公开(公告)号：US06770875B1

公开(公告)日：2004-08-03

申请号：US09762239

申请日：2001-06-28

Applicant: Roger Guevremont ,  Randy Purves

Inventor： Roger Guevremont ,  Randy Purves

IPC: H01J4904

CPC classification number: G01N27/624 ,  B01D59/46 ,  B01D59/48 ,  H01J49/004 ,  H01J49/044

Abstract: This invention provides an apparatus and method for desolvating and selectively transmitting and focussing ions, including ions produced by electrospray ionization (ESI), based on the ion focussing principles of high field asymmetric waveform ion mobility spectrometry (FAIMS), for introduction into a mass spectrometer. The ion focussing, trapping and desolvating effects of FAIMS, as identified by the inventors, provides high ion transmission efficiency and high sensitivity for the detection of ions. An apparatus comprising an ESI source, a FAIMS device and a mass spectrometer provides a way of desolvating and selectively transmitting highly solvated ions for introduction into a mass spectrometer for analysis.

Abstract translation: 本发明提供了一种基于高场非对称波形离子淌度光谱法（FAIMS）的离子聚焦原理，通过电喷雾离子化（ESI）产生的离子来去离子并选择性地透射和聚焦离子的设备和方法，用于引入质谱仪 。 如本发明人所确定的，FAIMS的离子聚焦，捕获和脱溶剂效应为离子的检测提供了高离子传输效率和高灵敏度。 包括ESI源，FAIMS装置和质谱仪的装置提供了一种解吸和选择性地透射高度溶剂化的离子以引入质谱仪进行分析的方法。

公开(公告)号：US20040056189A1

公开(公告)日：2004-03-25

申请号：US10362510

申请日：2003-02-25

Inventor： Scott D Tanner ,  Dmitry R. Bandura ,  Vladimir I. Baranov

IPC: G02F001/15

CPC classification number: H01J49/061 ,  H01J49/044

Abstract: A mass spectrometer has an ion source for producing sample ions. The ions pass through an ion interface, to a reaction/collision cell section. An ion-neutral decoupling device is provided between the ion interface and the reaction/collision cell section, to provide substantial separation between ions and neutral particles, whereby only ions pass on to the reaction/collision cell section. The supersonic jet entering the spectrometer can have sufficient energy to cause the plasma gases, such as argon, to overcome the pressure differential between the reaction/collision cell and an upstream section of the spectrometer so as to penetrate into the reaction/collision cell; the decoupling device prevents this. The decoupling device can have offset apertures provided by plates or rods or other comparable arrangements, or can comprise a quadrupolar electrostatic deflector, an electrostatic sector deflector or a magnetic sector deflector.

Abstract translation: 质谱仪具有用于产生样品离子的离子源。 离子通过离子界面到反应/碰撞电池部分。 在离子界面和反应/碰撞电池部分之间提供离子中性去耦装置，以提供离子和中性粒子之间的实质性分离，从而只有离子传递到反应/碰撞电池部分。 进入光谱仪的超音速喷射器可以具有足够的能量来引起诸如氩气的等离子体气体克服反应/碰撞池与光谱仪的上游部分之间的压力差，从而渗入反应/碰撞池中; 去耦设备防止这种情况。 去耦装置可以具有由板或杆或其他可比较的布置提供的偏移孔，或者可以包括四极静电偏转器，静电扇形偏转器或磁性扇形偏转器。

公开(公告)号：US06649907B2

公开(公告)日：2003-11-18

申请号：US09802322

申请日：2001-03-08

Applicant: Daniel D. Ebeling ,  Michael S. Westphall ,  Mark A. Scalf ,  Lloyd M. Smith

Inventor： Daniel D. Ebeling ,  Michael S. Westphall ,  Mark A. Scalf ,  Lloyd M. Smith

IPC: B01D5944

CPC classification number: H01J49/165 ,  H01J49/044 ,  Y10S977/786 ,  Y10S977/795

Abstract: Methods and devices for use in mass spectral analysis of samples. In particular, methods and devices for generating ions from liquid samples containing chemical species with high molecular masses. These methods and devices provide a continuous or pulsed stream of gas phase analyte ions of either positive polarity, negative polarity or both possessing either a selected fixed charge-state distribution or one that may be selectively varied with time. More specifically, ion sources with adjustable control of the charge-state distribution of the gas phase analyte ions generated are provided in which charged droplets and/or gas phase analyte ions are exposed to electrons and/or gas phase reagent ions generated by a reagent ion source to provide desired control. A corona discharge exemplifies the reagent ion source employed in charge-state distribution control. In a specific preferred ion source, a corona discharge is provided within a shielded region to minimize the deflection of gas phase analyte ions, charged droplets. The methods and devices provided herein are particularly well-suited to the analysis of polymers and biological species.

公开(公告)号：US20010054687A1

公开(公告)日：2001-12-27

申请号：US09931910

申请日：2001-08-20

Applicant: Hitachi, Ltd.,

Inventor： Yoshiaki Kato

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/044 ,  Y10T436/24 ,  Y10T436/25

Abstract: A solution containing nonvolatile salts is pumped from a pump to an electrospray nebulization probe in the LC/MS interface, and spouted out from a tip of the probe into an atmospheric pressure environment in a form of fine liquid droplets having charges. The sample ions contained in the droplets are deflected by a deflector and enter into a mass analysis portion through an ion sampling aperture to be mass analyzed. On the other hand, the nonvolatile salts travel straight without being affected by the deflector, and collide against and are collected on a wall of a particle collector. The collected salts are precipitated in a form of crystals. The collected salts are washed away by spraying a particle washing solution from the washing nozzle. The above-described structure can provide an atmospheric pressure ionization mass spectrometer which can prevent effects of nonvolatile salts on the mass analysis without deteriorating the vacuum condition of the mass analysis portion by the preventing action.

Abstract translation: 将包含非挥发性盐的溶液从泵泵送到LC / MS界面中的电喷雾雾化探针，并从具有电荷的细液滴的形式从探针的尖端喷出到大气压环境中。 包含在液滴中的样品离子被偏转器偏转并通过离子采样孔进入质量分析部分进行质量分析。 另一方面，非挥发性盐直接行进而不受偏转器的影响，并且碰撞并收集在颗粒收集器的壁上。 收集的盐以晶体的形式沉淀。 通过从洗涤喷嘴喷射颗粒洗涤溶液来洗涤收集的盐。 上述结构可以提供大气压离子化质谱仪，其能够防止非挥发性盐对质量分析的影响，而不会由于防止作用而使质量分析部的真空状态恶化。

公开(公告)号：US20010050337A1

公开(公告)日：2001-12-13

申请号：US09845287

申请日：2001-05-01

Applicant: SHIMADZU CORPORATION

Inventor： Yasufumi Tanaka

IPC: H01J049/00 ,  B01D059/44

CPC classification number: H01J49/067 ,  G01N30/724 ,  H01J49/044 ,  H01J49/063

Abstract: A liquid chromatograph mass spectrometer includes a solvent removing tube, a first ion lens and a second ion lens. Voltages applied to the solvent removing tube, and the first and second ion lenses corresponding to each mass number of a standard sample are studied in advance so that efficiencies of passing ions become best. A voltage scanning pattern is made based on the impressed voltages, and stored in a memory portion. When a scanning measurement is carried out, a control portion controls a current voltage source and a high frequency voltage source according to the voltage scanning pattern, synchronizing with the scanning of the impressed voltage to the quadrupole filter. As a result of the control, an objective ion which is generated by being atomized from a nozzle may effectively pass through the entrance of a quadrupole filter.

Abstract translation: 液相色谱质谱仪包括溶剂去除管，第一离子透镜和第二离子透镜。 预先施加到溶剂去除管的电压以及与标准样品的每个质量数对应的第一和第二离子透镜，使得通过离子的效率变得最佳。 基于外加电压进行电压扫描图案，并存储在存储器部分中。 当执行扫描测量时，控制部分根据电压扫描图案控制电流电压源和高频电压源，与向四极滤波器的外加电压的扫描同步。 作为控制的结果，通过从喷嘴雾化产生的客观离子可以有效地通过四极过滤器的入口。

公开(公告)号：US4977320A

公开(公告)日：1990-12-11

申请号：US467978

申请日：1990-01-22

Applicant: Swapan K. Chowdhury ,  Viswanatham Katta ,  Brian T. Chait

Inventor： Swapan K. Chowdhury ,  Viswanatham Katta ,  Brian T. Chait

IPC: H01J49/04 ,  H01J49/10

CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/0468 ,  H01J49/165

Abstract: An electrospray ion source is designed for ready and simple plugging into commercial mass analyzers for mass spectrometric analysis of organic molecules. The electrospray is carried out is the ambient air and the ions and other charged species enter the mass analyuzer through a long metal capillary tube and three stages of differential pumping. The use of the long tube allows (a) convenient injection of the ions into the mass analyzer (b) optimization of the spray by direct visualization in the air (c) efficient and controlled heat transfer to the droplets and (d) efficient pumping of the region between the capillary exit and the skinner. Desolvation of the solvated ions is carried out using a combination of controlled heat transfer to the charged droplets during the transit through the tube and collisional activation in a region of reduced pressure. Desolvation with this system does not involve use of a strong countercurrent flow of heated gas. The system also may be used to obtain the collisional activated fragmentation spectra of molecule ions. The use of a metal capillary tube avoids complications from charging that arise from the use of dielectric capilliary tubes.

Abstract translation: 电喷雾离子源设计用于准备和简单的插入商业质量分析仪，用于有机分子的质谱分析。 进行电喷雾是环境空气，离子和其他带电物质通过长金属毛细管进入质量分析仪和三级差动泵送。 使用长管允许（a）方便地将离子注入质量分析器中（b）通过在空气中直接可视化来优化喷雾（c）有效和可控制的热传递到液滴，以及（d）有效泵送 毛细管出口与皮肤之间的区域。 溶剂化离子的去溶剂使用在通过管的运输过程中受控的热传递到带电液滴和在减压区域中的碰撞活化的组合来进行。 该系统的去溶剂不涉及使用强逆流的加热气体。 该系统也可用于获得分子离子的碰撞激活的碎裂光谱。 使用金属毛细管避免了使用电介质毛细管引起的充电并发症。

公开(公告)号：WO2015100233A2

公开(公告)日：2015-07-02

申请号：PCT/US2014/071885

申请日：2014-12-22

Applicant: WATERS TECHNOLOGIES CORPORATION

Inventor： JARRELL, Joseph, A.

IPC: H01J49/26

CPC classification number: H01J49/0404 ,  H01J49/044 ,  H01J49/165

Abstract: An interface for a mass spectrometer system is provided. The interface can include an inner ceramic tube fabricated from a first ceramic material and an outer tube fabricated from a second ceramic material surrounding the inner ceramic tube. The inner ceramic tube can have high electrical resistivity and high thermal conductivity and the intermediate ceramic tube can have an electrical resistivity that is at least an order of magnitude higher than the electrical resistivity of the first ceramic material and a thermal conductivity that is at least an order of magnitude higher than the thermal conductivity of the first ceramic material.

Abstract translation: 提供了用于质谱仪系统的界面。 界面可以包括由第一陶瓷材料制成的内陶瓷管和由围绕内陶瓷管的第二陶瓷材料制成的外管。 内部陶瓷管可以具有高电阻率和高导热性，并且中间陶瓷管可以具有比第一陶瓷材料的电阻率高至少一个数量级的电阻率和至少为 数量级高于第一陶瓷材料的热导率。

公开(公告)号：WO2015040386A1

公开(公告)日：2015-03-26

申请号：PCT/GB2014/052819

申请日：2014-09-17

Applicant: MICROMASS UK LIMITED

Inventor： BAJIC, Stevan ,  GORDON, David ,  KENNY, Daniel James ,  MOULDS, Richard Barrington ,  O'BRIEN, Stephen ,  TRIVETT, Ian ,  WHYATT, Kate

IPC: H01J49/16

CPC classification number: H01J49/167 ,  H01J49/0027 ,  H01J49/044 ,  H01J49/165

Abstract: A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone 6 having an inlet aperture, wherein the gas cone 6 has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube 2 having an outlet and having a second longitudinal axis and a second capillary tube 3 which surrounds the first capillary tube 2. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube 2 so that the liquid exits the outlet of the first capillary tube 2 at a flow rate > 200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube 3 at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube 2 is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube 3 and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater 4 arranged and adapted to heat the desolvation gas to a temperature≥ 100° C and a fourth device arranged and adapted to supply a cone gas to the gas cone 6 at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.

Abstract translation: 公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体6，其中气体锥体6具有沿x轴布置的第一纵向轴线和电喷雾离子源，其包括具有出口的第一毛细管2 并且具有第二纵向轴线和围绕第一毛细管2的第二毛细管3.质谱仪还包括去溶剂化气体供应管和布置成适于经由第一毛细管2供应分析物液体的第一装置，使得 液体以>200μL/ min的流速离开第一毛细管2的出口。 质谱仪还包括第二装置，其布置并适于经由第二毛细管3以80-150L / hr的流速提供喷雾器气体，其中第一毛细管2的出口以一定距离 从气体入口孔的中心测量的沿着x轴的x mm，沿着从气体入口孔的中心测量的y轴的距离y mm和沿着z轴的距离z mm作为 从气锥入口孔的中心测量。 x轴，y轴和z轴相互正交。 去溶剂化气体供应管围绕第二毛细管3，质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体，加热器 4，其布置并适于将去溶剂化气体加热至≥100℃的温度，以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体6供应锥形气体，并且其中x为 在2.0-5.0mm的范围内，并且其中z / x的比率在1-5:1的范围内。

公开(公告)号：WO2009097064A2

公开(公告)日：2009-08-06

申请号：PCT/US2008087624

申请日：2008-12-19

Applicant: L LIVERMORE NAT SECURITY LLC ,  FERGENSON DAVID P ,  GARD ERIC E

Inventor： FERGENSON DAVID P ,  GARD ERIC E

IPC: H01J49/04

CPC classification number: H01J49/40 ,  H01J49/044 ,  H01J49/0445 ,  H01J49/164

Abstract: A system according to one embodiment includes a particle accelerator that directs a succession of polydisperse aerosol particles along a predetermined particle path; multiple tracking lasers for generating beams of light across the particle path; an optical detector positioned adjacent the particle path for detecting impingement of the beams of light on individual particles; a desorption laser for generating a beam of desorbing light across the particle path about coaxial with a beam of light produced by one of the tracking lasers; and a controller, responsive to detection of a signal produced by the optical detector, that controls the desorption laser to generate the beam of desorbing fight. Additional systems and methods are also disclosed.

Abstract translation: 根据一个实施方案的系统包括颗粒促进剂，其引导一系列多分散气溶胶颗粒沿着预定的颗粒路径; 用于在颗粒路径上产生光束的多个跟踪激光器; 位于颗粒路径附近的光学检测器，用于检测单个颗粒上的光束的撞击; 解吸激光器，用于产生与所述跟踪激光器之一产生的光束同轴的所述粒子路径上的解吸光束; 以及响应于检测由光学检测器产生的信号的控制器，其控制解吸激光器以产生解吸束的战斗。 还公开了附加的系统和方法。

公开(公告)号：WO2006065520A2

公开(公告)日：2006-06-22

申请号：PCT/US2005/043060

申请日：2005-11-28

Applicant: VARIAN, INC. ,  YANG, Zicheng ,  TONG, Roger, C.

Inventor： YANG, Zicheng ,  TONG, Roger, C.

IPC: H01J49/10 ,  H01J27/02

CPC classification number: H01J49/0477 ,  H01J49/044

Abstract: An apparatus for use in atmospheric pressure ionization includes a sample receiving chamber, a sample droplet source communicating with the sample receiving chamber, an outlet conduit, and a boundary. The outlet conduit defines a sampling orifice that communicates with the sample receiving chamber. The boundary is interposed between the sample receiving chamber and the sampling orifice and comprises an opening. The opening defines a first passage through which a drying gas is flowable into the sample receiving chamber in an elongated flow profile, and a second passage through which sample material is flowable from the sample receiving chamber toward the sampling orifice. The first passage is positioned in non-coaxial relation to the second passage. The first passage is configured to introduce the elongated flow profile of the drying gas into a pathway of droplets of the sample material flowing toward the second passage.

Abstract translation: 用于大气压电离的装置包括样品接收室，与样品接收室连通的样品液滴源，出口导管和边界。 出口导管限定了与样品接收室连通的采样孔。 边界置于样品接收室和采样孔之间，并包括开口。 开口限定第一通道，干燥气体可以通过该第一通道以细长的流动分布流入样品接收室，第二通道使样品材料从样品接收室朝向采样孔流动。 第一通道定位成与第二通道非同轴的关系。 第一通道被构造成将干燥气体的细长流动剖面引入流向第二通道的样品材料液滴的通路。