公开(公告)号：CA2546847A1

公开(公告)日：2005-12-22

申请号：CA2546847

申请日：2004-12-17

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  KIEFER PATRICK ,  HEINZLE ELMAR ,  ZELDER OSKAR ,  WITTMANN CHRISTOPH ,  HAFNER STEFAN

IPC: C12P13/08 ,  C12N1/21 ,  C12N9/12 ,  C12N15/54 ,  C12P20060101

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2004320598A1

公开(公告)日：2005-12-22

申请号：AU2004320598

申请日：2004-12-17

Applicant: BASF AG

Inventor： WITTMANN CHRISTOPH ,  HEINZLE ELMAR ,  SCHRODER HARTWIG ,  ZELDER OSKAR ,  KIEFER PATRICK ,  KROGER BURKHARD ,  HAFNER STEFAN ,  KLOPPROGGE CORINNA

IPC: C12P13/08 ,  C12P20060101

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2003242537A1

公开(公告)日：2003-12-02

申请号：AU2003242537

申请日：2003-05-13

Applicant: BASF AG

Inventor： KLOPPROGGE CORINNA ,  ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  LEE HEUNG-SHICK

IPC: C12N15/09 ,  C07K14/34 ,  C12N15/31 ,  C12P13/08

Abstract: Isolated polypeptide sequence having the sequence of SEQ ID NO:1 or muteins thereof having the ability to bind cAMP and repress the expression of the aceB gene of C. glutamicum and which can be obtained from SEQ ID NO:1 by inserting, deleting or substituting up to 20% of the amino acids.

公开(公告)号：NO20062494L

公开(公告)日：2006-09-06

申请号：NO20062494

申请日：2006-05-31

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12N9/16

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i.e., fructose-1,6-bisphosphatase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of fructose-1,6-bisphosphatase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：AU2003264109A1

公开(公告)日：2004-04-30

申请号：AU2003264109

申请日：2003-08-26

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KROGER BURKHARD

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12 ,  C12R1/15

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with O-acetylhomoserine-sulfhydrolase (metY) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：AU2003264108A1

公开(公告)日：2004-04-30

申请号：AU2003264108

申请日：2003-08-26

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N15/09 ,  C12P13/04 ,  C12P13/12

Abstract: Method for fermentative production of at least one sulfur-containing fine chemical (I) by fermenting a (I)-producing coryneform bacterium (A); concentrating (I) in medium or cells, then isolating it. (A) expresses at least one heterologous nucleotide sequence (II) that encodes a protein (III) with homoserine O-acetyltransferase (metA) activity. An Independent claim is also included for preparation of a feed additive (B) that contains L-methionine by culturing/fermenting an L-Met producing microorganisms; removing water from the fermentation broth and optionally also up to 100% of the biomass, then drying the treated broth to recover (B) in powdered or granular form.

公开(公告)号：NO20062447L

公开(公告)日：2006-09-14

申请号：NO20062447

申请日：2006-05-30

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12P20060101

Abstract: The present invention features methods of increasing the production of a fine chemical, e.g., lysine from a microorganism, e.g., Corynebacterium by way of deregulating an enzyme encoding gene, i. e., glycerol kinase. In a preferred embodiment, the invention provides methods of increasing the production of lysine in Corynebacterium glutamicum by way of increasing the expression of glycerol kinase activity. The invention also provides a novel process for the production of lysine by way of regulating carbon flux towards oxaloacetate (OAA). In a preferred embodiment, the invention provides methods for the production of lysine by way of utilizing fructose or sucrose as a carbon source.

公开(公告)号：NO20062447A

公开(公告)日：2006-09-14

申请号：NO20062447

申请日：2006-05-30

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KIEFER PATRICK ,  WITTMANN CHRISTOPH ,  KLOPPROGGE CORINNA ,  HEINZLE ELMAR

IPC: C12P13/08 ,  C12P20060101

CPC classification number: C12P13/08

公开(公告)号：AU2003238385A8

公开(公告)日：2003-12-12

申请号：AU2003238385

申请日：2003-05-23

Applicant: BASF AG

Inventor： ZELDER OSKAR ,  KROGER BURKHARD ,  SCHRODER HARTWIG ,  HAFNER STEFAN ,  KLOPPROGGE CORINNA

IPC: C12N15/09 ,  C12N1/21 ,  C12N9/10 ,  C12P13/12 ,  C12R1/15

Abstract: The invention relates to methods for the production of sulfur-containing fine chemicals, in particular L-methionine, by fermentation using bacteria in which a nucleotide sequence encoding an S-adenosylmethionine synthase (metK) gene is expressed.

公开(公告)号：AU2003229691A1

公开(公告)日：2003-10-27

申请号：AU2003229691

申请日：2003-04-16

Applicant: BASF AG

Inventor： KROGER BURKHARD ,  ZELDER OSKAR ,  KLOPPROGGE CORINNA ,  SCHRODER HARTWIG ,  HAFNER STEFAN

IPC: A23K1/00 ,  A23K1/16 ,  C12N1/15 ,  C12N9/10 ,  C12N15/09 ,  C12P11/00 ,  C12P13/12 ,  C12R1/15 ,  C12N15/63

Abstract: The invention relates to methods for the fermentative production of sulfur-containing fine chemicals, in particular L-methionine, by using bacteria which express a nucleotide sequence coding for a methionine synthase (metH) gene.