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公开(公告)号：JP2007330255A
公开(公告)日：2007-12-27
申请号：JP2007125905
申请日：2007-05-10
Inventor： SAWADA KAZUHISA , ARA KATSUTOSHI
Abstract: PROBLEM TO BE SOLVED: To obtain a recombinant microorganism improved in productivity of proteins or peptides and to provide a method for producing the proteins or peptides using the recombinant microorganism. SOLUTION: The recombinant microorganism is obtained by introducing a gene coding for the objective protein or peptide to a microorganism strain deleted or inactivated with any of at least one gene of any of Bacillus subtilis genes ptsG, sucC, sucD, proJ, asnO, asnH, argH, rocG, rocA or rocF, or genes corresponding to the above described genes. COPYRIGHT: (C)2008,JPO&INPIT
Abstract translation: 待解决的问题：获得提高蛋白质或肽的生产力的重组微生物，并提供使用重组微生物生产蛋白质或肽的方法。 解决方案：通过使用任何枯草芽孢杆菌基因ptsG，sucC，sucD，proJ，asnO中的至少一种基因将缺失或失活的微生物菌株引入编码目的蛋白质或肽的基因来获得重组微生物 ，asnH，argH，rocG，rocA或rocF，或与上述基因相对应的基因。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2007306912A
公开(公告)日：2007-11-29
申请号：JP2006257911
申请日：2006-09-22
Inventor： ENDO KEIJI , RYU SEIKO , ARA KATSUTOSHI
Abstract: PROBLEM TO BE SOLVED: To provide a recombinant microorganism improved with productivity of a protein or polypeptide, and a method for producing the protein or polypeptide by using the recombinant microorganism.
SOLUTION: This recombinant microorganism is provided by introducing a gene encoding the objective protein or polypeptide into a microorganism strain obtained by introducing a transcription initiation-regulating region or the transcription initiation-regulating region and a ribosome-binding region having a function in the microorganism to the upstream of the genome of a Bacillus subtilis prsA gene or a gene corresponding to that gene, or introducing a gene fragment obtained by joining the transcription initiation-regulating region or the transcription initiation-regulating region and the ribosome-binding region having the function in the microorganism to the upstream of the Bacillus subtilis prsA gene or a gene corresponding to that gene, and also deleting or inactivating ywhA gene, yvbA gene, yjbI gene or yllB gene, or a gene corresponding to the above genes.
COPYRIGHT: (C)2008,JPO&INPITAbstract translation: 待解决的问题：提供以蛋白质或多肽的生产力提高的重组微生物，以及通过使用重组微生物产生蛋白质或多肽的方法。 解决方案：通过将编码目的蛋白质或多肽的基因导入通过引入转录起始调节区或转录起始调节区和具有功能的核糖体结合区而获得的微生物菌株来提供该重组微生物 将微生物加入到枯草芽孢杆菌prsA基因的基因组的上游或与该基因相对应的基因，或者引入通过连接转录起始调节区或转录起始调节区获得的基因片段和具有 微生物对枯草芽孢杆菌prsA基因上游的功能或与该基因相对应的基因的功能，以及缺失或失活ywhA基因，yvbA基因，yjbI基因或yllB基因或与上述基因相对应的基因。 版权所有（C）2008，JPO＆INPIT
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公开(公告)号：JP2007130013A
公开(公告)日：2007-05-31
申请号：JP2006258829
申请日：2006-09-25
Applicant: Kao Corp , Nara Institute Of Science & Technology , 国立大学法人 奈良先端科学技術大学院大学 , 花王株式会社
Inventor： KADOYA KYOSUKE , ENDO KEIJI , TOHATA MASATOSHI , ARA KATSUTOSHI , OGASAWARA NAOKI
Abstract: PROBLEM TO BE SOLVED: To provide a new Bacillus subtilis mutant strain excellent in the productivity of various enzymes through comprehensively analyzing gene-disrupted strains derived from Bacillus subtilis. SOLUTION: The new Bacillus subtilis mutant strain has a genomic structure having the deletion of any one of the regions shown in the deleted region list. The Bacillus subtilis mutant strain shows a significantly improved ability of secreting and producing a desired secreted protein when a gene encoding the protein is expressably introduced into the strain, compared to a case where the gene is introduced into a wild-type strain. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 要解决的问题：通过全面分析源自枯草芽孢杆菌的基因破坏菌株，提供优异的各种酶的生产力的新的枯草芽孢杆菌突变菌株。 解决方案：新的枯草芽孢杆菌突变菌株具有删除缺失区域列表中所示区域的任何一个的基因组结构。 与将基因导入野生型菌株的情况相比，当将编码蛋白质的基因表达性引入菌株时，枯草芽孢杆菌突变菌株显示出分泌和产生所需分泌蛋白质的显着改善的能力。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2007053940A
公开(公告)日：2007-03-08
申请号：JP2005241457
申请日：2005-08-23
Inventor： KAWAMURA FUJIO , SHICHIMIYA HIDEAKI , ENDO KEIJI , ARA KATSUTOSHI , OZAKI KATSUYA
Abstract: PROBLEM TO BE SOLVED: To provide a recombinant microorganism more improved in productivity of a protein or a polypeptide than ever, and to provide a method for producing a target protein or polypeptide using the microorganism.
SOLUTION: This recombinant microorganism is given by introducing a gene which encodes the target protein or polypeptide into a microorganism strain in which any one of operons rrnA and rrnD of Bacillus subtilis or not less than one operon of any of operons corresponding to the operons is deleted or deactivated.
COPYRIGHT: (C)2007,JPO&INPITAbstract translation: 待解决的问题：提供比以往任何时候更好地提高蛋白质或多肽的生产力的重组微生物，并提供使用该微生物产生靶蛋白或多肽的方法。 解决方案：通过将编码靶蛋白或多肽的基因导入到枯草芽孢杆菌中的任何一个操纵子rrnA和rrnD或不少于一个与其对应的操纵子的一个操纵子的微生物菌株中， 操作符被删除或停用。 版权所有（C）2007，JPO＆INPIT
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公开(公告)号：JP2007049987A
公开(公告)日：2007-03-01
申请号：JP2006185623
申请日：2006-07-05
Inventor： ENDO KEIJI , RYU SEIKO , ARA KATSUTOSHI
CPC classification number: Y02P20/52
Abstract: PROBLEM TO BE SOLVED: To provide a microorganism whose target protein or polypeptide productivity is improved. SOLUTION: This recombinant microorganism is obtained by transducing a gene encoding a target protein or polypeptide into a microorganism obtained by transducing the transcription start control region functioning in a microorganism or the transcription start control region and a ribosome-bound site into an upstream on the genome of Bacillus subtilis prs A gene or a gene corresponding to the gene, or by transducing a gene fragment connected to the upstream of Bacillus subtilis prs A gene or a gene corresponding to the gene, with the transcription start control region functioning in a microorganism or the transcription start control region and a ribosome-bound site and deleting or inactivating a spore-related gene or flagellum-related gene or one or more of genes corresponding to these genes. COPYRIGHT: (C)2007,JPO&INPIT
Abstract translation: 待解决的问题：提供其目标蛋白质或多肽生产力提高的微生物。 解决方案：通过将编码目标蛋白质或多肽的基因转导到通过将微生物中起作用的转录起始控制区或转录起始控制区和与核糖体结合的位点转化为上游的微生物而获得该重组微生物 在枯草芽孢杆菌prs A的基因组上或与该基因相对应的基因，或通过转录连接到枯草芽孢杆菌prsA基因或相应于该基因的基因的上游的基因片段，转录起始控制区域在 微生物或转录起始控制区和核糖体结合位点，并删除或灭活孢子相关基因或鞭毛相关基因或与这些基因相对应的一个或多个基因。 版权所有（C）2007，JPO＆INPIT
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Patent Agency Ranking
公开(公告)号：JP2006345860A
公开(公告)日：2006-12-28
申请号：JP2006139335
申请日：2006-05-18
Applicant: UNIV SHINSHU , KAO CORP
Inventor： KODAMA TAKEKO , SEKIGUCHI JUNICHI , ENDO KEIJI , ARA KATSUTOSHI , OZAKI KATSUYA
Abstract: PROBLEM TO BE SOLVED: To provide a recombinant Bacillus bacterium having improved productivity of a protein or a polypeptide; and to provide a method for producing the protein or the polypeptide by using the bacteria. SOLUTION: The recombinant Bacillus bacterium is obtained by introducing a DNA fragment containing three regions comprising a transcription initiation-control region, a translation initiation-control region and a secretion signal region of an alkaline cellulase gene derived from the Bacillus bacterium, and a gene encoding the target protein or peptide to a Bacillus bacterium strain in which both of Bacillus subtilis genes spoOA and abrB, or genes corresponding to the genes are deleted or inactivated. The method for producing the protein or the polypeptide uses the recombinant Bacillus bacterium. COPYRIGHT: (C)2007,JPO&INPIT
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公开(公告)号：JP2006006242A
公开(公告)日：2006-01-12
申请号：JP2004190042
申请日：2004-06-28
Inventor： HAYASHI YASUHIRO , ARA KATSUTOSHI , SAITO HIDEKAZU , SEKIGUCHI HIROSHI
CPC classification number: Y02P20/52
Abstract: PROBLEM TO BE SOLVED: To provide an amelogenin-fused protein and a method for producing the same for producing the amelogenin in a good efficiency and in a large amount. SOLUTION: This amelogenin-fused protein obtained by fusing an amelogenin with the carboxy terminal or amino terminal of cystatin; a gene encoding the amelogenin-fused protein; and the method for producing the amelogenin-fused protein characterized by introducing a recombinant vector inserted with the gene into host cells, culturing the obtained transformed body to express the gene and collecting the protein produced/accumulated in the host cell or cultured material are provided. COPYRIGHT: (C)2006,JPO&NCIPI
Abstract translation: 待解决的问题：提供一种以高效率和大量生产朊蛋白原的蛋白质及其生产方法。 解决方案：通过将朊蛋白酶与半胱氨酸蛋白酶抑制剂的羧基末端或氨基末端融合而获得的这种牙釉蛋白融合蛋白; 编码牙合蛋白融合蛋白的基因; 以及用于生成牙合蛋白融合蛋白的方法，其特征在于，将插入有该基因的重组载体导入宿主细胞，培养获得的转化体以表达基因并收集生成/积累在宿主细胞或培养物中的蛋白质。 版权所有（C）2006，JPO＆NCIPI
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公开(公告)号：JP2005047841A
公开(公告)日：2005-02-24
申请号：JP2003204836
申请日：2003-07-31
Inventor： AKIBA SHUNICHI , ARA KATSUTOSHI , KUSUOKU HIROSHI , NISHIZAWA YOSHINORI
CPC classification number: A61K31/202
Abstract: PROBLEM TO BE SOLVED: To obtain a drug useful for maintaining nerves and accelerating their regeneration, preventing or treating diseases relating to the degeneration or injury of nerves by inhibiting the decomposition of apolipoprotein D in the living body.
SOLUTION: The subject apolipoprotein D decomposition inhibitor has lauric acid or oleic acid as an active ingredient. This apolipoprotein D decomposition inhibitor inhibits the decomposition of the apolipoprotein D in the living body, and accordingly, is useful as a drug for maintaining nerves and accelerating their regeneration, preventing or treating schizophrenia and diseases relating to the degeneration or injury of nerves.
COPYRIGHT: (C)2005,JPO&NCIPIAbstract translation: 要解决的问题：通过抑制生物体中载脂蛋白D的分解，获得用于维持神经并加速其再生的药物，预防或治疗与神经的变性或损伤有关的疾病。 解决方案：本发明的载脂蛋白D分解抑制剂具有月桂酸或油酸作为活性成分。 该载脂蛋白D分解抑制剂抑制活体中载脂蛋白D的分解，因此可用作维持神经并加速其再生，预防或治疗精神分裂症和与神经退化或损伤有关的疾病的药物。 版权所有（C）2005，JPO＆NCIPI
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公开(公告)号：JPH11322622A
公开(公告)日：1999-11-24
申请号：JP13353298
申请日：1998-05-15
Applicant: KAO CORP
Inventor： ARA KATSUTOSHI , YOSHIMATSU TADASHI , MEGURO SHINICHI , HASE TADASHI , TOKIMITSU ICHIRO
Abstract: PROBLEM TO BE SOLVED: To obtain a dermatosis improver capable of simply and effectively preventing and improving a dermatosis such as pimple, etc., by including a sporogenous lactic acid bacterium as an active ingredient. SOLUTION: This improver contains a sporogenous lactic acid bacterium as an active ingredient. A bacterium belonging to the genus sporogenous lactic acid bacterium as an active ingredient. A bacterium belonging to the genus Bacillus or Sporolactobacillus is preferable and a bacterium belonging to Bacillus coagulans is more preferable as the sporogenous lactic acid bacterium. In order to form a spore in an ascospore lactic acid bacterium, the environment of the ascospore lactic acid bacterium is made, for example, into an oligotrophic, dried or high-temperature state. The improver is obtained by properly manufacturing a sporogenous lactic acid bacterium into a preparation or processing it into a food form. The improver can prevent and improve dermatitis only by oral intake.
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公开(公告)号：JPH10108651A
公开(公告)日：1998-04-28
申请号：JP26617496
申请日：1996-10-07
Applicant: KAO CORP
Inventor： ARA KATSUTOSHI , OTSUJI KAZUYA
Abstract: PROBLEM TO BE SOLVED: To provide a lactic acid food having excellent flavor and mouth feeling without losing a health effect given from a treated coconut substance and a physiological function given from a fermented milk of lactic acid by subjecting the treated coconut substance (dried substance) to lactic acid fermentation. SOLUTION: The objective food is obtained by diluting a treated coconut substance or its dried substance to 2-50wt.% in water, adding polysaccharides such as glucose, a protein such as gelatin, a milk product, salts, vitamins, spices, a coloring material, etc., sterilizing at 70-130 deg.C for 2sec-30min, adding a starter containing a Lactobacillus and subjecting to lactic acid fermentation at 37-42 deg.C.
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