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1.发明申请
公开(公告)号：WO1997018803A1
公开(公告)日：1997-05-29
申请号：PCT/US1996017689
申请日：1996-11-06
Applicant: ALCON LABORATORIES, INC.
Inventor： ALCON LABORATORIES, INC. , PANG, Iok-Hou , KAPIN, Michael, A.
IPC: A61K31/19
CPC classification number: A61K31/19 , Y10S514/912
Abstract: The use of certain aliphatic carboxylic acid derivatives to treat persons suffering from retinal or optic nerve head damage is disclosed.
Abstract translation: 公开了使用某些脂族羧酸衍生物来治疗患有视网膜或视神经损伤的人。
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Patent Agency Ranking2.发明授权USE OF CERTAIN ISOQUINOLINESULFONYL COMPOUNDS FOR THE TREATMENT OF GLAUCOMA AND OCULAR ISCHEMIA 失效取代的异喹啉磺酰化合物用于用于治疗青光眼和高眼压缺血的治疗制剂中使用
公开(公告)号：EP0868186B1
公开(公告)日：2005-03-02
申请号：EP96945220.0
申请日：1996-12-20
Applicant: Alcon Laboratories, Inc.
Inventor： KAPIN, Michael, A. , DESANTIS, Louis, M., Jr.
IPC: A61K31/55 , A61K31/495 , A61K31/47 , A61K9/00 , A61P27/06
CPC classification number: A61K31/497 , A61K9/0048 , A61K31/551 , Y10S514/912 , Y10S514/913
Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
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公开(公告)号：EP0939635A1
公开(公告)日：1999-09-08
申请号：EP96940292.0
申请日：1996-11-06
Applicant: ALCON LABORATORIES, INC.
Inventor： DeSANTIS, Louis, Jr. , KAPIN, Michael, A.
CPC classification number: A61K9/0048 , A61K31/445
Abstract: Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more polyamine antagonists, and are useful for preventing or treating excitotoxicity associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.
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公开(公告)号：EP1126850A1
公开(公告)日：2001-08-29
申请号：EP99957471.8
申请日：1999-10-20
Applicant: ALCON LABORATORIES, INC.
Inventor： COLLIER, Robert, J., Jr. , HELLBERG, Mark, R. , KAPIN, Michael, A. , BARNES, George, E. , CHANDLER, Michael, L.
IPC: A61K31/445
CPC classification number: A61K31/00 , A61K31/445 , Y10S514/912
Abstract: Compositions and methods for treating disorders of the outer retina with glutamate antagonists are disclosed.
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公开(公告)号：EP0939635B1
公开(公告)日：2001-08-16
申请号：EP96940292.4
申请日：1996-11-06
Applicant: ALCON LABORATORIES, INC.
Inventor： DeSANTIS, Louis, Jr. , KAPIN, Michael, A.
IPC: A61K31/445 , A61K9/00
CPC classification number: A61K9/0048 , A61K31/445
Abstract: Pharmaceutical compositions useful in ophthalmic surgery are described. The compositions include one or more polyamine antagonists, and are useful for preventing or treating excitotoxicity associated with ophthalmic surgery. Methods of using the compositions in connection with ophthalmic surgical procedures are also described.
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6.发明公开USE OF CERTAIN ISOQUINOLINESULFONYL COMPOUNDS FOR THE TREATMENT OF GLAUCOMA AND OCULAR ISCHEMIA 失效取代的异喹啉磺酰化合物用于用于治疗青光眼和高眼压缺血的治疗制剂中使用
公开(公告)号：EP0868186A1
公开(公告)日：1998-10-07
申请号：EP96945220.0
申请日：1996-12-20
Applicant: Alcon Laboratories, Inc.
Inventor： KAPIN, Michael, A. , DESANTIS, Louis, M., Jr.
CPC classification number: A61K31/497 , A61K9/0048 , A61K31/551 , Y10S514/912 , Y10S514/913
Abstract: Isoquinolinesulfonyl compounds are used in ophthalmic compositions to treat glaucoma or other ischemic-borne ocular disorders such as retinopathies or optic neuropathies. These compounds vasodilate ocular blood vessels, lower IOP and prevent or reduce the progression of visual field loss.
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