公开(公告)号：US20160084512A1

公开(公告)日：2016-03-24

申请号：US14957795

申请日：2015-12-03

Applicant: Nortek Air Solutions Canada, Inc. ,  University of Saskatchewan

Inventor： Blake Erb ,  Robert W. Besant ,  Carey J. Simonson ,  Howard Heminggson

IPC: F24F3/147 ,  F24F12/00

CPC classification number: F24F3/147 ,  F24F3/1417 ,  F24F12/001 ,  F24F12/002 ,  F24F12/006 ,  F24F2001/0092 ,  F24F2003/1435 ,  F28D15/00 ,  F28D21/0015 ,  Y02B30/545 ,  Y02B30/563

Abstract: An energy exchanger is provided. The exchanger includes a housing having a front and a back. A plurality of panels forming desiccant channels extend from the front to the back of the housing. Air channels are formed between adjacent panels. The air channels are configured to direct an air stream in a direction from the front of the housing to the back of the housing. A desiccant inlet is provided in flow communication with the desiccant channels. A desiccant outlet is provided in flow communication with the desiccant channels. The desiccant channels are configured to channel desiccant from the desiccant inlet to the desiccant outlet in at least one of a counter-flow or cross-flow direction with respect to the direction of the air stream.

公开(公告)号：US20160083443A1

公开(公告)日：2016-03-24

申请号：US14789718

申请日：2015-07-01

Applicant: University of Saskatchewan

Inventor： Scott Kirk Napper ,  Kenneth Jason Kindrachuk ,  Samuel Kwadwo Attah-Poku

IPC: C07K14/47 ,  A61K39/002 ,  A61K39/02 ,  A61K39/00

CPC classification number: C07K14/4723 ,  A61K38/00 ,  A61K39/0002 ,  A61K39/0008 ,  A61K39/002 ,  A61K39/02 ,  A61K39/39 ,  A61K2039/55516 ,  A61K2039/572 ,  C07K2319/00

Abstract: Compositions and methods are provided for modulating an immune response in a vertebrate subject. Compositions and methods can comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to activate the immune response in the vertebrate subject, wherein the modified host defense peptide is inverted in amino acid sequence from an amino terminus to a carboxy terminus or modified to one or more D-amino acids, or both modifications, when compared to a host defense peptide. Compositions and methods are provided which comprise administering a modified host defense peptide to the vertebrate subject in an amount effective to modify an immune response in the vertebrate subject.

Abstract translation: 提供组合物和方法用于调节脊椎动物受试者的免疫应答。 组合物和方法可以包括以有效激活脊椎动物受试者中的免疫应答的量向脊椎动物受试者施用修饰的宿主防御肽，其中修饰的宿主防御肽在氨基酸序列从氨基末端反转到羧基末端或 修饰为一个或多个D-氨基酸，或两个修饰，与宿主防御肽相比。 提供了组合物和方法，其包括以有效修饰脊椎动物受试者的免疫应答的量向脊椎动物受试者施用修饰的宿主防御肽。

公开(公告)号：US20140121017A1

公开(公告)日：2014-05-01

申请号：US13660469

申请日：2012-10-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Regan Mandryk ,  Shane Dielschneider ,  Michael Kalyn ,  Andre Doucette

IPC: A63F13/00

CPC classification number: A63F13/06 ,  A63F13/10 ,  A63F13/12 ,  A63F13/212 ,  A63F13/352 ,  A63F13/53 ,  A63F2300/6653 ,  A63F2300/6692

Abstract: Systems and methods of controlling user interaction with an application. The systems and methods include executing an application, providing a graphical overlay coupled to the application where the graphical overlay is configured to display a visualization or a visual effect, measuring at least one engagement characteristic to provide a measured condition and providing the visualization based on the measured condition. Examples of engagement characteristic include user physiological condition, type of the application selected, duration of time spent interacting with the application, duration of time spent interacting with one or more input receiving devices, pressure exerted over one or more input receiving devices and noise level of the user.

Abstract translation: 控制用户与应用程序交互的系统和方法。 系统和方法包括执行应用程序，提供耦合到应用程序的图形覆盖图，其中图形覆盖层被配置为显示可视化或视觉效果，测量至少一个接合特征以提供测量条件并且基于 测量条件。 接合特征的示例包括用户生理状况，所选择的应用的类型，与应用交互花费的持续时间，与一个或多个输入接收设备交互的持续时间，在一个或多个输入接收设备上施加的压力和噪声水平 用户。

公开(公告)号：US20140065188A1

公开(公告)日：2014-03-06

申请号：US14077730

申请日：2013-11-12

Applicant: University of Saskatchewan ,  The University of British Columbia

Inventor： B. Brett Finlay ,  Andrew A. Potter

IPC: A61K39/108

CPC classification number: A61K39/0258 ,  A61K2039/55566 ,  C07K14/245 ,  Y02A50/474

Abstract: Compositions and methods for stimulating an immune response against a secreted enterohemorragic Escherichia coli (EHEC) antigen are disclosed. The compositions comprise EHEC cell culture supernatants.

Abstract translation: 公开了用于刺激针对分泌的肠道大肠杆菌（EHEC）抗原的免疫应答的组合物和方法。 组合物包含EHEC细胞培养物上清液。

公开(公告)号：US20030007981A1

公开(公告)日：2003-01-09

申请号：US10098808

申请日：2002-03-13

Applicant: University of Saskatchewan

Inventor： Andrew A. Potter ,  Clement Rioux ,  Anthony B. Schryvers

IPC: A61K039/02 ,  A61K039/102 ,  C07H021/04 ,  C07K014/195

CPC classification number: C07K14/285 ,  A61K39/00

Abstract: Cloning and expression of genes encoding H. somnus transferrin-binding proteins are described. The transferrin-binding proteins can be used in vaccine compositions for the prevention and treatment of H. somnus infections, as well as in diagnostic methods for determining the presence of H. somnus infections.

Abstract translation: 描述了编码嗜睡细胞转铁蛋白结合蛋白的基因的克隆和表达。 转铁蛋白结合蛋白可用于疫苗组合物中，用于预防和治疗嗜睡睡眠感染，以及用于确定睡眠嗜血杆菌感染存在的诊断方法。

公开(公告)号：US12268734B2

公开(公告)日：2025-04-08

申请号：US17156477

申请日：2021-01-22

Applicant: University of Saskatchewan ,  Kenya Agriculture and Livestock Research Organization (KALRO) ,  International Livestock Research Institute (ILRI)

Inventor： Andrew Potter ,  Volker Gerdts ,  Jose Perez-Casal ,  Yejun Wang ,  Hezron Wesonga ,  Reuben Soi ,  Jan Naessens ,  Joerg Jores

IPC: A61K39/02 ,  A61K39/00 ,  A61P31/04 ,  C07K14/30 ,  C12N15/62

Abstract: Immunogenic proteins comprising Mycoplasma mycoides subsp. mycoides and M. mycoides subsp. capri proteins, encoding polynucleotides, a method for producing said proteins, and use of compositions to prevent M. mycoides subsp. mycoides infections are disclosed.

公开(公告)号：US12151004B2

公开(公告)日：2024-11-26

申请号：US17163145

申请日：2021-01-29

Applicant: University of Saskatchewan

Inventor： Humphrey Fonge ,  Clarence Ronald Geyer ,  Siddesh Vrushabendra swamy Hartimath

IPC: A61K51/10 ,  A61K39/00 ,  A61K47/60 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  C07K16/28 ,  C07K16/32

Abstract: The disclosure provides radiolabeled and/or cytotoxin labelled antibodies and methods and uses of these antibodies. In one embodiment, provided is a cytotoxic agent comprising an antibody that specifically binds a target disease cell surface receptor, a cytotoxin, and a radiolabel, wherein the cytotoxin is linked directly or indirectly to the antibody, and wherein the radiolabel comprises a radionuclide and optionally a scaffold, wherein the scaffold is directly or indirectly coupled to the antibody. Also provided are methods of preparing the cytotoxic agent and methods of treating disease using the cytotoxic agent.

公开(公告)号：US20240199663A1

公开(公告)日：2024-06-20

申请号：US18556667

申请日：2022-04-22

Applicant: University of Saskatchewan ,  Battelle Energy Alliance, LLC

Inventor： Samuel Attah-Poku ,  George Mutwiri ,  Sylvia Van Den Hurk ,  Jan Van Den Hurk ,  John Klaehn ,  Volker Gerdts

IPC: C07F9/6593 ,  A61K39/00 ,  A61K39/39

CPC classification number: C07F9/65815 ,  A61K39/39 ,  A61K2039/55511

Abstract: Disclosed herein are cyclopolyphosphazenes of formula I:




methods for the preparation thereof and uses thereof in adjuvant compositions.

公开(公告)号：US20240124595A1

公开(公告)日：2024-04-18

申请号：US18277831

申请日：2022-02-25

Applicant: UNIVERSITY OF SASKATCHEWAN

Inventor： Maruti Uppalapati ,  Ekaterina Dadachova

IPC: C07K16/28 ,  A61K51/10 ,  A61P35/00 ,  G01N33/574

CPC classification number: C07K16/2863 ,  A61K51/103 ,  A61P35/00 ,  G01N33/57407 ,  G01N33/57492 ,  A61K2039/505 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/92

Abstract: The disclosure relates to antibodies that bind human, murine, and canine IGF2R, and methods of using said antibodies. Provided herein are antibodies having specific CDRs identified herein, including functional variants of specific variable domains and IgGs having the specified CDR sequences, and immunoconjugates of said antibodies and uses thereof. Also provided herein are compositions and kits comprising said antibodies, and methods and uses of said antibodies, immunoconjugates, compositions, and kits. Also provided herein are the use of said antibodies for radioimmunotherapy (RIT) for cancer including osteosarcoma.

公开(公告)号：US20240066111A1

公开(公告)日：2024-02-29

申请号：US18153483

申请日：2023-01-12

Applicant: University of Saskatchewan

Inventor： Heather Lynne Wilson ,  Milan Obradovic

IPC: A61K39/02 ,  A61K9/107 ,  A61P31/04 ,  C07K14/195 ,  C12N15/70

CPC classification number: A61K39/105 ,  A61K9/107 ,  A61P31/04 ,  C07K14/195 ,  C12N15/70 ,  A61K2039/552

Abstract: L intracellularis antigens for use in subunit vaccine compositions to elicit immune responses against L intracellularis infections such as proliferative enteropathy (PE) are described, as well as polynucleotides encoding therefor. Also described are methods for treating and preventing L intracellularis infections.