公开(公告)号：EP2016394A2

公开(公告)日：2009-01-21

申请号：EP07861282.7

申请日：2007-04-04

Applicant: Singulex, Inc.

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

IPC: G01N21/76 ,  G01N21/64

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供了方法，组合物，试剂盒和系统，用于心脏肌钙蛋白的灵敏的检测。 搜索方法，组合物，试剂盒和系统诊断，预后有重要意义，并在条件治疗方法的决心做了包括心肌肌钙蛋白的释放。

公开(公告)号：EP0193163A2

公开(公告)日：1986-09-03

申请号：EP86102418.0

申请日：1986-02-25

Applicant: Scheller, Klaus

Inventor： Scheller, Klaus

IPC: G01N21/47 ,  G01N21/55

CPC classification number: A61B5/441 ,  A61B5/0059 ,  G01N21/55 ,  G01N2021/3188 ,  G01N2201/062 ,  G01N2201/1247

Abstract: Bei einer Vorrichtung zur Ermittlung einer jeweils akuten Sonnen-schutzfaktorzahl zwecks Auswahl des zum Schutze der Haut geeigneten Sonnenschutzmittels ist in einem Gehäuse mit einer Anzeigeeinrichtung für die Sonnenschutzfaktorzahl eine Energiequelle. vorzugsweise eine Batterie, ein Einschalter sowie eine auf den Braunheitswert der Haut ansprechende Sensoreinrichtung mit einem Meßwertgeber vorgesehen, der über eine elektronische Auswertschaltung mit der Anzeigeeinrichtung in Schaltverbindung steht. Die Anzeigevorrichtung kann außerdem Angaben über die Zeit in Minuten machen, die eine Person ohne Haut- bzw. Sonnenschutzcremes sich der Sonne aussetzen kann.

Abstract translation: 在用于确定用于选择用于保护皮肤的防晒在具有用于防晒系数数目的显示装置的壳体中的适当数量的目的的相应的急性防晒系数的装置是能量的来源。 与设置优选的电池，电源开关以及响应于所述皮肤传感器装置，其经由与电路连通的显示装置的电子求值电路连接的布劳恩单元值的发送器。 显示设备还可以提供关于太阳会暴露一个人没有皮肤或防晒霜的分钟数的信息。

公开(公告)号：EP3156799A1

公开(公告)日：2017-04-19

申请号：EP16186528.2

申请日：2007-04-04

Applicant: Singulex, Inc.

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

IPC: G01N33/53 ,  G01N21/64 ,  G01N33/58 ,  G01N33/68 ,  G01N15/14

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: Disclosed is an analyzer for determining the presence, absence or amount of an analyte in a sample, wherein the analyzer comprises: (a) an electromagnetic radiation source (301) that emits electromagnetic radiation that defines an interrogation space comprising a focused spot of a beam from the electromagnetic radiation source (301); (b) a capillary flow cell (313) for passing a sample through the interrogation space; (c) a source of motive force for moving the sample in the capillary flow cell (313); (d) an electromagnetic radiation detector (309) operatively connected to the interrogation space that detects photons emitted from the interrogation space during a plurality of bins; and (e) a processor (310) operatively connected to the detector (309), wherein the processor determines the presence, absence or amount of an analyte in a sample by:
(i) determining a threshold photon value corresponding to a background signal in the interrogation space, (ii) determining the presence of a photon emitting species comprising or corresponding to the analyte in the interrogation space in each bin of the plurality of bins by identifying bins having a photon value greater than the threshold value, (iii) comparing the number of bins having a photon value greater than the threshold value to a standard curve that is generated using one or more samples of known standard concentrations.

Abstract translation: 公开了一种用于确定样品中分析物的存在，不存在或数量的分析器，其中所述分析仪包括：（a）电磁辐射源（301），其发射限定询问空间的电磁辐射，所述电磁辐射源包括光束的聚焦点 来自所述电磁辐射源（301）; （b）用于使样品通过询问空间的毛细管流通池（313） （c）用于使毛细管流通池中的样品移动的动力源; （d）可操作地连接到询问空间的电磁辐射检测器（309），其在多个箱中检测从询问空间发射的光子; 和（e）可操作地连接到检测器（309）的处理器（310），其中处理器通过以下步骤来确定样品中分析物的存在，不存在或量：（i）确定对应于背景信号的阈值光子值 询问空间，（ii）通过识别具有大于阈值的光子值的箱，确定在多个箱的每个箱中的询问空间中包含或对应于分析物的光子发射物质的存在，（iii）比较 具有大于阈值的光子值的箱数与使用已知标准浓度的一个或多个样品产生的标准曲线。

公开(公告)号：EP2929322A1

公开(公告)日：2015-10-14

申请号：EP13815048.7

申请日：2013-12-04

Applicant: SP3H

Inventor： OBERTI, Sylvain ,  FOURNEL, Johan

IPC: G01N21/35 ,  G01N21/27 ,  G01N21/31

CPC classification number: G01N21/3577 ,  G01N21/274 ,  G01N21/3504 ,  G01N2021/3181 ,  G01N2201/062 ,  G01N2201/0624 ,  G01N2201/121 ,  G01N2201/1211 ,  G01N2201/124 ,  G01N2201/1242 ,  G01N2201/1247 ,  G01N2201/127 ,  G01N2201/12723

Abstract: The invention relates to a method of controlling a product analysis spectrometer, the spectrometer comprising a light source (LS) comprising several light-emitting diodes (LD1-LD4) having respective emission spectra covering in combination a band of analysis wavelengths, the method comprising steps consisting in: providing a supply current (I1-I4) to at least one of the light-emitting diodes so as to illuminate it, measuring a luminous intensity (LFL1- LFL4) emitted by the light source by measuring a current at a terminal of at least one other of the light-emitting diodes which is kept unlit, determining as a function of each measurement of luminous intensity a setpoint value (LC1-LC4) of the supply current for each lit diode, and regulating the supply current for each lit diode so that it corresponds to the setpoint value.

公开(公告)号：EP2472258A3

公开(公告)日：2012-11-28

申请号：EP11188077.9

申请日：2007-04-04

Applicant: Singulex, Inc. ,  The Regents of the University of California

Inventor： Goix, Philippe ,  Puskas, Robert ,  Todd, John ,  Livingston, Richard ,  Held, Douglas ,  Wu, Alan H.

IPC: G01N33/53 ,  G01N33/68 ,  G01N33/58 ,  G01N21/64

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供了用于敏感检测心脏肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统可用于涉及心肌肌钙蛋白释放的病症的诊断，预后和治疗方法的确定。

公开(公告)号：EP2002260A4

公开(公告)日：2009-08-05

申请号：EP07754941

申请日：2007-04-04

Applicant: SINGULEX INC

Inventor： GOIX PHILIPPE ,  PUSKAS ROBERT ,  TODD JOHN ,  LIVINGSTON RICHARD ,  HELD DOUGLAS

IPC: G01N33/53

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

Abstract translation: 本发明提供用于敏感检测心肌肌钙蛋白的方法，组合物，试剂盒和系统。 这些方法，组合物，试剂盒和系统可用于涉及心肌肌钙蛋白释放的病症中的治疗方法的诊断，预后和测定。

公开(公告)号：EP2002260A2

公开(公告)日：2008-12-17

申请号：EP07754941.8

申请日：2007-04-04

Applicant: Singulex, Inc.

Inventor： GOIX, Philippe ,  PUSKAS, Robert ,  TODD, John ,  LIVINGSTON, Richard ,  HELD, Douglas

IPC: G01N33/53

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/577 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  G01N2800/52 ,  Y10T436/105831

Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin. Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.

公开(公告)号：EP0193163A3

公开(公告)日：1986-12-03

申请号：EP86102418

申请日：1986-02-25

Applicant: Scheller, Klaus

Inventor： Scheller, Klaus

IPC: G01N21/47 ,  G01N21/55

CPC classification number: A61B5/441 ,  A61B5/0059 ,  G01N21/55 ,  G01N2021/3188 ,  G01N2201/062 ,  G01N2201/1247

Abstract: Bei einer Vorrichtung zur Ermittlung einer jeweils akuten Sonnen-schutzfaktorzahl zwecks Auswahl des zum Schutze der Haut geeigneten Sonnenschutzmittels ist in einem Gehäuse mit einer Anzeigeeinrichtung für die Sonnenschutz faktorzahl eine Energiequelle. vorzugsweise eine Batterie, ein Einschalter sowie eine auf den Braunheitswert der Haut ansprechende Sensoreinrichtung mit einem Meßwertgeber vorgesehen, der über eine elektronische Auswertschaltung mit der Anzeigeeinrichtung in Schaltverbindung steht. Die Anzeigevorrichtung kann außerdem Angaben über die Zeit in Minuten machen, die eine Person ohne Haut- bzw. Sonnenschutzcremes sich der Sonne aussetzen kann.

公开(公告)号：JP6001028B2

公开(公告)日：2016-10-05

申请号：JP2014200798

申请日：2014-09-30

Applicant: シングレックス,インコーポレイテッド

Inventor： ゴイックス,フィリッペ ,  プスカシュ,ロバート ,  トッド,ジョン ,  リビングストン,リチャード ,  ヘルド,ダグラス

IPC: G01N33/53 ,  G01N33/536 ,  G01N33/543 ,  G01N21/78 ,  G01N15/14 ,  C09K11/06 ,  G01N21/64

CPC classification number: G01N33/6887 ,  G01N15/06 ,  G01N15/1459 ,  G01N21/6428 ,  G01N33/582 ,  G01N2015/0693 ,  G01N2015/1006 ,  G01N2015/1486 ,  G01N2201/1247 ,  G01N2201/12761 ,  G01N2800/32 ,  G01N2800/324 ,  Y10T436/105831

公开(公告)号：JP2009264868A

公开(公告)日：2009-11-12

申请号：JP2008113584

申请日：2008-04-24

Applicant: Ushio Inc ,  ウシオ電機株式会社

Inventor： TOMITA MAMORU

IPC: G01N21/77 ,  G01N33/49 ,  G01N35/02 ,  G01N37/00

CPC classification number: G01N21/07 ,  G01N21/59 ,  G01N35/00584 ,  G01N35/025 ,  G01N2035/00148 ,  G01N2201/0415 ,  G01N2201/0446 ,  G01N2201/1247

Abstract: PROBLEM TO BE SOLVED: To make it possible to obtain the quantity of light required for measurement and to enable high-precision measurement, even if a rotary body or the like is deformed due to a change in an environmental temperature or the like.
SOLUTION: As an initializing processing which is performed before a μTAS chip holding a sample (blood) is set, a measuring chamber is heated to a preset temperature by a heating means 35. A rotational position where a light value of the light received at a light-receiving part 43 through an aperture part 23 reaches a threshold value or more is sought while a rotary body 25 is rotated by a minute amount, and the rotational position is stored as a measurement position. Next, the μTAS chip is set to a chip holding part 22, and a processing before measurement, which includes weighing of a sample liquid in the μTAS chip, mixing of the sample liquid and a reagent, delivering a measurement liquid to a measuring area or the like, is performed. Then the rotary body 25 is rotated to the measurement position, a light from a light source 41 is introduced into the measuring area of the μTAS chip through the aperture 23, the light passing through the measuring area is received by the light-receiving part 43, and thus absorbance of this measurement liquid is measured.
COPYRIGHT: (C)2010,JPO&INPIT

Abstract translation: 要解决的问题为了使得可以获得测量所需的光量并且能够进行高精度测量，即使旋转体等由于环境温度等的变化而变形 。

解决方案：作为在设置保持样品（血液）的μTAS芯片之前进行的初始化处理，通过加热装置35将测量室加热到预设温度。光的光值 当旋转体25旋转微小时，在光接收部分43处通过孔部分23被接收达到阈值或更大，并且旋转位置被存储为测量位置。 接下来，将μTAS芯片设置为芯片保持部22，以及测量前的处理，包括称量μTAS芯片中的样品液体，将样品液体和试剂混合，将测量液体输送到测量区域，或 等等。 然后旋转体25旋转到测量位置，来自光源41的光通过孔23被引入μTAS芯片的测量区域中，通过测量区域的光被光接收部分43接收 ，测定该测定液的吸光度。 版权所有（C）2010，JPO＆INPIT