公开(公告)号：WO1989009777A1

公开(公告)日：1989-10-19

申请号：PCT/US1989001473

申请日：1989-04-07

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  SUKHATME, Vikas, P.

IPC: C07H15/12

CPC classification number: C07K14/4702 ,  C07K14/475 ,  C07K16/18 ,  C07K2319/75 ,  C07K2319/81

Abstract: DNA sequences associated with regulation of early stages of cell growth are described. Illustratively provided are human and mouse origin DNA sequence encoding early growth regulatory (''Egr'') proteins which include ''zinc finger'' regions of the type involved in DNA binding. Immunological methods and materials for detection of Egr proteins and hybridization methods and materials for detection and quantification of Egr protein related nucleic acids are also disclosed.

Abstract translation: 描述了与调节细胞生长早期相关的DNA序列。 说明性地提供了编码早期生长调节（“Egr”）蛋白质的人和小鼠来源DNA序列，其包括涉及DNA结合的类型的“锌指”区域。 还公开了用于检测Egr蛋白的免疫学方法和材料以及用于检测和定量Egr蛋白相关核酸的杂交方法和材料。

公开(公告)号：WO1989005820A1

公开(公告)日：1989-06-29

申请号：PCT/US1988004552

申请日：1988-12-20

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GURNEY, Mark, E. ,  HO, David, D.

IPC: C07K07/08

CPC classification number: C07K14/005 ,  A61K39/00 ,  C07K16/1063 ,  C07K2317/24 ,  C07K2319/00 ,  C12N2740/16122

Abstract: Disclosed are novel immunochemical reagents including non-neurotoxic peptides having amino acid sequence homology to residues 254 to 280 of the gp120 glycoprotein of HIV-IIIB and antibodies thereto that are capable of in vitro inhibition of HIV-1 infectivity. The peptides and antibodies are useful in diagnostic assays and as active components of vaccine compositions for active and passive vaccination procedures.

Abstract translation: 公开了新的免疫化学试剂，包括与能够体外抑制HIV-1感染性的HIV-IIIB的gp120糖蛋白及其抗体的残基254至280具有氨基酸序列同源性的非神经毒性试剂。 肽和抗体可用于诊断测定和作为主动和被动接种程序的疫苗组合物的活性组分。

公开(公告)号：WO1998015575A1

公开(公告)日：1998-04-16

申请号：PCT/US1997016204

申请日：1997-08-29

Applicant: ARCH DEVELOPMENT CORPORATION ,  PARMACEK, Michael, S. ,  SOLWAY, Julian

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: C07K14/47

CPC classification number: C07K14/4716 ,  A01K2217/05 ,  A61K48/00 ,  C12N2799/022

Abstract: Disclosed is a smooth muscle cell specific promoter, the SM22 alpha gene promoter as well as the murine cDNA and genomic SM22 alpha nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22 alpha promoter.

Abstract translation: 公开了平滑肌细胞特异性启动子，SM22α基因启动子以及鼠cDNA和基因组SM22α核酸序列。 还公开了通过在SM22α启动子的控制下，通过表达细胞周期控制基因或平滑肌细胞中的收缩抑制肽来抑制球囊血管成形术后的再狭窄的方法和基于平滑肌细胞增殖抑制来治疗哮喘的方法。

公开(公告)号：WO1998004709A2

公开(公告)日：1998-02-05

申请号：PCT/US1997012904

申请日：1997-07-23

Applicant: ARCH DEVELOPMENT CORPORATION ,  LEOPARDI, Rosario ,  ROIZMAN, Bernard

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: C12N15/38

CPC classification number: C07K14/005 ,  A61K38/00 ,  A61K48/00 ,  C12N2710/16622

Abstract: The ICP4 protein of herpes simplex virus plays an important role in the transactivation of viral genes. The present invention discloses that ICP4 also has the ability to inhibit apoptosis. This function appears to reside in functional domain distinct from the transactivating function, as indicated by studies using temperature sensitive mutants of ICP4 that transactivating function at elevated temperatures. Also disclosed are methods for inhibition of apoptosis using ICP4 or an ICP4 encoding gene, such as an alpha 4 gene, methods of inhibiting ICP4's apoptosis-inhibiting function, and methods for the production of recombinant proteins and treatment of HSV infections.

Abstract translation: 单纯疱疹病毒的ICP4蛋白在病毒基因的反式激活中起重要作用。 本发明公开了ICP4还具有抑制细胞凋亡的能力。 该功能似乎存在于与反式激活功能不同的功能区域中，如使用ICP4的温度敏感突变体在高温下的反式激活功能的研究所指出的。 还公开了使用ICP4或ICP4编码基因（例如α4基因）抑制凋亡的方法，抑制ICP4的细胞凋亡抑制功能的方法，以及用于产生重组蛋白质和治疗HSV感染的方法。

公开(公告)号：WO1997044042A1

公开(公告)日：1997-11-27

申请号：PCT/US1997009188

申请日：1997-05-22

Applicant: ARCH DEVELOPMENT CORPORATION ,  VAN CAUTER, Eve ,  COPINSCHI, Georges

Inventor： ARCH DEVELOPMENT CORPORATION

IPC: A61K31/505

CPC classification number: A61K31/527 ,  A61K31/438 ,  A61K31/454

Abstract: Methods for restablishing normal sleep patterns in adults with age-related sleep disorders are provided. In particular, methods are disclosed wherein a compound that stimulates growth hormone and/or prolactin secretion is orally administered to subjects just prior to retiring.

Abstract translation: 提供了与年龄相关的睡眠障碍的成年人恢复正常睡眠模式的方法。 特别地，公开了其中刺激生长激素和/或催乳素分泌的化合物在退休前口服给予受试者的方法。

公开(公告)号：WO1997040205A1

公开(公告)日：1997-10-30

申请号：PCT/US1997006567

申请日：1997-04-24

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  ERDEMIR, Ali ,  BINDAL, Cuma ,  FENSKE, G., R.

IPC: C23C08/02

CPC classification number: C23C8/80

Abstract: Ultralow friction properties available through the annealation and subsequent cooling of various boron-containing substrates, articles and/or components.

Abstract translation: 通过对各种含硼基材，制品和/或组分的退火和随后的冷却可获得的超低摩擦特性。

公开(公告)号：WO1997014105A1

公开(公告)日：1997-04-17

申请号：PCT/US1996016092

申请日：1996-10-08

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  GROSS, Kenneth, C. ,  SINGER, Ralph, M.

IPC: G06F17/14

CPC classification number: G05B19/4184 ,  G05B2219/34048 ,  G05B2219/37325 ,  G05B2219/37326 ,  Y02P90/14 ,  Y10S706/906

Abstract: A method and system (110) for monitoring both an industrial process and a sensor (104). The method and system include determining a minimum number of sensor pairs needed to test the industrial process as well as the sensor (104) for evaluating the state of operation of both. After obtaining two signals associated with one physical variable, a difference function is obtained by determining the arithmetic difference between the pair of signals over time. A frequency domain transformation is made of the difference function to obtain Fourier modes describing a composite function. A residual function is obtained by subtracting the composite function from the difference function and the residual function (free of nonwhite noise) is analyzed by a statistical probability ratio test.

Abstract translation: 一种用于监测工业过程和传感器（104）的方法和系统（110）。 所述方法和系统包括确定测试工业过程所需的传感器对的最小数量以及用于评估两者的操作状态的传感器（104）。 在获得与一个物理变量相关联的两个信号之后，通过确定一对信号随时间的算术差异来获得差分函数。 由差分函数进行频域变换，以获得描述复合函数的傅里叶模式。 通过从差分函数中减去复合函数获得残差函数，并通过统计概率比检验分析剩余函数（无非噪声）。

公开(公告)号：WO1997009617A1

公开(公告)日：1997-03-13

申请号：PCT/US1996014125

申请日：1996-08-29

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  ROIZMAN, Bernard ,  CHOU, Joany

IPC: G01N33/50

CPC classification number: G01N33/5011 ,  G01N33/5008 ,  G01N33/5017 ,  G01N33/6893 ,  G01N2500/10 ,  G01N2510/00

Abstract: Methods for the identification of inducers and inhibitors of apoptosis are described. The method exploits the finding that the exposure of cells to apoptotic stress and its concurrent shutdown of cellular protein synthesis is accompanied by phosphorylation of IF-2 alpha and a novel protein termed p90.

Abstract translation: 描述了鉴定诱导物和凋亡抑制剂的方法。 该方法利用了细胞暴露于凋亡应激及其同时停止细胞蛋白合成的发现伴随着IF-2α和称为p90的新型蛋白质的磷酸化。

公开(公告)号：WO1997008627A1

公开(公告)日：1997-03-06

申请号：PCT/US1996013899

申请日：1996-08-30

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  VILIM, Richard, B. ,  GROSS, Kenneth, C. ,  WEGERICH, Stephan, W.

IPC: G06F15/18

CPC classification number: G06K9/00536 ,  G05B23/024 ,  G06N3/08 ,  G21D3/001 ,  G21Y2002/202 ,  G21Y2004/403 ,  Y02E30/40 ,  Y10S706/904 ,  Y10S706/906

Abstract: A method and system for performing surveillance of transient signals of an industrial device to ascertain the operating state. The method and system involves the steps of reading into a memory training data, determining neural network weighting values until achieving target outputs close to the neural network output. If the target outputs are inadequate, wavelet parameters are determined to yield neural network outputs close to the desired set of target outputs and then providing signals characteristic of an industrial process and comparing the neural network output to the industrial process signals to evaluate the operating state of the industrial process.

Abstract translation: 一种用于对工业设备的瞬态信号进行监视以确定操作状态的方法和系统。 该方法和系统包括读取存储器训练数据，确定神经网络加权值直到达到靠近神经网络输出的目标输出的步骤。 如果目标输出不足，则确定小波参数以产生接近期望的目标输出集合的神经网络输出，然后提供工业过程的特征信号，并将神经网络输出与工业过程信号进行比较，以评估目标输出的运行状态 工业过程。

公开(公告)号：WO1997003372A1

公开(公告)日：1997-01-30

申请号：PCT/US1996011276

申请日：1996-07-03

Applicant: ARCH DEVELOPMENT CORPORATION

Inventor： ARCH DEVELOPMENT CORPORATION ,  WINSTON, Roland ,  JENKINS, David, Gerard

IPC: G02B05/10

CPC classification number: G02B5/10 ,  F24S23/00 ,  F24S23/80 ,  F24S2023/838 ,  Y02E10/44

Abstract: A nonimaging concentrator (50) of light. The concentrator has a shape defined by dR/dphi=Rtanalpha, where R is a radius vector from an origin to a point of reflection of a light edge ray (70) from a reflector surface (90) and phi is an angle between the R vector and an exit aperture (80) of the concentrator and coordinates (R, phi) represent a point on the reflector surface and alpha is an angle the light edge ray from an origin point makes with a normal to the reflector surface.

Abstract translation: 非成像聚光器（50）的光。 集中器具有由dR / dphi = Rtanalpha定义的形状，其中R是从反射器表面（90）起始到光束（70）的反射点的半径向量，并且phi是R 聚焦器的出射孔（80）和坐标（R，phi）表示反射器表面上的点，α是来自原点的光边缘光线与反射器表面垂直的角度。