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公开(公告)号：KR101554091B1
公开(公告)日：2015-09-30
申请号：KR1020140008313
申请日：2014-01-23
Applicant: 동국대학교 산학협력단 , 성보화학주식회사
Abstract: 본발명은황토슬러리를이용한배추과작물의뿌리혹병방제조성물및 이의제조방법에관한것으로, 구체적으로본 발명의황토슬러리를이용한배추과작물의뿌리혹병방제조성물을정식전에뿌리를침지시켜전처리한후, 경엽처리하면배추과작물에서치명적인뿌리혹병의방제가가능하므로유기농또는친환경농업을할 수있어국민의안전을위협하고토양과수질을악화시키는요소를방지하여친환경농업발전에이바지할수 있다.
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公开(公告)号：KR101548534B1
公开(公告)日：2015-09-02
申请号：KR1020130124784
申请日：2013-10-18
Applicant: 동국대학교 산학협력단
CPC classification number: C12N13/00 , C12N5/0696 , C12N2529/00
Abstract: 본발명은전자기장을이용한성체세포를유도만능줄기세포로역분화시키는방법에관한것이다. 본발명에따른전자기장을이용한유도만능줄기세포로역분화시키는방법은성체세포를유도만능줄기세포로역분화시키는효율이우수하고, 유도만능줄기세포를용이하게수득할수 있다. 또한, 상기방법으로제조된유도만능줄기세포는역분화인자의발현양이높고, 마우스에이식하는경우, 전분화능이나타난다. 따라서, 상기역분화된유도만능줄기세포를세포치료제개발및 재생의학분야의연구등에유용하게사용할수 있다.
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公开(公告)号：KR1020150088014A
公开(公告)日：2015-07-31
申请号：KR1020140008313
申请日：2014-01-23
Applicant: 동국대학교 산학협력단 , 성보화학주식회사
CPC classification number: A01N59/00
Abstract: 본발명은황토슬러리를이용한배추과작물의뿌리혹병방제조성물및 이의제조방법에관한것으로, 구체적으로본 발명의황토슬러리를이용한배추과작물의뿌리혹병방제조성물을정식전에뿌리를침지시켜전처리한후, 경엽처리하면배추과작물에서치명적인뿌리혹병의방제가가능하므로유기농또는친환경농업을할 수있어국민의안전을위협하고토양과수질을악화시키는요소를방지하여친환경농업발전에이바지할수 있다.
Abstract translation: 本发明涉及包含用于控制芸苔属植物根茎的红粘土浆料的组合物及其制备方法。 具体地说，将根浸入含有用于控制种植前的芸苔属植物根茎的红粘土浆料的组合物进行预处理，然后进行叶面处理，以控制棒菜根为芸苔属植物的致死病， 用户进行有机农业或环境友好型农业，防范威胁人民群众安全的因素，恶化水土质量，促进生态友好型农业发展。 制备根据本发明的用于控制芸苔属植物根茎的红粘土浆料的组合物的方法包括以下步骤：1）将10-40重量％的氢氧化钠（NaOH）与60-90重量％的红 容器中的粘土; 2）在具有石墨坩埚的炉中在1100-1200℃下进行步骤1的混合物的熔融反应; 3）通过粉碎机冷却然后粉碎步骤2的熔融产物; 4）向步骤3的粉碎产物中加入水，再次粉碎混合物以制备红泥浆; 5）向步骤4中制备的红泥浆中加入硫酸进行中和; 和6）将步骤5中和的红土浆料稀释至基于100重量份水的0.1-2重量份。
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公开(公告)号：KR101287690B1
公开(公告)日：2013-07-24
申请号：KR1020120015371
申请日：2012-02-15
Applicant: 서울대학교산학협력단 , 동국대학교 산학협력단
CPC classification number: B01L3/5027 , B01L2300/14 , C12M23/16 , C12N5/0619
Abstract: PURPOSE: A cell damage modeling apparatus using a microfluidic element and a cell damage modeling method using the same are provided to simulate an environment which is similar to a real cell pressurizing condition through the configuration that is able to pressurize cells by supplying air to an air channel. CONSTITUTION: A cell damage modeling apparatus comprises: a cell culture channel (110) for culturing nerve cells; an air channel (120) formed at one side of the cell culture channel; an intermediate layer which is formed between the cell culture channel and the air channel and has an elastically transformable material; and an air supply unit which supplies air to the air channel to pressurize cells in the cell culture channel. The cell culture channel and the air channel form an interlayer in a main body (100) of a PDMS material.
Abstract translation: 目的：提供使用微流体元件的细胞损伤造型装置和使用其的细胞损伤建模方法，以通过能够通过向空气供应空气来加压细胞的构造来模拟类似于真实细胞加压状态的环境 渠道。 构成：细胞损伤造型装置，包括：培养神经细胞的细胞培养通道（110） 形成在细胞培养通道一侧的空气通道（120） 中间层，其形成在细胞培养通道和空气通道之间，并具有可弹性变形的材料; 以及向空气通道供给空气以对细胞培养通道中的细胞加压的空气供给单元。 细胞培养通道和空气通道在PDMS材料的主体（100）中形成中间层。
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公开(公告)号：KR1020130061970A
公开(公告)日：2013-06-12
申请号：KR1020110128317
申请日：2011-12-02
Applicant: 동국대학교 산학협력단
IPC: C12N13/00 , C12N5/0775 , C12N5/079 , A61K35/12
Abstract: PURPOSE: A method and an apparatus for differentiating stem cells using composite waves are provided to quickly differentiate the stem cells into nerve cells. CONSTITUTION: A method for differentiating mesenchymal stem cells into nerve cells comprises a step of simultaneously or sequentially treating the mesenchymal stem cells by an electromagnetic field and sound wave. The mesenchymal stem cells are derived from embryos or adult tissue. The mesenchymal stem cells are derived from bone marrow, fat, umbilical cord blood, or umbilical cord. The differentiated nerve cells are treated by an electromagnetic field and sound wave. A pharmaceutical composition for treating neurological disorders contains the nerve cells.
Abstract translation: 目的：提供用于使用复合波分化干细胞的方法和装置，以将干细胞快速分化成神经细胞。 构成：将间充质干细胞分化成神经细胞的方法包括通过电磁场和声波同时或依次处理间充质干细胞的步骤。 间充质干细胞衍生自胚胎或成体组织。 间充质干细胞衍生自骨髓，脂肪，脐带血或脐带。 分化神经细胞通过电磁场和声波进行治疗。 用于治疗神经障碍的药物组合物含有神经细胞。
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Patent Agency Ranking
公开(公告)号：KR1020130033938A
公开(公告)日：2013-04-04
申请号：KR1020120050142
申请日：2012-05-11
Applicant: 서울대학교산학협력단 , 동국대학교 산학협력단
Abstract: PURPOSE: A three dimensional cell culture device and a three dimensional cell culture method using the same are provided to form a floating spheroid in a culture medium without a separate treatment such as inoculation of cells on a cover part. CONSTITUTION: A three dimensional cell culture device comprises a culture plate part, a cover part, and a protrusion part(50). The culture plate part has wells for culturing cells. The cover part covers the culture plate part. The protrusion part is extended toward the inside of the well from the surface which touches the culture plate part.
Abstract translation: 目的：提供三维细胞培养装置和使用该三维细胞培养装置的三维细胞培养方法，以在培养基中形成浮球体，而无需单独处理，例如在盖部分上接种细胞。 构成：三维细胞培养装置包括培养板部分，盖部分和突出部分（50）。 培养板部分具有培养细胞的孔。 盖部覆盖培养板部。 突起部分从接触培养板部分的表面延伸到井的内部。
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公开(公告)号：KR101186227B1
公开(公告)日：2012-09-27
申请号：KR1020110004935
申请日：2011-01-18
Applicant: 동국대학교 산학협력단
Abstract: 본 발명은 임플란트의 코팅층 표면에 효과적으로 골형성 단백질을 고정시키기 위하여 천연 칼슘 킬레이팅제를 사용하는 방법에 관한 것으로서, 이식 후에 면역반응을 최소화할 수 있고, 생착율이 높으면서도 세포 적합성, 생체적합성, 그리고 친수성이 향상되어 빠른 골융합을 유도할 수 있는 생체재료를 제조하는 기술을 제공하는 것이다.
본 발명에 따른 천연 칼슘 킬레이팅제를 이용한 골형성 단백질 고정화 기술은, 골형성 단백질의 손실을 줄이고, 안정적인 고정(juxtacrine) 효과를 유지할 수 있다. 따라서 이식 후에 면역반응을 최소화하고 세포 적합성, 생체적합성, 그리고 골형성 단백질의 도입으로 무기질 생체재료의 친수성이 향상되어 세포의 부착과 분화를 향상시킴으로써 생착율이 높으면서도 빠른 골융합을 유도할 수 있는 생체재료를 제조하는 기술로 유용하게 사용될 수 있다.-
公开(公告)号：KR1020110134253A
公开(公告)日：2011-12-14
申请号：KR1020100101652
申请日：2010-10-19
Applicant: 동국대학교 산학협력단
IPC: C12N13/00 , C12N5/0775 , C12N5/079
CPC classification number: C12N5/0619 , C12N5/0618 , C12N13/00 , C12N2506/1346 , C12N2506/1353 , C12N2506/1361 , C12N2506/1369 , C12N2506/1384 , C12N2529/00
Abstract: PURPOSE: A method for differentiating mesenchymal stem cells is provided to induce differentiation in a cheap medium and to treat cranial nervous diseases. CONSTITUTION: A method for differentiating mesenchymal stem cells into neural cells comprises a step of treating stem cells by sound wave at 1-500Hz. The mesenchymal stem cells are derived from bone marrow, adipose, or umbilical cord blood. A composition for treating nervous diseases contains neural cell differentiated by the method.
Abstract translation: 目的：提供一种区分间充质干细胞的方法，以便在廉价的培养基中诱导分化并治疗颅神经疾病。 构成：将间充质干细胞分化成神经细胞的方法包括用1-500Hz的声波处理干细胞的步骤。 间充质干细胞衍生自骨髓，脂肪或脐带血。 用于治疗神经疾病的组合物含有通过该方法分化的神经细胞。
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公开(公告)号：KR100937736B1
公开(公告)日：2010-01-21
申请号：KR1020080093339
申请日：2008-09-23
Applicant: 동국대학교 산학협력단
IPC: A61F2/28
CPC classification number: A61F2/2846 , A61F2310/00365 , A61L27/12 , A61L27/20 , A61L27/22 , A61L27/24 , A61L2300/412
Abstract: PURPOSE: A porous scaffold for guided tissue regeneration and a method for manufacturing the same are provided, which make mechanical property excellent even and improve engraft rate. CONSTITUTION: A method for manufacturing a porous scaffold for guided tissue regeneration comprises a step for forming a silk layer using woven silk from which the sericin is removed; a step for forming a collagen sponge layer by freeze-drying after applying collagen on the silk layer; and a step for cross-linking the silk layer and collagen sponge layer. The collagen sponge layer is produced using more than one mixture selected from a group consisting of glycosaminoglycan, collagen, or hyaluronic acid.
Abstract translation: 目的：提供用于引导组织再生的多孔支架及其制造方法，使机械性能均匀均匀，提高移植率。 构成：用于制造用于引导组织再生的多孔支架的方法包括使用从其中除去丝胶蛋白的编织丝形成丝绸层的步骤; 通过在丝绸层上施加胶原蛋白之后通过冷冻干燥形成胶原蛋白海绵层的步骤; 以及交联丝层和胶原海绵层的步骤。 使用多于一种选自葡糖胺聚糖，胶原蛋白或透明质酸的混合物来生产胶原蛋白海绵层。
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公开(公告)号：KR1020100004966A
公开(公告)日：2010-01-13
申请号：KR1020097017056
申请日：2007-07-20
Applicant: 동국대학교 산학협력단
CPC classification number: C12N5/0627 , C12N2500/32 , C12N2500/38 , C12N2501/12 , C12N2501/39 , C12N2502/025 , C12N2502/1358 , C12N2502/1382 , C12N2502/1388
Abstract: PURPOSE: A method for preparing dermal papilla tissue is provided to produce the dermal papilla in vitro and treat baldness. CONSTITUTION: A method for preparing dermal papilla comprises: a step of culturing mesenchymal stem cells in a medium containing 600-1,900 mg/L of amino acid and 12-36 mg/L of vitamin; a step of transferring the cells a serum free medium and adding growth factor; a step of treating trypsin or collagenase to the culture to adhere cell mass; and a step of collecting dermal papilla tissue and culturing the dermal papilla tissue.
Abstract translation: 目的：提供一种制备真皮乳头组织的方法，以在体外产生真皮乳头并治疗秃发。 构成：制备真皮乳头的方法包括：在含有600-1999mg / L氨基酸和12-36mg / L维生素的培养基中培养间充质干细胞的步骤; 将细胞转移到无血清培养基中并加入生长因子的步骤; 将培养物中的胰蛋白酶或胶原酶处理以粘附细胞块的步骤; 以及收集真皮乳头组织并培养真皮乳头组织的步骤。
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