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公开(公告)号：WO2014025254A1
公开(公告)日：2014-02-13
申请号：PCT/NL2013/050581
申请日：2013-08-06
Applicant: STICHTING VU-VUMC
Inventor： PEGTEL, Dirk Michiel
CPC classification number: C12Q1/6883 , C12Q1/686 , C12Q1/705
Abstract: The present invention relates to an in vitro method for diagnosis and/or determining severity of Systemic Lupus Erythematosus. The method determines presence and/or quantity of at least one EBV marker, preferably EBV-EBER and/or antibody against EBV antigen, in a sample obtained from a subject. The method may further be used to discriminate between Systemic Lupus Erythematosus, and rheumatoid arthritis.
Abstract translation: 本发明涉及用于诊断和/或确定系统性红斑狼疮严重性的体外方法。 该方法在从受试者获得的样品中确定至少一种EBV标志物，优选EBV-EBER和/或抗EBV抗原抗体的存在和/或量。 该方法还可用于区分系统性红斑狼疮和类风湿性关节炎。
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82.发明申请DEVICE COMPRISING A TRANSPARENT STRUCTURE, SOLAR COLLECTOR OR GREENHOUSE PROVIDED WITH SUCH DEVICE 审中-公开包含透明结构的设备，具有这种设备的太阳能收集器或温室
公开(公告)号：WO2013165249A1
公开(公告)日：2013-11-07
申请号：PCT/NL2013/050334
申请日：2013-05-03
Applicant: STICHTING VU-VUMC
Inventor： GRIESSEN, Ronald , SLAMAN, Marinus Johannes
Abstract: The invention relates to a device for transmission of incoming radiation comprising a plate of a transparent material provided with a first flat side and a second side opposed to the first side, the second side being provided with a prismatic structure with certain magic apex angle which has a first and a second angle, wherein the apex angle of the prismatic structure is equal to a magic apex angle. The device can be applied advantageously in greenhouses and solar collectors to maintain a substantially constant transmission of incoming radiation from the sun during a long period of the day. To adjust the level of the limited transmission between a minimum transmission of 50% and the Fresnel transmission the prismatic structure can be provided with flat portions between the prisms.
Abstract translation: 本发明涉及一种用于传输入射辐射的装置，包括具有第一平坦侧面和与第一侧相对的第二侧面的透明材料板，第二侧面设置有具有某些魔法顶角的棱镜结构， 第一和第二角度，其中棱柱结构的顶角等于魔法顶角。 该装置可以有利地应用于温室和太阳能收集器中，以在一天的长时间内保持来自太阳的进入辐射的基本恒定的传输。 为了调节50％的最小透射率与菲涅耳透射之间的有限透射率的水平，棱镜结构可以在棱镜之间设置有平坦部分。
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公开(公告)号：WO2013162368A1
公开(公告)日：2013-10-31
申请号：PCT/NL2013/050316
申请日：2013-04-26
Applicant: STICHTING VU-VUMC
Inventor： BOSCH, Linda Janna Willemien , DE WIT, Meike , PINTO MORAIS DE CARVALHO, Beatriz , FIJNEMAN, Remond Johannes Adriaan , MEIJER, Gerrit Albert , JIMENEZ, Cornelia Ramona , PIERSMA, Sander Rogier , PHAM, Viet Thang , OUDGENOEG, Gideon
IPC: G01N33/574
CPC classification number: G01N33/57419 , G01N33/6848 , G01N2500/10 , G01N2570/00 , G01N2800/7028
Abstract: The invention provides a method for screening for colorectal cancer, the method comprising: screening a biological sample from an individual for one or more biomarkers selected from the group defined in Table 1 and/or Table 6, wherein the presence of or increased expression of the one or more biomarkers relative to a control sample is indicative that the individualis at risk of suffering from or is suffering from colorectal cancer.The invention also provides an array and kit suitable for use in the methods of the invention, methods of treating colorectal cancer and therapeutic agents for use in methods of treating cancer.
Abstract translation: 本发明提供了筛选结肠直肠癌的方法，该方法包括：从个体中筛选一种或多种选自表1和/或表6中定义的组的生物标志物的生物样品，其中存在或增加表达 相对于对照样品的一种或多种生物标志物表明个体患有或正在患有结肠直肠癌的风险。本发明还提供了适用于本发明方法的阵列和试剂盒，治疗结肠直肠癌的方法和 用于治疗癌症的方法的治疗剂。
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公开(公告)号：WO2013154429A1
公开(公告)日：2013-10-17
申请号：PCT/NL2013/050264
申请日：2013-04-11
Applicant: STICHTING VU-VUMC
Inventor： NILSSON, Rolf, Jonas , VAN RIJN, Sjoerd , WÜRDINGER, Thomas
CPC classification number: C12Q1/66 , G01N33/5008
Abstract: The disclosure relates to multiplex assays for monitoring multiple variables, such as the effects of a biological condition on a biological system. Reporter systems are provided for performing such assays.
Abstract translation: 本公开涉及用于监测多个变量的多重测定，例如生物学条件对生物系统的影响。 提供记录系统用于进行此类测定。
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公开(公告)号：WO2013151440A2
公开(公告)日：2013-10-10
申请号：PCT/NL2013/050256
申请日：2013-04-05
Applicant: STICHTING VU-VUMC
IPC: C12Q1/68
CPC classification number: C12Q1/689 , C12Q2600/142 , C12Q2600/158
Abstract: A method for determining toxicity of a sample, particularly a soil sample suspected of containing polycyclic aromatic hydrocarbon pollutants, is provided. The method allows for quantification of toxicity levels based on gene expression profiling of a test organism, for example Folsomia candida,exposed to the sample.
Abstract translation: 提供了一种确定样品毒性的方法，特别是怀疑含有多环芳烃污染物的土壤样品。 该方法允许基于暴露于样品的测试生物（例如，假丝酵母菌）的基因表达谱来定量毒性水平。
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Patent Agency Ranking86.发明申请COMPOSITIONS AND METHODS FOR DIAGNOSING AND TREATING INTELLECTUAL DISABILITY SYNDROME, AUTISM AND AUTISM RELATED DISORDERS 审中-公开诊断和治疗知识障碍综合症，异常和相关疾病的组合物和方法
公开(公告)号：WO2013133708A1
公开(公告)日：2013-09-12
申请号：PCT/NL2013/050147
申请日：2013-03-07
Applicant: STICHTING VU-VUMC
IPC: C12Q1/68
CPC classification number: C12Q1/6883 , C12Q1/6827 , C12Q2600/156 , C12Q2533/107 , C12Q2537/143
Abstract: The disclosure relates to methods of diagnosing and treating autism. The disclosure provides diagnostic methods based on identifying alterations in the AUTS2 gene, in particular in the AUTS2 short isoform. The disclosure further relates to therapeutic interventions utilizing the newly identified alternative transcript.
Abstract translation: 本公开涉及诊断和治疗自闭症的方法。 本公开提供了基于识别AUTS2基因，特别是在AUTS2短型同工型中的改变的诊断方法。 本公开还涉及使用新鉴定的替代转录物的治疗性干预。
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87.发明申请Molecular manipulation apparatus and method for investigating a plurality of molecules 审中-公开用于研究多个分子的分子操作装置和方法
公开(公告)号：WO2013051932A1
公开(公告)日：2013-04-11
申请号：PCT/NL2012/050690
申请日：2012-10-03
Applicant: VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS,WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG , STICHTING VU-VUMC
Inventor： LAURENS, Niels , SITTERS, Gerrit , WUITE, Gijs Jan Lodewijk , PETERMAN, Erwin Johannes Gerard
Abstract: A molecular manipulation apparatus for investigating molecules attached on one side to a surface of a sample and on another side to a bead. The apparatus having a radiation system for providing a radiation beam of radiation with a radiation intensity to the sample and the surface of the sample is transmissive for the radiation. The apparatus is provided with a sample holder for holding the sample with its transmissive surface within the beam of radiation. The apparatus has a detector for detecting a position of the beads; and, a computer programmed for calculating a physical property of the molecules as a function of the position of the plurality of beads.
Abstract translation: 一种分子操作装置，用于研究一侧附着在样品表面上的分子，另一侧用于研究珠粒。 具有用于向样品和样品表面提供具有辐射强度的辐射辐射束的辐射系统的装置对于辐射是透射的。 该装置设置有用于将样品保持在其辐射束内的透射表面的样品保持器。 该装置具有用于检测珠的位置的检测器; 以及被编程用于根据多个珠的位置计算分子的物理性质的计算机。
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88.发明申请SYSTEM AND METHOD FOR PREDICTING THE VIABILITY OF A BODY TISSUE IN A PATIENT, AND MEASURING DEVICE USED THEREIN 审中-公开用于预测患者身体组织的可能性的系统和方法，以及使用其测量的装置
公开(公告)号：WO2013006053A1
公开(公告)日：2013-01-10
申请号：PCT/NL2012/050472
申请日：2012-07-04
Applicant: STICHTING VU-VUMC , VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIËNTENZORG ET AL , VEENHOF MEDICAL DEVICES B.V. , CUESTA VALENTIN, Miguel Angel , VEENHOF, Alexander Arnold Frederik Adriaan
CPC classification number: A61B5/4848 , A61B5/0053 , A61B5/0205 , A61B5/0215 , A61B5/02233 , A61B5/026 , A61B5/0261 , A61B5/14551 , A61B5/42
Abstract: The invention relates to a system for predicting the viability of a body tissue in a patient. The system comprises a computing device (1), and a first pressure measuring device (2) for measuring local perfusion pressure in the body tissue of the patient. This measuring device is connected to the computing device. A second pressure measuring device (5) is provided for measuring the systemic perfusion pressure of the patient, said second pressure measuring device being connected to the computing device. A feedback indicator (6) is connected to the computing device and is adapted to indicate the viability of the tissue calculated by the computing device on the basis of the measured local and systemic perfusion pressures. The invention also includes a method of predicting the viability of the body tissue and to the first pressure measuring device.
Abstract translation: 本发明涉及一种用于预测患者体内组织活力的系统。 该系统包括计算装置（1）和用于测量患者身体组织中的局部灌注压力的第一压力测量装置（2）。 该测量装置连接到计算设备。 提供第二压力测量装置（5），用于测量患者的全身灌注压力，所述第二压力测量装置连接到计算装置。 反馈指示器（6）连接到计算设备，并且适于基于测量的局部和系统灌注压力来指示计算设备计算出的组织的存活力。 本发明还包括预测身体组织和第一压力测量装置的活力的方法。
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公开(公告)号：WO2016122320A1
公开(公告)日：2016-08-04
申请号：PCT/NL2016/050064
申请日：2016-01-27
Applicant: STICHTING VU-VUMC , STICHTING VUMC
Inventor： VAN DER VLIET, Johannes Jelle , DE GRUIJL, Tanja Denise , VERHEUL, Hendrik Marinus Willem , DE BRUIN, Renée Cornelia Gerarda , LAMERIS, Roland
IPC: C07K16/28
CPC classification number: C07K16/2809 , C07K16/2833 , C07K16/30 , C07K2317/565 , C07K2317/569 , C07K2317/75
Abstract: The invention relates to compounds, in particular polypeptides that specifically bind to the non-classical MHC protein CD1d and modulate CD1d-mediated biological functions. The invention in particular relates to such compounds and polypeptides comprising or consisting of at least one single domain antibody, and wherein at least one single domain antibody specifically binds to CD1d. Also provided is for methods and use employing such compounds, polypeptides and/or single-domain antibodies.
Abstract translation: 本发明涉及化合物，特别是与非经典MHC蛋白质CD1d特异性结合并调节CD1d介导的生物功能的多肽。 本发明特别涉及包含至少一个单结构域抗体或由至少一个单结构域抗体组成的这样的化合物和多肽，并且其中至少一个单结构域抗体特异性结合CD1d。 还提供了使用这种化合物，多肽和/或单域抗体的方法和用途。
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公开(公告)号：WO2016079194A1
公开(公告)日：2016-05-26
申请号：PCT/EP2015/076989
申请日：2015-11-18
Applicant: STICHTING KATHOLIEKE UNIVERSITEIT , STICHTING VU-VUMC
IPC: C12Q1/68
CPC classification number: G01N33/5748 , A61K2039/505 , C07K14/71 , C07K16/2863 , C12Q1/6883 , C12Q1/6886 , C12Q2600/106 , C12Q2600/156 , G01N33/574 , G01N33/74 , G01N2333/71
Abstract: The present invention relates to the fields of medicine and molecular diagnostics. In particular, it relates to a novel method for the treatment, prevention and/or delay of cancer and to a diagnostic method involving detection of a novel auto-active and intracellular mutant of MET.
Abstract translation: 本发明涉及药物和分子诊断领域。 特别涉及用于治疗，预防和/或延缓癌症的新方法以及涉及检测MET的新型自身活性和细胞内突变体的诊断方法。
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