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81.发明公开
公开(公告)号：KR1020150119741A
公开(公告)日：2015-10-26
申请号：KR1020140045547
申请日：2014-04-16
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: A61K48/00 , A61K39/395 , A61K8/96 , A61P17/00 , A61Q19/02
CPC classification number: C07K16/28 , A61K2039/505 , C07K16/2896
Abstract: 본발명은캐드헤린11(Cadherin 11) 및 N-캐드헤린(N-cadherin) 중하나이상의발현억제물질을유효성분으로포함하는피부개선용조성물및 이를포함하는피부개선키트를제공함으로써피부과색소침착증을개선할수 있으며, 피부미백효과를제공할수 있다. 피부주름생성을방지또는완화할수 있으므로, 우수한항노화효과를제공한다. 또한, 본발명은섬유아세포(fibroblast), 각질형성세포(keratinocyte) 및멜라닌생성세포(melanocyte) 중 2종이상의공배양물을포함하는피부개선물질스크리닝시스템, 및상기피부개선물질스크리닝시스템의공배양물에후보물질을처리하는단계, 및캐드헤린11 및 N-캐드헤린중 하나이상의발현변화를측정하는단계를포함하는것을특징으로하는피부개선물질의스크리닝방법을제공함으로써, 생체외(in vitro)에서도임상적으로캐드헤린11, N-캐드헤린의발현변화를용이하게측정하여, 피부개선물질을효과적으로스크리닝할수 있다.
Abstract translation: 本发明提供一种皮肤改善组合物，其包含抑制钙粘蛋白11和N-钙粘蛋白中的至少一种的表达的作为活性物质的材料，以及包含其的皮肤改善剂。 根据本发明，可以减轻皮肤色素沉着过度; 可以提供皮肤美白效果; 并且由于皮肤改善组合物可以防止或减轻皱纹的产生，因此可以提供优异的抗老化效果。 本发明提供了一种用于筛选皮肤改善材料的系统，其包括来自成纤维细胞，角质形成细胞和黑素细胞的至少两种的共培养产物，以及用于筛选皮肤改善材料的方法。 该方法包括以下步骤：用候选材料处理系统的共培养产物以筛选皮肤改善材料; 并测定钙粘蛋白11和N-钙粘蛋白中至少一种的表达变化。 钙粘蛋白11和N-钙粘蛋白中至少一种的表达变化可以在体外和容易的方式进行临床测定。 因此，可以有效地筛选皮肤改善材料。
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公开(公告)号：KR1020140009660A
公开(公告)日：2014-01-23
申请号：KR1020120075941
申请日：2012-07-12
Applicant: (주)아모레퍼시픽
Abstract: The present invention relates to a composition for skin whitening comprising ARP101. The composition for skin whitening, as one aspect of the present invention, reduces the amount of melanin by reducing the expression of melanogenesis-related proteins, thereby having whitening effects without cytotoxicity.
Abstract translation: 本发明涉及一种包含ARP101的皮肤美白组合物。 作为本发明的一个方面，用于皮肤美白的组合物通过减少黑素生成相关蛋白的表达来减少黑色素的量，从而具有无细胞毒性的美白效果。
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公开(公告)号：KR1020130049589A
公开(公告)日：2013-05-14
申请号：KR1020110114689
申请日：2011-11-04
Applicant: (주)아모레퍼시픽 , 동국대학교 산학협력단
IPC: C12N15/63 , C12N15/861 , C12Q1/68 , G01N33/53
CPC classification number: C12N15/635 , C12N15/861 , C12Q1/6883 , C12Q2600/148 , C12Q2600/158 , G01N33/5023 , G01N33/5302 , G01N33/6881
Abstract: PURPOSE: A method for screening a material which enhances a skin barrier function is provided to effectively screening the material, and to diagnose diseases related to the skin barrier function. CONSTITUTION: A method for screening a material which enhances a skin barrier function comprises a step of determining a material which suppresses the expression of PDZK1 genes as the material which enhances the skin barrier function by screening the material which suppresses the expression of the PDZK1 genes. The method comprises a step of treating a nucleic acid molecule of PDZK1 with a candidate material, and a step of detecting expression change. The treatment with the candidate material comprises a step of treating a skin cell which is transformed with a vector containing the nucleic acid molecule with the candidate material. The skin cell is keratinocyte. The vector is adenovirus. A composition for enhancing the skin barrier function contains the material which suppresses the expression of the PDZK1 genes as an active ingredient. [Reference numerals] (AA) Comparative example 1; (BB) Example 1
Abstract translation: 目的：提供一种筛选增强皮肤屏障功能的材料的方法，以有效筛选材料，并诊断与皮肤屏障功能相关的疾病。 构成：用于筛选增强皮肤屏障功能的材料的方法包括测定通过筛选抑制PDZK1基因表达的材料来抑制PDZK1基因表达的材料作为增强皮肤屏障功能的材料的步骤。 该方法包括用候选物质处理PDZK1的核酸分子的步骤和检测表达变化的步骤。 用候选材料的处理包括用候选材料处理用含有核酸分子的载体转化的皮肤细胞的步骤。 皮肤细胞是角质形成细胞。 载体是腺病毒。 用于增强皮肤屏障功能的组合物含有抑制作为活性成分的PDZK1基因表达的材料。 （附图标记）（AA）比较例1; （BB）实施例1
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公开(公告)号：KR1020130035935A
公开(公告)日：2013-04-09
申请号：KR1020120108461
申请日：2012-09-28
Applicant: (주)아모레퍼시픽
Abstract: PURPOSE: A keratinocyte-adapted melanocyte and a method for preparing the same are provided to obtain melanocyte with excellent adhesion and high survival rate. CONSTITUTION: A method for preparing keratinocyte-adapted melanocytes comprises: a step of culturing keratinocytes in a keratinocyte medium; a step of removing keratinocytes from a culture; and a step of collecting cells adhered on the bottom of a dish and culturing the cells in a melanocyte medium.
Abstract translation: 目的：提供角质形成细胞适应的黑素细胞及其制备方法，以获得具有优异粘附性和高存活率的黑素细胞。 构成：一种制备角质形成细胞适应黑素细胞的方法，包括：在角质细胞培养基中培养角化细胞的步骤; 从培养物中去除角质形成细胞的步骤; 以及收集附着在皿底部并在黑素细胞培养基中培养细胞的细胞的步骤。
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Patent Agency Ranking
公开(公告)号：KR1020130000038A
公开(公告)日：2013-01-02
申请号：KR1020110060483
申请日：2011-06-22
Applicant: (주)아모레퍼시픽
IPC: C12N15/11 , A61K31/7105 , A61P17/14 , A61Q19/02
Abstract: PURPOSE: A composition containing miRNA or antisense nucleic acid molecules for preventing grey hair or improving a skin whitening effect is provided to regulate the expression of genes expressing tyrosinase, tyrosinase-related proteins, and melan-A. CONSTITUTION: A composition for regulating the expression of pigmentation-related genes contains miRNA of sequence number 1 as an active ingredient. The miRNA is selected among base sequences of sequence number 1, and contains 15-22 continuous base sequences including ugaaaug. The pigmentation-related genes express tyrosinase, tyrosinase-related protein 1, or melan-A. A method for screening a material which regulates the expression of the pigmentation-related genes among test materials comprises: a step of transfectioning the miRNA of sequence number 1 or antisense nucleic acid molecules of sequence number 2 into cells; a step of treating the test materials to the cells; and a step of identifying if the test materials promote or suppress the expression of the pigmentation-related genes. [Reference numerals] (AA) Relative mRNA expression of TYRP1/GAPDH; (BB) Comparative embodiment 1; (CC) Comparative embodiment 2; (DD) Embodiment 1
Abstract translation: 目的：提供含有用于预防灰白发或改善皮肤美白效果的miRNA或反义核酸分子的组合物，以调控表达酪氨酸酶，酪氨酸酶相关蛋白和黑色素A的基因的表达。 构成：用于调节色素沉着相关基因表达的组合物含有序列号1的miRNA作为活性成分。 miRNA选自序列号1的碱基序列，并且包含15-22个连续碱基序列，包括ugaaaug。 色素沉着相关基因表达酪氨酸酶，酪氨酸酶相关蛋白1或黑色素A。 用于筛选调节试验材料中色素沉着相关基因表达的材料的方法包括：将序列号1的miRNA或序列号2的反义核酸分子转染入细胞的步骤; 将测试材料处理到细胞的步骤; 以及鉴定测试物质是否促进或抑制色素沉着相关基因表达的步骤。 （AA）相关mRNA表达TYRP1 / GAPDH; （BB）比较实施例1; （CC）比较实施例2; （DD）实施例1
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公开(公告)号：KR1020120043349A
公开(公告)日：2012-05-04
申请号：KR1020100104608
申请日：2010-10-26
Applicant: (주)아모레퍼시픽
CPC classification number: A61K8/97 , A61K8/925 , A61Q1/10 , A61Q19/007
Abstract: PURPOSE: A cosmetic composition for makeup containing phytochrome is provided to enable moisture makeup without skin dryness. CONSTITUTION: A cosmetic composition for makeup contains 0.1-5 wt% of phytochrome as an active ingredient. The composition is used for improving color visibility. The composition further contains 0.1-5 wt% of omega 3, 6, and 9 oil. The composition is used for improving moisturizing. The omega 3, 6, and 9 oil is extracted from a plant inhabiting in Amazon area and contains essential fatty acid alpha-omega-3 linoleic acid(48% or more), omega-6 acid linoleic(36% or more), and omega-9(85% or more).
Abstract translation: 目的：提供含有植物色素的化妆品化妆品组合物，以防止化妆而无皮肤干燥。 构成：用于化妆的化妆品组合物含有0.1-5重量％的植物色素作为活性成分。 该组合物用于提高颜色可视性。 组合物还含有0.1-5重量％的ω3，6和9油。 该组合物用于改善保湿。 欧米加3，6和9油从亚马逊地区的植物中提取，含有必需脂肪酸α-ω-3亚油酸（48％或更多），ω-6酸亚油酸（36％或更高），和 ω-9（85％以上）。
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公开(公告)号：KR101072641B1
公开(公告)日：2011-10-11
申请号：KR1020040025053
申请日：2004-04-12
Applicant: (주)아모레퍼시픽
Abstract: 본발명은방선균() 균주또는방선균() 배양물추출물을유효성분으로함유하는피부미백용조성물에관한것으로서, 본발명에의한조성물은멜라닌생합성에관여하는효소인타이로시네이즈(tyrosinase)를합성하는글라이코실레이션(glycosylation)의과정에관여하는중요한효소인베타-글루코시다제(beta-glucosidase)의효소활성을억제함으로써, 타이로시네이즈의글라이코실레이션을억제하여멜라닌생성을저해함으로써미백효과를나타내므로, 본발명에의한피부미백용조성물을이용하면, 방선균균주또는방선균배양물추출물의효능으로인해부작용없이멜라닌생성을효과적으로억제할수 있다.
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公开(公告)号：KR1020100000391A
公开(公告)日：2010-01-06
申请号：KR1020080059872
申请日：2008-06-24
Applicant: (주)아모레퍼시픽 , 서울대학교산학협력단
Abstract: PURPOSE: A method for screening a cosmetic material and cosmetic composition containing a material suppressing TRPV-1(transient receptor potential family V-1) are provided to select a target material which is effective in anti-aging and reduce skin irritation. CONSTITUTION: A material which suppresses activation of TRPV-1(transient receptor potential family V-1) contains extract isolated from one or more selected from Prunus mume Sieb. et Zucc., Pleuropterus multflorus, and Atractylodes japonica Koidxumi or Atractylodes ovate Koidzumi. A cosmetic composition contains 0.001-10 weight%, preferably 0.01-5 weight% of the extract. The cosmetic composition is used in the form of nutrition skin, massage cream, pack gel or lotion, ointment, cream, patch or spray.
Abstract translation: 目的：提供一种筛选含有抑制TRPV-1（瞬时受体潜能家族V-1）的物质的美容材料和化妆品组合物的方法，以选择有效抗衰老和降低皮肤刺激性的目标材料。 构成：抑制TRPV-1（瞬时受体电位家族V-1）活化的物质含有从一种或多种选自杏仁酵母中分离的提取物。 等等，Pleuropterus multflorus和Atractylodes japonica Koidxumi或Atractylodes ovate Koidzumi。 化妆品组合物含有0.001-10重量％，优选0.01-5重量％的提取物。 化妆品组合物以营养皮肤，按摩膏，包装凝胶或洗剂，软膏，霜剂，贴剂或喷雾剂的形式使用。
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公开(公告)号：KR1020090092235A
公开(公告)日：2009-08-31
申请号：KR1020090015228
申请日：2009-02-24
Applicant: (주)아모레퍼시픽
Abstract: A composition containing a sprout extract of plant is provided to enhance viability and proliferation of skin stem cell and delay skin aging. A composition for suppressing skin aging comprises Sequoia sprout extract, sun flower sprout extract and kale sprout extract as active ingredients. The composition further comprises bilberry sprout extract, peach sprout extract, broccoli sprout extract as active ingredients. The composition is used in the form of lotion, massage cream, nutrition cream, pack gel or skin viscosity type make-up material.
Abstract translation: 提供含有植物发芽提取物的组合物以增强皮肤干细胞的活力和增殖并延缓皮肤老化。 用于抑制皮肤老化的组合物包括红杉芽提取物，太阳花芽提取物和羽衣甘蓝提取物作为活性成分。 该组合物还含有越橘发芽提取物，桃芽提取物，西兰花发芽提取物作为活性成分。 该组合物以洗剂，按摩霜，营养霜，包装凝胶或皮肤粘度型补充材料的形式使用。
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