公开(公告)号：AU1848197A

公开(公告)日：1997-09-02

申请号：AU1848197

申请日：1997-02-03

Applicant: ORTHOLOGIC CORP

Inventor： KAUFMAN JONATHON J ,  CHIABRERA ALESSANDRO

IPC: A61B8/08 ,  A61B8/00

Abstract: A method for assessment of bone properties comprises passing ultrasonic signal through a bone tissue, modeling an output signal and a reference output signal and subjecting parameters of the models to comparative analysis. An apparatus is also disclosed for practicing the method.

公开(公告)号：AU7488296A

公开(公告)日：1997-06-05

申请号：AU7488296

申请日：1996-11-14

Applicant: ORTHOLOGIC CORP

Inventor： SARINGER JOHN H ,  CULHANE JEFFREY J ,  SOLOMON ALEXANDER G

IPC: A61H1/02 ,  A63B21/005 ,  A63B22/06 ,  A63B23/04 ,  A63B24/00

公开(公告)号：DE69119865D1

公开(公告)日：1996-07-04

申请号：DE69119865

申请日：1991-10-16

Applicant: ORTHOLOGIC CORP

Inventor： LAMOND DONALD R ,  HEINZELMAN BERT

IPC: A61N2/00 ,  A61B19/00 ,  A61G13/12 ,  A61N2/02

Abstract: A medical treatment device (20) is disclosed which includes a medical treatment element (36,38) and resilient securing members (32,34) which adjust or deform to conform to the particular dimensions of that part of the patient's anatomy which is to be treated. The resilient securing members (32, 34) move or deform outwardly away from the patient (22) as the device is applied to conform to the size of the patient and ensure that the patient is centered within the treatment device. The medical treatment elements (36,38) are thus accurately positioned with respect to the patient (22). This is particularly important in treatments involving the application of magnetic fields to the patient (22). In addition, the disclosed medical device (20) is relatively comfortable and can be worn by a patient (22) for a relatively long period of time. The invention also extends to the method of applying the medical treatment device (20) to the patient (22).

公开(公告)号：AU3954695A

公开(公告)日：1996-05-15

申请号：AU3954695

申请日：1995-10-04

Applicant: ORTHOLOGIC CORP

Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALLESSANDRO E

IPC: A61N1/00 ,  A61B17/00 ,  A61F2/28 ,  A61H23/02 ,  A61N7/00

Abstract: A method of ultrasonic bone-therapy subjects a bone to an ultrasonic excitation pulse signal of finite duration, supplied to a transducer next to the bone, and involving a sinusoidal signal in the ultrasonic region to approximately 2 MHz peculiarly modulated by a sinusoidal signal with frequency between about 0 Hz and about 25 kHz; the excitation signal is repeated in the range of 1 to 5000 Hz. The exposure time for therapy is chosen to be in the range of 5 minutes to 1 hour, for 1 to 3 times a day, for a period of days as necessary for healing or for promoting bone growth and ingrowth. An apparatus for implementing the above method for ultrasonic bone therapy is disclosed comprising a transducer having a transmitting and a receiving element, a special waveform signal generator, and a computer for performing the necessary operations defining a preferred treatment regime.

公开(公告)号：CA2174139A1

公开(公告)日：1995-04-20

申请号：CA2174139

申请日：1993-11-08

Applicant: ORTHOLOGIC CORP

Inventor： KAUFMAN JONATHAN J ,  CHIABRERA ALESSANDRO

IPC: A61M11/08 ,  A61B8/00 ,  A61B8/08 ,  A61B17/56 ,  A61H23/02 ,  A61J7/04 ,  A61M15/00 ,  A61M16/00 ,  A61N7/00 ,  G01N29/30 ,  G01N29/34

Abstract: Non-invasive therapeutic treatment and/or quantitative evaluation of musculoskeletal tissue are performed in vivo by subjecting musculoskeltal tissue (11) to an ultrasonic acoustic signal pulse extraction, involving a composite sine wave signal consisting of plural discrete frequencies that are spaced in the ultrasonic region to approximately 2 MHZ, and repeated substantially in the range of 1 Hz to 1000 Hz. In a quantitative evaluation the signal is supplied to one of two transducers (12, 13) on opposite sides of the tissue, and the signal received by the other transducer is processed (14): (a) to obtain an averaged per-pulse signal and (b) to produce a Fourier transform of the averaged per-pulse tissue transmittal signal. In a separate operation, the same transducers are subjected to the same excitation, reception and processing, using a medium of known acoustic properties and path length to produce a reference Fourier transform. In a therapeutic treatment, the transducer (12) excited by the composite sine wave signal is applied for a time period and magnitude.

公开(公告)号：CA2551525C

公开(公告)日：2013-02-19

申请号：CA2551525

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID W ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/16 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K38/48 ,  A61K47/06 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02 ,  A61P19/00

Abstract: Disclosed are pharmaceutical compositions comprising a thrombin peptide derivatives and a chelating agent and/or a pharmaceutically acceptable thiol~containing compound. The pharmaceutical compositions optionally further comprise an antioxidant. Also, disclosed are methods for activating the non~proteolytically activated thrombin receptor in a subject in need of such treatment. The methods comprise the step of administering an effective amount of a thrombin peptide derivative in the pharmaceutical composition described above.

公开(公告)号：CA2719940A1

公开(公告)日：2009-11-26

申请号：CA2719940

申请日：2009-03-26

Applicant: ORTHOLOGIC CORP

Inventor： STEER RANDOLPH C ,  SHELLER MICHAEL R ,  WAGSTAFF JOHN D

IPC: A61K38/48 ,  A61K38/10 ,  A61P9/10

Abstract: The present invention includes methods of treating acute myocardial infarction in a subject, comprising administer-ing to the subject a therapeutically effective amount of a non-proteolytically activated thrombin receptor agonist.

公开(公告)号：AU2009229399A1

公开(公告)日：2009-10-01

申请号：AU2009229399

申请日：2009-03-24

Applicant: ORTHOLOGIC CORP ,  TEXAS A & M UNIV SYS

Inventor： OLSZEWSKA-PAZDRAK BARBARA ,  FOSSUM THERESA W ,  CARNEY DARRELL H

IPC: A61K38/48 ,  A61P21/02

Abstract: Agonists of a non-proteolytically activated thrombin receptor, and more particularly, thrombin peptide derivatives, can be used in methods to cause smooth muscle relaxation. Compositions comprising thrombin peptide derivatives can be administered to a subject with a disease or disorder that can be ameliorated by relaxation of smooth muscle. Such compositions can also be administered to a subject to facilitate medical, diagnostic or surgical procedures.

公开(公告)号：CA2663547A1

公开(公告)日：2008-03-27

申请号：CA2663547

申请日：2007-09-21

Applicant: ORTHOLOGIC CORP ,  TEXAS A & M UNIV SYS

Inventor： OLSZEWSKA-PAZDRAK BARBARA ,  FOSSUM THERESA W ,  CARNEY DARRELL H

IPC: A61K38/48 ,  A61P9/08 ,  A61P9/10 ,  C12N9/74

Abstract: Endothelial dysfunction (ED) is associated with a number of diseases and disorders. Agonists of the non-proteolytically activated thrombin receptor c an be used in methods to treat ED or ED-related diseases and disorders.

公开(公告)号：ES2287660T3

公开(公告)日：2007-12-16

申请号：ES04258191

申请日：2004-12-30

Applicant: ORTHOLOGIC CORP

Inventor： HOBSON DAVID M ,  CROWTHER ROGER S ,  CARNEY DARRELL H ,  TANG ANDREW PO KWAN

IPC: A61K38/48 ,  A61K9/06 ,  A61K31/198 ,  A61K31/473 ,  A61K31/4745 ,  A61K38/36 ,  A61K47/10 ,  A61K47/12 ,  A61K47/16 ,  A61K47/18 ,  A61K47/20 ,  A61P17/02

Abstract: Una composición farmacéutica que comprende: a) un derivado peptídico de trombina con una longitud de 14 a 23 aminoácidos y que comprende la secuencia de aminoácidos Asp- Ala-R, en la que R es el dominio conservado de la esterasa de la serina; y b) un agente quelante y/o un compuesto que contiene tiol aceptable desde el punto de vista farmacéutico.