Abstract:
Conformationally rigid aryl prostaglandins are useful in the treatment of glaucoma and ocular hypertension. Also disclosed are ophthalmic, pharmaceutical compositions comprising said prostaglandins.
Abstract:
Polyhydroxy mono- and dicarboxylic acids, and their lactones, are useful as solubility-enhancing agents in aqueous ophthalmic compositions of weakly basic ophthalmic drugs.
Abstract:
A process for preparing defined molecular weight polymers, particularly polyquaternary ammonium compounds, is disclosed. As the molecular weights of these compounds can be absolutely defined, rather than defined merely in terms of "number average molecular weight", these compounds are particularly useful as identification standard for other polymers which are made using conventional polymerization processes. The polyquaternary ammonium compounds described are further suitable for use as antimicrobial agents, particularly in ophthalmic compositions.
Abstract:
The present invention is directed to compositions containing chroman-type or benzfuran type compounds and methods for their use in preventing pathological neovascularization.
Abstract:
Ophthalmic compositions containing squalamine or its analogues antimicrobial agents have good antifungal activity. Squalamine is particularly useful as a disinfectant in contact lens care products and as preservatives in other types of ophthalmic compositions, such as artificial tears or topical pharmaceutical preparations.
Abstract:
Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
Abstract:
Compositions and methods directed to the use of adenosine uptake inhibitors for the treatment of retinal and optic nerve head damage following acute or chronic glaucoma, edema, ischemia, hypoxia or trauma are disclosed.
Abstract:
A cutting tip wrench with a generally long, hollow body with an interior capable of receiving an engageable clutch. The clutch has a projection containing a bore, preferably in the shape of a square and capable of frictionally engaging a nut from a cutting tip. The clutch is one-way engaging with the hollow body, such that torque can only be applied to the projection bore in one direction. This allows the wrench to be capable of only removing cutting tips from surgical equipment. The exterior of the body contains ridges, grooves, knurling or other suitable texture so as to provide a gripable wrench.