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    3-SUBSTITUTED PYRIDO [3',4': 4,5] THIENO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE
    87.
    发明专利
    3-SUBSTITUTED PYRIDO [3',4': 4,5] THIENO [2,3-D] PYRIMIDINE DERIVATIVES, THEIR PREPARATION AND USE 未知

    公开(公告)号：MY132993A

    公开(公告)日：2007-10-31

    申请号：MYPI9802644

    申请日：1998-06-13

    Applicant: BASF AG

    Inventor： BACH ALFRED ,  STARCK DOROTHEA DR ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ ,  STEINER GERD DR ,  TESCHENDORF HANS-JURGEN ,  WICKE KARSTEN ,  DULLWEBER UTA

    IPC: A61K31/495 ,  A61K31/505 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/14

    Abstract: 3-SUBSTITUTED 3,4,S,6,7,8-HEXAHYDROPYRIDO [3',4':4,5]-THIENO[2,3-D]PYRIRNIDINE DERIVATIVES OF THE FORMULA I WHERE RL IS A HYDROGEN ATOM, A CL-C4-ALKYL GROUP, AN ACETYL GROUP, A PHENYLALKYL CL-C4 RADICAL, THE AROMATIC SYSTEM BEING UNSUBSTITUTED OR SUBSTITUTED BY HALOGEN, CL-C4-ALKYL, TRIFLUOROMETHYL, HYDROXYL, CL-C4-ALKOXY, AMINO, CYANO OR NITRO GROUPS, OR IS A PHENYLALKANONE RADICAL, IT BEING POSSIBLE FOR THE PHENYL GROUP TO BE SUBSTITUTED BY HALOGEN, R2 IS A PHENYL, PYRIDYL, PYRIMIDINYL OR PYRAZINYL GROUP WHICH IS UNSUBSTITUTED OR'MONO- OR DISUBSTITUTED BY HALOGEN ATOMS, CL-C4-ALKYL, TRIFLUOROMETHYL, TRIFLUOROMETHOXY, HYDROXYL, CL-C4- ALKOXY, AMINO, MONOMETHYLAMINO, DIMETHYLAMINO, CYANO OR NITRO GROUPS AND WHICH MAY BE FUSED TO A BENZENE NUCLEUS WHICH CAN BE UNSUBSTITUTED OR MONO- OR DISUBSTITUTED BY HALOGEN ATOMS, CL-C4 ALKYL, HYDROXYL, TRIFLUOROMETHYL, CL-C4-ALKOXY, AMINO, CYANO OR NITRO GROUPS AND MAY CONTAIN 1 NITROGEN ATOM, OR TO A 5- OR 6-MEMBERED RING WHICH MAY CONTAIN 1-2 OXYGEN ATOMS, A IS NH OR AN OXYGEN ATOM, Y IS CH2, CH2-CH2, CH2-CH2-CH2 OR CH2-CH, Z IS A NITROGEN ATOM, CARBON ATOM OR CH, IT ALSO BEING POSSIBLE FOR THE LINKAGE BETWEEN Y AND Z TO BE A DOUBLE BOND, AND N IS 2, 3 OR 4, AND THE PHYSIOLOGICALLY TOLERATED SALTS THEREOF.

    3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives, process of their preparation and use
    90.
    发明专利
    3-Substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives, process of their preparation and use 未知

    公开(公告)号：CZ290464B6

    公开(公告)日：2002-07-17

    申请号：CZ443199

    申请日：1998-05-29

    Applicant: BASF AG

    Inventor： STEINER GERD ,  DULLWEBER UTA ,  STARCK DOROTHEA ,  BACH ALFRED ,  WICKE KARSTEN ,  TESCHENDORF HANS-JURGEN ,  GARCIA-LADONA FRANCISCO-JAVIER ,  EMLING FRANZ

    IPC: A61K31/495 ,  A61K31/519 ,  A61P25/00 ,  A61P25/24 ,  A61P43/00 ,  C07D495/04

    Abstract: In the present invention there are disclosed 3-substituted 3,4-dihydrothieno[2,3-d]pyrimidine derivatives of the general formula I, in which Re1 and Re2 represent a hydrogen atom or an alkyl group containing 1 to 4 carbon atoms, Re3 represents a phenyl, pyridyl, pyrimidinyl or pyrazinyl group, which can be optionally mono- or disubstituted with a halogen atom or with the following groups; alkyl containing 1 to 4 carbon atoms, trifluoromethyl, trifluoromethoxy, hydroxy, alkoxy containing 1 to 4 carbon atoms, amino, monomethylamino, dimethylamino, cyano or nitro and which can be condensed with a benzene nucleus that can be optionally mono- or disubstituted with a halogen atom or with the following groups; alkyl containing 1 to 4 carbon atoms, hydroxy, trifluoromethyl, alkoxy containing 1 to 4 carbon atoms, amino, cyano or nitro and which can optionally contain 1 nitrogen atom, or with 5- or 6-membered ring that can contain 1 to 2 oxygen atoms, A represents NH or an oxygen atom, Y represents CHi2, CHi2-CHi2, CHi2-CHi2-CHi2 or CHi2-CH, Z represents a nitrogen atom, a carbon atom or CH, whereby the bond between Y and Z can be also a double bond and n is 2, 3 or 4, and their physiologically acceptable salts. The invented derivatives are intended for treating depressions and related disorders with activity as selective antagonist 5-HTi1B and 5-HTi1A.

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