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    Organisms for the production of 1,3-butanediol
    85.
    发明专利
    Organisms for the production of 1,3-butanediol 未知

    公开(公告)号：AU2013202628B2

    公开(公告)日：2016-03-10

    申请号：AU2013202628

    申请日：2013-04-05

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  BURK MARK J ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/21 ,  C12N1/20 ,  C12P7/16 ,  C12P7/18

    Abstract: A non-naturally occurring microbial organism includes a microbial organism having a 1,3-butanediol (1,3-BDO) pathway having at least one exogenous nucleic acid encoding a 1,3 BDO pathway enzyme expressed in a sufficient amount to produce 1,3-BDO. The pathway includes an enzyme selected from a 2-amino-4-ketopentanoate (AKP) thiolase, an AKP dehydrogenase, a 2-amino-4-hydroxypentanoate aminotransferase, a 2-amino-4 hydroxypentanoate oxidoreductase (deaminating), a 2-oxo-4-hydroxypentanoate decarboxylase, a 3-hydroxybutyraldehyde reductase, an AKP aminotransferase, an AKP oxidoreductase (deaminating), a 2,4-dioxopentanoate decarboxylase, a 3-oxobutyraldehyde reductase (ketone reducing), a 3-oxobutyraldehyde reductase (aldehyde reducing), a 4-hydroxy-2-butanone reductase, an AKP decarboxylase, a 4-aminobutan-2-one aminotransferase, a 4-aminobutan-2 one oxidoreductase (deaminating), a 4-aminobutan-2-one ammonia-lyase, a butenone hydratase, an AKP ammonia-lyase, an acetylacrylate decarboxylase, an acetoacetyl-CoA reductase (CoA dependent, aldehyde forming), an acetoacetyl-CoA reductase (CoA-dependent, alcohol forming), an acetoacetyl-CoA reductase (ketone reducing), a 3-hydroxybutyryl-CoA reductase (aldehyde forming), a 3-hydroxybutyryl-CoA reductase (alcohol forming), a 4-hydroxybutyryl CoA dehydratase, and a crotonase. A method for producing 1,3-BDO, includes culturing such microbial organisms under conditions and for a sufficient period of time to produce 1,3-BDO. Cl) 74 c I- o9 Co 0 MA C6 ~ 4) a CN m~ N' zI

    MICROORGANISMOS Y METODOS PARA LA BIOSINTESIS DE BUTADIENO.
    86.
    发明专利
    MICROORGANISMOS Y METODOS PARA LA BIOSINTESIS DE BUTADIENO. 未知

    公开(公告)号：MX336229B

    公开(公告)日：2016-01-08

    申请号：MX2012012827

    申请日：2011-05-04

    Applicant: GENOMATICA INC

    Inventor： PHARKYA PRITI ,  BURGARD ANTHONY P ,  OSTERHOUT ROBIN E ,  BURK MARK J ,  SUNJUN

    IPC: C12P7/02 ,  C12N1/20 ,  C12N1/21 ,  C12P5/02 ,  C12P7/16

    Abstract: La presente invención se refiere a organismos microbianos que no se encuentran en la naturaleza que tienen una trayectoria butadieno. La invención adicionalmente proporciona métodos para utilizar tales organismos para producir butadieno. Un organismo microbiano de origen no natural que comprende, una senda biosintética para la producción de alcohol crotílico en donde dicha senda biosintética comprende por lo menos un ácido nucleico exógeno que codifica por lo menos una enzima de senda metabólica expresada en una cantidad suficiente para producir alcohol crotílico, en donde dicha enzima de la senda metabólica se selecciona a partir del grupo que consiste en una reductasa de4 crotonil-CoA, (formadora de aldehído), una reductasa de crotonaldehído (formadora de alcohol), una hidrolasa, sintetasa o transferasa, una reductasa de crotonil-CoA, una reductasa de crotonato, y una reductasa de crotonil-CoA (formadora de alcohol). Un método para la producción de alcohol crotílico que comprende cultivar el organismo microbiano de origen no natural, bajo condiciones y durante un periodo de tiempo suficiente para producir alcohol crotílico.

    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO
    87.
    发明专利
    MICROORGANISMS FOR PRODUCING 1,4-BUTANEDIOL AND METHODS RELATED THERETO 未知

    公开(公告)号：AU2015249173A1

    公开(公告)日：2015-11-26

    申请号：AU2015249173

    申请日：2015-10-30

    Applicant: GENOMATICA INC

    Inventor： BURGARD ANTHONY P ,  SUN JUN ,  OSTERHOUT ROBIN E ,  PHARKYA PRITI

    IPC: C12N1/12 ,  C12P7/04

    Abstract: The invention provides non-naturally occurring microbial organisms comprising a 1,4-butanediol (BDO), 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine pathway comprising at least one exogenous nucleic acid encoding a BDO, 4 hydroxybutyryl-CoA, 4- hydroxybutanal or putrescine pathway enzyme expressed in a sufficient amount to produce BDO, 4-hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine and further optimized for expression of BDO. The invention additionally provides methods of using such microbial organisms to produce BDO, 4 hydroxybutyryl-CoA, 4-hydroxybutanal or putrescine.

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