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公开(公告)号：CY1113454T1
公开(公告)日：2016-06-22
申请号：CY121101187
申请日：2012-12-04
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , HURLEY BRIAN T , MARLOW ALLISON L
IPC: A61K31/4184 , A61P35/00 , C07D235/04 , C07D235/06
Abstract: 6-(4-Βρωμο-2-χλωρο-φαινυλαιμινο)-7-φθορο-3-μεθυλ-3Η-βενζοϊμιδαζολο-5-καρβοξυλικούοξέος (2-υδροξυ-αιθόξυ)-αμίδιοή φαρμακευτικέςσυνθέσειςαυτούγιαχρήσηστηναναστολήμηκανονικήςανάπτυξηςκυττάρου.
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公开(公告)号：HK1199021A1
公开(公告)日：2015-06-19
申请号：HK14112451
申请日：2014-12-10
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , CHEN HUIFEN , CHICARELLI MARK JOSEPH , DEMEESE JASON , GARREY RUSTAM FERDINAND , GAUDINO JOHN , GAZZARD LEWIS , KAUS ROBERT J , KINTZ SAMUEL , MOHR PETER J , MORENO DAVID A , SCHWARZ JACOB , SIEDEM CHRISTOPHER S , WALLACE ELI M
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：CA2852516C
公开(公告)日：2015-06-02
申请号：CA2852516
申请日：2005-10-18
Applicant: ARRAY BIOPHARMA INC
Inventor： HANS JEREMY , WALLACE ELI M , ZHAO QIAN , LYSSIKATOS JOSEPH P , AICHER TOM , LAIRD ELLEN , ROBINSON JOHN , ALLEN SHELLEY
IPC: C07D285/12
Abstract: This invention relates to processes for preparing inhibitors of mitotic kinesins, particularly KSP.
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公开(公告)号：HK1190714A1
公开(公告)日：2014-07-11
申请号：HK14103851
申请日：2014-04-23
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , DELISLE ROBERT KIRK , DE MEESE LISA A , GRAHAM JAMES M , LE HUEROU YVAN , LYON MICHAEL , ROBINSON JOHN E , WALLACE ELI M , WANG BIN , XU RUI
IPC: C07D20060101 , A61K20060101 , A61P20060101
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公开(公告)号：CA2608201C
公开(公告)日：2013-12-31
申请号：CA2608201
申请日：2006-05-17
Applicant: ARRAY BIOPHARMA INC , ASTRAZENECA AB
Inventor： MARLOW ALLISON L , WALLACE ELI M , SEO JEONGBEOB , LYSSIKATOS JOSEPH P , YANG HONG WOON , BLAKE JAMES , STOREY RICHARD ANTHONY , BOOTH REBECCA JANE , PITTAM JOHN DAVID , LEONARD JOHN , FIELDING MARK RICHARD
IPC: C07D213/84 , A61K31/44 , C07D213/63
Abstract: Disclosed are MEK inhibitors useful in the treatment of hyperproliferative diseases, such as cancer and inflammation, in mammals, and inflammatory conditions. Also disclosed are methods of using such compounds in the treatment of hyperproliferative diseases in mammals and pharmaceutical compositions containing such compounds.
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Patent Agency Ranking
公开(公告)号：CR20130460A
公开(公告)日：2013-10-16
申请号：CR20130460
申请日：2013-09-11
Applicant: ARRAY BIOPHARMA INC
Inventor： BLAKE JAMES F , DELISLE ROBERT KIRK , DE MEESE LISA A , GRAHAM JAMES M , LE HUEROU YVAN , LYON MICHAEL , ROBINSON JOHN E , WALLACE ELI M , WANG BIN , XU RUI
IPC: C07D401/06 , A61K31/4709 , A61P29/00 , C07D471/04 , C07D519/00
Abstract: COMPUESTOS DE FÓRMULA I: DONDE R1, R2, R3, R4 Y R10 TIENEN LOS SIGNIFICADOS DADOS EN LA MEMORIA DESCRIPTIVA, SON INHIBIDORES DEL RECEPTORES TIROSINA ÚTILES EN EL TRATAMIENTO DE ENFERMEDADES MEDIDAS POR PIM-1 Y/O PIM-2 Y/O PIM-3 CINASAS.-
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公开(公告)号：AU2013218743A1
公开(公告)日：2013-09-05
申请号：AU2013218743
申请日：2013-08-19
Applicant: ARRAY BIOPHARMA INC
Inventor： WANG BIN , CHICARELLI MARK , GUNWARDANA INDRANI W , BLAKE JAMES F , WALLACE ELI M , LYON MICHAEL , MOHR PETER J , LE HUEROU YVAN
IPC: C07D471/04 , A61K31/437 , A61P35/00
Abstract: [00678] Compounds of Formula (I) are useful for inhibition of CHK1 and/or CHK2. Methods of using compounds of Formula (I) and stereoisomers and pharmaceutically acceptable salts thereof, for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions are disclosed.
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公开(公告)号：DOP2013000023A
公开(公告)日：2013-06-30
申请号：DO2013000023
申请日：2013-01-28
Applicant: ARRAY BIOPHARMA INC
Inventor： HURLEY T BRIAN , WALLACE ELI M , LYSSIKATOS JOE P , MARLOW ALLISON L
IPC: C07D235/08 , A61K31/4184 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P1/18 , A61P3/10 , A61P9/08 , A61P9/10 , A61P13/08 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D235/04 , C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
Abstract: La presente invención revela un compuesto seleccionado del ácido 6-(4-Bromo-2-cloro-fenilamino)-7-fluoro-3-metil-3H- benzoimidazol5-carboxílico (2-hidroxi-etoxi) amida y sales farmacéuticamente aceptables del mismo, y composiciones farmacéuticas que contienen dicho compuesto.
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公开(公告)号：PL401637A1
公开(公告)日：2013-05-27
申请号：PL40163703
申请日：2003-03-13
Applicant: ARRAY BIOPHARMA INC
Inventor： WALLACE ELI M , LYSSIKATOS JOSEPH P , BURLEY T BRIAN , MARLOW ALISON
IPC: C07D235/04 , A61K31/4184 , C07D235/08 , A61K31/422 , A61K31/4245 , A61K31/427 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/00 , A61P1/18 , A61P3/10 , A61P9/08 , A61P9/10 , A61P13/08 , A61P13/12 , A61P17/00 , A61P17/04 , A61P17/06 , A61P19/02 , A61P27/02 , A61P29/00 , A61P35/00 , A61P43/00 , C07D235/06 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/06 , C07D413/04 , C07D413/06 , C07D417/06 , C07D417/12
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90.发明专利
公开(公告)号：SG188905A1
公开(公告)日：2013-04-30
申请号：SG2013019468
申请日：2007-07-05
Applicant: ARRAY BIOPHARMA INC , GENENTECH INC
Inventor： MITCHELL IAN S , BLAKE JAMES F , XU RUI , KALLAN NICHOLAS C , XIAO DENGMING , SPENCER KEITH LEE , BENCSIK JOSEF R , LIANG JUN , SAFINA BRIAN , ZHANG BIRONG , CHABOT CHRISTINE , DO STEVEN , WALLACE ELI M , BANKA ANNA L , SCHLACHTER STEPHEN T
Abstract: 201 AbstractHYDROXYLATED AND METHOXYLATED CYCLOPENTA [D] PYRIMIDINES AS AKT PROTEIN KINASE INHIBITORSThe present invention provides compounds, including resolved enantiomers, resolved diastereomers, solvates and pharmaceutically acceptable salts thereof, comprising the Formula (I). Also provided are methods of using the compounds of this invention as AKT protein kinase inhibitors and for the treatment of hyperproliferative diseases such as cancer.No Figure
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