公开(公告)号：US20220372630A1

公开(公告)日：2022-11-24

申请号：US17878868

申请日：2022-08-01

Applicant: The University of Connecticut

Inventor： Eric Jordan ,  Maurice Gell ,  Rishi Kumar ,  Chen Jiang

IPC: C23C28/00 ,  C23C28/04

Abstract: A coating on a substrate is disclosed having layers including yttrium aluminum garnet (YAG) and yttrium aluminum monoclinic (YAM).

公开(公告)号：US20220364083A1

公开(公告)日：2022-11-17

申请号：US17663378

申请日：2022-05-13

Applicant: Yale University ,  University of Connecticut

Inventor： Farida Ahangari ,  Naftali Kaminski ,  Carlos Fernandez-Hernando ,  Raman Bahal

IPC: C12N15/11 ,  C12N15/113 ,  A61K31/713 ,  A61P9/10

Abstract: In one aspect, the present disclosure provides a microRNA-33 (miR-33) inhibitor comprising a peptide nucleic acid covalently bound to a pH low insertion peptide. In another aspect, the present disclosure provides a method of treating pulmonary fibrosis in a subject, the method comprising administering to the subject a therapeutically effective amount of the miR-33 inhibitor. In some embodiments, the pulmonary fibrosis is idiopathic pulmonary fibrosis.

公开(公告)号：US11497197B2

公开(公告)日：2022-11-15

申请号：US16515856

申请日：2019-07-18

Applicant: University of Connecticut

Inventor： Mary Anne Amalaradjou

IPC: A01K45/00 ,  A01K29/00 ,  A23K10/18 ,  A61K35/744

Abstract: Methods for enhancing embryonic and post-hatch growth and performance of poultry by administration of a probiotic composition, such as a composition containing a mixture of one or more bacterial cultures, to the surface of the shells of fertilized eggs prior to setting. Optionally, the method further includes administration of the same probiotic composition at the same concentration to chicks hatched from the eggs that had received the topical in ovo administration to the shell. The probiotic composition is administered to the chicks orally, such as in feed.

公开(公告)号：US20220355089A1

公开(公告)日：2022-11-10

申请号：US17871490

申请日：2022-07-22

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US11487099B2

公开(公告)日：2022-11-01

申请号：US16819041

申请日：2020-03-14

Applicant: University of Connecticut

Inventor： Guoan Zheng

IPC: G02B21/36 ,  G01N15/10 ,  G01N1/28 ,  G01N15/14

Abstract: An imaging system includes a sample mount for holding a sample to be imaged, a light source configured to emit a light beam to be incident on the sample, a translation mechanism coupled to the sample mount and configured to scan the sample to a plurality of sample positions in a plane substantially perpendicular to an optical axis of the imaging system, a mask positioned downstream from the sample along the optical axis, and an image sensor positioned downstream from the mask along the optical axis. The image sensor is configured to acquire a plurality of images as the sample is translated to the plurality of sample positions. Each respective image corresponds to a respective sample position. The imaging system further includes a processor configured to process the plurality of images to recover a complex profile of the sample based on positional shifts extracted from the plurality of images.

公开(公告)号：US20220325117A1

公开(公告)日：2022-10-13

申请号：US17635773

申请日：2020-10-16

Applicant: THE UNIVERSITY OF CONNECTICUT ,  KANEKA AMERICAS HOLDING ,  KANEKA CORPORATION

Inventor： LUYI SUN ,  ANNA MARIE LACHANCE ,  TIANLEI ZHOU ,  YOUNG LIM

IPC: C09D7/40 ,  C09D129/04 ,  C09D7/61 ,  C09D7/20

Abstract: The invention relates to a nanocomposite coating system that exhibits superior barrier properties for reducing the ingress of unwanted guest species such as moisture (e.g., water vapor) and a facile method for preparing the same nanocoating system on an industrial scale. The current coating materials are able to reduce the overall ingress of unwanted guest species in a substantial improvement over the prior art.

公开(公告)号：US11461592B2

公开(公告)日：2022-10-04

申请号：US17251327

申请日：2019-08-07

Applicant: University of Connecticut

Inventor： Bahram Javidi ,  Adam Markman

IPC: G06K9/62 ,  G06V10/143 ,  G06V10/25 ,  G06V20/64

Abstract: Described herein is an object recognition system in low illumination conditions. A 3D InIm system can be trained in the low illumination levels to classify 3D objects obtained under low illumination conditions. Regions of interest obtained from 3D reconstructed images are obtained by de-noising the 3D reconstructed image using total-variation regularization using an augmented Lagrange approach followed by face detection. The regions of interest are then inputted into a trained CNN. The CNN can be trained using 3D InIm reconstructed under low illumination after TV-denoising. The elemental images were obtained under various low illumination conditions having different SNRs. The CNN can effectively recognize the 3D reconstructed faces after TV-denoising.

公开(公告)号：US11447655B2

公开(公告)日：2022-09-20

申请号：US16639010

申请日：2018-08-17

Applicant: KANEKA CORPORATION ,  THE UNIVERSITY OF CONNECTICUT

Inventor： Luyi Sun ,  Jingjing Liu ,  Songshan Zheng ,  Thomas D'Auria ,  Young Hoon Lim ,  Tianlei Zhou ,  Masaya Kotaki

IPC: C09D129/04 ,  C09D7/61 ,  C23C14/18 ,  C23C14/34 ,  B05D1/00 ,  B05D1/02 ,  C08K3/34

Abstract: Hybrid organic/inorganic coating compositions of nanometer thickness are described, where the organic layer is a clay-containing layer comprising a clay and a hydrophilic polymer and the inorganic layer is a metal-containing layer comprising a metal with a refractive index greater than 1.5, where the coating compositions allow for the generation and tenability of iridescent color through control of the coat thickness.

公开(公告)号：US11426570B2

公开(公告)日：2022-08-30

申请号：US16293588

申请日：2019-03-05

Applicant: University of Connecticut

Inventor： Thanh D. Nguyen ,  Khanh Tran

IPC: A61M37/00 ,  A61B17/20 ,  B29C41/00 ,  B29C43/00 ,  B29C65/02 ,  B29C43/32 ,  B29C43/02 ,  B29C39/00 ,  B29C39/02

Abstract: A core-shell microneedle system and a method of manufacturing the microneedle system provides a pulsatile drug delivery system which is programmed to release drugs/vaccines at predictable times using biodegradable polymers and with controllable dosages. This microneedle system can be fully embedded into the skin and then release drugs/vaccines as sharp bursts in a timely manner, similar to multiple bolus injections.

公开(公告)号：US20220194858A1

公开(公告)日：2022-06-23

申请号：US17552178

申请日：2021-12-15

Applicant: University of Connecticut

Inventor： Douglas H. Adamson ,  Garrett Kraft

IPC: C04B35/14 ,  C01B32/19 ,  C04B41/50

Abstract: Porous, electrically conductive ceramic foams incorporating continuous self-assembled graphene networks are described. The disclosed approach uses interfacial trapping to spontaneously exfoliate and assemble pristine graphite, not graphite oxide, in a ceramic sol-gel. The composite foams display electrical conductivity and joule heating, with anticipated applications as, for example, catalyst supports, thermoelectrics, and porous electrodes.