公开(公告)号：BG64075B1

公开(公告)日：2003-12-31

申请号：BG10202197

申请日：1997-11-05

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/135 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/08 ,  B05D5/08 ,  B05D7/22 ,  B05D7/24 ,  B65D83/14 ,  B65D85/14

Abstract: The inhaler has partially or completely covered inner surfaces with one or more fluorohydrocarbon polymers, optionally in a combination with one or more non-fluorohydrocarbon polymers. It is used for dosing inhalation medicaments consisting of albuterol or its physiologically acceptable salt and flurorhydrocarbon propellent, optionally in combination with one or more pharmacologically active substances in one or more fillers. 23 claims

公开(公告)号：RO118564B1

公开(公告)日：2003-07-30

申请号：RO9700561

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/72 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: Prezenta invenţie se referă la o compoziţie farmaceutică de aerosol, pentru utilizarea în administrarea medicamentelor prin inhalare, în tratamentul medical. Compoziţia farmaceutică de aerosol, conform invenţiei, cuprinde 0,005 până la 10% în greutate din unul sau mai multe medicamente sub formă de particule, raportat la greutatea totală a compoziţiei, unul sau mai mulţi agenţi propulsori pe bază de fluorocarburi sau clorofluorocarburi, care conţin hidrogen, şi 0,05 până la 15% în greutate, raportat la medicament, dintr-un agent tensioactiv cu formula generală Ia sau Ib: în care Rreprezintă: R-(CH)-(CH=CH)-(CH)-(CH=CH)-(CH)-A-; R-(CH)-OCHCH(CHOH)-CH-A-; R-(CH)g-OCHCH(CHOH)-A-.

公开(公告)号：OA10626A

公开(公告)日：2001-04-24

申请号：OA70104

申请日：1997-10-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: A metered dose inhaler characterised in that part or all of its internal surfaces are coated with a polymer blend of one or more fluorocarbon polymers in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising salmeterol, or a physiologically acceptable salt thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients, wherein a) the fluorocarbon polymer is selected from the group consisting of PTFE, PFA, FEP and mixtures thereof, b) the non-fluorocarbon polymer is selected from the group consisting of polyamideimides, polyimides, polyethersulfones, polyphenylene sulfides and amine-formaldehyde thermosetting resins, (c) the inhaler comprises a can made of metal whose interior surfaces are coated with the polymer blend.

公开(公告)号：SK281519B6

公开(公告)日：2001-04-09

申请号：SK39397

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：OA10624A

公开(公告)日：2001-03-15

申请号：OA70102

申请日：1997-10-10

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61K9/12 ,  A61K31/56 ,  A61K31/569 ,  A61M15/00 ,  A61M15/08 ,  A61M16/00 ,  A61P11/00 ,  B05D5/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising fluticasone propionate, or a physiologically acceptable solvate thereof, and a fluorocarbon propellant optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：AP835A

公开(公告)日：2000-05-12

申请号：AP9701112

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  RIEBE MICHAEL T ,  LI-BOVET LI

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14 ,  A61

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fiuorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.

公开(公告)号：DE69513671T2

公开(公告)日：2000-04-06

申请号：DE69513671

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH

IPC: A61K9/00 ,  A61K9/72 ,  A61K9/12 ,  A61K47/06 ,  C07F9/09 ,  C07F9/10 ,  C09K23/20

Abstract: PCT No. PCT/IB95/00866 Sec. 371 Date Mar. 27, 1997 Sec. 102(e) Date Mar. 27, 1997 PCT Filed Sep. 27, 1995 PCT Pub. No. WO96/09816 PCT Pub. Date Apr. 4, 1996 (I) A pharmaceutical aerosol formulation which comprises particulate medicament, a fluorocarbon of hydrogen-containing chlorofluorocarbon propellant and a surfactant of general formula (I), wherein n is an integer of 1 to 18; m is an integer of 0 to 17; and R1, R2 and R3 are each independently a hydrogen atom or a C1-4alkyl group.

公开(公告)号：SI0783302T1

公开(公告)日：2000-02-29

申请号：SI9530345

申请日：1995-09-27

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  JOHNSON KEITH ARTHUR

IPC: A61K9/72 ,  C07F9/10

公开(公告)号：BG102022A

公开(公告)日：1998-07-31

申请号：BG10202297

申请日：1997-11-05

Applicant: GLAXO WELLCOME INC

Inventor： ASHURST IAN C ,  HERMAN CRAIG S ,  LI-BOVET LI ,  RIEBE MICHAEL T

IPC: A61M15/00 ,  B05D5/08 ,  B65D83/00 ,  B65D83/14

Abstract: The inhaler is used for metering of inhalation medicamentouscompositions including salmetrol or its physiologically acceptablesalt and hydrogen fluoride propellant, optionally in combinationwith one or more other phyrmacologically active substances and oneor more fillers. It has partially or completely covered innersurfaces with one or more hydrogen fluoride polymers, optionallyin combination with one or more non hydrogen fluoride polymers.22 claims

公开(公告)号：BR9604979A

公开(公告)日：1998-06-09

申请号：BR9604979

申请日：1996-04-11

Applicant: GLAXO WELLCOME INC

Inventor： LI-BOVET LI ,  ASHURST IAN C ,  RIEBE MICHAEL T ,  HERMAN CRAIG S

IPC: B65D83/38 ,  A61K9/00 ,  A61K9/12 ,  A61K9/72 ,  A61K31/137 ,  A61K31/57 ,  A61K31/573 ,  A61M15/00 ,  A61P11/00 ,  B05D5/08 ,  B65D83/14

Abstract: A metered dose inhaler having part or all of its internal surfaces coated with one or more fluorocarbon polymers, optionally in combination with one or more non-fluorocarbon polymers, for dispensing an inhalation drug formulation comprising beclomethasone dipropionate or a physiologically acceptable solvate thereof, and a fluorocarbon propellant, optionally in combination with one or more other pharmacologically active agents or one or more excipients.