公开(公告)号：AU2003229691A1

公开(公告)日：2003-10-27

申请号：AU2003229691

申请日：2003-04-16

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N1/15 ,  C12N9/10 ,  C12N15/09 ,  C12P11/00 ,  C12P13/12 ,  C12R1/15 ,  C12N15/63

Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.

公开(公告)号：AU2002361951A1

公开(公告)日：2003-05-19

申请号：AU2002361951

申请日：2002-10-31

Applicant: BASF AG

Inventor： SCHRODER HARTWIG ,  ZELDER OSKAR ,  KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  HABERHAUER GREGOR ,  POMPEJUS MARKUS

IPC: C07K14/34 ,  C12N1/21 ,  C12N9/00 ,  C12P13/08 ,  C12R1/15 ,  C12N15/77 ,  C12Q1/68 ,  C12P1/04 ,  C12N15/63

Abstract: Isolated nucleic acid (I) that encodes any of 50 amino acid sequences (II) that have, at specific positions, an amino acid (aa) alteration. The specification includes (i) a table identifying the function of (II) and the nature/position of the amino acid exchange and (ii) sequences for (I) and (II). Independent claims are also included for the following: (1) vector that contains at least one (I); (2) host cell transfected with at least one vector of component (1); and (3) preparing fine chemicals by culturing cells of component (2).

公开(公告)号：AU2002361950A1

公开(公告)日：2003-05-19

申请号：AU2002361950

申请日：2002-10-31

Applicant: BASF AG

Inventor： HABERHAUER GREGOR ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  KROGER BURKHARD ,  POMPEJUS MARKUS

IPC: C12N1/21 ,  C12N15/52 ,  C12P13/04 ,  C12N15/77 ,  C12N15/00

Abstract: The invention relates to novel nucleic acid molecules, to the use thereof for constructing genetically improved microorganisms and to methods for preparing fine chemicals, in particular amino acids, with the aid of said genetically improved microorganisms.

公开(公告)号：CA2321264A1

公开(公告)日：1999-08-26

申请号：CA2321264

申请日：1999-02-17

Applicant: BASF AG

Inventor： SCHRODER HARTWIG

IPC: C12N15/09 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N9/10 ,  C12N15/54 ,  C12N15/60 ,  C12P17/18 ,  C12R1/19

Abstract: The invention relates to a genetic recombination product, containing an Sadenosyle-methionine-synthase gene, with the sequence SEQ ID no. 1 and a biotin biosynthesis gene bioS1, bioS2 and/or bioS3 with the sequences SEQ ID no. 3, SEQ ID no. 5 or SEQ ID no.7 and possibly at least one additional biotin synthesis gene sequence chosen from the group bioA, bioB, bioF, bioC, bioD, bioH, bioP, bioW, bioX, bioY or bioR. The invention also relates to organisms containing said genetic recombination product and to the use of same for producing biotin, as well as to a method for producing biotin.