M2037/0053 ,  B26F1/24 ,  B29C33/0033 ,  B29C33/42 ,  B29C37/0053 ,  B29C45/2628 ,  B29C51/00 ,  B29C2059/023 ,  B29L2031/7544 ,  B29L2031/756 ,  B81B2201/055 ,  B81C1/00111 ,  B81C2201/036

    Abstract: One embodiment of a microneedle array is constructed of silicon and silicon dioxide compounds using MEMS technology and standard microfabrication techniques to create hollow cylindrical individual microneedles. The resulting array of microneedles is designed to penetrate the stratum corneum and epidermis layers of skin, but not into the dermis. In a second embodiment, an array of hollow (or solid) microneedles are constructed of molded plastic, in which a micro-machining technique is used to fabricate the molds used in a plastic microforming process. Such molds contain a micropillar array and/or microhole array. The manufacturing procedures for creating plastic arrays of microneedles include: nullself-molding,null micromolding, microembossing, and microinjection techniques. In the nullself-moldingnull method, a plastic (e.g., polymer) film is placed on a micropillar array, the plastic is then heated, and plastic deformation due to gravitational force causes the plastic film to deform and create the microneedle structure. Using this procedure, only a single mold-half is required. When using the micromolding technique, a similar micropillar array is used along with a second mold-half, which is then closed over the plastic film to form the microneedle structure. The micro-embossing method uses a single mold-half that contains an array of micropillars and conical cut-outs (microholes) which is pressed against a flat surface (which essentially acts as the second mold-half) upon which the plastic film is initially placed. In the microinjection method, a molten plastic substance is injected between two micro-machined molds that contain microhole and micropillar arrays.

    Abstract translation: 微针阵列的一个实施例由使用MEMS技术和标准微细加工技术的硅和二氧化硅化合物构成以产生中空圆柱形单独的微针。 所得的微针阵列被设计成穿透皮肤角质层和表皮层，但不能穿入真皮层。 在第二实施例中，空心（或固体）微针阵列由模制塑料构成，其中使用微加工技术来制造用于塑料微成型工艺中的模具。 这种模具包含微柱阵列和/或微孔阵列。 用于制造微针的塑料阵列的制造方法包括：“自成型”，微胶印，微压印和显微注射技术。 在“自成型”方法中，将塑料（例如，聚合物）膜放置在微柱阵列上，然后加热塑料，并且由于重力引起的塑性变形导致塑料膜变形并产生微针结构。 使用此程序，只需要一个半模。 当使用微型成型技术时，类似的微柱阵列与第二半模一起使用，然后将其封闭在塑料膜上以形成微针结构。 微压花方法使用单个半模，其包含微柱和圆锥形切口阵列（微孔），其被压靠在最初的塑料膜上的平坦表面（其基本上作为第二半模）上 放置 在显微注射方法中，将熔融塑料物质注入包含微孔和微柱阵列的两个微加工模具之间。

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