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    85.
    发明专利
    未知

    公开(公告)号：DE2039185A1

    公开(公告)日：1971-03-18

    申请号：DE2039185

    申请日：1970-08-06

    Applicant: INDIANA UNIVERSITY FOUNDATION

    Inventor： CHARLES MUHLER JOSEPH

    IPC: A61K6/06 ,  A61C13/00 ,  A61K20060101 ,  C09K3/00 ,  A61K5/00

    Abstract: 1275249 Dental cement INDIANA UNIVERSITY FOUNDATION 31 July 1970 [2 Sept 1969] 37117/70 Heading C3N A dental cement comprises (A) a dental cement powder which comprises (a) sintered zinc oxide having a particle size of 2 to 10 microns; (b) not more than 0À5% magnesium oxide, by weight of the cement powder; and (c) 0À5-20% by weight of the cement powder of one or more of the following fluorine containing compounds: stannous fluoride, stannous hexafluorozirconate, indium fluorozirconate, zirconium hexafluorogermanite, zirconyl hexafluorofluorogermanite or indium hexafluorogermanate; and (B) phosphoric acid. The dental cement may further comprise 3-15% by weight of a tin oxide which assists in the sintering of the zinc oxide. The zinc oxide may be present in an amount 65-99À5% by weight of the powder. The zinc oxide is sintered at 1800-2500‹ F. and subsequently ground to the desired particle size.

    Indium fluorogermanate
    86.
    发明专利
    Indium fluorogermanate 未知

    公开(公告)号：FR2035794A1

    公开(公告)日：1970-12-24

    申请号：FR6909677

    申请日：1969-03-31

    Applicant: INDIANA UNIVERSITY FOUNDATION

    IPC: A61K8/21 ,  A61Q11/00 ,  C01G17/00 ,  A61K27/00

    Abstract: Indium fluorogermanate Anticaries prophylaxis. Compound has high activity, does not discolour oral tissues, is stable and is non-toxic. By coprecipitation, e.g. by indium chloride and ammonium fluorogermanate, or by fusion of the two reactants. Dentifrices contain pref. 0.1-1.0% of the cpd.; prophylactic pastes may contain 10-30%. Mouse LD50 85 mg/kg. (that of NaF is 36mg/kg). A prophylactic paste contained indium fluorogermanate 20%, zirconium silicate 55%, liquid and minor ingredients 25%. A dentifrice contained indium fluorogermanate 0.2%, zirconium silicate 40%, sorbitol 20%, glycerol 10%, Na CMC 1.08%, coconut acid-monoglyceride-Na sulphonate 0.81%, Na lauryl sulphate 0.7%, minor ingredients and aromatic agents 1.84%, water to 100%.

    Toothpaste contg zr silicate, phosphate compds - talc, tremolite
    87.
    发明专利
    Toothpaste contg zr silicate, phosphate compds - talc, tremolite 未知

    公开(公告)号：DE1916177A1

    公开(公告)日：1970-10-08

    申请号：DE1916177

    申请日：1969-03-28

    Applicant: INDIANA UNIVERSITY FOUNDATION

    Inventor： C MUHLER JOSEPH

    IPC: A61K8/24 ,  A61K8/28 ,  A61Q11/00

    Abstract: Toothpaste Prepd. from ZrSO4 with particle size of less than 8u, pref. a mixture of sizes such as 0-3 u, (80-95%); 3-5 mu, (0-15%); and 5-8 mu, (0.12%), which is dispersed in a mixture of Ca2P2O7, CaHPO4, CaHPO42H2O, a high polymer resin such as melamine-formaldehyde, insoluble sodium metaphosphate, CaCO3, talc and tremolite, together with disinfectants and fluorides. The new product is a valuable aid to dental cleansing and polishing.

    New Compound Indium Fluorozirconate, process for preparing same and Anticariogenic Compositions containing the same
    89.
    发明专利
    New Compound Indium Fluorozirconate, process for preparing same and Anticariogenic Compositions containing the same 未知

    公开(公告)号：GB1198379A

    公开(公告)日：1970-07-15

    申请号：GB5874668

    申请日：1968-12-10

    Applicant: INDIANA UNIVERSITY FOUNDATION

    Inventor： MUHLER JOSEPH CHARLES

    IPC: A61K8/21 ,  A61Q11/00 ,  C01G25/00

    Abstract: 1,198,379. Dentifrices. INDIANA UNIVERCITY FOUNDATION. 10 Dec., 1968, No. 58746/68. Heading A5B. [Also in Division Cl] In Zr F, may be added to dentifrice compositions to yield anticariogenic properties. Preferably ionically compatible adjunctives are used; zirconium silicate, calcium pyrophosphate, insoluble metaphosphates, alumina and resinous materials have been used as abrasives, being between 0.5-95% by weight of the total composition. The conventional binder substances, thickening agents, sudsing agents, humectants, flavoring and sweetening agents may also be added. The toxicity of In Zr F 7 in mice is shown to be less than 3 times the toxicity of NaF, In Zr F 7 is more soluble and its solutions more stable than prior art anticariogenic agents

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