公开(公告)号：WO1994015464A1

公开(公告)日：1994-07-21

申请号：PCT/US1994000617

申请日：1994-01-13

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  DEMICHELE, Stephen, Joseph ,  KARLSTAD, Michael, Donald ,  BISTRIAN, Bruce, Ryan ,  MASCIOLI, Edward, Anthony

IPC: A01N37/06

CPC classification number: C07C69/587 ,  A23L33/115 ,  A23L33/12 ,  A61K31/23 ,  A61K31/232

Abstract: There is disclosed structured lipid containing either a gamma-linolenic acid or a dihomogamma-linolenic acid residue, together with an n-3 fatty acid residue and a medium chain fatty acid residue on the same glycerol backbone. This structured lipid is particularly well adapted to the treatment of disease or stress states. The gamma-linolenic or dihomogamma-linolenic acid residues modify the prostanoid synthesis pathway, reducing the level of series "2" prostanoids and elevating the levels of series "1" and "3" prostanoids. The n-3 fatty acid residue enhances the level of series "1" prostanoids as well as increases the production of series "3" prostanoids. The medium chain fatty acid residues enhances the absorption of the structured lipid. There is also disclosed enteral and parenteral diets as well as nutritional supplements containing the structured lipids of the invention.

Abstract translation: 公开了在同一甘油主链上含有γ-亚麻酸或二亚麻酸 - 亚麻酸残基以及n-3脂肪酸残基和中链脂肪酸残基的结构化脂质。 这种结构化脂质特别适用于治疗疾病或应激状态。 γ-亚麻酸或二亚麻酸亚麻酸残基改变前列腺素合成途径，降低“2”前列腺素类的水平，提高“1”和“3”前列腺素类的水平。 n-3脂肪酸残基提高了“1”型前列腺素类的水平，并增加了“3”型前列腺素类的产生。 中链脂肪酸残基增强了结构化脂质的吸收。 还公开了肠内和肠胃外饮食以及含有本发明的结构化脂质的营养补充剂。

公开(公告)号：WO1994015293A1

公开(公告)日：1994-07-07

申请号：PCT/US1993010142

申请日：1993-10-22

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  LOWELL, Augustus, P.

IPC: G06F13/00

CPC classification number: G06F9/542 ,  G06F9/546 ,  H04L67/26 ,  H04L69/329

Abstract: A dynamic data distribution network (12) for use with a software package (10), which includes modules (14, 16, and 18) that produce data and modules (20, 22, 24, and 26) that consume data. The network includes source files (30) and sink files (32). Each data-consuming module contains one or more sink files, each of which serves as a buffer for one type of data used by the module. Each source file serves as a buffer for one type of data that is generated by a data-producing module. Each source file also contains a sink link table (40) that identifies the individual sink files, which serve as buffers for the data consumers that use that data. Whenever new data is generated, a data distribution task (34) initially stores the data in the associated source file and, then based on the contents of the sink link table, copies the data into the appropriate sink files associated with the data consumers that use the data. The data distribution function also informs the data consumers that new data are available in the sink file with which the data consumer is associated, enabling the data consumers to retrieve the data from the sink files.

Abstract translation: 一种与软件包（10）一起使用的动态数据分发网络（12），其包括产生消耗数据的数据和模块（20,22,24和26）的模块（14,16和18）。 网络包括源文件（30）和宿文件（32）。 每个数据消耗模块包含一个或多个宿文件，每个宿文件用作模块使用的一种类型的数据的缓冲区。 每个源文件用作由数据生成模块生成的一种数据类型的缓冲区。 每个源文件还包含一个宿链接表（40），它标识个别宿文件，它们作为使用该数据的数据使用者的缓冲区。 每当生成新数据时，数据分发任务（34）最初将数据存储在相关联的源文件中，然后基于宿链接表的内容将数据复制到与使用的数据消费者相关联的适当的宿文件中 数据。 数据分发功能还向数据消费者通知数据消费者与之相关联的接收器文件中的新数据可用，使数据消费者能够从接收器文件中检索数据。

公开(公告)号：WO1994015270A1

公开(公告)日：1994-07-07

申请号：PCT/US1993011934

申请日：1993-12-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  EASON, Reginald, L. ,  FORREST, Keith

IPC: G06F03/00

CPC classification number: G16H10/40 ,  G06F19/00 ,  G16H10/60 ,  G16H40/63 ,  G16H50/20 ,  Y10S707/99933

Abstract: A data interface (508) which is capable of receiving test information from a variety of biological fluid testing instruments (530) employs first and second processes (512, 522). The first process determines the type of data which is provided by analyzing the format of the test information using a master rules file. Once the type of the source is identified, the first process passes the data and a set of rules to use to parse the data to the second process. The second process extracts the test data from the information provided by the testing instruments using the set of rules identified by the first process. Furthermore, if the test information is received in pieces the present invention can marry the pieces to provide a complete data set to be stored in the database.

Abstract translation: 能够从各种生物流体测试仪器（530）接收测试信息的数据接口（508）采用第一和第二过程（512,522）。 第一个过程通过使用主规则文件分析测试信息的格式来确定提供的数据类型。 一旦识别出源的类型，第一个进程将传递数据和一组规则，以将数据解析到第二个进程。 第二个过程使用由第一个过程确定的一组规则，从测试仪器提供的信息中提取测试数据。 此外，如果接收到测试信息，本发明可以结合这些片段来提供要存储在数据库中的完整数据集。

公开(公告)号：WO1994014341A1

公开(公告)日：1994-07-07

申请号：PCT/US1993010867

申请日：1993-11-10

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ACOSTA, Phyllis, Jean, Brown ,  GRONDALSKI, Richard, Andrew ,  LIEBRECHT, Jeffrey, Wayne ,  REYNOLDS, Patricia, Ann

IPC: A23L01/29

CPC classification number: A61K45/06 ,  A23L33/115 ,  A23L33/12 ,  A23L33/16 ,  A23L33/40 ,  Y10S514/904 ,  Y10S514/905

Abstract: The present invention relates generally to a novel generic powder base rich in fats, carbohydrates, vitamins, minerals and trace elements which can be readily admixed with specific amino acids to yield several different therapeutic products for use in nutritional support of adults/children having various inherited metabolic diseases.

Abstract translation: 本发明一般涉及富含脂肪，碳水化合物，维生素，矿物质和微量元素的新型通用粉末基质，其可以容易地与特定氨基酸混合，以产生用于具有各种遗传的成年人/儿童的营养支持的几种不同的治疗产品 代谢疾病

公开(公告)号：WO1994013313A1

公开(公告)日：1994-06-23

申请号：PCT/US1993011628

申请日：1993-11-30

Applicant: ABBOTT LABORATORIES ,  GREER, Jonathan ,  HAVIV, Fortuna ,  FITZPATRICK, Timothy, D. ,  SWENSON, Rolf, E. ,  NICHOLS, Charles, J. ,  MORT, Nicholas, A.

Inventor： ABBOTT LABORATORIES

IPC: A61K37/02

CPC classification number: C07K7/23 ,  A61K38/00

Abstract: The present invention provides a class of decapeptide compounds which are potent antagonists of LHRH activity and which have the structure A -D -E -G -J -L -M -Q -R -T . The compounds of the percent invention are characterized by having an OMEGA -amino-functionalized side chain on the D-aminoacyl residue at position 6. The OMEGA -amino group of this side chain is further derivatized by the attachment of an extending group which likewise has a terminal amino group which is capped by an acyl group.

Abstract translation: 本发明提供一类十肽化合物，其是LHRH活性的有效拮抗剂，其具有结构A 1 -D 2 -E 3 -G 4 -J 5 -L 6， -M <7> -Q <8> -R <9> -T <10>。 本发明百分比的化合物的特征在于在第6位的D-氨基酰基残基上具有OMEGA-氨基官能化侧链。该侧链的OMEGA-氨基通过连接一个延伸基团 被酰基封端的末端氨基。

公开(公告)号：WO1994012179A1

公开(公告)日：1994-06-09

申请号：PCT/US1993010992

申请日：1993-11-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  BROOKS, Dee, W. ,  WOODS, Keith, W. ,  RODRIQUES, Karen, E.

IPC: A61K31/41

CPC classification number: C07D401/12 ,  C07D209/30 ,  C07D403/12 ,  C07D409/12 ,  C07D417/12

Abstract: Compounds of structure (1), where A is straight or branched divalent alkylene or divalent cycloalkylene, R1 is selected from hydrogen; alkylthio; optionally substituted phenylthio; optionally substituted phenylalkylthio; optionally substituted 2-, 3-, and 4-pyridyl; optionally substituted 2-, and 3-thienylthio; and optionally substituted 2-thiazolylthio, R2 is selected from -COOB; -COOalkyl; -COOalkyl(carbocyclic aryl); -CONR5R6; -COR6; and -OH, R3 is selected from phenylalkyl and heteroarylalkyl, and R4 is selected from optionally substituted alkoxy(carbocyclic aryl); optionally substituted carbocyclic aryloxy; optionally substituted heteroarylalkoxy; and optionally substituted heteroaryloxy are potent inhibitors of lipoxygenase enzymes and thus inhibit the biosynthesis of leukotrienes. These compounds are useful in the treatment or amelioration of allergic and inflammatory disease states.

Abstract translation: 结构（1）的化合物，其中A是直链或支链二价亚烷基或二价亚环烷基，R 1选自氢; 烷; 任选取代的苯硫基; 任选取代的苯基烷硫基; 任选取代的2-，3-和4-吡啶基; 任选取代的2-和3-噻吩基硫基; 和任选取代的2-噻唑基硫基，R 2选自-COOB; -COO烷基; -COO烷基（碳环芳基）; -CONR5R6; -COR 6; 和-OH，R 3选自苯基烷基和杂芳基烷基，并且R 4选自任选取代的烷氧基（碳环芳基）; 任选取代的碳环芳氧基; 任选取代的杂芳基烷氧基; 和任选取代的杂芳氧基是脂氧合酶的有效抑制剂，因此抑制白细胞三烯的生物合成。 这些化合物可用于治疗或改善过敏性和炎性疾病状态。

公开(公告)号：WO1994009361A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009595

申请日：1993-10-12

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  GERMANY, Cheryl, Denise ,  FONG, Conrad, Tusen, Oi ,  DUKE, Steven, Barry ,  VUREK, Gerald, G.

IPC: G01N33/00

CPC classification number: A61B5/1495 ,  A61B5/1491 ,  G01N33/0006 ,  G01N33/4925

Abstract: A calibration system and method for calibrating a medical sensor (16) that monitors chemical blood gases. A calibrator (12) is used in connection with a tray (14) in which the medical sensor is stored in a sterile environment, both before and during the calibration process. The medical sensor is immersed in a liquid (30) in a tonometry chamber (28) defined in the tray and covered by a membrane (120/122) that is permeable to gas, but impermeable to bacteria. During the calibration process, the tray is inserted into the calibrator, bringing a heated platen (26) into contact with the tonometry chamber, so that the liquid can be heated to a calibration temperature substantially equal to the temperature at which the medical sensor will subsequently be used.

Abstract translation: 一种用于校准监测化学血液气体的医疗传感器（16）的校准系统和方法。 校准器（12）结合托盘（14）使用，其中医疗传感器在校准过程之前和期间都存储在无菌环境中。 医疗传感器被浸入定义在托盘中的眼压测定室（28）中的液体（30）中，并被可渗透气体但对细菌不透过的膜（120/122）覆盖。 在校准过程中，托盘插入到校准器中，使加热的压板（26）与眼压测定室接触，使得液体可以被加热到基本上等于医疗传感器随后温度的校准温度 使用。

公开(公告)号：WO1994008992A1

公开(公告)日：1994-04-28

申请号：PCT/US1993009662

申请日：1993-10-08

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  ABREO, Melwyn, A. ,  GUNN, David, E. ,  LIN, Nan-Horng ,  ELLIOTT, Richard, L. ,  GARVEY, David, S. ,  LEBOLD, Suzanne, A. ,  WASICAK, James, T.

IPC: C07D401/12

CPC classification number: C07D401/12 ,  C07D403/12 ,  C07D417/12

Abstract: Novel heterocyclic ether compounds of formula (I), wherein A, B and R are specifically defined, or pharmaceutically-acceptable salts or prodrugs thereof, which are selective and potent ligands at cholinergic channel receptors, useful in the treatment of cognitive, neurological and mental disorders characterized by decreased cholinergic function.

Abstract translation: 具体定义的其中A，B和R 2的式（I）的新型杂环醚化合物或其药学上可接受的盐或前药，其是胆碱能通道受体的选择性和有效配体，可用于治疗认知， 以胆碱能功能下降为特征的神经和精神障碍。

公开(公告)号：WO1994007872A1

公开(公告)日：1994-04-14

申请号：PCT/US1993008090

申请日：1993-08-26

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  WITTENBERGER, Steven, J. ,  NARAYANAN, Bikshandar, A. ,  HAIGHT, Anthony, R. ,  SCARPETTI, David

IPC: C07D257/04

CPC classification number: C07D257/04 ,  C07D239/42 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14

Abstract: The present invention relates to a process for the preparation of 5-aryl tetrazoles of formula (I) or a salt thereof comprising reacting an aryl nitrile with a trisubstituted silyl azide and a disubstituted tin oxide.

Abstract translation: 本发明涉及一种制备式（I）的5-芳基四唑或其盐的方法，其包括使芳基腈与三取代的甲硅烷基叠氮化物和二取代的氧化锡反应。

公开(公告)号：WO1994006940A1

公开(公告)日：1994-03-31

申请号：PCT/US1993008759

申请日：1993-09-16

Applicant: ABBOTT LABORATORIES

Inventor： ABBOTT LABORATORIES ,  TASKAR, Suhas, P. ,  MALIEKAL, George ,  SPRONK, Adrian, M.

IPC: C12Q01/70

CPC classification number: G01N33/54366 ,  G01N33/5764

Abstract: The present invention provides an assay device (10) having a plurality of strips (2) affixed to one another by a handling means (4) which may (i) either contact the distal ends of the strips (2), wherein the strips (2) are separated by a distance suitable to allow the strips (2) to be simultaneously contacted to individual test samples; or, (ii) may involve a card upon which each of the strips (2) is individually mounted. The test samples travel from the proximal end (12) to the distal end of each strip (2) by capillary action, and the strips contain an immobilized capture reagent (6) which binds target analyte, an ancillary specific binding member or a labeled reagent, in proportion to the amount or presence of target analyte in the test sample. The handling means (4) simplifies the assay procedure and decreases the amount of time needed to perform a large number of assays. Preferably, a procedural control is provided on each strip (2).

Abstract translation: 本发明提供一种测定装置（10），其具有通过处理装置（4）彼此固定的多个条带（2），所述处理装置可以（i）接触条带（2）的远端，其中条带 2）分开一段距离，适合于允许条带（2）同时接触各个测试样品; 或者，（ii）可以涉及一个卡片，每个条带（2）单独安装在该卡片上。 测试样品通过毛细管作用从近端（12）移动到每条（2）的远端，并且条含有固定的捕获试剂（6），其结合靶分析物，辅助特异性结合成员或标记试剂 ，与测试样品中的目标分析物的量或存在成比例。 处理装置（4）简化了测定程序并减少了进行大量测定所需的时间。 优选地，在每个条带（2）上提供程序控制。