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公开(公告)号：AU2829799A
公开(公告)日：1999-08-09
申请号：AU2829799
申请日：1999-01-23
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P1/18 , A61P7/02 , A61P11/06 , A61P17/04 , A61P19/02 , A61P27/16 , A61P29/00 , C07K5/06 , C07K5/065 , A61K38/05
Abstract: Novel five-membered heterocyclic amidines, their preparation and use as competitive inhibitors of trypsin-like serine proteases, especially thrombin and kininogenases such as kallikrein. Pharmaceutical compositions which contain the compounds as active ingredients, and use of the compounds as thrombin inhibitors, anticoagulants and antiinflammatory agents.
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公开(公告)号：AU2424499A
公开(公告)日：1999-08-09
申请号：AU2424499
申请日：1999-01-23
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61P7/02 , A61P29/00 , A61P43/00 , C07D405/12 , C07D409/12 , C07D417/12 , C07K5/02 , C07K5/06 , C07D205/04
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公开(公告)号：TR199900310T2
公开(公告)日：1999-04-21
申请号：TR9900310
申请日：1997-07-29
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
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公开(公告)号：ZA977240B
公开(公告)日：1999-02-15
申请号：ZA977240
申请日：1997-08-13
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K31/44 , A61K38/00 , A61K38/05 , A61P1/18 , A61P7/02 , A61P11/02 , A61P11/06 , A61P17/00 , A61P19/02 , A61P29/00 , A61P43/00 , C07D207/22 , C07D211/78 , C07K5/00 , C07K5/02 , C07K5/083 , C07K , A61K , C07D
Abstract: Compounds of the formula Iwhere R, R1, R2, R3, R4, R5 and R6, and l, m and n have the meanings stated in the description, and their preparation are described. The novel compounds are suitable for controlling diseases.
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公开(公告)号：TR9700803T1
公开(公告)日：1998-02-21
申请号：TR9700803
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOEHM HANS JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , ZIERKE THOMAS , SEITZ WERNER
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078
CPC classification number: C07D213/78 , C07D205/04 , C07D207/16 , C07D239/28 , C07D241/24 , C07D401/12 , C07K5/06165
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Patent Agency Ranking
公开(公告)号：ID17873A
公开(公告)日：1998-02-05
申请号：ID972839
申请日：1997-08-14
Applicant: BASF AG
Inventor： BAUCKE DORIT , LANGE UDO , MACK HELMUT , SEITZ WERNER , ZIERKE THOMAS , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K38/00 , A61K38/05 , A61P7/02 , A61P29/00 , A61P35/00 , A61P35/04 , C07K5/06 , C07K5/062 , C07K5/065 , C07D403/00 , C07D407/00 , C07D411/00 , A61K31/33
Abstract: PCT No. PCT/EP97/04104 Sec. 371 Date Feb. 10, 1999 Sec. 102(e) Date Feb. 10, 1999 PCT Filed Jul. 29, 1997 PCT Pub. No. WO98/06741 PCT Pub. Date Feb. 19, 1998Compounds of the formula where A, B, E and D have the meanings indicated in the description, and their preparation are described. The substances are suitable for controlling diseases.
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公开(公告)号：MX9705970A
公开(公告)日：1997-11-29
申请号：MX9705970
申请日：1996-02-06
Applicant: BASF AG
Inventor： SEITZ WERNER , MACK HELMUT , ZIERKE THOMAS , BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , KOSER STEFAN , PFEIFFER THOMAS , HORNBERGER WILFRIED
Abstract: Se describen inhibidores de la tromba de la formula I: donde R1, A, B y D tienen los significados indicados en la descripcion, y productos intermedios para la preparacion de los mismos. Los compuestos I son adecuados para controlar enfermedades.
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公开(公告)号：MX9706069A
公开(公告)日：1997-10-31
申请号：MX9706069
申请日：1996-02-12
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K31/00 , A61K38/55 , A61P7/02 , C07D205/04 , C07D207/16 , C07D213/53 , C07D213/63 , C07D213/72 , C07D213/78 , C07D213/79 , C07D239/28 , C07D241/14 , C07D241/24 , C07D401/12 , C07K5/06 , C07K5/062 , C07K5/078 , C07K05/06 , A61K31/40 , A61K31/445
Abstract: Se describen compuestos de la Formula (I): en los cuales A, B, D, R1 y R2 tienen los significados indicados en la memoria. Los compuestos son apropiados para combatir enfermedades. Los nuevos compuestos se preparan usando un compuesto intermedio de la formula donde G y M tienen los significados indicados en la cláusula 4.
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公开(公告)号：CZ371396A3
公开(公告)日：1997-10-15
申请号：CZ371396
申请日：1995-06-06
Applicant: BASF AG
Inventor： BOHM HANS-JOACHIM , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , HOFFKEN HANS WOLFGANG , HORNBERGER WILFRIED
IPC: A61K31/40 , A61K38/00 , A61K38/05 , A61K38/55 , A61K47/48 , A61P7/02 , C07C279/00 , C07D205/04 , C07D207/06 , C07D207/16 , C07D207/48 , C07D211/60 , C07K5/06 , C07K5/065 , C07K5/072 , C07K5/078
Abstract: Compounds of the formula and the salts thereof with physiologically tolerated acids and the stereoisomers thereof, in which the substituents have the meanings stated in the description, are described. Also disclosed are intermediates for their preparation. The compounds are suitable for controlling diseases.
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公开(公告)号：ZA961276B
公开(公告)日：1997-08-19
申请号：ZA961276
申请日：1996-02-19
Applicant: BASF AG
Inventor： BOEHM HANS-JOACHIM , HOEFFKEN HANS WOLFGANG , HORNBERGER WILFRIED , KOSER STEFAN , MACK HELMUT , PFEIFFER THOMAS , SEITZ WERNER , ZIERKE THOMAS
IPC: A61K20060101 , C07K20060101 , C12N20060101 , C07K , A61K , C12N
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