公开(公告)号：KR101449575B1

公开(公告)日：2014-10-08

申请号：KR1020120152548

申请日：2012-12-24

Applicant: 원광대학교산학협력단

Inventor： 김윤철 ,  오현철 ,  이동성 ,  김경수 ,  고원민

IPC: A61K31/7048 ,  A61K31/7024 ,  A61K31/70 ,  A61P29/00

Abstract: 본 발명은 테뉴폴리사이드 A(tenuifoliside A)를 유효성분으로 포함하는 염증성 질환의 예방 또는 치료용 조성물에 관한 것이다. 본 발명에 따른 테뉴폴리사이드 A는 대식세포에서 마이토겐 활성 단백질 키나아제(MAPKs) 중 p-JNK 경로 억제를 통한 염증 반응 억제 효과가 우수하여, 염증성 질환의 예방 또는 치료에 유용하게 이용될 수 있다.

公开(公告)号：KR1020130032750A

公开(公告)日：2013-04-02

申请号：KR1020110096530

申请日：2011-09-23

Applicant: 원광대학교산학협력단

Inventor： 김옥진 ,  오홍근 ,  박상호 ,  김윤철 ,  이현아 ,  홍선화 ,  한상준 ,  김동우 ,  최용식

IPC: A61K36/57 ,  A61P35/00

CPC classification number: A61K36/575 ,  A23V2200/308 ,  A61K2236/331 ,  A61K2236/333

Abstract: PURPOSE: A composition containing a Magnolia obovata extract is provided to ensure anticancer activity in vivo and in vitro, and to prevent and treat gastric cancer and breast cancer. CONSTITUTION: A pharmaceutical composition for preventing and treating gastric cancer and breast cancer contains a Magnolia obovata extract as an active ingredient. The extract is prepared by using water, C1-C4 alcohol, or a mixture thereof. The extract suppresses the proliferation of SNU-15 cells, tumor induced by SNU-15 cells, MCF-7 cells, and tumor induced by MCF-7 cells. [Reference numerals] (a) Injection concentration of a Magnolia obovata extract; (b) Cancer volume = (Cancer length x Cancer width^2)/2;

Abstract translation: 目的：提供含有玉兰提取物的组合物，以确保体内和体外的抗癌活性，并预防和治疗胃癌和乳腺癌。 构成：用于预防和治疗胃癌和乳腺癌的药物组合物含有玉兰提取物作为活性成分。 提取物通过使用水，C 1 -C 4醇或其混合物制备。 提取物抑制SNU-15细胞增殖，SNU-15细胞诱导的肿瘤，MCF-7细胞和MCF-7细胞诱导的肿瘤。 [附图标记]（a）木兰提取物的注射浓度; （b）癌体积=（癌症长×癌宽^ 2）/ 2;

公开(公告)号：KR1020110015040A

公开(公告)日：2011-02-14

申请号：KR1020110005533

申请日：2011-01-19

Applicant: 원광대학교산학협력단

Inventor： 박현 ,  김성연 ,  김윤철 ,  이주영 ,  김범석 ,  김옥진 ,  윤용갑

IPC: A23K1/16 ,  A61K36/488 ,  A61P37/00

CPC classification number: A23K10/30 ,  A61K36/488

Abstract: PURPOSE: A livestock feed additive containing a puerariae radix extract, and a feed using thereof are provided to secure the secretion function effect of TNF-a inside a macrophage Raw 264.7. CONSTITUTION: A livestock feed additive for improving the immunity contains a puerariae radix water extract as an active ingredient. A producing method of the puerariae radix water extract comprises the following steps: adding 10L of distilled water to 1kg of dried puerariae radix; heat-extracting the mixture for 3hours at100deg C, and repeating the process for 3times; and vacuum filtering, before compress-condensing and freeze-drying.

Abstract translation: 目的：提供含有葛根提取物的饲料添加剂及其使用的饲料，以确保巨噬细胞Raw 264.7中TNF-α的分泌功能作用。 构成：用于提高免疫力的家畜饲料添加剂含有葛根提取物作为活性成分。 葛根提取物的制备方法如下：将10L蒸馏水加入1kg干葛根中; 在100℃下将混合物热解3小时，重复该过程3次; 并进行真空过滤，然后进行压缩冷凝和冷冻干燥。

公开(公告)号：KR101008463B1

公开(公告)日：2011-01-14

申请号：KR1020070140663

申请日：2007-12-28

Applicant: 삼광생명과학 주식회사 ,  원광대학교산학협력단

Inventor： 김동열 ,  박현 ,  윤용갑 ,  손동환 ,  김윤철 ,  김옥진 ,  김경민

IPC: A61K31/19 ,  A61K31/192 ,  A61K36/22 ,  A61P31/04

Abstract: 본 발명은 항균 및 항바이러스 활성을 갖는 조성물에 관한 것으로, 상세하게는 오배자 추출물 또는 이로부터 분리된 화합물을 유효성분으로 함유하는 본 발명의 조성물은 돼지 호흡기 또는 소화기 질환에 대한 뛰어난 항균 및 항바이러스 효과를 나타내므로, 상기 질환의 예방 및 치료를 위한 수의학적 조성물 및 사료첨가제로 유용하게 이용될 수 있다.
오배자, 항균, 항바이러스

公开(公告)号：KR1020100089384A

公开(公告)日：2010-08-12

申请号：KR1020090008599

申请日：2009-02-03

Applicant: 원광대학교산학협력단

Inventor： 박현 ,  김성연 ,  김윤철 ,  김옥진 ,  윤용갑 ,  이주영 ,  장문희 ,  오현철

IPC: A61K36/232 ,  A61P37/04

Abstract: PURPOSE: A composition containing Angelicae Dahuricae Radix extract is provided to enhance generation of intracelluar immune enhancing factor and to treat and prevent immune deficiency. CONSTITUTION: A pharmaceutical composition for enhancing immunity contains 0.1-50 weight% of Angelicae Dahuricae Radix extract as an active ingredient. The Angelicae Dahuricae Radix extract is isolated using water, low alcohol of 1-4 carbon atoms, or mixture solvent thereof. A health food for enhancing immunity contains Angelicae Dahuricae Radix extract as an active ingredient. The health food is used in the form of powder, granule, tablet, capsule, or beverage.

Abstract translation: 目的：提供含有Angelicae Dahuricae Radix提取物的组合物，以增强细胞内免疫增强因子的产生并治疗和预防免疫缺陷。 构成：用于增强免疫力的药物组合物含有0.1-50重量％的当归Dahuricae Radix提取物作为活性成分。 使用水，1-4个碳原子的低级醇或其混合溶剂分离当归Dahuricae Radix提取物。 一种用于增强免疫力的保健食品含有当归Dahuricae Radix提取物作为活性成分。 保健食品以粉末，颗粒，片剂，胶囊或饮料的形式使用。

公开(公告)号：KR1020100021794A

公开(公告)日：2010-02-26

申请号：KR1020080080406

申请日：2008-08-18

Applicant: 삼광생명과학 주식회사 ,  원광대학교산학협력단

Inventor： 박현 ,  김윤철 ,  김옥진 ,  김경민 ,  정길생 ,  김동열

IPC: A61K36/73 ,  A61K36/22 ,  A61K36/254 ,  A61P1/00

CPC classification number: A61K36/00 ,  A23K20/00 ,  A23K50/00 ,  A61K36/254 ,  A61K36/65 ,  A61K36/73 ,  A61K2236/33

Abstract: PURPOSE: A composition having anti-bacterial and anti-viral activity is provided to use in veterinary medicinal composition and feed supplement. CONSTITUTION: A veterinary medicine composition for preventing and treating porcine respiratory or digestive disease contains 0.1-50 weight% of Rubi Fructus, Galla Rhois, Acanthopanacis Cortex and Paeoniae Radix. The extract is isolated using water, low alcohol of C1-C4, or their mixture solvent. The animal feed additive for preventing and treating porcine respiratory or digestive diseases contains the Rubi Fructus, Galla Rhois, Acanthopanacis Cortex and Paeoniae Radix.

Abstract translation: 目的：提供具有抗细菌和抗病毒活性的组合物用于兽医药物组合物和饲料添加剂。 构成：用于预防和治疗猪呼吸道或消化疾病的兽药组合物含有0.1-50重量％的Rubi Fructus，Galla Rhois，Acanthopanacis Cortex和Paeoniae Radix。 使用水，C1-C4的低级醇或其混合溶剂分离提取物。 用于预防和治疗猪呼吸或消化疾病的动物饲料添加剂含有Rubi Fructus，Galla Rhois，Acanthopanacis Cortex和Paeoniae Radix。

公开(公告)号：KR100931527B1

公开(公告)日：2009-12-14

申请号：KR1020070125969

申请日：2007-12-06

Applicant: 원광대학교산학협력단

Inventor： 손동환 ,  김윤철 ,  박은전

IPC: A61K31/35 ,  A61K31/352 ,  A61P1/16

Abstract: 본 발명은 오록실린 A (Oroxylin A)를 유효성분으로 함유하는 조성물에 관한 것으로, 더욱 상세하게는, 간세포의 DNA 단편화 억제, 캐스파제-3 및 캐스파제-8 활성 억제, 폴리(ADP-리보오소)폴리머라제의 저해 및 JNK 인산화의 억제 효과를 나타내어 간세포의 자가사멸을 억제하는 효능을 확인함으로써, 간질환 치료 및 예방 효과가 뛰어난 약학조성물 및 건강기능식품으로 유용하게 이용될 수 있다.
오록실린 A, 간보호, 간세포 자가사멸, 담즙울체

Abstract translation: 提供了用于预防和治疗肝脏疾病的组合物以确保DNA片段化抑制，半胱天冬酶-3和半胱天冬酶-8活性抑制，聚（ADP-核糖）聚合酶抑制和JNK磷酸化抑制的效果。 用于治疗和预防肝病的组合物包含化学式A的奥洛菌素A作为活性成分。 oroxylin A抑制胆汁淤积引起的肝细胞损伤。 肝病选自自身免疫性肝病，药物引诱性肝病，肾上腺脑白质营养不良，感染性肝病，先天性代谢性肝病，胆汁淤血，急性肝炎，永久性暴露，肝硬化，脂肪变性或肝癌。 基于总重量，组合物以0.1-50重量％的比例包含。 含有用于预防肝病并改善其治愈的奥诺菌素A的保健功能食品以粉末，颗粒，片剂，胶囊和饮料的形式使用。

公开(公告)号：KR1020090072527A

公开(公告)日：2009-07-02

申请号：KR1020070140664

申请日：2007-12-28

Applicant: 삼광생명과학 주식회사 ,  원광대학교산학협력단

Inventor： 김동열 ,  박현 ,  윤용갑 ,  손동환 ,  김윤철 ,  김옥진

IPC: A61K31/19 ,  A61K31/192 ,  A61K36/22 ,  A61P31/04

CPC classification number: Y02A50/486 ,  Y02A50/488

Abstract: A composition containing a Galla rhois extract or compound isolated from the extract as an active ingredient is provided to prevent and treat zoonosis. An anti-bacterial composition against zoonosis comprises a Galla rhois extract or compound isolated from the extract as an active ingredient. The compound contains a compound selected from gallic acid, mixture of methyl p-digallic acid and methyl m-digallic acid, penta-O-galloyl glucose, ethyl gallate, or mixture of ethyl p-digallate and ethyl m-digallate as an active ingredient. The extract or compound is contained in 0.1-50 weight%.

Abstract translation: 提供含有作为活性成分从提取物中分离出的加洛氏提取物或化合物的组合物，以预防和治疗动物传染病。 针对动物传染病的抗菌组合物包括从提取物中分离的加洛氏提取物或化合物作为活性成分。 该化合物含有选自没食子酸，对二壬酸甲基和双马来酸甲酯的混合物，五-O-乙酰基葡萄糖，没食子酸乙酯或对二乙酸乙酯和间二乙酸乙酯的混合物的化合物作为活性成分 。 提取物或化合物的含量为0.1-50重量％。

公开(公告)号：KR1020080084477A

公开(公告)日：2008-09-19

申请号：KR1020070026278

申请日：2007-03-16

Applicant: 원광대학교산학협력단

Inventor： 박현 ,  윤용갑 ,  손동환 ,  김윤철 ,  김옥진

IPC: A61K36/65 ,  A61K36/22 ,  A61P11/00 ,  A61P31/00

CPC classification number: A61K36/22 ,  A23V2200/314 ,  A23V2200/32 ,  A61K36/65 ,  A61K2236/331 ,  A61K2236/333 ,  Y10S514/867

Abstract: A composition comprising the extracts of Galla Rhois and Moutan Cortex Radicis is provided to improve antibacterial and antiviral activity, minimize damage of conventional antibiotics including antibiotic remaining and antibiotic resistance, and inhibit toxicity or side effects in employment, so that the composition is useful for prevention and treatment of porcine respiratory and digestive disease in mammals. A composition for prevention and treatment of porcine respiratory and digestive disease in mammals including human comprises 0.1-50 wt.% of the extracts of Galla Rhois and Moutan Cortex Radicis in a mixing ratio of 1-3:1, which are prepared by extracting them with a solvent selected from water, C1-C4 lower alcohol and a mixture thereof, wherein the porcine respiratory disease is selected from porcine Pasteurella pneumonia, porcine Mycoplasma pneumonia, pircine atrophic rhinitis, porcine pleuropneumonia, Glasser's disease, PRRS(porcine reproductive and respiratory syndrome), PMWS(post-weaning multisystemic wasting syndrome) and PRDC(porcine respiratory disease complex); and the porcine digestive disease is selected from Yersinia enteritis, proliferative enteropathies, colitis, swine dysentery, non-infectious colitis, Salmonella enteritis, Escherichia coli diarrhea, TGE(transmissible gastroenteritis) and PED(porcine epidemic diarrhea). Further, infectious bacteria of the porcine respiratory disease are selected from Mannheimia haemolytica, Haemopilus somnus, Pasteurella multocida, Mycoplasma hyopheumonia and Actinobacillus pleuropneumonia.

Abstract translation: 提供包含加拉罗非鱼提取物和Moutan Cortex Radicis提取物的组合物以改善抗菌和抗病毒活性，使常规抗生素（包括抗生素残留和抗生素抗性）的损伤最小化，并且抑制就业中的毒性或副作用，使得该组合物可用于预防 和哺乳动物猪呼吸道和消化系统疾病的治疗。 用于预防和治疗包括人在内的哺乳动物中的猪呼吸和消化疾病的组合物包含0.1-50重量％的加拉罗非鱼和Moutan Cortex Radicis的提取物，其混合比为1-3:1，它们通过提取它们制备 其中选自水，C1-C4低级醇及其混合物的溶剂，其中猪呼吸道疾病选自猪巴斯德氏杆菌肺炎，猪肺炎支原体肺炎，气腹萎缩性鼻炎，猪胸膜肺炎，格列斯氏病，PRRS（猪繁殖与呼吸综合征 ），PMWS（断奶后多系统消耗综合征）和PRDC（猪呼吸系统疾病综合征）; 猪消化病选自耶尔森氏菌肠炎，增殖性肠病，结肠炎，猪痢疾，非传染性结肠炎，沙门氏菌肠炎，大肠杆菌腹泻，TGE（传染性胃肠炎）和PED（猪流行性腹泻）。 此外，猪呼吸道疾病的感染性细菌选自溶血性马氏解热血液病，睡莲血型，多杀巴斯德氏菌，支原体肺炎支原体和放线杆菌胸膜肺炎。

公开(公告)号：KR1020080069818A

公开(公告)日：2008-07-29

申请号：KR1020070007511

申请日：2007-01-24

Applicant: 원광대학교산학협력단

Inventor： 박현 ,  김윤철 ,  강경화 ,  김혜숙 ,  와타야유우스케 ,  카마타마사키

IPC: C07D493/08 ,  A61K31/357

Abstract: A 1,5-diphenyl-8-methyl-6,7-dioxa-bicyclo[3.2.2]nonane having an endoperoxide ring is provided to show excellent inhibitory effect on proliferation of Toxoplasma gondii, thereby being used for a pharmaceutical composition for preventing and treating toxoplasmosis. A pharmaceutical composition for preventing and treating toxoplasmosis comprises 0.1-50 wt.% of a 1,5-diphenyl-8-methyl-6,7-dioxa-bicyclo[3.2.2]nonane having an endoperoxide ring represented by a formula(A) as an effective ingredient.

Abstract translation: 提供具有内过氧化物环的1,5-二苯基-8-甲基-6,7-二氧杂双环[3.2.2]壬烷，以显示对弓形虫增殖的优异抑制作用，从而用于预防药物组合物 并治疗弓形虫病。 用于预防和治疗弓形体病的药物组合物包含0.1-50重量％的具有由式（A）表示的内过氧化物环的1,5-二苯基-8-甲基-6,7-二氧杂 - 双环[3.2.2]壬烷 ）作为有效成分。