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公开(公告)号：CA2648385C
公开(公告)日：2020-09-01
申请号：CA2648385
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin.
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2.发明专利
公开(公告)号：AU2007313488A1
公开(公告)日：2008-04-24
申请号：AU2007313488
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： PUSKAS ROBERT , HELD DOUGLAS , GOIX PHILIPPE , LIVINGSTON RICHARD , TODD JOHN
Abstract: The invention provides methods for diagnosing, predicting or prognosing acute myocardial infarction in an individual based on the sensitive detection of cardiac troponin.
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公开(公告)号：ES2560864T3
公开(公告)日：2016-02-23
申请号：ES07754941
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
IPC: G01N33/53
Abstract: Un método para determinar la presencia o ausencia de una única molécula de troponina, o un fragmento o complejo de la misma, en una muestra, que comprende: i) marcar dicha molécula, fragmento o complejo con una etiqueta que comprende una unidad estructural fluorescente; y ii) detectar la presencia o ausencia de dicha etiqueta haciendo pasar dicha etiqueta a través de una única molécula de detección, en donde la detección de la presencia de dicha etiqueta indica la presencia de dicha única molécula, fragmento o complejo de troponina en dicha muestra; y en donde dicha detección es capaz de detectar dicha única molécula de troponina en un límite de detección de menos 3 pg/mL con un coeficiente de variación (CV) de 10% o menos.
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4.发明专利
公开(公告)号：CA2648382C
公开(公告)日：2016-10-11
申请号：CA2648382
申请日：2007-04-04
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Abstract: Disclosed are methods, kits, and compositions for fluorescent detection of single biomolecules, e.g. proteins, using highly sensitive fluorescent dyes and a flow cell with one interrogation space for irradiation by focused laser beam. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
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公开(公告)号：AU2014200749B2
公开(公告)日：2016-04-14
申请号：AU2014200749
申请日：2014-02-12
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. WO 2007/114947 PCT/US2007/008506 30 3 7 0 630 5 Figure 1A
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Patent Agency Ranking
公开(公告)号：HK1163818A1
公开(公告)日：2012-09-14
申请号：HK12104461
申请日：2012-05-08
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
IPC: G01N20060101
Abstract: The invention provides methods for diagnosing, predicting or prognosing acute myocardial infarction in an individual based on the sensitive detection of cardiac troponin.
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7.发明申请METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 审中-公开标记物敏感性分析方法与组合物及分子检测
公开(公告)号：WO2008048371A2
公开(公告)日：2008-04-24
申请号：PCT/US2007008394
申请日：2007-04-04
Applicant: SINGULEX INC , GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
CPC classification number: G01N33/6887 , G01N15/06 , G01N15/1459 , G01N21/6428 , G01N33/577 , G01N33/582 , G01N2015/0693 , G01N2015/1006 , G01N2015/1486 , G01N2201/1247 , G01N2201/12761 , G01N2800/32 , G01N2800/324 , G01N2800/52 , Y10T436/105831
Abstract: Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution.
Abstract translation: 公开了用于分子的高灵敏度检测的方法，试剂盒和组合物。 方法，试剂盒和组合物可用于测定样品中分子的浓度为1飞摩尔，1 attomolar或更低的水平。 方法，试剂盒和组合物还允许在宽范围内测定浓度，例如7-log范围，而不需要样品稀释。
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公开(公告)号：ES2703813T3
公开(公告)日：2019-03-12
申请号：ES16193284
申请日：2007-04-04
Applicant: SINGULEX INC , UNIV CALIFORNIA
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN H
IPC: G01N33/68
Abstract: Un método para determinar un diagnóstico o pronóstico en un individuo que comprende: (i) medir la concentración de troponina cardiaca I (cTnI) a partir de una muestra de suero del individuo, en el que dicha concentración se determina mediante un ensayo de cTnI con un límite de detección para dicha cTnI en dicha muestra de menos de 5 pg/ml; (ii) comparar la concentración medida a una concentración umbral de 7 pg/ml; y (iii) determinar un diagnóstico o pronóstico de infarto de miocardio en el individuo, si la concentración de la muestra es mayor que la concentración umbral; en el que el individuo es un ser humano.
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9.发明专利
公开(公告)号：AU2013219225B2
公开(公告)日：2015-04-09
申请号：AU2013219225
申请日：2013-08-23
Applicant: SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS
Abstract: METHODS AND COMPOSITIONS FOR HIGHLY SENSITIVE ANALYSIS OF MARKERS AND DETECTION OF MOLECULES 5OF THE DISCLOSURE Disclosed are methods, kits, and compositions for the highly sensitive detection of molecules. The methods, kits, and compositions are useful in determining concentrations of molecules in samples to levels of 1 femtomolar, 1 attomolar, or lower. The methods, kits, and compositions also allow the determination of concentration over a wide range, e.g., 7-log range, without need for sample dilution. WO 2008/048371 PCT/US2007/008394 Figur IA1 308 307 306 305 Figure 1A
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公开(公告)号：AU2014200749A1
公开(公告)日：2014-03-06
申请号：AU2014200749
申请日：2014-02-12
Applicant: UNIV CALIFORNIA , SINGULEX INC
Inventor： GOIX PHILIPPE , PUSKAS ROBERT , TODD JOHN , LIVINGSTON RICHARD , HELD DOUGLAS , WU ALAN
IPC: G01N33/53
Abstract: The invention provides methods, compositions, kits, and systems for the sensitive detection of cardiac troponin, Such methods, compositions, kits, and systems are useful in diagnosis, prognosis, and determination of methods of treatment in conditions that involve release of cardiac troponin. WO 2007/114947 PCT/US2007/008506 30 3 7 0 630 5 Figure 1A
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