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81.发明授权
公开(公告)号：KR101494488B1
公开(公告)日：2015-02-24
申请号：KR1020107017557
申请日：2008-12-03
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/15
Abstract: 화학식 1로 나타내어지는 2-사이클로펜텐-1-온 옥심유도체를 포함하는 비만, 이상지질혈증, 당뇨 등과 같은 지방대사질환 예방 및 치료용 약학조성물이 개시된다. 구체적으로 상기 화합물은 분화된 지방세포 (3T3-L1)에서의 지방분해를 촉진시켜 결과적으로 체내 지방을 감소시킴으로써, 비만, 이상지질혈증, 당뇨 등과 같은 지방대사 질환의 예방 및 치료에 이용될 수 있다. 화학식 1에서 R
1 은 선형 또는 분지형 C
1 -C
6 알킬기, 또는 사이클로알킬기, 또는 치환기를 갖거나 갖지 않는 페닐기를 의미하고, R
2 는 치환기를 가지거나 가지지 않는 방향족기를 의미한다.-
公开(公告)号：KR1020150005882A
公开(公告)日：2015-01-15
申请号：KR1020140179034
申请日：2014-12-12
Applicant: (주)아모레퍼시픽
Abstract: 본 발명은 인간 중간엽줄기세포의 지방세포로의 분화를 촉진하는 조성물에 관한 것으로, 보다 상세하게는 계혈등, 고량강, 독활 및 천련자 추출물 중 적어도 1종 이상을 유효성분으로 함유하여 인간 중간엽줄기세포를 지방세포로 분화하는 것을 촉진시킴으로써 지방체(Lipid droplet)를 생성하여 피부의 볼륨과 탄력을 증진시키고 주름을 개선시키는 조성물에 관한 것이다.
Abstract translation: 本发明涉及促进人间充质干细胞向脂肪细胞分化的组合物。 更具体地，该组合物含有一种或多种作为活性成分的木瓜木瓜，高甘蓝，禾谷镰刀菌和楝树甜菜提取物，以促进人间充质干细胞向脂肪细胞的分化。 因此，产生液滴，从而可以改善皮肤体积和弹性，并可以减轻皱纹。
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公开(公告)号：KR1020120139430A
公开(公告)日：2012-12-27
申请号：KR1020110059227
申请日：2011-06-17
Applicant: (주)아모레퍼시픽
IPC: C12N15/113 , A61K31/7088 , A61Q19/00 , A61Q7/00
Abstract: PURPOSE: A composition containing miRNA for controlling pigmentation gene expression is provided to suppress tyrosinase, tyrosinase-related proteins, and melan-A expression. CONSTITUTION: A composition for controlling pigmentation gene expression contains miRNA containing a base of sequence number 1 as an active ingredient. The miRNA has continuous 27 bases containing ccuucuu of sequence number 1 and a base which suppresses pigmentation gene expression. The pigmentation gene is tyrosinase, tyrosinase-related protein 1, or melan-A gene. The miRNA targets 909-915th nucleic acids of melan A mRNA 3'-UTR. The composition is a cosmetic or pharmaceutical composition for skin whitening. A composition for controlling pigmentation gene expression contains a complementary base with miRNA of sequence number 1. [Reference numerals] (AA) Relative TYR/GAPDH mRNA expression level; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有miRNA用于控制色素沉着基因表达的组合物，以抑制酪氨酸酶，酪氨酸酶相关蛋白和黑色素A表达。 构成：用于控制色素沉着基因表达的组合物含有含有序列号1的碱基作为活性成分的miRNA。 miRNA具有连续的27个碱基，其含有序列号1的碱基和抑制色素沉着基因表达的碱基。 色素沉着基因是酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A基因。 miRNA靶向黑色A mRNA 3'-UTR的第909-915个核酸。 该组合物是用于皮肤美白的化妆品或药物组合物。 用于控制色素沉着基因表达的组合物含有与序列号1的miRNA的互补碱基。[参考数字]（AA）相对TYR / GAPDH mRNA表达水平; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR1020120058687A
公开(公告)日：2012-06-08
申请号：KR1020100116410
申请日：2010-11-22
Applicant: (주)아모레퍼시픽
IPC: A61K8/37 , A61K8/368 , A61K8/36 , A61K8/49 , A61K8/89 , A61Q17/04 , A61K31/41 , A61K31/192 , A61K31/215 , A61K31/60
CPC classification number: A61K8/37 , A61K8/36 , A61K8/368 , A61K8/4966 , A61K8/89 , A61K31/192 , A61K31/215 , A61K31/41 , A61K31/60 , A61Q17/04
Abstract: PURPOSE: A composition containing cinnamic acid derivatives, triazine derivatives, and methoxy phenyl acrylate derivatives is provided to remarkably reduce chemical decomposition in case of irradiating with light. CONSTITUTION: A composition for sun screening contains cinnamic acid derivatives, triazine derivatives, and methoxy phenyl acrylate derivatives as an active ingredient. The triazine derivative includes bis-ethyl hexcyloxyphenyl methoxy phenyl triazine, tris(diisobutyl-aminobenzalmalonate)triazine, or combination thereof. The methoxyphenyl acrylate derivative is ethyl hexyl methoxy crylene. The composition further contains salicylic acid derivatives and benzalonate derivatives.
Abstract translation: 目的：提供含有肉桂酸衍生物，三嗪衍生物和甲氧基苯基丙烯酸酯衍生物的组合物，以显着减少在照射光时的化学分解。 构成：防晒组合物含有肉桂酸衍生物，三嗪衍生物和甲氧基苯基丙烯酸酯衍生物作为活性成分。 三嗪衍生物包括二乙基己氧基苯基甲氧基苯基三嗪，三（二异丁基 - 氨基苯甲醛丙二酸）三嗪或其组合。 甲氧基苯基丙烯酸酯衍生物是乙基己基甲氧基二烯丙基。 该组合物还含有水杨酸衍生物和苯甲酸酯衍生物。
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公开(公告)号：KR1020120002964A
公开(公告)日：2012-01-09
申请号：KR1020110137404
申请日：2011-12-19
Applicant: (주)아모레퍼시픽
IPC: A61K36/49 , A61K36/898 , A61K36/537 , A61P17/00
CPC classification number: A61K36/49 , A61K8/97 , A61K36/537 , A61K36/898 , A61Q19/08
Abstract: PURPOSE: A composition for promoting differentiation of human mesenchymal stem cells into adipocytes is provided to enhance skin volume. CONSTITUTION: An external use skin composition for enhancing skin elasticity contains 0.0001-30 wt% of extract of Castaneae Semen, Selaginella tamariscina, Aloe vera L., Mentha arvensis var. piperascens Makinv., Pinellia ternata (Thunb.) Breit., Triticum aestivum L., Saururus chinensis Baill., Polygala tenuifolia Willd., or Gleditsia sinensis Lam. as an active ingredient. The composition promotes differentiation of mesenchymal stem cells into adipocytes. The mesenchymal stem cells are derived from human. A pharmaceutical composition for promoting differentiation of adipocytes contains the extract as an active ingredient.
Abstract translation: 目的：提供用于促进人间充质干细胞分化为脂肪细胞的组合物，以增强皮肤体积。 构成：用于增强皮肤弹性的外用皮肤组合物含有0.0001-30重量％的蓖麻精，卷柏，芦荟提取物， （Piellens Makinv。），Pinellia ternata（Thunb。）Breit。，Triticum aestivum L.，Saururus chinensis Baill。，Polygala tenuifolia Willd。或Gleditsia sinensis Lam。 作为活性成分。 该组合物促进间充质干细胞分化为脂肪细胞。 间充质干细胞来源于人。 用于促进脂肪细胞分化的药物组合物含有提取物作为活性成分。
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Patent Agency Ranking
公开(公告)号：KR1020120002482A
公开(公告)日：2012-01-05
申请号：KR1020110064247
申请日：2011-06-30
Applicant: (주)아모레퍼시픽
IPC: A61K38/16 , A61K31/7105 , A61P17/00
CPC classification number: A61K31/7105 , A61K8/64 , A61K31/7115 , A61K38/005 , A61K48/005 , A61Q19/08
Abstract: PURPOSE: A composition containing an oligonucleotide or mimic acting as an inhibitor of miRNA-526b is provided to control collagen generation and to prevent or treat aging. CONSTITUTION: A composition for controlling collagen contains 15-23 serial nucleotides of sequence number 1. The collagen is controlled by regulating the expression of matrix metalloproteinase 1(MMP1). The oligonucleotide reduces or suppresses the expression of MMP1 by hybridization with MMP1 mRNA. The composition is used for anti-aging.
Abstract translation: 目的：提供含有作为miRNA-526b抑制剂的寡核苷酸或模拟物的组合物，以控制胶原蛋白的产生和预防或治疗老化。 构成：用于控制胶原的组合物含有序列1的15-23个连续核苷酸。通过调节基质金属蛋白酶1（MMP1）的表达来控制胶原蛋白。 寡核苷酸通过与MMP1 mRNA杂交降低或抑制MMP1的表达。 该组合物用于抗衰老。
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公开(公告)号：KR1020110000715A
公开(公告)日：2011-01-05
申请号：KR1020100117490
申请日：2010-11-24
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A composition containing medicinal herb extract for skin care or plasty is provided to promote differentiation of mesenchymal stem cells to adipocytes. CONSTITUTION: A composition for promoting adipocyte differentiation contains Linderae Radix extract as an active ingredient. The composition increases fat tissue and promotes differentiation of mesenchymal stem cells to adipocytes. The mesenchymal stem cells are derived from human bone marrow.
Abstract translation: 目的：提供含有用于护肤或整形的药草提取物的组合物，以促进间充质干细胞向脂肪细胞的分化。 构成：用于促进脂肪细胞分化的组合物含有紫草提取物作为活性成分。 组合物增加脂肪组织并促进间充质干细胞向脂肪细胞的分化。 间充质干细胞衍生自人骨髓。
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88.发明公开
公开(公告)号：KR1020100103671A
公开(公告)日：2010-09-27
申请号：KR1020107017557
申请日：2008-12-03
Applicant: (주)아모레퍼시픽
CPC classification number: A61K31/15
Abstract: PURPOSE: A pharmaceutical composition containing 2-cyclopentene-1-one oxime derivative is provided to promote adipose lysis in adipocytes(3T3-L1) and to prevent and treat lipid metabolic diseases including obesity and diabetes. CONSTITUTION: A pharmaceutical composition for preventing and treating lipid metabolic diseases contains 2-cyclopenten-1-one oxime derivative compound of chemical formula 1 or pharmaceutically acceptable salt thereof as an active ingredient. In chemical formula 1, R1 is linear or branched C1-C10 alkyl group or C3-C7 cycloalkyl group, or phenyl group with or without substituent. The phenyl group is denoted by chemical formula 2. The pharmaceutical composition is used for preventing and treating obesity, diabetes, or dyslipidemia.
Abstract translation: 目的：提供含有2-环戊烯-1-酮肟衍生物的药物组合物，以促进脂肪细胞（3T3-L1）中的脂肪裂解，并预防和治疗脂肪代谢疾病，包括肥胖和糖尿病。 构成：用于预防和治疗脂质代谢疾病的药物组合物含有化学式1的2-环戊烯-1-酮肟衍生物化合物或其药学上可接受的盐作为活性成分。 在化学式1中，R 1为直链或支链C 1 -C 10烷基或C 3 -C 7环烷基，或具有或不具有取代基的苯基。 苯基由化学式2表示。药物组合物用于预防和治疗肥胖症，糖尿病或血脂异常。
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公开(公告)号：KR100864677B1
公开(公告)日：2008-10-23
申请号：KR1020070029255
申请日：2007-03-26
Applicant: (주)아모레퍼시픽
IPC: C07C233/07 , C07C233/10
Abstract: 본 발명은 항비만 효과를 나타내는 하기 화학식 1로 표시되는 3,5-디히드록시벤조산 유도체 화합물 및 이의 제조방법에 관한 것이다:
[화학식 1]
상기 식 중, R은 아다만틸, 시클로헥실 또는 헥실이다.
3,5-디히드록시벤조산 유도체, 항비만, 루시퍼라아제, IDH3α, CPT1, 혈당-
公开(公告)号：KR1020080067823A
公开(公告)日：2008-07-22
申请号：KR1020070005217
申请日：2007-01-17
Applicant: (주)아모레퍼시픽
Abstract: A transgenic mouse is provided to show obese-inhibiting characteristic by over-express an isocitrate dehydrogenase 3 alpha(IDH3A), there by being used as a model animal for treating and studying obesity. An expression vector pcDNA-IDH3A comprises: a CMV promoter; an IDH3A gene; and a polyadenylated sequence. A method for preparing a transgenic Mus musculus comprises the steps of: (a) preparing the expression vector pcDNA-IDH3A; and (b) micro-injecting the expression vector into a pronucleus of a Mus musculus fertilized egg. Further, the IDH3A gene is cDNA synthesized from mRNA derived form human heart.
Abstract translation: 提供转基因小鼠以通过过表达异柠檬酸脱氢酶3α（IDH3A）来显示肥胖抑制特征，其被用作用于治疗和研究肥胖症的模型动物。 表达载体pcDNA-IDH3A包含：CMV启动子; IDH3A基因; 和多聚腺苷酸化序列。 一种制备转基因小鼠的方法包括以下步骤：（a）制备表达载体pcDNA-IDH3A; 和（b）将表达载体微注射到小家鼠受精卵的原核中。 此外，IDH3A基因是从人心脏衍生的mRNA合成的cDNA。
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